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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis显示文摘Polyreactive 天生类型的 B 房间说明在圆周表示自我反应的许多 B 房间。这些 B 房间的不适当的规定可以是位于自体免疫的疾病下面的一个重要因素。这里,我们在导致骨胶原的关节炎(中央情报局) 的开发探索了自我反应的天生的 B 房间的影响,风湿性关节炎的一个鼠标模型。我们显示出那个脾的边缘的地区(MZ ) ,然而并非 B-1 B 房间在 naı 展出自发的 IgM 反应到自体同源的骨胶原 II; ¨ ve 老鼠。在有在完全的 Freund’ 的 heterologous 骨胶原 II 的免疫之上;骨胶原反应的 MZ B 房间很快扩展了的 s 助手,当 B-1 B 房间显示出谦虚反骨胶原回答时。MZ B 房间被像使用费的受体(TLR ) 容易激活 4 并且在 vitro,导致的增长和 cytokine 分泌物的 9-ligands,暗示 B 房间受体和 TLR 的那个双约会可以把有免疫力的反应提升到自我抗原。而且,告知骨胶原的 MZ B 房间显示出在 vivo 在 IgG 反骨胶原抗体的 vitro 和正式就职由血缘的 T 房间增长思考了的重要介绍抗原的能力。在 1 和 2 表明了的补充受体是缺乏的 MZ B 房间增加了增长和 cytokine 生产,当时 Fcγ房间的受体 IIb 缺乏导致增加的 cytokine 生产和抗原表示。在结论,我们的数据在中央情报局作为自体免疫的反应的开始者加亮自我反应的 MZ B 房间,在补充和 Fc 受体在在房间控制自我反应是相关的的地方。 | Anna-Karin E Palm Heike C Friedrich Anja Mezger Maya Salomonsson Linda K Myers Sandra Kleinau | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 4 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 5 | A multiple scattering solution for the effective permittivity of a sphere mixture显示文摘 | Chew W C Friedrich J A Geiger R | 1990 | IEEE Trans Geosci Remote Sensing1990，28，2： | 1 |
| 6 | A modular DNA signal translator for the controlled release of a protein by an aptamer显示文摘 | Stefan Beyer Friedrich C Simmel | 2006 | Nucleic Acids Research2006，34，5： | 1 |
| 7 | Angiotensin Ⅱ directly increases transforming growth factor beta1 and osteopontin and indirectly affects collagen mRNA expression in the human heart显示文摘 | Kupfahl C Pink D Friedrich K | 2000 | Cardiovasc Res2000，46，3： | 1 |
| 8 | Acetyl chloride promoted cyclopropanations of alkenes with dibromomethane using zinc dust and copper (I) chloride in ether 显示文摘 | Friedrich E C | 1990 | J Org Chem1990，55，： | 1 |
| 9 | Characterization of solidified reverse micellellar solutions (SRMS) and production development of SRMS-based nanosuspensions显示文摘 | Friedrich I Muller-Goymann C C | 2003 | Eur J Pharm Biopharm2003，56，1： | 1 |
| 10 | Determination of tempera- ture elevation in tissue during the application of the harmolfic scal- pel显示文摘 | Koch C Friedrich T Metternich F | 2003 | Ultrasound Med Biol2003，29，2： | 1 |
| 11 | $100 protein and specific enolase concentrations in blood as indieators of in- farction voluroe and prognosis in acute jachemie stroke 显示文摘 | Missler U Wiesmann M Friedrich C | 1997 | Stroke1997，28，10： | 1 |
| 12 | Protonated titanates and TiO2 nanostructured materials : synthesis, properties, and applications 显示文摘 | Bavykin D V Friedrich J M Walsh F C | 2006 | Advanced Materials2006，18，： | 1 |
| 13 | Estimating bottom stress in tidal boundary layer from acoustic Doppler velocimeter data显示文摘 | Kim S C Friedrichs C T Maa J P | 2000 | Journal of Hydraulic Engineering2000，126，6： | 1 |
| 14 | Linagliptin,a novel DPP-4 inhibitor:no need for dose adjustment in patients with renal impairment (Abstract 822)显示文摘 | Graefe-Mody U Friedrich C Port A | 2010 | Diabetologia2010，53，1： | 1 |
| 15 | BTA copper complexes显示文摘 | FRIEDRICH M RUIZ J C G KLAPOLTKE T M | 2005 | Inorg Chem2005，44，22： | 1 |
| 16 | Bottom -boundary - layer processes associated with fine sediment accumulation in coast- al seas and bays 显示文摘 | Friedrichs C T Wrigbt L D Hepworth D A | 2000 | Continental Shelf Research2000，，20： | 1 |
| 17 | Protonated titanates and TiO2 nanostructured materials:Synthesis,properties,and applications显示文摘 | Bavykin D V Friedrich J M Walsh F C | 2006 | Advanced Materials2006，18，21： | 1 |
| 18 | Spatial trends in tidal flatshape and associated environmental parameters in South SanFrancisco Bay显示文摘 | BEARMAN J A FRIEDRICHS C T JAFFE B E | 2010 | Journal of Coastal Research2010，26，2： | 1 |
| 19 | Primitive neuroectodermal tumor (PNET)in the differential diagnosis of malignant kidney tumors 显示文摘 | Vorreuther R Poremba C | 2002 | Pathol Res Pract2002，198，8： | 1 |
| 20 | Angiotensin Ⅱ directly increases transforming growth factor betal and osteopontin and indirectly affects collagen mRNA expression in the human heart显示文摘 | Pink D Friedrich K | 2000 | Cardiovasc Res2000，46，3： | 1 |
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