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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | Tight junction disruption: Helicobacter pylori and dysregulation of the gastric mucosal barrier显示文摘Long-term chronic infection with Helicobacter pylori(H. pylori) is a risk factor for gastric cancer development. In the multi-step process that leads to gastric cancer,tight junction dysfunction is thought to occur and serve as a risk factor by permitting the permeation of luminal contents across an otherwise tight mucosa. Mechanisms that regulate tight junction function and structure in the normal stomach,or dysfunction in the infected stomach,however,are largely unknown. Although conventional tight junction components are expressed in gastric epithelial cells,claudins regulate paracellular permeability and are likely the target of inflammation or H. pylori itself. There are 27 different claudin molecules,each with unique properties that render the mucosa an intact barrier that is permselective in a way that is consistent with cell physiology. Understanding the architecture of tight junctions in the normal stomach and then changes that occur during infection is important but challenging,because most of the reports that catalog claudin expression in gastric cancer pathogenesis are contradictory. Furthermore,the role of H. pylori virulence factors,such as cytotoxin-associated gene A and vacoulating cytotoxin,in regulating tight junction dysfunction during infection is inconsistent in different gastric cell lines and in vivo,likely because non-gastric epithelial cell cultures were initially used to unravel the details of their effects on the stomach. Hampering further study,as well,is the relative lack of cultured cell models that have tight junction claudins that are consistent with native tissues. This summary will review the current state of knowledge about gastric tight junctions,normally and in H. pylori infection,and make predictions about the consequences of claudin reorganization during H. pylori infection. | Tyler J Caron Kathleen E Scott James G Fox Susan J Hagen | 2015 | World Journal of Gastroenterology2015，21，40： | 7 |
| 4 | Heterogeneity in mouse spasmolytic polypeptide-expressing metaplasia lineages identifies markers of metaplastic progression显示文摘 | Victoria G Weis Josane F Sousa Bonnie J LaFleur Ki Taek Nam Jared A Weis Paul E Finke Nadia A Ameen James G Fox James R Goldenring | 2013 | Gut2013，，9： | 3 |
| 5 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 6 | Coating characteristics and tribological properties of sputterdeposited MoS2/metal composite coatings deposited by closed field unbalanced magnetron sputter ion plating显示文摘 | Renevier N M Fox V C Teer D G | 2000 | Surface and Coatings Technology2000，127，： | 2 |
| 7 | Chronic proliferative hepatitis in A / J Cr mice associated with persistent Helicobacter hepaticus infection: a model of Helicobacter-induced carcinogenesis 显示文摘 | Fox J G Li X Yan L | 1996 | Infect Immun1996，64，5： | 1 |
| 8 | Efficacy of me-mantine on behavioral and psychological symptoms related to dementia:a systematic meta-analysis显示文摘 | MAIDMENT I D FOX C G BOUSTANI M | 2008 | Ann Pharmacother2008，42，1： | 1 |
| 9 | Mice lacking inducible nitric oxide synthase develop spontaneous hypercholestemlaemia and aortic atheromas显示文摘 | Ihrig M Dangler C A Fox J G | 2001 | Atherosclerosis2001，156，1： | 1 |
| 10 | Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing 显示文摘 | Chamberlain G Fox J Ashton B | 2007 | Stem Cdls2007，25，11： | 1 |
| 11 | High-salt diet induces Helicobacter pylori colonization in epithelial hyperplasia and parietal cell loss, and enhances helicobacter pylori colonization in C57BL/6 mice显示文摘 | Fox J G Dangler C A Taylor N S | 1999 | Cancer Res1999，59，9： | 1 |
| 12 | Eight histidine residues are catalytically essential in a membrane-associated iron enzyme, stettroyl-CoA desaturase, and are cmmerved in alkane hydroxylase and xylene monooxygenase显示文摘 | Shankin J Whittle E Fox B G | 1994 | Bichemistry1994，33，12： | 1 |
| 13 | HIV replication in IL-2-stimulated peripheral blood mononuclear cells is driven in an autocrine/paracrine manner by endogenous cytokines显示文摘 | Kinter AL Poli G Fox L | 1995 | J Immunol1995，154，5： | 1 |
| 14 | Prediction of ruminal volatile fatty acids and pH within the net carbohydrate and protein system显示文摘 | Pitt R E Van KesselJ S Fox D G | 1996 | J Anita Sci1996，74，： | 1 |
| 15 | Helicobacter canis isolated from a dog liver with multifocal necrotizing hepatitis 显示文摘 | Fox J G Drolet R Higgins R | 1996 | J Clin Microbiol1996，34，10： | 1 |
| 16 | Nuclear locali- zation of Myomesin-l: Possible functions显示文摘 | Reddy K B Fox J E Priee M G | 2008 | Muscle Res Cell Motil2008，29，1： | 1 |
| 17 | Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus 显示文摘 | Fox J G Yan L Shames B | 1996 | Infect Immun1996，64，9： | 1 |
| 18 | Methanogens: reevaluation of a unique biological group显示文摘 | BALCH W E FOX G E MAGRUM L J | 1979 | Microbiological Reviews1979，43，2： | 1 |
| 19 | Synthesis and characterization of copper-doped carbon aerogels显示文摘 | BAUMANN T F FOX G A SATCHER J H | 2002 | Langmuir2002，18，： | 1 |
| 20 | The role of titanium in the non-metallic inclusions which nucleate acicular ferrite in the submerged arc weld fusion zones of navy HY - 100 steel显示文摘 | Fox A G Brothers D G | 1995 | Scripta Metallurgica Materialia1995，32，7： | 1 |
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