|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury显示文摘Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host defense.However,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of inflammation.Recent studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung injury.However,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain unclear.In this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model mice.Furthermore,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing CXCR4.Sulfatide,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface CXCR4.Our findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of L-selectin.The CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death. | Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku | 2011 | Cellular & Molecular Immunology2011，8，4： | 6 |
| 2 | A potent chemotherapeutic strategy in prostate cancer: S-(methoxytrityl)-L-cysteine, a novel Eg5 inhibitor显示文摘基于 Docetaxel 的联合化疗为阉割抵抗的前列腺癌症仍然是占优势的治疗。然而, taxane 相关的药抵抗和 neurotoxicity 提示了我们开发代用品治疗策略。Eg5 (kinesin 锭子蛋白质) 为双极的锭子形成关键并且在有丝分裂的早阶段期间复制染色体分离,为癌症化疗作为一个吸引人的目标出现了。这研究的目的是调查 S-(methoxytrityl )-L-cysteine (S (MeO ) TLC ) 的 anticancer 功效,在前列腺癌症的一个新奇 Eg5 禁止者。Eg5 表示在人的前列腺癌症房间线被检验,织物 microarrays 从临床的标本被构造。在前列腺癌症房间的 S (MeO ) TLC 的 Antiproliferative 活动被房间生存能力试金估计。anticancer 效果和在前列腺癌症房间的 S (MeO ) TLC 的禁止的机制被 Hoechst 染色,流动 cytometry 和 immunofluorescence 进一步探索。另外,下的异种皮移植模型上的 S (MeO ) TLC 的 antitumor 效果被估计。Eg5 表示在 PC3, DU145 和 LNCaP 房间被识别。多于前列腺癌症的一半,临床的标本显示了 Eg5 表示。S (MeO ) TLC 与测试的另外的四个 Eg5 禁止者相比在前列腺癌症房间展出了更多的强大的 anticancer 活动。S (MeO ) TLC 在逮捕与不同 monopolar 锭子形成在有丝分裂划分房间以后导致了房间死亡。S (MeO ) TLC 展出了它的重要禁止的活动(P < 0.05 ) 通过有丝分裂的拘捕的正式就职也在下的异种皮移植上当模特儿。我们断定 Eg5 是为前列腺癌症化疗的一个好目标,并且 S (MeO ) TLC 是在前列腺癌症答应 anticancer 代理人的一个有势力。 | Nai-Dong Xing Sen-Tai Ding Ryoichi Saito Koji Nishizawa Takashi Kobayashi Takahiro Inoue Shinya Oishi Nobutaka Fujii Jia-Jv Lv Osamu Ogawax Hiroyuki Nishiyama | 2011 | Asian Journal of Andrology2011，13，2： | 4 |
| 3 | Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes显示文摘 | Osamu Fujii Jyunichi Hiratsuka Naomi Nagase Ryuji Tokiya Eisaku Yoden Hiroshi Sonoo Nobutaka Murashima Shigemichi Iha Yoshinari Imajyo | 2008 | Breast Cancer2008，，1： | 2 |
| 4 | Binding of Tachyplesin I to DNA Revealed by Footprinting Analysis: Significant Contribution of Secondary Structure to DNA Binding and Implication for Biological Action显示文摘 | Atsuo Yonezawa Jun Kuwahara Nobutaka Fujii | 1992 | Biochemistry1992，31，11： | 1 |
| 5 | Stromal cell derived factor 1 (SDF 1 ) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells ( CFU-MK ) 显示文摘 | Keiko Hodohara Nobutaka Fujii Naoki Yamamoto | 2000 | Blood2000，95，3： | 1 |
| 6 | Multicenter cooperative observational study of idiopathic pulmonary fibrosis with non-small cell lung cancer显示文摘AIM: To research the natural course of idiopathic pulmonary fibrosis(IPF) with advanced non-small cell lung cancer(NSCLC) and the association between acuteMETHODS: From May 2007 through April 2011, 17 CT naive patients with IPF and advanced NSCLC were enrolled. Patients were classified into best supportive care(BSC) group or CT group based on the patient's preference. Patients in the CT group received carboplatin(CBDCA)(AUC 5-6) plus paclitaxel(PTX)(175-200 mg/m2) on day 1 of each 21-d cycle as first-line therapy.RESULTS: All patients but one chose the CT group. In the CT group, the objective response rate was 38%. The most frequent toxicity ≥ grade 3 was neutropenia(88%). Two patients(12.5%) developed AE-IPF. The median progression-free survival, the median survival time and the 1-year survival rate were 4.1 mo, 8.7 mo and 35%, respectively. Second-line CT-related AE and CT-unrelated AE occurred in 2 and 3 patients(1: BSC group; 2: CT group), respectively. Seven(41%) of all patients developed AE-IPF throughout the clinical course, and 6 of 7 patients with AE-IPF died within one month.CONCLUSION: The incidence of AE-IPF was higher among IPF patients with advanced NSCLC than among those without NSCLC. CBDCA plus PTX regimen was tolerable and effective. However, AE-IPF has a fatal toxicity with or without CT in IPF patients with advanced NSCLC. | Noriyuki Ebi Shoji Tokunaga Kazunobu Itoh Isamu Okamoto Nobutaka Edakuni Shinji Fujii Kentaro Watanabe Shinichiro Hayashi Takashige Maeyama Yoichi Nakanishi | 2016 | World Journal of Respirology2016，6，1： | 1 |
| 7 | Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria显示文摘 | Katsumi Matsuzaki Ken-ichi Sugishita Mitsunori Harada Nobutaka Fujii Koichiro Miyajima | 1997 | BBA - Biomembranes1997，，： | 1 |
| 8 | Silver trifluoromethanesulphonate as an S- deprotecting reagent for the synthesis of cystine peptides显示文摘 | Nobutaka Fujii Akira Otaka Toshihiro Watanabe | 1989 | J Chem Soc Chem Commun1989，，： | 1 |
| 9 | The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche显示文摘 | Yoshiki Omatsu Tatsuki Sugiyama Hiroshi Kohara Gen Kondoh Nobutaka Fujii Kenji Kohno Takashi Nagasawa | 2010 | Immunity2010，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员