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| 1 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 2 | Peeling behavior and spalling resistance of CFRP sheets bonded to bent concrete surfaces显示文摘在这份报纸,脱皮的行为和碳纤维的 spalling 抵抗效果增强了聚合物(CFRP ) 表外部地结合了到偏好水泥表面第一试验性地被调查。 21 个弄弯的标本和七个飞机标本在纸,有结合的 CFRP 表的弄弯的标本能在隧道在模仿具体 spalling 被学习,水道电缆,拱门桥等等,而有结合的 CFRP 表的飞机标本能在横梁模仿具体 spalling ,衔接,平板桥牌和步行桥牌。有弯曲的不同半径的三种弄弯的标本被指实际隧道结构选择,并且飞机标本与弄弯的被用于比较。脱皮的负担被装载从弄弯的具体表面放进横梁的中央槽口到 debond CFRP 表的一个圆形的钢试管在 FRP 表上使用,同时完整范围的负担鈥揹e 弯曲曲线被记录由一山 831.10 弹性体测试系统。基于试验性的结果,理论分析也为标本被进行。理论、试验性的结果显示出那二个仅仅材料参数, CFRP 具体的接口的界面的破裂精力和 CFRP 表的张力的僵硬,为描述界面的 spalling 行为被需要。弯曲的半径在剥负担鈥揹e 弯曲曲线上有显著影响,这被发现。在纸给的测试方法和测试结果对隧道加强的设计者的参考有用、可得到。关键词 FRP 表 - 界面的破裂精力 - Debonding - Spalling 抵抗 - 偏好水泥表面工程被广东省的科技的计划支持,中国(2005B32801002 ) 。 | Hong Yuan Faping Li | 2010 | Acta Mechanica Sinica2010，26，2： | 3 |
| 3 | Locating Error Considering Dimensional Errors Modeling for Multistation Manufacturing System显示文摘Multistation machining process is widely applied in contemporary manufacturing environment.Modeling of variation propagation in multistation machining process is one of the most important research scenarios.Due to the existence of multiple variation streams,it is challenging to model and analyze variation propagation in a multi-station system.Current approaches to error modeling for multistation machining process are not explicit enough for error control and ensuring final product quality.In this paper,a mathematic model to depict the part dimensional variation of the complex multistation manufacturing process is formulated.A linear state space dimensional error propagation equation is established through kinematics analysis of the influence of locating parameter variations and locating datum variations on dimensional errors,so the dimensional error accumulation and transformation within the multistation process are quantitatively described.A systematic procedure to build the model is presented,which enhances the way to determine the variation sources in complex machining systems.A simple two-dimensional example is used to illustrate the proposed procedures.Finally,an industrial case of multistation machining part in a manufacturing shop is given to testify the validation and practicability of the method.The proposed analytical model is essential to quality control and improvement for multistation systems in machining quality forecasting and design optimization. | ZHANG Faping LU Jiping TANG Shuiyuan SUN Houfang JIAO Li | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 2 |
| 4 | A polyethylene microsphere-coated separator with rapid thermal shutdown function for lithium-ion batteries显示文摘Thermal runaway is the main factor contributing to the unsafe behaviors of lithium-ion batteries(LIBs)in practical applications.The application of separators for the thermal shutdown has been proven as an effective approach to protecting LIBs from thermal runaway.In this work,we developed a thermal shutdown separator by coating a thin layer of low-density polyethylene microspheres(PM)onto a commercial porous polypropylene(PP)membrane and investigated the thermal response behaviors of the as-prepared PM/PP separator in LIBs.The structural and thermal analysis results revealed that the coated PM layer had a porous structure,which facilitated the occurrence of normal charge-discharge reactions at ambient temperature,although it could melt completely and fuse together within very short time periods:3 s at 110℃and 1 s at 120℃,to block off the pores of the PP substrate,thereby cutting off the ion transportation between the electrodes and interrupting the battery reaction.Consequently,the PM/PP separator exhibits very similar electrochemical performance to that of a conventional separator at ambient temperature.However,it performs a rapid thermal shutdown at an elevated temperature of^110℃,thus controlling the temperature rise and maintaining the cell in a safe status.Due to its synthetic simplicity and low cost,this separator shows promise for possible application in building safe LIBs. | Chongrong Zhang Hui Li Shixuan Wang Yuliang Cao Hanxi Yang Xinping Ai Faping Zhong | 2020 | Journal of Energy Chemistry2020，29，5： | 2 |
| 5 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | Chengfu Yuan Xiuning Huang Li Cheng Youquan Bu Geli Liu Faping Yi Zhengmei Yang Fangzhou Song | 2008 | Food Chemistry2008，，2： | 1 |
| 6 | A New Aim-Points-Choosing Model for Attacking Mobile Missile Systems显示文摘A new aim-points-choosing model for attacking mobile missile systems in sector region is presented and realized in this paper. The model has the generality for attacking mobile target andis also useful for making an operational decision. | Wu Faping Bi Yiding & Li Jingwen(Xi’an Research Inst. of Hi-Tech., HongQing Town, 710025, P. R. China) | 1999 | Journal of Systems Engineering and Electronics1999，10，4： | 0 |
| 7 | Boosting rate and cycling performance of K-doped Na_(3)V_(2)(PO_(4))_(2)F_(3) cathode for high-energy-density sodium-ion batteries显示文摘As a promising cathode material,Na_(3)V_(2)(PO_(4))_(2)F_(3)(NVPF)has attracted wide attention for sodium-ion batteries(SIBs)because of its high operating voltage and high structural stability.However,the low intrinsic electronic conductivity and insufficient Na ion mobility of NVPF limit its development.Herein,K-doping NVPF is prepared through a facile ball-milling combined calcination method.The effects of K-doping on the crystal structure,kinetic properties and electrochemical performance are investigated.The results demonstrate that the Na_(2.90)K_(0.10)V_(2)(PO_(4))_(3)F_(3)(K0.10-NVPF)exhibits a high capacity(120.8 mAh g^(-1) at 0.1 C),high rate capability(66 mAh g^(-1) at 30 C)and excellent cycling performance(a capacity retention of 97.5%at 1 C over 500 cycles).Also,the occupation site of K ions in the lattice,electronic band structure and Na-ion transport kinetic property in K-doped NVPF are investigated by density functional theory(DFT)calculations,which reveals that the K-doped NVPF exhibits improved electronic and ionic conductivities,and located K^(+) ions in the lattice to contribute to high reversible capacity,rate capability and cycling stability.Therefore,the K-doped NVPF serves as a promising cathode material for high-energy and high-power SIBs. | Jiexin Zhang YangYang Lai Peng Li Yanxia Wang Faping Zhong Xiangming Feng Weihua Chen Jianjun Liu Xinping Ai Hanxi Yang Yuliang Cao | 2022 | Green Energy & Environment2022，7，6： | 0 |
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