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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Biological therapy in inflammatory bowel diseases:Access in Central and Eastern Europe显示文摘Biological drugs opened up new horizons in the management of inflammatory bowel diseases(IBD).This study focuses on access to biological therapy in IBD patients across 9 selected Central and Eastern European(CEE)countries,namely Bulgaria,the Czech Republic,Estonia,Hungary,Latvia,Lithuania,Poland,Romania and Slovakia.Literature data on the epidemiology and disease burden of IBD in CEE countries was systematically reviewed.Moreover,we provide an estimation on prevalence of IBD as well as biological treatment rates.In all countries with the exception of Romania,lower biological treatment rates were observed in ulcerative colitis(UC)compared to Crohn’s disease despite the higher prevalence of UC.Great heterogeneity(up to 96-fold)was found in access to biologicals across the CEE countries.Poland,Bulgaria,Romania and the Baltic States are lagging behind Hungary,Slovakia and the Czech Republic in their access to biologicals.Variations of reimbursement policy may be one of the factors explaining the differences to a certain extent in Bulgaria,Latvia,Lithuania,and Poland,but association with other possible determinants(differences in prevalence and incidence,price of biologicals,total expenditure on health,geographical access,and cost-effectiveness results)was not proven.We assume,nevertheless,that healthdeterioration linked to IBD might be valued differently against other systemic inflammatory conditions in distinct countries and which may contribute to the immense diversity in the utilization of biological drugs for IBD.In conclusion,access to biologicals varies widely among CEE countries and this difference cannot be explained by epidemiological factors,drug prices or total health expenditure.Changes in reimbursement policy could contribute to better access to biologicals in some countries. | Fanni Rencz Márta Péntek Martin Bortlik Edyta Zagorowicz Tibor Hlavaty Andrzej Sliwczyński Mihai M Diculescu Limas Kupcinskas Krisztina B Gecse László Gulácsi Peter L Lakatos | 2015 | World Journal of Gastroenterology2015，21，6： | 4 |
| 3 | Pneumocystis jirovecii pneumonia显示文摘 | Emilie C Fanny L Marie EB | 2010 | Infect Dis Clin N Am2010，24，10： | 1 |
| 4 | Interleukin-12 induces sustained activation of fiaultiple host inflammatory mediator systems in chimpanzees 显示文摘 | FANNY N L PASCALE E P DEKKERS A A | 1999 | The Journal of Infectious Diseases1999，179，： | 1 |
| 5 | Impact of subsistence production on the management options to reduce the food exposure of the Martinican population to Chlordecone显示文摘 | CARINE D FANNY H JEAN-CHARLES L | 2007 | Regulatory Toxicology and Pharmacology2007，49，： | 1 |
| 6 | Neural circuitry underlying voluntary suppression of sadness显示文摘 | Johanne Lévesque Fanny Eugène Yves Joanette Vincent Paquette Boualem Mensour Gilles Beaudoin Jean-Maxime Leroux Pierre Bourgouin Mario Beauregard | 2003 | Biological Psychiatry2003，，6： | 1 |
| 7 | Role of endogenous interleuldn-12 in immune response to staphylococcal enterotoxin B in mice 显示文摘 | FANNY N L SANDRINE F PETER S | 2001 | Infection and Immunity2001，69，9： | 1 |
| 8 | Evaluation of seafood toxicity in the Australes archipelago (French Polynesia) using the neuroblastoma cell-based assay显示文摘 | Ralph Pawlowiez HélèneTaiana Darius Philippe Cruchet Fanny Rossi Amandine Caillaud Dominique Laurent Mireille Chinain | 2013 | Food Additives & Contaminants: Part A2013，，3： | 1 |
| 9 | The NLRP3 inflammasomeis activated by nanoparticles through ATP,ADP and adenosine 显示文摘 | Baron L Gombault A Fanny M | 2015 | Cell Death Dis2015，6，： | 1 |
| 10 | c-texture versus a-texture low pressure metalorganic chemical vapor deposition ZnO films: Lower resistivity despite smaller grain size 显示文摘 | Fanni L Aebersold B A Alexander D T L | 2014 | Thin Solid Films2014，565，1： | 1 |
| 11 | Tailoring the sur- face morphology of zinc oxide films for high-performance micromorph solar cells 显示文摘 | Ding L Fanni L Messerschmidt D | 2014 | Solar Energy Materials and So- lar Cells2014，128，1： | 1 |
| 12 | Possibilities for Co(III) dissolution from an oxidized ore through simultaneous bioleaching of pyrite显示文摘 | Léon Zeka Fanny Lambert Jean Frenay Stoyan Gaydardzhiev Augustin IlungaNdala | 2014 | Minerals Engineering2014，，： | 1 |
| 13 | Health technology assessment in Poland, the Czech Republic, Hungary, Romania and Bulgaria显示文摘 | László Gulácsi Alexandru M. Rotar Maciej Niewada Olga L?blová Fanni Rencz Guenka Petrova Imre Boncz Niek S. Klazinga | 2014 | The European Journal of Health Economics2014，，1： | 1 |
| 14 | Transferability of results of cost utility analyses for biologicals in inflammatory conditions for Central and Eastern European countries显示文摘 | László Gulácsi Fanni Rencz Márta Péntek Valentin Brodszky Ruth Lopert Noémi V. Hevér Petra Baji | 2014 | The European Journal of Health Economics2014，，1： | 1 |
| 15 | Clinical manifestations, Laboratory findings, and therapeutic regimen in hospitalized children with brucellosis in an Iranian Referral Children Medical Centre显示文摘 | Fanni F Shahbaznejad L Pourakbari B | 2013 | J Health Popul Nutr2013，31，2： | 1 |
| 16 | Annexin Ⅱ incorporated into influenza virus particles supports virus replication by converting plasminogen into plasmin显示文摘 | FANNY L ERIC M GUUS F R | 2008 | J Virol2008，82，14： | 1 |
| 17 | Potentiation of a Dendritic Cell Vaccine for Murine Renal Cell Carcinoma by CpG Oligonucleotides显示文摘 | Fanny C Simon T Ozdem L | 2005 | Clinical Cancer Research2005，11，2： | 1 |
| 18 | Annexin H inorporated into influenza vires particles supports virus replication by converting plasminogen in- to plasmin显示文摘 | Fanny L Eri M Guus F R | 2008 | J Viral2008，82，14： | 1 |
| 19 | Updated spirumetric referenee values for adult Chinese in Hung Kong and impli- cations on clinical utilization 显示文摘 | Mary Sauman IP Fanny Waisan KO Arthur Chunwing L | 2006 | Chest2006，129，2： | 1 |
| 20 | Seasonal power fluctuations of amorphoussilicon thin-film solar modules:distinguishing betweendifferent contributions显示文摘 | Virtuani A Fanni L | 2014 | Progress in Photovoltaics:Research and Applications2014，22，2： | 1 |
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