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| 1 | Hepatitis B genotypes: Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia显示文摘AIM: To identify the most common hepatitis B virus (HBV) genotype in Saudi Arabia, and correlate the prevailing genotypes with the clinical outcome of patients. METHODS: Patients were consecutively recruited from the hepatology clinics of two tertiary care referral cen- ters. Patients were categorized into 4 different groups: group 1, patients with hepatitis B and normal liver en- zymes; group 2, patients with hepatitis B and abnormal liver enzymes but without cirrhosis; group 3, patients with hepatitis B and liver cirrhosis; group 4, patients with hepatitis B and hepatocellular carcinoma. All patients had a positive hepatitis B surface antigen (HBsAg). Ge- notyping of HBV was performed by nested PCR-mediated amplification of the target sequence and hybridization with sequence-specific oligonucleotides. RESULTS: Seventy patients were enrolled in this study. They were predominantly male (72.9%) in their mid- forty’s (mean age 47 years). Forty-nine (70%) patients were hepatitis B envelope antigen (HBeAg) negative. The majority of patients (64%) acquired HBV through unknown risk factors. Hepatitis B genotyping revealed that 57 patients (81.4%) were genotype D, 1 patient (1.4%) had genotype A, 1 patient (1.4%) had geno- type C, and 4 patients (5.7%) had genotype E, while 7 patients (10%) had mixed genotype (4 patients ADG, 1 patient DE, 1 patient DF, and 1 patient ADFG). Based on univariate analysis of genotype D patients, significant predictors of advanced liver disease were age, gender, aspartate transaminase, alanine transaminase, albumin,bilirubin, and alkaline phosphatase (all P < 0.001). In multivariate analysis decreased hemoglobin (r = -0.05; 95% CI: -0.08 to -0.03; P = 0.001) and albumin levels (r = -0.004; 95% CI: -0.007 to -0.001; P = 0.002) were highly significant predictors of advanced liver disease. In patients with HBV genotype D, HBeAg negativity was found to increase across advancing stages of liver dis- ease (P = 0.024). CONCLUSION: This study highlights that the vast ma- jority of Saudi patients with chronic hepatitis B have genotype D. No correlation could be observed between the different genotypes and epidemiological or clinical factors. The relationship between genotype D and HBeAg status in terms of disease severity needs to be further elucidated in larger longitudinal studies. | Ayman A Abdo Badr M Al-Jarallah Faisal M Sanai Ahmad S Hersi Khalid Al-Swat Nahla A Azzam Manal Al-Dukhayil Amira Al-Maarik Faleh Z Al-Faleh | 2006 | World Journal of Gastroenterology2006，12，43： | 7 |
| 2 | Changing patterns of hepatitis A prevalence within the Saudi population over the last 18 years显示文摘AIM: To determine the seroprevalence of Hepatitis A (HAV) amongst Saudi children and compare it with previously reported prevalence data from the same population. METHODS: A total of 1357 students were randomly selected between the ages of 16 and 18 years (689 males and 668 females) from three different regions of Saudi Arabia (Madinah, Al-Qaseem, and Aseer) and tested for anti-HAV-IgG. RESULTS: The overall prevalence of anti-HAV-IgG among the study population was 18.6%. There was no difference between males and females but there was a significant difference in the seroprevalence (P = 0.0001) between the three different regions, with Ma- dinah region showing the highest prevalence (27.4%). When classified according to socioeconomic status, lower class students had a prevalence of 36.6%, lower middle class 16.6%, upper middle class 9.6%, and up- per class 5.9% (P = 0.0001). Comparing the current study results with those of previous studies in 1989 and 1997 involving the same population, there was a marked reduction in the overall prevalence of HAV from 52% in 1989, to 25% in 1997, to 18.6% in 2008 (P < 0.0001). CONCLUSION: Over the last 18 years, there has been a marked decline in the prevalence of HAV in Saudi children and adolescents. The current low prevalence rates call for strict adherence to vaccination policies in high-risk patients and raises the question of a univer- sal HAV vaccination program. | Faleh Al Faleh Suliman Al Shehri Saleh Al Ansari Mohammed Al Jeffri Yaqoub Al Mazrou Ahmad Shaffi Ayman A Abdo | 2008 | World Journal of Gastroenterology2008，14，48： | 2 |
| 3 | Osseointegration of dental implants in 3D-printed synthetic onlay grafts customized according to bone metabolic activity in recipient site显示文摘 | Faleh Tamimi Jesus Torres Khadijeh Al-Abedalla Enrique Lopez-Cabarcos Mohammad H. Alkhraisat David C. Bassett Uwe Gbureck Jake E. Barralet | 2014 | Biomaterials2014，，21： | 2 |
| 4 | Cutaneous manifestations of gastrointestinal diseases显示文摘 | Erin E Boh Raed Mahmoud Faleh al-Smadi | 2002 | Dermatologic Clinics2002，，3： | 1 |
| 5 | Amblyopia screening for first and second-grade children in Jordan显示文摘AIM:To share the results of a national screening program for amblyopia in school children in the north of Jordan.METHODS:This is a prospective national screening study for amblyopia.The program rolls first and second-grade children(6 to 7 years old) in the north of Jordan.The eye examination included:best-corrected visual acuity,cover-uncover test,and cycloplegic retinoscopy.Monocular visual acuity was tested using an ETDRS visual acuity chart without correction.Moreover,children were tested with full cycloplegic refraction when the test criteria were met.Unilateral amblyopia was defined as a best-corrected visual acuity difference of 2 or more lines.In comparison,bilateral amblyopia was defined as a best-corrected visual acuity of 20/40 or worse in the best eye.RESULTS:The prevalence of amblyopia for the total sample tested(n=17 203) was 2.78%(n=479).The most common cause of amblyopia was hypermetropia(64.45%),followed by previous ocular surgeries(15.1%),myopia(10.43%),strabismus(9.39%),and congenital cataract(0.63%).CONCLUSION:This is the first and only study,identifing modifiable risk factors in Jordanian children with amblyopia.In their first couple of years of elementary education,many Jordanian children are affected by amblyopia and pass unnoticed.A more governmental effort is needed into screening programs to improve vision in the Jordanian population. | Khalil M.Al-Salem Mohammad S.Saleem Ismat Ereifej Hamzeh M.Alrawashdeh Rayed Falah Hussein Obeidat Asma Ali Abdlmohdi Raeda Zaki Al-Momani Layal Mohammed Hammad Omar Ahmad al-Habahbeh Yaqeen M.Assassfeh Laith Ramzi Najib Al-Qsous Ashraf Hatim Adeeb Nasraween Tariq A.Al Maaitah Deya'-Aldin Muneer Hasan Aqeel Ibtehal Eyadeh Awad Alabdulrazzg Abdullah Mahmoud Mohammad Murad Amany Jehad Faleh AL-Zurqan Enas Jamal Mohammad Jaradat Slsabela Emad Suliman Aldhoon Ala'a Majed Dmour Ahmad Talal Asassfeh Jeries Ayman Halaseh Abdel Aziz Ammar Daoud Waha Ayman Alkasasbeh Kholoud GH.Matar | 2022 | International Journal of Ophthalmology(English edition)2022，15，2： | 1 |
| 6 | Brushite-collagen composites for bone regeneration 显示文摘 | Faleh T Balamurugan K Charles D | 2008 | Acta Biomater2008，4，： | 1 |
| 7 | Dicalcium phosphate ce- ments: brushite and monetite 显示文摘 | Faleh T Zeeshan S Jake B | 2012 | Acta Biomaterial2012，8，2： | 1 |
| 8 | Seroprevalence of celiac disease among healthy adolescents in Saudi Arabia显示文摘AIM: To identify the seroprevalence of celiac disease among healthy Saudi adolescents. METHODS: Between December 2007 and January 2008, healthy students from the 10th to 12th grades were randomly selected from three regions in Saudi Arabia. These regions included the following: (1) Aseer region, with a student population of 25512; (2) Madinah, with a student population of 23852; and (3) Al-Qaseem, with a student population of 16067. Demographic data were recorded, and a venous blood sample (5-10 mL) was taken from each student. The blood samples were tested for immunoglobulin A and immunoglobulin G endomysial antibodies (EMA) by indirect immunofluorescence.RESULTS: In total, 1167 students (614 males and 553 females) from these three regions were randomly selected. The majority of the study population was classified as lower middle class (82.7%). There were 26 (2.2%) students who had a positive anti-EMA test, including 17 females (3.1%) and 9 males (1.5%). Al-Qaseem region had the highest celiac disease prevalence among the three studied regions in Saudi Arabia (3.1%). The prevalence by region was as follows: Aseer 2.1% (10/479), Madinah 1.8% (8/436), and Al-Qaseem 3.2% (8/252). The prevalence in Madinah was significantly lower than the prevalence in Aseer and Al-Qaseem (P=0.02). CONCLUSION: Our data suggest celiac disease prevalence might be one of the highest in the world. Further studies are needed to determine the real prevalence. | Abdulrahman M Aljebreen Majid A Almadi Alwaleed Alhammad Faleh Z Al Faleh | 2013 | World Journal of Gastroenterology2013，19，15： | 1 |
| 9 | Epidemiology of hip fracture in Norway显示文摘 | Faleh JA 11ebekk A Slungaard LS | | 0，，： | 1 |
| 10 | Why the Uprisings Failed显示文摘 | | 1992 | Middle East Report1992，，3： | 1 |
| 11 | Anorectal malig- nant melanoma : extensive 45-year review and proposal for a novel stag- ing classification显示文摘 | Faleh C Stojadiuovic A Hann-von-Weyhern C | 2013 | J Am Coil Surg2013，217，2： | 1 |
| 12 | Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis :results from 394 patients in the Oslo County Rheumatoid Arthritis register显示文摘 | Flaugeberg G Uhlig T Faleh JA | 2000 | Arthritis Rheum2000，43，3： | 1 |
| 13 | The Worldly Roots of Religiosity in Post-Saddam Iraq 显示文摘 | | 2003 | Middle East Report2003，，3： | 1 |
| 14 | Using Pol- lution Load Index (PLI) and Geoaccumulation In- dex (I-Geo) for the assessment of heavy metals pollution in Tigris River sediment in Baghdad Re- gion显示文摘 | Adel Mashaan Rabee Yaaroub Faleh Al-Fatlawy Abd-Al-Husain Najim Abd own | 2011 | Journal of A1-Nahrain University (Sci- ence)2011，14，4： | 1 |
| 15 | Using pollu- tion load index (PLI) and geoaccumulation index (I- Geo) for the assessment of heavy metals pollution in Tigris River sediment in Baghdad Region显示文摘 | Adel Mashaan Rabee Yaaroub Faleh AI-Fatlawy Abd-A1-Husain Najim Abd own | 2011 | Jour- nal of AI-Nahrain University(Science)2011，14，4： | 1 |
| 16 | Missed opportunities for the detection of abdominal aortic aneurysms显示文摘 | MACDONALD A J FALEH O WELCH G | 2008 | Eur J Vase Endovasc Surg2008，35，6： | 1 |
| 17 | Gastric outlet obstruc- tion by Brunners gland hyperplasia in an 8-year-old child显示文摘 | EI Faleh I Lutz N Osterheld M C | 2009 | J Pediatr Surg2009，44，4： | 1 |
| 18 | Success rate and neonatal morbidities associated with early extubation in extremely low birth weight infants 显示文摘 | A1 Faleh K Liew K Anabrees J | 2011 | Ann Saudi Med2011，31，6： | 1 |
| 19 | Effect of grafting materials on osseointegration of dental implants surrounded by circunfferential bone defects: An experimental study in the dog 显示文摘 | Faleh Abushahba Stefan Renvert loannis Polyzois | 2008 | Clin Oral Impl Res2008，19，： | 1 |
| 20 | Mirizzi Syndrome: Ten Years Experience from a Teaching Hospital in Riyadh显示文摘 | Mohammed H.A. Al-Akeely MBBS CABS Mohammed K. Alam MBBS Hayan Abdulrahman Bismar CABS Kamran Khalid Ibrahim Al-Teimi MBBS Nasser Faleh Al-Dossary MBBS MD | 2005 | World Journal of Surgery2005，，12： | 1 |
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