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| 1 | Pharmacological effects of saw palmetto extract in the lower urinary tract显示文摘锯矮棕榈条摘录(SPE ) ,从美国矮子手掌的成熟果浆的一篇摘录,广泛地在欧洲由于良性的 prostatic 增生(BPH ) 为尿机能障碍被用作治疗学的疗法。行动的众多的机制为 SPE 被建议了,包括 5 伪 - reductase 的抑制。今天,伪 1 -adrenoceptor 对手和 muscarinic cholinoceptor 对手通常与对 BPH 第二等的 voiding 症状在人的治疗被使用。在拿 SPE 的病人的 voiding 症状的改进可以在更低的尿道从它的绑定产生到 pharmacologically 相关的受体,例如伪 1 -adrenoceptors, muscarinic cholinoceptors, 1,4-dihyropyridine 受体和 vanilloid 受体。而且, SPE 的口头的管理被显示了在睾丸激素导致的老鼠前列腺稀释伪 1 -adrenoceptors 的起来规定。因此,在临床上相关的剂量的 SPE 可以在更低的尿道在药理学受体上施加直接效果,在有 BPH 和一个 overactive 膀胱的病人的从而改善的尿机能障碍。SPE 没在血与共同管理的药或严肃的不利事件有相互作用生物化学的参数,它的相对安全暗示,甚至与长期的吸入。与 BPH 在人进行的 SPE 的临床的试用(控制安慰剂、活跃控制的试用) 也被考察。这评论应该与 BPH 在病人的治疗贡献 SPE 的药理学效果的理解并且联系更低的尿道症状(LUTS ) 。 | Mayumi SUZUKI Yoshihiko ITO Tomomi FUJINO Masayuki ABE Keizo UMEGAKI Satomi ONOUE Hiroshi NOGUCHI Shizuo YAMADA | 2009 | Acta Pharmacologica Sinica2009，30，3： | 17 |
| 2 | Perioperative management of distal pancreatectomy显示文摘Recent advances in surgical techniques and perioperative management have markedly reduced operative morbidity after distal pancreatectomy(DP).However,some questions remain regarding the protocol for the perioperative management of DP,in particular,with regard to the development of pancreatic fistula(PF).A review of DP was therefore conducted in order to standardize the management of patients for a favorable outcome.Overall,operative technique and perioperative management emerged as two critical factors contributing to favorable outcome in DP patients.As for the operative method,surgical and closure techniques exhibited differences in outcome.Laparoscopic DP generally yields more favorable perioperative outcomes compared to open DP,and is applicable for benign tumors and some ductal carcinomas of the pancreas.Robotic DP is also available for safe pancreatic surgery.En bloc celiac axis resection offers a high R0 resection rate and potentially allows for some local control in the case of advanced pancreatic cancer.Following resection,staple closure was not found to reduce the rate of PF when compared to hand-sewn closure.In addition,ultrasonic dissection devices,fibrin glue sealing,and staple closure with mesh reinforcement were shown to significantly reduce PF,although there was some bias in these studies.In perioperative management,both preoperative and postoperative treatment affected outcome.First,preoperative endoscopic pancreatic stenting may be an effective prophylactic measure against fistula development following DP in selected patients.Second,in postoperative management,a multifactorial approach including prophylactic antibiotics improved high surgical site infection rates following complex hepato-pancreatobiliary surgery.Furthermore,although conflicting results have been reported,somatostatin analogues should be administered selectively to patients considered to have a high risk for PF.Finally,careful drain management also facilitates a favorable outcome in patients with PF after DP.The results of the review indicate that laparoscopic DP coupled with perioperative management influences outcome in DP patients. | Yasuhiro Fujino | 2015 | World Journal of Gastroenterology2015，21，11： | 7 |
| 3 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 4 | Research and Implementations of Structural Monitoring for Bridges and Buildings in Japan显示文摘This paper provides a review on the development of structural monitoring in Japan, with an emphasis on the type, strategy, and utilization of monitoring systems. The review focuses on bridge and building structures using vibration-based techniques. Structural monitoring systems in Japan historically started with the objective of evaluating structural responses against extreme events. In the development of structural monitoring, monitoring systems and collected data were used to verify design assumptions, update speci cations, and facilitate the ef cacy of vibration control systems. Strategies and case studies on monitoring for the design veri cation of long-span bridges and tall buildings, the performance of seismic isolation systems in building and bridges, the veri cation of structural retro t, the veri cation of structural control systems (passive, semi-active, and active), structural assessment, and damage detec- tion are described. More recently, the application of monitoring systems has been extended to facilitate ef cient operation and effective maintenance through the rationalization of risk and asset management using monitoring data. This paper also summarizes the lessons learned and feedback obtained from case studies on the structural monitoring of bridges and buildings in Japan. | Yozo Fujino Dionysius MSiringoringo Yoshiki Ikeda Tomonori Nagayama Tsukasa Mizutani | 2019 | Engineering2019，5，6： | 5 |
| 5 | Perturbation of Wood Cellulose Synthesis Causes Pleiotropic Effects in Transgenic Aspen显示文摘在树上的纤维素生合成的基因操作可以提供新奇卓见进树的生长和发展。探索这可能性,一棵白杨的 overexpression 第二等的联系墙的纤维素 synthase (PtdCesA8 ) 基因在转基因的白杨(Populus tremuloides L.) 被尝试并且出人意料地象它的内长的对应物一样导致了 transgene 的 silencing。转基因的白杨植物的主要的轴快速停止成长,并且弱树枝采用了一个哭泣的生长习惯。而且,转基因的植物开始开发了更小的叶子和一个不太广泛的根系统。几乎没象 10% 纤维素一样包含的转基因的白杨植物的第二等的木部(木头) 使正常化与典型地在正常白杨木头发现的 41% 纤维素相比弄干重量。在纤维素的这巨大的减小被木质素(35%) 和非有纤维质的多糖(55%) 的比例的增加在控制植物与 22% 木质素和 36% 非有纤维质的多糖相比伴随。生产的转基因的茎典型崩溃或改变了第二等的墙形态学并且极大地包含了的不规则的木部容器减少了水晶的纤维素的数量。这些结果在维持要求在树上建立垂直生长习惯的力量和结构的正直在第二等的木部以内表明第二等的墙纤维素的基本角色。 | Chandrashekhar R Joshi Shivegowda Thammannagowda Takeshi Fujino Ji-Qing Gou Utku Avci Candace H. Haigler Lisa M. McDonnell Shawn D. Mansfield Bemnet Mengesha Nicholas C. Carpita Darby Harris Seth DeBolt Gary F. Peter | 2011 | Molecular Plant2011，4，2： | 4 |
| 6 | HSST-100的全面运行试验与名古屋东山坡线工程显示文摘:介绍了日本 HSST系统的发展过程、HSST- 10 0车辆的技术参数 。 | M asaaki Fujino 罗芳 韩亮 | 2001 | 国外铁道车辆2001，38，2： | 3 |
| 7 | High dose intravenous methylprednisolone resolves esophageal stricture resistant to balloon dilatation with intralesional injection of dexamethasone显示文摘 | Nobuyuki Morikawa Toshiro Honna Tatsuo Kuroda Koji Watanabe Hideaki Tanaka Hajime Takayasu Akihiro Fujino Hiroko Tanemura Makoto Matsukubo | 2008 | Pediatric Surgery International2008，，10： | 2 |
| 8 | Stereotactic Body Radiotherapy (SBRT) for Operable Stage I Non–Small-Cell Lung Cancer: Can SBRT Be Comparable to Surgery?显示文摘 | Hiroshi Onishi Hiroki Shirato Yasushi Nagata Masahiro Hiraoka Masaharu Fujino Kotaro Gomi Katsuyuki Karasawa Kazushige Hayakawa Yuzuru Niibe Yoshihiro Takai Tomoki Kimura Atsuya Takeda Atsushi Ouchi Masato Hareyama Masaki Kokubo Takuyo Kozuka Takuro Arimo | 2011 | International Journal of Radiation Oncology, Biology, Physics2011，，5： | 2 |
| 9 | Helicobacter pylori infection and gastropathy:A comparison between Indonesian and Japanese patients显示文摘AIM:To compare the effects of Helicobacter pylori(H pylori) infection on gastropathy between Indonesian and Japanese patients.METHODS:Biopsy specimens were obtained during upper gastrointestinal endoscopy from 167 subjects(125 Indonesians and 42 Japanese) with uninvestigated symptoms of dyspepsia.The specimens were analyzed for the presence of H pylori using urease analysis,histopathology,and cell culture.The grade and activity of gastritis was assessed using the updated Sydney system.RESULTS:The percentages of Indonesian and Japanese patients who were H pylori-positive at the antrum or body of the stomach were similar(68% and 59.5%,respectively;P=0.316).Of those who were H pylori-positive,more Japanese patients than Indonesian patients had high levels of polymorphonuclear cells(P=0.001),mononuclear cells(P=0.013),glandular atrophy(P=0.000),and intestinal metaplasia(P=0.011) in both the antrum and body of the stomach.CONCLUSION:The grade of gastritis and prevalence of mucosal atrophy and intestinal metaplasia were higher in Japanese patients.The difference between Indonesian and Japanese patients was signifi cant. | Murdani Abdullah Hiroyuki Ohtsuka Abdul Aziz Rani Tadashi Sato Ari F Syam Masayuki A Fujino | 2009 | World Journal of Gastroenterology2009，15，39： | 2 |
| 10 | 环境振动响应下悬索桥的系统识别显示文摘对环境振动响应下悬索桥系统识别的应用进行研究和评估。为获得桥的动力特征,采用只有两个输出时间域的系统识别方法,即与Ibrahim时域方法相结合的随机衰减法,与特征系统实现算法相结合的自然励磁技术。研究两种方法的精度和效果并与有限元方法结果进行了比较。两种方法论证的系统识别的结果表明,环境振动测量可以提供桥动态特征的可靠信息。然而,与特征系统实现算法相结合的自然励磁技术更实用和有效,尤其是应用于多波段测量庞大数据时。3天的测量结果显示,风速与自然频率和阻尼比率相关,尤其在低阶模态时。 | Dionysius M. Siringoringo Yozo Fujino | 2008 | 钢结构2008，23，8： | 2 |
| 11 | SREBP-1c, regulated by the insulin and AMPK signaling pathways, playsa role in nonalcoholic fatty liver disease显示文摘 | Motoyuki Kohjima Nobito Higuchi Masaki Kato Kazuhiro Kotoh Tsuyoshi Yoshimoto Tatsuya Fujino Masayoshi Yada Ryoko Yada Naohiko Harada Munechika Enjoji Ryoichi Takayanagi Makoto Nakamuta | 2008 | International Journal of Molecular Medicine2008，，4： | 2 |
| 12 | Conservative reconstruction using stents as salvage therapy for disruption of esophago-gastric anastomosis显示文摘Esophagectomy with extended lymphadenectomy and gastric conduit reconstruction is a radical procedure for the treatment of esophageal cancer that is associated with a high morbidity rate.Gastric conduit necrosis is a fatal complication that occurs in 2%of patients.Conventionally,two-stage salvage surgery consisting of removal of the necrotic gastric conduit followed by reconstruction has been performed;however,this procedure has a high morbidity rate.We describe a61-year-old man who underwent minimally invasive esophagectomy complicated by slowly progressive gastric conduit necrosis associated with complete neck drainage and a stable overall condition.There was a 2 cm gap in the anastomosis.Because there was no evidence of residual gastric conduit necrosis,a removable,covered self-expanding metal stent(SEMS)was inserted to bridge the anastomosis.The stent was fixed to the patient's ear with silk thread through the lasso on its proximal end to prevent migration.Eight weeks after insertion,the stent was removed easily without any associated complications.The anastomotic defect was completely bridged with granulation tissue,showing progressive epithelialization without leakage or stenosis.The patient was discharged home in good general health.This is the first report of the successful conservative management of esophago-gastric conduit anastomosis disruption with SEMS placement. | Taro Oshikiri Yoshinobu Yamamoto Ikuya Miki Masahiro Tsuda Tetsu Nakamura Yasuhiro Fujino Masahiro Tominaga Yoshihiro Kakeji | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 13 | Thioredoxin and protein kinases in redox signaling显示文摘 | Go Fujino Takuya Noguchi Kohsuke Takeda Hidenori Ichijo | 2006 | Seminars in Cancer Biology2006，，6： | 2 |
| 14 | Intestinal subepithelial myofibroblasts in inflammatory bowel diseases 显示文摘 | Andoh A Fujino S Okuno T | 2002 | J Gastroenterol2002，37，14： | 1 |
| 15 | A simple formula for the dynamic stress intensity factor of an impacted freely-supported bend speci men 显示文摘 | Fujino Y Aoki S and Sakata M | 1990 | JSME International Journal Series1990，33，： | 1 |
| 16 | Performance of heated humidifiers with a heated wire according to ventilatory settings显示文摘 | Nishida T Nishimura M Fujino Y | 2001 | J Aerosol Med2001，14，1： | 1 |
| 17 | Ultrastructural changes in the compound middle lamella of Piuns thunbergii during lignification and lignin removal 显示文摘 | Hafren J Fujino T Itoh T | 2000 | Holzforschung2000，54，： | 1 |
| 18 | Wiew electric dischargegrinding for micro machining显示文摘 | Masuzawa T Fujino M Kobayashi K | 1985 | Annals of the CIRP1985，34，1： | 1 |
| 19 | 显示文摘 | Wilde K Gardoni P Fujino Y | 2000 | Engineering Structures2000，22，： | 1 |
| 20 | A non-linear dynamic model for cables and its application to a cable-structure system显示文摘 | Warnitchai P Fujino Y Susumpow T | 1995 | Journal of Sound and Vibration1995，187，4： | 1 |
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