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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | Liver toxicity of rosuvastatin therapy显示文摘We report here a case of clinically significant liver toxicity after a brief course of rosuvastatin, which is the first statin approved by the regulatory authorities since the withdrawal of cerivastatin. Whether rosuvastatin has a greater potential compared with other statins to damage the liver is unclear and the involved mechanisms are also unknown. However, rosuvastatin is taken up by hepatocytes more selectively and more efficiently than other statins, and this may reasonably represent an important variable to explain the hepatotoxic potential of rosuvastatin. Our report supports the view that a clinically significant risk of liver toxicity should be considered even when rosuvastatin is given at the range of doses used in common clinical practice. | Giuseppe Famularo Luca Miele Giovanni Minisola Antonio Grieco | 2007 | World Journal of Gastroenterology2007，13，8： | 8 |
| 3 | Resilience Against Replay Attacks:A Distributed Model Predictive Control Scheme for Networked Multi-Agent Systems显示文摘In this paper,a resilient distributed control scheme against replay attacks for multi-agent networked systems subject to input and state constraints is proposed.The methodological starting point relies on a smart use of predictive arguments with a twofold aim:1)Promptly detect malicious agent behaviors affecting normal system operations;2)Apply specific control actions,based on predictive ideas,for mitigating as much as possible undesirable domino effects resulting from adversary operations.Specifically,the multi-agent system is topologically described by a leader-follower digraph characterized by a unique leader and set-theoretic receding horizon control ideas are exploited to develop a distributed algorithm capable to instantaneously recognize the attacked agent.Finally,numerical simulations are carried out to show benefits and effectiveness of the proposed approach. | Giuseppe Franzè Francesco Tedesco Domenico Famularo | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，3： | 5 |
| 4 | Is there a role for treatment-oriented surgery in liver metastases from gastric cancer?显示文摘BACKGROUND Distant metastases are found in approximately 35%of patients with gastric cancer at their first clinical observation,and of these,4%-14%involves the liver.Unfortunately,only 0.4%-2.3%of patients with metastatic gastric cancer are eligible for radical surgery.Although surgical resection for gastric cancer metastases is still debated,there have been changes in recent years,although several clinical issues remain to be defined and that must be taken into account before surgery is proposed.AIM To analyze the clinicopathological factors related to primary gastric tumor and metastases that impact the survival of patients with liver metastatic gastric cancer.METHODS We performed a systematic review of the literature from 2000 to 2018 according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.The study protocol was based on identifying studies with clearly defined purpose,eligibility criteria,methodological analysis,and patient outcome.RESULTS We selected 47 studies pertaining to the purpose of the review,which involved a total of 2304 patients.Median survival was 7-52.3 mo,median disease-free survival was 4.7-18 mo.The 1-,2-,3-,and 5-year overall survival(OS)was 33%-90.1%,10%-60%,6%-70.4%,and 0%-40.1%,respectively.Only five papers reported the 10-year OS,which was 5.5%–31.5%.The general recurrence rate was between 55.5%and 96%,and that for hepatic recurrence was between 15%and 94%.CONCLUSION Serous infiltration and lymph node involvement of the primary cancer indicate an unfavorable prognosis,while the presence of single metastasis or≤3 metastases associated with a size of<5 cm may be considered data that do not contraindicate liver resection. | Fabio Uggeri Lorenzo Ripamonti Enrico Pinotti Mauro Alessandro Scotti Simone Famularo Mattia Garancini Luca Gianotti Marco Braga Fabrizio Romano | 2020 | World Journal of Clinical Oncology2020，11，7： | 3 |
| 5 | A Resilient Control Strategy for Cyber-Physical Systems Subject to Denial of Service Attacks:A Leader-Follower Set-Theoretic Approach显示文摘Multi-agent systems are usually equipped with open communication infrastructures to improve interactions efficiency,reliability and sustainability.Although technologically costeffective,this makes them vulnerable to cyber-attacks with potentially catastrophic consequences.To this end,we present a novel control architecture capable to deal with the distributed constrained regulation problem in the presence of time-delay attacks on the agents’communication infrastructure.The basic idea consists of orchestrating the interconnected cyber-physical system as a leader-follower configuration so that adequate control actions are computed to isolate the attacked unit before it compromises the system operations.Simulations on a multi-area power system confirm that the proposed control scheme can reconfigure the leader-follower structure in response to denial ofservice(DoS)attacks. | Giuseppe Franzè Domenico Famularo Walter Lucia Francesco Tedesco | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，5： | 3 |
| 6 | Mesenteric and portal vein thrombosis associated with hyperhomocysteinemia and heterozygosity for factor V Leiden mutation显示文摘TO THE EDITOR
A 79-year-old man was hospitalized because of worsening upper abdominal pain which started two days before admission and was continuously present. His personal and family historywas uneventful, he did not smoke and denied toxic habits or using any medications, including over the-counter medications, herbal remedies or any vitamin supplements. | Giuseppe Famularo Giovanni Minisola Giulio Cesare Nicotra Claudio De Simone | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 7 | Microecology, bacterial vaginosis and probiotics: perspectives for bacteriotherapy 显示文摘 | FAMULARO G PIELUIGI M CFOCCIA R | 2001 | Med Hypotheses2001，56，4： | 1 |
| 8 | The puzzle of neuronal death and life:is mannitol the right drug for the treatment of brain oedema associated with ischaemic stroke显示文摘 | Famularo G | | 0，，04： | 1 |
| 9 | A patient with cerebral Whipple's disease and a stroke-like syndrome 显示文摘 | Famularo G Minisola G Simone C | 2005 | Scand J Gastroenterol2005，40，： | 1 |
| 10 | Catastrophic antiphospholipid syndrome in a patient with Behcet' s disease显示文摘 | Famularo G Antonelli S BarracchiniA | | 0，，： | 1 |
| 11 | Coronary aneurysms in patients with systemic lupus erythematosus显示文摘 | Famularo G Vallone A Pizzicannella M | 2015 | The American Journal of Emergency Medicine2015，33，1： | 1 |
| 12 | Probable celecoxib-induced hepatorenal syndrome显示文摘 | FAMULARO G GASBARRONE L MINISOLA G | 2012 | Ann Pharmacother2012，46，4： | 1 |
| 13 | Robust non-fragile LQ controller:the static state feedback case显示文摘 | Dorato P | 2000 | Int J Control2000，73，2： | 1 |
| 14 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1- infected subjects treated with zidovudine and didanosine 显示文摘 | Moretti S Famularo G Marcellini S | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 15 | Catastrophic antiphospholipid syndrome in a patient with Behcet,sdisease显示文摘 | Famularo G Antonell S Barracchini A | 2002 | Scand J Rheumatol2002，31，2： | 1 |
| 16 | A patient with cerebral Whipple's disease and a stroke - like syndrome 显示文摘 | Famularo G Minisola G Simone C | 2005 | Scand J Gastroenterol2005，40，： | 1 |
| 17 | Ceramide concentrations in septic patients: a possible marker of multiple organ dysfunction syndrome显示文摘 | Delogu G Famularo G Amati F | 1999 | Crit Care Med1999，27，11： | 1 |
| 18 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine显示文摘 | Moretti S Famularo G Marcellini S | | 0，，03： | 1 |
| 19 | Eosinophilic gastroenteritis in a young man显示文摘 | Famularo G Prantera C Nunnari J | | 0，，： | 1 |
| 20 | Probiotic lactobacilli an innovative tool to correct the malabsorption syndrone of vegetarians显示文摘 | Famularo G De Simone C Pandey V | 2005 | Medical Hypotheses2005，65，6： | 1 |
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