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| 1 | Nine compounds from the root bark of Lycium chinense and their anti-inflammatory activities显示文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L. | Yanan Yang Yawen An Wei Wang Ning Du Jinghua Zhang Ziming Feng Jianshuang Jiang Peicheng Zhang | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 9 |
| 2 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 3 | Bioactive thionic compounds and aromatic glycosides from Ligusticum chuanxiong显示文摘Three new thionic compounds,(S)-2-(2-carboxyl-2-hydroxyethylthio)-ferulic acid(1),(E)-2-methoxy-4-(3-(methylsulfonyl)prop-1-en-1-yl)phenol(2), and thiosenkyunolide C(3), together with two new aromatic glycosides(4 and 5) were isolated from the rhizome of Ligusticum chuanxiong Hort. Two known compounds(6 and 7) were also obtained. Their structures were elucidated based on extensive spectroscopic data(UV, IR, 1D and 2D NMR, and HR-ESI-MS). Furthermore the absolute configurations were established by comparison of their calculated and experimental circular dichroism spectra and by a dimolybdenum tetraacetate [Mo_2(AcO)_4]-induced circular dichroism procedure. All compounds were evaluated against lipopolysaccharide(LPS)-induced NO production in BV2 cells, and compounds 4 and 5 showed strong inhibitory activities with IC_(50) values of 2.03 and 3.09 μmol/L, respectively(positive control curcumin, IC_(50)=6.17 μmol/L). In addition, compound 1 showed weak proteintyrosine phosphatase-1 B(PTP1B) inhibitory activity. | Xu Zhang Bing Han Ziming Feng Jianshuang Jiang Yanan Yang Peicheng Zhang | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 5 |
| 4 | Three-dimensional silk fibroin scaffolds enhance the bone formation and angiogenic differentiation of human amniotic mesenchymal stem cells:a biocompatibility analysis显示文摘Silk fibroin(SF)is a fibrous protein with unique mechanical properties,adjustable biodegradation,and the potential to drive differentiation of mesenchymal stem cells(MSCs)along the osteogenic lineage,making SF a promising scaffold material for bone tissue engineering.In this study,hAMSCs were isolated by enzyme digestion and identified by multiple-lineage differentiation.SF scaffold was fabricated by freeze-drying,and the adhesion and proliferation abilities of hAMSCs on scaffolds were determined.Osteoblast differentiation and angiogenesis of hAMSCs on scaffolds were further evaluated,and histological staining of calvarial defects was performed to examine the cocultured scaffolds.We found that hAMSCs expressed the basic surface markers of MSCs.Collagen type I(COLI)expression was observed on scaffolds cocultured with hAMSCs.The scaffolds potentiated the proliferation of hAMSCs and increased the expression of COL-I in hAMSCs.The scaffolds also enhanced the alkaline phosphatase activity and bone mineralization,and upregulated the expressions of osteogeniorelated factors in vitro.The scaffolds also enhanced the an gioge nic differe ntiati on of hAMSCs.The cocultured scaffolds in creased bone formati on in treating critical calvarial defects in mice.This study first demonstrated that the application of 3D SF scaffolds co-cultured with hAMSCs greatly enhaneed osteogenic differentiation and angiogenesis of hAMSCs in vitro and in vivo.Thus,3D SF scaffolds cocultured with hAMSCs may be a better alter native for bone tissue engin eering. | Yuwan Li Ziming Liu Yaping Tang Qinghong Fan Wei Feng Changqi Luo Guangming Dai Zhen Ge Jun Zhang Gang Zou Yi Liu Ning Hu Wei Huang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
| 5 | New hepatoprotective coumarinolignoids from Mallotus apeha 显示文摘 | Xu Jianfu Feng Ziming Liu Jian | 2008 | Chemistry & biodiversity2008，5，5： | 1 |
| 6 | Anthraquinone-benzisochromanquinone dimers from the roots of Berchemia floribunda 显示文摘 | WEI Xin JIANG Jianshuang FENG Ziming | 2008 | Chem Pharm Bull2008，56，9： | 1 |
| 7 | Three-Year Consecutive Field Application of Erythromycin Fermentation Residue Following Hydrothermal Treatment:Cumulative Effect on Soil Antibiotic Resistance Genes显示文摘Fermentation-based antibiotic production results in abundant nutrient-rich fermentation residue with high potential for recycling,but the high antibiotic residual concentration restricts its usefulness(e.g.,in land application as organic fertilizer).In this study,an industrial-scale hydrothermal facility for the treatment of erythromycin fermentation residue(EFR)was investigated,and the potential risk of the long-term soil application of treated EFR promoting environmental antibiotic resistance development was evaluated.The treatment effectively removed bacteria and their DNA,and an erythromycin removal ratio of up to approximately 98%was achieved.The treated EFR was utilized as organic fertilizer for consecutive field applications from 2018 to 2020,with dosages ranging from 3750 to 15000 kg·hm^(-2),resulting in subinhibitory levels of erythromycin(ranging from 0.83-76.00μg·kg^(-1))in soils.Metagenomic shotgun sequencing was then used to characterize the antibiotic resistance genes(ARGs),mobile genetic elements(MGEs),and bacterial community composition of the soils.The soil ARG abundance and diversity did not respond to the treated EFR application in the first year,but gradually changed in the second and third year of application.The highest fold change in relative abundance of macrolide-lincosamide-streptogramin(MLS)and total ARGs were 12.59 and 2.75 times,compared with the control(CK;without application),respectively.The soil MGEs and taxonomic composition showed similar temporal trends to those of the ARGs,and appeared to assist in driving increasing ARG proliferation,as revealed by correlation analysis and structural equation models(SEMs).The relative abundance of particular erm resistance genes(RNA methyltransferase genes)increased significantly in the third year of treated EFR application.The close association of erm with MGEs suggested that horizontal gene transfer played a critical role in the observed erm gene enrichment.Metagenomic binning results demonstrated that the proliferation of mac genecarrying hosts was responsible for the increased abundance of mac genes(efflux pump genes).This study shows that sub-inhibitory levels of erythromycin in soils had a cumulative effect on soil ARGs over time and emphasizes the importance of long-term monitoring for assessing the risk of soil amendment with treated industrial waste. | Ziming Han Haodi Feng Xiao Luan Yunpeng Shen Liren Ren Liujie Deng D.G.Joakim Larsson Michael Gillings Yu Zhang Min Yang | 2022 | Engineering2022，8，8： | 1 |
| 8 | Cctpillary eleetrophoresis - ehemi]umineseenee detection for eareino-embryonic antigen based on aptamer/graphene oxide strueture 显示文摘 | Ziming Zhou Zhe Feng Jun Zhou | 2015 | Biosensors and Bioelectronics2015，64，： | 1 |
| 9 | New hepatoprotective coumarinolignoids from Mallotus apelta 显示文摘 | Xu Jianfu Feng Ziming Liu Jian | 2008 | Chem Biodivers2008，5，4： | 1 |
| 10 | Lig-nans from the root of Rhodiola crenulata 显示文摘 | YANG Yanan LIU Zhaozhen FENG Ziming | 2012 | Journal ofAgricultural and Food Chemistry2012，60，： | 1 |
| 11 | Three quinolizidine dimers from the seeds of Sophora alopecuroides and their hepatoprotective activities显示文摘Sophoralines A–C,three novel[2+2]cycloaddition dimers of matrine-based alkaloids with an unprecedented 6/6/6/6/4/6/6/6/6 nonacyclic skeleton containing 11 stereogenic centers,were isolated from Sophora alopecuroides.Their structures were determined by spectroscopic methods,and the absolute configurations were further determined by single-crystal X-ray diffraction analysis for 1 and quantum chemical calculations of electronic circular dichroism(ECD)spectra for 2 and 3.Moreover,1 exhibited excellent hepatoprotective activities in acetaminophen-induced liver injury in vitro and in vivo. | Xiang Yuan Jianshuang Jiang Yanan Yang Xu Zhang Ziming Feng Peicheng Zhang | 2022 | Chinese Chemical Letters2022，33，6： | 1 |
| 12 | Alopecuroidines A-C, three matrine-derived alkaloids from the seeds of Sophora alopecuroides显示文摘Three matrine-derived alkaloids, alopecuroidine A(1), alopecuroidine B(2 a) and alopecuroidine C(2 b)were isolated from the seeds of Sophora alopecuroides. Their structures were elucidated by extensive spectroscopic analyses and X-ray diffraction. Three compounds possess an unprecedented rearranged fused7/6/5/6 tetracyclic skeleton with a diazacycloheptane structure. Their plausible biosynthetic pathway was also proposed. The anti-proliferative activities of compounds 1 and 2 a were examined by the MTT assay.Compound 1 inhibited the viability of human lung cancer A549 cells, having a half maximal inhibitory concentration(IC50) of 7.58 ± 2.47 μmol/L at 72 h. The flow cytometric analysis suggested that 1 inhibited A549 cell growth by inducing apoptosis and cell-cycle arrest. Additionally, 1 induced the loss of mitochondrial membrane potential, elevated intracellular reactive oxygen species, increased the Bax/Bcl-2 ratio, stimulated cleaved-caspase-3 and P53 protein levels, and suppressed the pro-caspase-3 level. Thus,1 appeared to induce A549 cells apoptosis through a mitochondria-mediated apoptotic pathway. | Xiang Yuan Zhenyuan Li Ziming Feng Jianshuang Jiang Yanan Yang Peicheng Zhang | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 13 | Galangin mitigates glucocorticoid-induced osteoporosis by activating autophagy of BMSCs via triggering the PKA/CREB signaling pathway显示文摘Glucocorticoid-induced osteoporosis(GIOP),one of the most common and serious adverse effects associated with glucocorticoid administration,manifests as decreased bone formation and increased bone resorption,eventually culminating in bone loss.Galangin(GAL)is a flavonoid extracted from the medicinal herbal galangal that possesses a variety of pharmacological activities and can inhibit osteoclastogenesis.However,the effects of GAL on GIOP remain unclear.Our study aims to explore the effects of GAL on GIOP in mice and the underlying mechanism.Our results show that GAL markedly mitigates the severity of dexamethasone(Dex)-induced osteoporosis in mice and potentiates osteogenic differentiation in mouse bone marrow-derived mesenchymal stem cells(BMSCs).Furthermore,GAL also significantly counteracts Dex-mediated suppression of osteogenic differentiation and autophagy in human BMSCs.GAL augments PKA/CREB-mediated autophagic flux in BMSCs and the bones of osteoporotic mice.GAL-mediated osteogenic differentiation in Dex-treated BMSCs is significantly decreased by the PKA inhibitor H89 and autophagy inhibitor 3-methyladenine.Collectively,our data indicate that GAL can ameliorate GIOP,partly by augmenting the mineralization of BMSCs by potentiating PKA/CREB-mediated autophagic flux,highlighting its potential therapeutic use in treating glucocorticoid-related osteoporosis. | Chenying Zeng Shan Wang Huimin Gu Fenglei Chen Ziming Wang Jinteng Li Zhongyu Xie Pei Feng Huiyong Shen Yanfeng Wu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 14 | Check dam extraction from remote sensing images using deep learning and geospatial analysis:A case study in the Yanhe River Basin of the Loess Plateau,China显示文摘Check dams are widely used on the Loess Plateau in China to control soil and water losses,develop agricultural land,and improve watershed ecology.Detailed information on the number and spatial distribution of check dams is critical for quantitatively evaluating hydrological and ecological effects and planning the construction of new dams.Thus,this study developed a check dam detection framework for broad areas from high-resolution remote sensing images using an ensemble approach of deep learning and geospatial analysis.First,we made a sample dataset of check dams using GaoFen-2(GF-2)and Google Earth images.Next,we evaluated five popular deep-learning-based object detectors,including Faster R-CNN,You Only Look Once(version 3)(YOLOv3),Cascade R-CNN,YOLOX,and VarifocalNet(VFNet),to identify the best one for check dam detection.Finally,we analyzed the location characteristics of the check dams and used geographical constraints to optimize the detection results.Precision,recall,average precision at intersection over union(IoU)threshold of 0.50(AP_(50)),IoU threshold of 0.75(AP_(75)),and average value for 10 IoU thresholds ranging from 0.50-0.95 with a 0.05 step(AP_(50-95)),and inference time were used to evaluate model performance.All the five deep learning networks could identify check dams quickly and accurately,with AP_(50-95),AP_(50),and AP_(75)values higher than 60.0%,90.0%,and 70.0%,respectively,except for YOLOv3.The VFNet had the best performance,followed by YOLOX.The proposed framework was tested in the Yanhe River Basin and yielded promising results,with a recall rate of 87.0%for 521 check dams.Furthermore,the geographic analysis deleted about 50%of the false detection boxes,increasing the identification accuracy of check dams from 78.6%to 87.6%.Simultaneously,this framework recognized 568 recently constructed check dams and small check dams not recorded in the known check dam survey datasets.The extraction results will support efficient watershed management and guide future studies on soil erosion in the Loess Plateau. | SUN Liquan GUO Huili CHEN Ziyu YIN Ziming FENG Hao WU Shufang Kadambot H M SIDDIQUE | 2023 | Journal of Arid Land2023，15，1： | 0 |
| 15 | Metagenomic insights into microorganisms and antibiotic resistance genes of waste antibiotic fermentation residues along production,storage and treatment processes显示文摘Antibiotic fermentation residue(AFR)is nutrient-rich solid waste generated from fermentative antibiotic production process.It is demonstrated that AFR contains high-concentration of remaining antibiotics,and thus may promote antibiotic resistance development in receiving environment or feeding farmed animals.However,the dominate microorganisms and antibiotic resistance genes(ARGs)in AFRs have not been adequately explored,hampering understanding on the potential antibiotic resistance risk development caused by AFRs.Herein,seven kinds of representative AFRs along their production,storage,and treatment processes were collected,and multiple methods including amplicon sequencing,metagenomic sequencing,and bioinformatic approaches were adopted to explore the biological characteristics of AFRs.As expected,antibiotic fermentation producer was found as the predominant species in raw AFRs,which were collected at the outlet of fermentation tanks.However,except for producer species,more environment-derived species persisted in stored AFRs,which were temporarily stored at a semi-open space.Lactobacillus genus,classified as Firmicutes phylum and Bacilli class,became predominant bacterial taxa in stored AFRs,which might attribute to its tolerance to high concentration of antibiotics.Results from metagenomic sequencing together with assembly and binning approaches showed that these newly-colonizing species(e.g.,Lactobacillus genus)tended to carry ARGs conferring resistance to the remaining antibiotic.However,after thermal treatment,remaining antibiotic could be efficiently removed from AFRs,and microorganisms together with DNA could be strongly destroyed.In sum,the main risk from the AFRs was the remaining antibiotic,while environment-derived bacteria which tolerate extreme environment,survived in ARFs with high content antibiotics,and may carry ARGs.Thus,hydrothermal or other harmless treatment technologies are recommended to remove antibiotic content and inactivate bacteria before recycling of AFRs in pharmaceutical industry. | Ziming Han Xiao Luan Haodi Feng Yanqin Deng Min Yang Yu Zhang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 16 | 1,2-Dibromoethane and KI mediated α-acyloxylation of ketones with carboxylic acids显示文摘The 1,2-dibromoethane-and Kl-mediatedα-acyloxylation of ketones is reported in moderate to good yield without the use of transition metals and strong oxidants.Various acids are well tolerated with wide functional group compatibility.An 1,2-dibromoethane-and Kl-catalysed reaction mechanism is proposed based on the results of control experiments. | Xujie Wang Gangsheng Li Yanan Yang Jianshuang Jiang Ziming Feng Peicheng Zhang | 2020 | Chinese Chemical Letters2020，31，3： | 0 |
| 17 | An ESS System for ECRIS Emittance Research显示文摘There are many characteristics to describe the performance of an ion source, such as beam current, emittance, energy spread of the extracted beam and so on. Among them, the beam emittance is always the one that make us suspicious. So it is especially important to measure and study the emittance of ion beams. Now, there are two kinds of methods to measure ion beam emittance. One is destructive method. With this method, | Cao Yun, Sun Liangting, Ma Baohua, Zhang Ziming, Wang Hui, He Wei, Li Xixia Feng Yucheng, Li Jingyu, Guo Xiaohong, Zhang Xuezhen and Zhao Huanyu | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 18 | Characteristics of Self-Healing Microcapsules for Cementitious Composites显示文摘Urea formaldehyde/epoxy resin microcapsules were prepared by an in situ polymerization method and the effect of emulsifier on the syntheses process of the microcapsules was discussed. The surface morphology of the microcapsules was observed by optical microscopy and scanning electron microscopy(SEM). Chemical structure was characterized by Fourier transform infrared spectroscopy(FTIR). Thermal stability was obtained using simultaneous thermal analysis(STA). The microcapsules were composed of urea-formaldehyde resin shell and epoxy resin core. Emulsifier played an important role in the polymerization process when the core material was packed by pre-polymer, so the effects of different emulsifiers(OP-10, SDS and SDBS) were discussed respectively. Results showed that the particle size of the microcapsules was uniform when SDBS as an emulsifier. Microcapsules showed good thermal stability below 240 ℃ and the initial decomposition temperature of the microcapsules was 265 ℃. The core materials released after microcapsules rupturing, which could be proven by the images of SEM. When implanted in cementitious composites, complete shape of microcapsules and good interface between microcapsules and cement specimen substrate could also be observed. | 毛倩瑾 FENG Xiaojuan LIANG Peng WANG Rui WANG Ziming CUI Suping LAN Mingzhang | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，5： | 0 |
| 19 | Advances in the Application of Perovskite Materials显示文摘Nowadays, the soar of photovoltaic performance of perovskite solar cells has set off a fever in the study of metal halide perovskite materials. The excellent optoelectronic properties and defect tolerance feature allow metal halide perovskite to be employed in a wide variety of applications. This article provides a holistic review over the current progress and future prospects of metal halide perovskite materials in representative promising applications, including traditional optoelectronic devices(solar cells, light-emitting diodes, photodetectors, lasers), and cutting-edge technologies in terms of neuromorphic devices(artificial synapses and memristors) and pressure-induced emission. This review highlights the fundamentals, the current progress and the remaining challenges for each application, aiming to provide a comprehensive overview of the development status and a navigation of future research for metal halide perovskite materials and devices. | Lixiu Zhang Luyao Mei Kaiyang Wang Yinhua Lv Shuai Zhang Yaxiao Lian Xiaoke Liu Zhiwei Ma Guanjun Xiao Qiang Liu Shuaibo Zhai Shengli Zhang Gengling Liu Ligang Yuan Bingbing Guo Ziming Chen Keyu Wei Aqiang Liu Shizhong Yue Guangda Niu Xiyan Pan Jie Sun Yong Hua Wu‑Qiang Wu Dawei Di Baodan Zhao Jianjun Tian Zhijie Wang Yang Yang Liang Chu Mingjian Yuan Haibo Zeng Hin‑Lap Yip Keyou Yan Wentao Xu Lu Zhu Wenhua Zhang Guichuan Xing Feng Gao Liming Ding | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 20 | Effectiveness of Fuling(Poria) and its extracts against spleen deficiency in rats via tonifying spleen显示文摘OBJECTIVE:To observe and explore the effect of Fuling(Poria) in alleviating the spleen deficiency symptom pattern(SDSP).METHODS:We established an animal model of SDS in Sprague-Dawley(SD) rats by treating them with deficiency-inducing factors,including irregular feeding and tail clamping.Mice were administered Fuling(Poria) and its extracts(raw/cooked powder,aqueous/alcohol extract) by gavage once a day for 21 d.The body weight,rectal temperature,and spleen and thymus organ coefficients were calculated.The levels of motilin(MTL),gastrin(GAS),aquaporin 2(AQP2),interleukin 2(IL-2),IL-4,and 5-hydroxytryptamine(5-HT) in the serum and the level of AQP2 in the kidneys were evaluated by enzyme-linked immunosorbent assay.RESULTS:Fuling(Poria) and its extracts did not change the body weight,rectal temperature,and organ coefficients of the spleen and thymus.However,it reduced the levels of MTL and GAS and increased the levels of IL-2 and AQP2.In addition,the levels of IL-4 and 5-HT showed no significant alteration.CONCLUSIONS:These results suggested the crucial function of Fuling(Poria) in SDSP,especially promoting digestive function and water metabolism. | FENG Min JIA Ziming WAN Ming FAN Bolin TANG Xiaoqiao CHENG Wenhua SUN Fanzhong | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 0 |
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