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| 1 | Physical design of target station and neutron instruments for China Spallation Neutron Source显示文摘The China Spallation Neutron Source(CSNS)is the first accelerator-based multidiscipline user facility to produce pulsed neutrons by tungsten target under collision of a pulsed proton beam with a beam power of 100 kW at a repetition rate of 25 Hz.In this paper,we focus on the physical design of CSNS target station and neutron instruments.Under optimized design,the flat tungsten target and the compact target-moderator-reflector coupling enhance effective cold and thermal neutron output from moderators.Three wing-type moderators supply four different characteristics of neutrons to 19 beamlines primarily for neutron scattering applications.Layout of neutron instruments are conceptually planned for total 20 beamlines,the configuration and specification have been determined for three day-one neutron instruments.All designs are optimized for the Phase I of 100 kW with a upgradable capacity to 500 kW. | WANG FangWei LIANG TianJiao YIN Wen YU QuanZhi HE LunHua TAO JuZhou ZHU Tao JIA XueJun ZHANG ShaoYing | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，12： | 7 |
| 2 | Rural households’livelihood responses to industry-based poverty alleviation as a sustainable route out of poverty显示文摘Industrialization is one way to achieve a sustainable route out of poverty.During the implementation of industry-based poverty alleviation projects,rural households’livelihood responses to change are crucial.A stronger livelihood response is conducive to multidimensional poverty relief due to industry-based poverty alleviation projects.Effective poverty alleviation can also stimulate stronger household responses.There is a positive cycle between livelihood response and multidimensional poverty relief effects that can help achieve sustainable poverty alleviation goals.Using a synergistic perspective on the relationship between“people–industry–land”,this paper explains the poverty alleviation logic connecting livelihood response,multidimensional poverty relief,and sustainable routes out of poverty by constructing a four-dimensional livelihood response measurement system with three elements of intensity.We analyzed survey data collected from 2363 households from 4 sample counties in 4 contiguous poverty-stricken areas,and measured and compared the characteristics of rural households’livelihood responses and the factors influencing poverty alleviation projects.Rural households’livelihood responses in four sample counties were moderate.The four dimensions of responses were ranked as livelihood strategy response,livelihood space response,livelihood output response,and livelihood capital response.The three intensities indicated that the perception and willingness elements of livelihood response were very similar,but there was a big gap between those elements and livelihood response actions.At the group level,poor households had higher and more consistent livelihood response than non-poor households.External environment factors(such as location,industry type,village organizational ability,and village atmosphere)and internal family factors(such as resource endowment,income sources,health,education,labor quantity,policy trust,credit availability,and social networks)had a significant impact on households’livelihood response.However,this impact varied across different dimensions and had different intensities.This paper proposes a multidimensional poverty relief mechanism and suggests sustainable routes out of poverty. | Jianjun Ding Zhang Wang Yanhong Liu Fangwei Yu | 2020 | Regional Sustainability2020，1，1： | 5 |
| 3 | Insulating materials for realising carbon neutrality:Opportunities,remaining issues and challenges显示文摘The 2050 carbon-neutral vision spawns a novel energy structure revolution,and the construction of the future energy structure is based on equipment innovation.Insulating material,as the core of electrical power equipment and electrified transportation asset,faces unprecedented challenges and opportunities.The goal of carbon neutral and the urgent need for innovation in electric power equipment and electrification assets are first discussed.The engineering challenges constrained by the insulation system in future electric power equipment/devices and electrified transportation assets are investigated.Insulating materials,including intelligent insulating material,high thermal conductivity insulating material,high energy storage density insulating material,extreme environment resistant insulating material,and environmental-friendly insulating material,are cat-egorised with their scientific issues,opportunities and challenges under the goal of carbon neutrality being discussed.In the context of carbon neutrality,not only improves the understanding of the insulation problems from a macro level,that is,electrical power equipment and electrified transportation asset,but also offers opportunities,remaining issues and challenges from the insulating material level.It is hoped that this paper en-visions the challenges regarding design and reliability of insulations in electrical equipment and electric vehicles in the context of policies towards carbon neutrality rules.The authors also hope that this paper can be helpful in future development and research of novel insulating materials,which promote the realisation of the carbon-neutral vision. | Chuanyang Li Yang Yang Guoqiang Xu Yao Zhou Mengshuo Jia Shaolong Zhong Yu Gao Chanyeop Park Qiang Liu Yalin Wang Shakeel Akram Xiaoliang Zeng Yi Li Fangwei Liang Bin Cui Junpeng Fang Lingling Tang Yulin Zeng Xingtao Hu Jiachen Gao Giovanni Mazzanti Jinliang He Jianxiao Wang Davide Fabiani Gilbert Teyssedre Yang Cao Feipeng Wang Yunlong Zi | 2022 | High Voltage2022，7，4： | 4 |
| 4 | High-capacity lithium-rich cathode oxides with multivalent cationic and anionic redox reactions for lithium ion batteries显示文摘Lithium-rich cathode oxides with capability to realize multivalent cationic and anionic redox reactions have attracted much attention as promising candidate electrode materials for high energy density lithium ion batteries because of their ultrahigh specific capacity. However, redox reaction mechanisms, especially for the anionic redox reaction of these materials, are still not very clear. Meanwhile, several pivotal challenges associated with the redox reactions mechanisms, such as structural instability and limited cycle life, hinder the practical applications of these high-capacity lithium-rich cathode oxides. Herein, we review the lithium-rich oxides with various crystal structures. The multivalent cationic/anionic redox reaction mechanisms of several representative high capacity lithium-rich cathode oxides are discussed, attempting to understand the origins of the high lithium storage capacities of these materials. In addition, we provide perspectives for the further development of these lithium-rich cathode oxides based on multivalent cationic and anionic redox reactions, focusing on addressing the fundamental problems and promoting their practical applications. | Enyue Zhao Xiqian Yu Fangwei Wang Hong Li | 2017 | Science China Chemistry2017，60，12： | 3 |
| 5 | Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice显示文摘 | Ying Chen Cuiying Li Dong Weng Laiyu Song Wen Tang Wujing Dai Ye Yu Fangwei Liu Ming Zhao Chunwei Lu Jie Chen | 2013 | Toxicology and Applied Pharmacology2013，，： | 1 |
| 6 | Starch modification using reactive extrusion显示文摘 | Yu Long Liu Hongshen | 2006 | Starch/Starke2006，58，： | 1 |
| 7 | Paralogous cyp51 genes in Fusarium graminearum mediate differential sensitivity to sterol demethylation inhibitors 显示文摘 | LIU Xin YU Fangwei SCHNABEL G | 2011 | Fungal Genes Biol2011，48，2： | 1 |
| 8 | An R2R3-type myeloblastosis transcription factor MYB103 is involved in phosphorus remobilization显示文摘The members of myeloblastosis transcription factor(MYB TF)family are involved in the regulation of biotic and abiotic stresses in plants.However,the role of MYB TF in phosphorus remobilization remains largely unexplored.In the present study,we show that an R2R3 type MYB transcription factor,MYB103,is involved in phosphorus(P)remobilization.MYB103 was remarkably induced by P deficiency in cabbage(Brassica oleracea var.capitata L.).As cabbage lacks the proper mutant for elucidating the mechanism of MYB103 in P deficiency,another member of the crucifer family,Arabidopsis thaliana was chosen for further study.The transcript of its homologue AtMYB103 was also elevated in response to P deficiency in A.thaliana,while disruption of AtMYB103(myb103)exhibited increased sensitivity to P deficiency,accompanied with decreased tissue biomass and soluble P concentration.Furthermore,AtMYB103 was involved in the P reutilization from cell wall,as less P was released from the cell wall in myb103 than in wildtype,coinciding with the reduction of ethylene production.Taken together,our results uncover an important role of MYB103 in the P remobilization,presumably through ethylene signaling. | Fangwei Yu Shenyun Wang Wei Zhang Hong Wang Li Yu Zhangjun Fei Jianbin Li | 2020 | Food Production, Processing and Nutrition2020，2，1： | 0 |
| 9 | Creep behavior and effect factors of a TiAl-Nb alloy at high temperatu显示文摘The effect of solution treatment on the microstructure and creep properties of forged TiAl-Nb alloys was investigated.The results showed that the microstructure of forged alloy mainly consisted ofγ/α2 lamellar colonies and fine equiaxed recrystallizedγ/α2 grains.During the solution treatment the microstructure of the alloy transformed into a fully lamellar structure due to the lamellar colonies growth by consuming equiaxed grains.Compared with the forged alloy the creep life of the solution treated alloy at 800℃/220 MPa increased from 116 h to 339 h.The better creep resistance may be attributed to the transform of fine equiaxedγ/α2 grain to the lamellar colonies with serrated grain boundaries due to the solution treatment.The deformation mechanism of the solution treated alloy during creep is considered to be dislocation slipping within the lamellarγ/α2 phases,and the dislocation movement may be hindered by theγ/α2 interface and the formation of dislocation tangles.The interaction of the dislocations with the tangles may increase the resistance of the dislocation motion and hence improve the creep resistance of the alloy.It was found that during the creep of the forged alloys the cracks mainly initiated at the equiaxed grain,and in the solution treated alloy the cracks initiated at the grain boundaries.As creep continued the cracks propagated and connected to each other,leading to the damage and rupture of the forged and solution treated alloys. | Shunke Zhang Sugui Tian Gengyu Li Ning Tian Fangwei Jin Huichen Yu Xiaoxia Lv Guangyan Wang Deyuan Li | 2021 | Progress in Natural Science:Materials International2021，31，3： | 0 |
| 10 | Use of recombinant microRNAs as antimetabolites to inhibit human non-small cell lung cancer显示文摘During the development of therapeutic microRNAs(miRNAs or miRs),it is essential to define their pharmacological actions.Rather,miRNA research and therapy mainly use miRNA mimics synthesized in vitro.After experimental screening of unique recombinant miRNAs produced in vivo,three lead antiproliferative miRNAs against human NSCLC cells,miR-22-3p,miR-9-5p,and miR-218-5p,were revealed to target folate metabolism by bioinformatic analyses.Recombinant miR-22-3p,miR-9-5p,and miR-218-5p were shown to regulate key folate metabolic enzymes to inhibit folate metabolism and subsequently alter amino acid metabolome in NSCLC A549 and H1975 cells.Isotope tracing studies further confirmed the disruption of one-carbon transfer from serine to folate metabolites by all three miRNAs,inhibition of glucose uptake by miR-22-3p,and reduction of serine biosynthesis from glucose by miR-9-5p and-218-5p in NSCLC cells.With greater activities to interrupt NSCLC cell respiration,glycolysis,and colony formation than miR-9-5p and-218-5p,recombinant miR-22-3p was effective to reduce tumor growth in two NSCLC patient-derived xenograft mouse models without causing any toxicity.These results establish a common antifolate mechanism and differential actions on glucose uptake and metabolism for three lead anticancer miRNAs as well as antitumor efficacy for miR-22-3p nanomedicine,which shall provide insight into developing antimetabolite RNA therapies. | Yixin Chen Mei-Juan Tu Fangwei Han Zhenzhen Liu Neelu Batra Primo N.Lara Hong-Wu Chen Huichang Bi Ai-Ming Yu | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 11 | Particle breakage of sand subjected to friction and collision in drum tests显示文摘This paper presents a laboratory experimental study on particle breakage of sand subjected to friction and collision,by a number of drum tests on granular materials(silica sand No.3 and ceramic balls)to investigate the characteristics of particle breakage and its effect on the characteristics of grain size distribution of sand.Particle breakage increased in up convexity with increasing duration of drum tests,but increased linearly with increasing number of balls.Particle breakage showed an increase,followed by a decrease while increasing the amount of sand.There may be existence of a characteristic amount of sand causing a maximum particle breakage.Friction tests caused much less particle breakage than collision tests did.Friction and collision resulted in different mechanisms of particle breakage,mainly by abrasion for friction and by splitting for collision.The fines content increased with increasing relative breakage.Particle breakage in the friction tests(abrasion)resulted in a sharper increase but with a smaller total amount of fines content in comparison with that in the collision tests(splitting).For the collision tests,the fines content showed a decrease followed by an increase as the amount of sand increased,whereas it increased in up convexity with increasing number of balls.The characteristic grain sizes D_(10) and D_(30) decreased in down convexity with increasing relative breakage,which could be described by a natural exponential function.However,the characteristic grain sizes D50 and D60 decreased linearly while increasing the relative breakage.In addition,the coefficients of uniformity and curvature of sand showed an increase followed by a decrease while increasing the relative breakage. | Fangwei Yu Chonglei Zhang Qijun Xie Lijun Su Tao Zhao M.Qasim Jan | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，2： | 0 |
| 12 | DICE方案与CHOP方案治疗中高度恶性非霍奇金淋巴瘤的随机对照研究(英文)显示文摘Objective: To compare efficacies and safeties of DICE and CHOP regimens in treating intermediate and high grade non-Hodgkin's lymphoma (NHL), and indicate the standard treatment for it. Methods: A total of 74 patients with moder- ately or highly malignant NHL, verified by pathology or histology, were randomized into the trial group (37 patients treated with DICE regimen) and the control group (37 patients treated with CHOP regimen). Survival rate was analyzed by Kaplan-Meier method. Chi-square test was performed between groups. Results: The complete response rate, partial response rate, and response rate were significantly higher in DICE group than in CHOP group (40.5% vs. 29.7%, 37.8% vs. 27.0%, and 78.3% vs. 56.7%, respectively, P < 0.05). The 1-, 3-, and 5-year survival rates were significantly higher in DICE group than in CHOP group (89.2% vs. 81.2%, 76.0% vs. 52.6%%, and 46.7% vs. 36.4%, respectively, P < 0.05). The major side effects, appeared with no differences (P > 0.05) in incidences between the two groups, were leukopenia, thrombocytopenia, and nausea. There were only three episodes of clinical cystitis or gross haematuria in DICE regimen. Conclusion: The results showed higher efficacy of DICE regimen over CHOP regimen. DICE regimen may prolong the survival time of patients with moderately and highly malignant NHL. | Wenwu Wang Xuenong OuYang Zhangshu Cheng Yonghai Peng Fangwei Xie Zongyang Yu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 0 |
| 13 | Ti_(4)O_(7) supported IrO_(x) for anode reversal tolerance in proton exchange membrane fuel cell显示文摘Fuel starvation can occur and cause damage to the cell when proton exchange membrane fuel cells operate under complex working conditions.In this case,carbon corrosion occurs.Oxygen evolution reaction(OER)catalysts can alleviate carbon corrosion by introducing water electrolysis at a lower potential at the anode in fuel shortage.The mixture of hydrogen oxidation reaction(HOR)and unsupported OER catalyst not only reduces the electrolysis efficiency,but also influences the initial performance of the fuel cell.Herein,Ti_(4)O_(7) supported IrO_(x) is synthesized by utilizing the surfactant-assistant method and serves as reversal tolerant components in the anode.When the cell reverse time is less than 100 min,the cell voltage of the MEA added with IrO_(x)/Ti_(4)O_(7) has almost no attenuation.Besides,the MEA has a longer reversal time(530 min)than IrO_(x)(75 min),showing an excellent reversal tolerance.The results of electron microscopy spectroscopy show that IrO_(x) particles have a good dispersity on the surface of Ti_(4)O_(7) and IrO_(x)/Ti_(4)O_(7) particles are uniformly dispersed on the anode catalytic layer.After the stability test,the Ti_(4)O_(7) support has little decay,demonstrating a high electrochemical stability.IrO_(x)/Ti_(4)O_(7) with a high dispersity has a great potential to the application on the reversal tolerance anode of the fuel cell. | Yonghuan LI Wei SONG Guang JIANG Yue YANG Hongmei YU Zhigang SHAO Fangwei DUAN Yingxuan YANG | 2022 | Frontiers in Energy2022，16，5： | 0 |
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