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| 1 | Use of probiotics for prevention of radiation-induced diarrhea显示文摘AIM: To investigate the efficacy of a high-potency probiotic preparation on prevention of radiation-induced diarrhea in cancer patients. METHODS: This was a double-blind, placebo-controlled trial. Four hundred and ninety patients who underwent adjuvant postoperative radiation therapy after surgery for sigmoid, rectal, or cervical cancer were assigned to either the high-potency probiotic preparation VSL#3 (one sachet t.i.d.,) or placebo starting from the first day of radiation therapy. Efficacy endpoints were incidence and severity of radiation-induced diarrhea, daily number of bowel movements, and the time from the start of the study to the use of loperamide as rescue medication. RESULTS: More placebo patients had radiation-induced diarrhea than VSL#3 patients (124 of 239 patients, 51.8%, and 77 of 243 patients, 31.6%; P < 0.001) and more patients given placebo suffered grade 3 or 4 diarrhea compared with VSL#3 recipients (55.4% and 1.4%, P < 0.001). Daily bowel movements were 14.7 ± 6 and 5.1 ± 3 among placebo and VSL#3 recipients (P < 0.05), and the mean time to the use of loperamide was 86 ± 6 h for placebo patients and 122 ± 8 h for VSL#3 patients (P < 0.001). CONCLUSION: Probiotic lactic acid-producing bacteria are an easy, safe, and feasible approach to protect cancer patients against the risk of radiation-induced diarrhea. | P Delia G Sansotta V Donato P Frosina G Messina C De Renzis G Famularo | 2007 | World Journal of Gastroenterology2007，13，6： | 29 |
| 2 | Microecology, bacterial vaginosis and probiotics: perspectives for bacteriotherapy 显示文摘 | FAMULARO G PIELUIGI M CFOCCIA R | 2001 | Med Hypotheses2001，56，4： | 1 |
| 3 | The puzzle of neuronal death and life:is mannitol the right drug for the treatment of brain oedema associated with ischaemic stroke显示文摘 | Famularo G | | 0，，04： | 1 |
| 4 | A patient with cerebral Whipple's disease and a stroke-like syndrome 显示文摘 | Famularo G Minisola G Simone C | 2005 | Scand J Gastroenterol2005，40，： | 1 |
| 5 | Catastrophic antiphospholipid syndrome in a patient with Behcet' s disease显示文摘 | Famularo G Antonelli S BarracchiniA | | 0，，： | 1 |
| 6 | Coronary aneurysms in patients with systemic lupus erythematosus显示文摘 | Famularo G Vallone A Pizzicannella M | 2015 | The American Journal of Emergency Medicine2015，33，1： | 1 |
| 7 | Probable celecoxib-induced hepatorenal syndrome显示文摘 | FAMULARO G GASBARRONE L MINISOLA G | 2012 | Ann Pharmacother2012，46，4： | 1 |
| 8 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1- infected subjects treated with zidovudine and didanosine 显示文摘 | Moretti S Famularo G Marcellini S | 2002 | Antioxid Redox Signal2002，4，3： | 1 |
| 9 | Catastrophic antiphospholipid syndrome in a patient with Behcet,sdisease显示文摘 | Famularo G Antonell S Barracchini A | 2002 | Scand J Rheumatol2002，31，2： | 1 |
| 10 | A patient with cerebral Whipple's disease and a stroke - like syndrome 显示文摘 | Famularo G Minisola G Simone C | 2005 | Scand J Gastroenterol2005，40，： | 1 |
| 11 | Ceramide concentrations in septic patients: a possible marker of multiple organ dysfunction syndrome显示文摘 | Delogu G Famularo G Amati F | 1999 | Crit Care Med1999，27，11： | 1 |
| 12 | L-carnitine reduces lymphocyte apoptosis and oxidant stress in HIV-1-infected subjects treated with zidovudine and didanosine显示文摘 | Moretti S Famularo G Marcellini S | | 0，，03： | 1 |
| 13 | Eosinophilic gastroenteritis in a young man显示文摘 | Famularo G Prantera C Nunnari J | | 0，，： | 1 |
| 14 | Probiotic lactobacilli an innovative tool to correct the malabsorption syndrone of vegetarians显示文摘 | Famularo G De Simone C Pandey V | 2005 | Medical Hypotheses2005，65，6： | 1 |
| 15 | Mitochondrial perturbations and oxidant stress in lymphocytes from patients undergoing surgery and generalanesthesia显示文摘 | Moretti S Famularo G | 2001 | Arch Surg2001，136，： | 1 |
| 16 | Atorvastatin-associated necrotising inflammatory myopathy显示文摘 | Famularo G Gasbarrone L Galluzzo M | 2012 | Clin Exp Rheumatol2012，30，： | 1 |
| 17 | The puzzle of neuronal death and life: is man- nitol the right drug for the treatment of brain edema associated with ischaemic stroke? 显示文摘 | FAMULARO G | 1999 | Eur J Emerg Med1999，6，4： | 1 |
| 18 | A patient with cerebral Whipple's disease and a stroke-like syndrome显示文摘 | Famularo G Minisola G De Simone C | 2005 | Scand J Gastroenterol2005，40，5： | 1 |
| 19 | A robust deconvolution scheme for fault detection and isolation of uncertain linear systems an LMI approach 显示文摘 | Casavola A Famularo D Franze G | 2005 | Automatica2005，41，8： | 1 |
| 20 | Inflammatory bowel disease显示文摘 | Famularo G Trinchieri V De Simone C | | 0，，24： | 1 |
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