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| 1 | The epigallocatechin gallate derivative Y_6 reverses drug resistance mediated by the ABCB1 transporter both in vitro and in vivo显示文摘Previously, we reported that Y_6, a new epigallocatechin gallate derivative, is efficacious in reversing doxorubicin(DOX)–mediated resistance in hepatocellular carcinoma BEL-7404/DOX cells. In this study, we evaluated the efficacy of Y_6 in reversing drug resistance both in vitro and in vivo by determining its effect on the adenosine triphosphate-binding cassette protein B1 transporter(ABCB1 or P-glycoprotein, P-gp). Our results showed that Y_6 significantly sensitized cells overexpressing the ABCB1 transporter to anticancer drugs that are ABCB1 substrates. Y_6 significantly stimulated the adenosine triphosphatase activity of ABCB1. Furthermore, Y_6 exhibited a higher docking score as compared with epigallocatechin gallate inside the transmembrane domain of ABCB1. In addition, in the nude mousetumor xenograft model, Y_6(110 mg/kg, intragastric administration), in combination with doxorubicin(2 mg/kg, intraperitoneal injection), significantly inhibited the growth of BEL-7404/DOX cell xenograft tumors, compared to equivalent epigallocatechin gallate. In conclusion, Y_6 significantly reversed ABCB1-mediated multidrug resistance and its mechanisms of action may result from its competitive inhibition of the ABCB1 drug efflux function. | Yan Wen Ruiqiang Zhao Pranav Gupta Yingfang Fan Yunkai Zhang Zhenguang Huang Xiaohui Li Yuangang Su Lijuan Liao Yu-An Xie Donghua Yang Zhe-Sheng Chen Gang Liang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 2 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 3 | Medical Additive Manufacturing: From a Frontier Technology to the Research and Development of Products显示文摘1.Research and development(R&D)and the challenges of raw materials for medical additive manufacturing Raw materials for medical additive manufacturing have a wide range of commonalities that are also seen in many other fields,making them an important basis in the field of three-dimensional(3D)printing.Problems and challenges related to material types,powder properties,formability,viscoelasticity,and so forth also share common features.For example,many metal materials are used in the field of aviation,while metals,polymers,and inorganic materials are used in the field of biomedicine.The most widely used materials in biomedicine are biocompatible.Various homogeneous and non-homogeneous composites are also available for 3D printing,and impose an additional challenge in additive manufacturing;the use of heterogeneous composites in 3D printing is particularly challenging. | Guixing Qiu Wenjiang Ding Wei Tian Ling Qin Yu Zhao Lianmeng Zhang Jian Lu Daijie Chen Guangyi Yuan Chengtie Wu Bingheng Lu Ruxu Du Jimin Chen Mo Elbestawi Zhongwei Gu Dichen Li Wei Sun Yuanjin Zhao Jie He Dadi Jin Bin Liu Kai Zhang Jianmo Li Kam WLeong Dewei Zhao Dingjun Hao Yingfang Ao Xuliang Deng Huilin Yang ShaoKeh Hsu Yingqi Chen Long Li Jianping Fan Guohui Nie Yun Chen Hui Zeng Wei Chen Yuxiao Lai | 2020 | Engineering2020，6，11： | 1 |
| 4 | Application of grey system theory to study the bond strength between corroded rebar and concrete显示文摘 | Zhang Yingzi Fan yingfang hu yudong lidong | 2007 | in GSIS2007，，： | 1 |
| 5 | A new approach for evaluating the resectability of pancreatic and periampullary neoplasms显示文摘 | Chi-hua Fang Wen Zhu Huaizhi Wang Nan Xiang Yingfang Fan Jian Yang Xiaojun Wang Shi zheng Zhong | 2012 | Pancreatology2012，，4： | 1 |
| 6 | METHODS FOR IDENTIFYING SUB-REGIONAL MATERIAL PARAMETERS OF CONCRETE DAMS USING MODAL DATA显示文摘Methods for identifying sub-regional material parameters of concrete dams using in-complete modal data are presented.With the measurements of the first frequency and incompletemode shape,identification methods were built by both the output error approach and the minimumdeviation approach.The minimum deviation approach was introduced as physical constraints tothe output error approach,allowing the output error-minimum deviation coupled approach to bedeveloped.The simulated annealing-simplex shape algorithm was applied to solve the identifi-cation models.Numerical simulations were carried out with noisy incomplete measurements toillustrate the robustness of the methods. | Feng Xin Zhou Jing Fan Yingfang | 2003 | Acta Mechanica Solida Sinica2003，16，1： | 0 |
| 7 | Study on the interactions between anti-tumor metal complexes and mononucleotides using trans-[en2Os(h^2-H2)(CF3SO3)](CF3SO3) as a 1H NMR probe in a competitive mode显示文摘The interaction of several anti-tumor metal complexes with dGMP have been investigated using trans-[en2Os(η2-H2)]2+ as a 1H NMR probe in a competitive mode. Me2SnCl2, Bu2SnCl2, Et2Sn(phen)Cl2 and Et2SnCl2 can bind to dGMP mainly via phosphate; Cp2TiCl2 binds to dGMP mainly via phosphate and N7. The binding constant for (CH3)2SnCl2 binding to phos-phate of dGMP exceeds 2.71×104. The binding constant for Cp2TiCl2 to phosphate is even greater than that of Sn(IV). Cis-platin has high affinity for both N7 and phosphate, but mainly for N7. Binding of the probe to N7 of dGMP reduces the binding affinity for phosphate of the same dGMP molecule by a factor of 5 to 6. Much the same factor is expected to apply to other metals containing agents interacting with dGMP. | YANG Pin CHEN Huili FAN Yingfang YUE Lijun MENG Xiangli | 2005 | Science China Chemistry2005，48，3： | 0 |
| 8 | Property of Corroded Concrete under Compressive Uniaxial Loads显示文摘以便学习侵蚀的水泥的压缩性质,加速的腐蚀试验在具体 C30.6 腐蚀剂答案上被执行包括水力的酸液(pH=2 ) ,水力的酸液(pH=3 ) 作为腐蚀剂媒介被使用。包括 111 个标本,腐蚀试验的 6 系列被执行。所有侵蚀的标本的机械性质分别地被测试。侵蚀的标本的压缩性质(例如压缩强度,压力紧张关系,有弹性的模量等等) 被完成。作为损坏索引拿力量降级比率和紧张精力损失,侵蚀的水泥的压缩性质上的腐蚀答案的效果详细被讨论。在损坏索引和标本的腐蚀状态之间的关系被完成。 | FAN Yingfang HU Zhiqiang ZHOU Jing LI Xin | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，2： | 0 |
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