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| 1 | Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease显示文摘Mitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease(PD),presenting within the form of excessive reactive oxygen species(ROS)generation as well as energy metabolism.Overcoming this dysfunction within brain tissues is an effective approach to treat PD,while unluckily,the blood-brain barrier(BBB)substantially impedes intracerebral drug delivery.In an effort to improve the delivery of efficacious therapeutic drugs to the brain,a drug delivery platform hydrogel(MAG-NCs@Gel)was designed by complexing magnolol(MAG)-nanocrystals(MAG-NCs)into the noninvasive thermosensitive poly(Nisopropylacrylamide)(PNIPAM)with self-gelation.The as-prepared MAG-NCs@Gel exhibited obvious improvements in drug solubility,the duration of residence with the nasal cavity,and the efficiency of brain targeting,respectively.Above all,continuous intranasal MAG-NCs@Gel delivery enabled MAG to cross the BBB and enter dopaminergic neurons,thereby effectively alleviating the symptoms of MPTP-induced PD.Taking advantage of the lower critical solution temperature(LCST)behavior of this delivery platform increases its viscoelasticity in nasal cavity,thus improving the efficiency of MAG-NCs transit across the BBB.As such,MAG-NCs@Gel represented an effective delivery platform capable of normalizing ROS and adenosine triphosphate(ATP)in the mitochondria of dopaminergic neurons,consequently reversing the mitochondrial dysfunction and enhancing the behavioral skills of PD mice without adversely affecting normal tissues. | Yun Tan Yao Liu Yujing Liu Rui Ma Jingshan Luo Huijie Hong Xiaojia Chen Shengpeng Wang Chuntai Liu Yi Zhang Tongkai Chen | 2021 | Research2021，，1： | 1 |
| 2 | Highly Robust and Wearable Facial Expression Recognition via Deep-Learning-Assisted, Soft Epidermal Electronics显示文摘The facial expressions are a mirror of the elusive emotion hidden in the mind,and thus,capturing expressions is a crucial way of merging the inward world and virtual world.However,typical facial expression recognition(FER)systems are restricted by environments where faces must be clearly seen for computer vision,or rigid devices that are not suitable for the time-dynamic,curvilinear faces.Here,we present a robust,highly wearable FER system that is based on deep-learning-assisted,soft epidermal electronics.The epidermal electronics that can fully conform on faces enable high-fidelity biosignal acquisition without hindering spontaneous facial expressions,releasing the constraint of movement,space,and light.The deep learning method can significantly enhance the recognition accuracy of facial expression types and intensities based on a small sample.The proposed wearable FER system is superior for wide applicability and high accuracy.The FER system is suitable for the individual and shows essential robustness to different light,occlusion,and various face poses.It is totally different from but complementary to the computer vision technology that is merely suitable for simultaneous FER of multiple individuals in a specific place.This wearable FER system is successfully applied to human-avatar emotion interaction and verbal communication disambiguation in a real-life environment,enabling promising human-computer interaction applications. | Meiqi Zhuang Lang Yin Youhua Wang Yunzhao Bai Jian Zhan Chao Hou Liting Yin Zhangyu Xu Xiaohui Tan YongAn Huang | 2022 | Research2022，，1： | 0 |
| 3 | Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson’s Disease显示文摘Mitochondrial dysfunction is commonly detected in individuals suffering from Parkinson’s disease(PD),presenting within the form of excessive reactive oxygen species(ROS)generation as well as energy metabolism.Overcoming this dysfunction within brain tissues is an effective approach to treat PD,while unluckily,the blood-brain barrier(BBB)substantially impedes intracerebral drug delivery.In an effort to improve the delivery of efficacious therapeutic drugs to the brain,a drug delivery platform hydrogel(MAG-NCs@Gel)was designed by complexing magnolol(MAG)-nanocrystals(MAG-NCs)into the noninvasive thermosensitive poly(Nisopropylacrylamide)(PNIPAM)with self-gelation.The as-prepared MAG-NCs@Gel exhibited obvious improvements in drug solubility,the duration of residence with the nasal cavity,and the efficiency of brain targeting,respectively.Above all,continuous intranasal MAG-NCs@Gel delivery enabled MAG to cross the BBB and enter dopaminergic neurons,thereby effectively alleviating the symptoms of MPTP-induced PD.Taking advantage of the lower critical solution temperature(LCST)behavior of this delivery platform increases its viscoelasticity in nasal cavity,thus improving the efficiency of MAG-NCs transit across the BBB.As such,MAG-NCs@Gel represented an effective delivery platform capable of normalizing ROS and adenosine triphosphate(ATP)in the mitochondria of dopaminergic neurons,consequently reversing the mitochondrial dysfunction and enhancing the behavioral skills of PD mice without adversely affecting normal tissues. | Yun Tan Yao Liu Yujing Liu Rui Ma Jingshan Luo Huijie Hong Xiaojia Chen Shengpeng Wang Chuntai Liu Yi Zhang Tongkai Chen | 2022 | Research2022，，1： | 0 |
| 4 | 纳米药物在非肌层浸润性膀胱癌灌注治疗中的应用显示文摘膀胱癌是泌尿系统最常见的肿瘤之一,其中非肌层浸润性膀胱癌(NMIBC)占比高达75%以上.鉴于单纯手术治疗后好复发、易进展的特点,多个指南均推荐手术切除结合术后灌注治疗作为其标准治疗方案.化疗作为膀胱灌注治疗的主要手段,对NMIBC治疗具有重要意义.然而,尿液稀释、膀胱排空以及药物直接暴露等多重因素限制,极大地制约了小分子化疗药物在膀胱灌注治疗中的应用.为改善治疗过程的安全性和疗效,多种新型给药装置或技术相继被应用于NMIBC灌注治疗,但仍难以解决毒副作用难题.随着纳米技术的发展,其在膀胱灌注治疗中的应用逐渐受到重视,为灌注治疗过程的安全性改善带来机遇.本文简要总结了目前NMIBC临床治疗或临床研究中的用药方案及新兴给药技术,并对临床NMIBC灌注治疗中所使用的纳米递送技术进行了归纳.进一步结合作者和国内外同行在膀胱灌注化疗纳米药物研究方面所开展的系列研究工作,对本领域的最新研究进展进行了总结,最后对膀胱灌注治疗纳米药物的发展趋势做出展望. | 喻青松 甘志华 | 2023 | 高分子学报2023，54，1： | 0 |
| 5 | 10-羟基喜树碱不同载体材料纳米粒的研究进展显示文摘10-羟基喜树碱(10-hydroxycampothecin,10-HCPT)是从植物喜树中提取的一种天然生物碱,通过靶向肿瘤细胞内拓扑异构酶I而显示出较强的抗肿瘤活性,但是10-HCPT的溶解度低、稳定性差和副作用大,严重限制了药物在临床上的应用。为了提高10-HCPT的溶解度和稳定性,同时实现“减毒增效”的作用,目前已经开发了多种10-HCPT纳米递送系统。本文重点综述采用不同的有机材料和无机材料制备的10-HCPT纳米粒、无载体10-HCPT纳米制剂的研究进展,为更优良的10-HCPT制剂开发提供参考。 | 王志强 黄何松 雷铭道 孙勇兵 | 2023 | 广东药科大学学报2023，39，4： | 0 |
| 6 | Highly Robust and Wearable Facial Expression Recognition via Deep-Learning-Assisted,Soft Epidermal Electronics显示文摘The facial expressions are a mirror of the elusive emotion hidden in the mind,and thus,capturing expressions is a crucial way of merging the inward world and virtual world.However,typical facial expression recognition(FER)systems are restricted by environments where faces must be clearly seen for computer vision,or rigid devices that are not suitable for the time-dynamic,curvilinear faces.Here,we present a robust,highly wearable FER system that is based on deep-learning-assisted,soft epidermal electronics.The epidermal electronics that can fully conform on faces enable high-fidelity biosignal acquisition without hindering spontaneous facial expressions,releasing the constraint of movement,space,and light.The deep learning method can significantly enhance the recognition accuracy of facial expression types and intensities based on a small sample.The proposed wearable FER system is superior for wide applicability and high accuracy.The FER system is suitable for the individual and shows essential robustness to different light,occlusion,and various face poses.It is totally different from but complementary to the computer vision technology that is merely suitable for simultaneous FER of multiple individuals in a specific place.This wearable FER system is successfully applied to human-avatar emotion interaction and verbal communication disambiguation in a real-life environment,enabling promising human-computer interaction applications. | Meiqi Zhuang Lang Yin Youhua Wang Yunzhao Bai Jian Zhan Chao Hou Liting Yin Zhangyu Xu Xiaohui Tan YongAn Huang | 2021 | Research2021，，1： | 0 |
| 7 | 微纳米马达在药物递送的应用进展显示文摘微纳米马达药物递送技术是一种基于药物载体自身可发生自主运动的新型体内药物递送模式,可以在无损模式下促进治疗药物在病变部位的有效富集、滞留与渗透。简述了微纳米马达药物递送技术的研究进展,阐述了微纳米马达的给药方式、药物负载方式、微纳米马达药物递送体系的靶向能力、微纳米马达在生理环境下的药物递送运动、微纳米马达自主运动在提高细胞摄取和组织渗透性方面的促进作用,以及微纳米马达药物递送体系的具体应用案例等,展望了该领域的未来发展趋势。 | 万密密 陈田田 毛春 沈健 | 2021 | 科技导报2021，39，20： | 0 |
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