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| 1 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 2 | 5-Ethynyl-2′-deoxyuridine as a molecular probe of cell proliferation for high-content siRNA screening assay by “click” chemistry显示文摘Labelling and identification of proliferating cells is important for the study of physiological or pathological processes in high-content screening (HCS) assays. Here we describe ethynyl deoxyuridine (EdU) as a biomarker for the assessment of cell proliferation and clearly demonstrate the feasibility of the EdU-labelling method for use in HCS assays. EdU detection is highly robust, reproducible, technically simple, and well suited for automated segmentation, which provides an excellent al- ternative for setting up multiplexed HCS assays of siRNA, miRNA and small-molecule libraries. | CHEN MiaoJuan QU DeZhong CHI WeiLin WANG Wei REN XiaoShuai CONG ShuJie LIANG PeiZhou FENG ShiPeng ZHANG BiLiang | 2011 | Science China Chemistry2011，54，11： | 6 |
| 3 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 4 | Lifting-based wavelet transform with direetionally spatial prediction显示文摘 | Ding Wenpeng Wu Feng Li Shipeng | 2004 | Picture Coding Symposium2004，4，： | 1 |
| 5 | Seamless switching of scalable video bitstreams for efficient streaming显示文摘 | Sun Xiaoyan Wu Feng Li Shipeng | 2004 | IEEE Trans on Multimedia2004，6，2： | 1 |
| 6 | A framework for efficient progressive fine granularity scalable video coding显示文摘 | Wu Feng Li Shipeng Zhang YaQin | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，3： | 1 |
| 7 | A Framework for Efficient Progressive Fine Granularity Scalable Video Coding显示文摘 | Feng Wu Shipeng Li Ya-Qin Zhang | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，3，11： | 1 |
| 8 | A framework for efficient progressive fine granularity scalable video coding 显示文摘 | WU Feng LI Shipeng ZHANG Yaqin | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，3： | 1 |
| 9 | A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts显示文摘 | Ronghui Li Jialiang Liang Su Ni Ting Zhou Xiaobing Qing Huapeng Li Wenzhi He Jiekai Chen Feng Li Qiang Zhuang Baoming Qin Jianyong Xu Wen Li Jiayin Yang Yi Gan Dajiang Qin Shipeng Feng Hong Song Dongshan Yang Biliang Zhang Lingwen Zeng Liangxue Lai Miguel | 2010 | Cell Stem Cell2010，，1： | 1 |
| 10 | Resource types, formation, distribution and prospects of coal-measure gas显示文摘Coal-measure gas is the natural gas generated by coal, carbonaceous shale, and dark shale in coal-measure strata. It includes resources of continuous-type coalbed methane (CBM), shale gas and tight gas reservoirs, and trap-type coal-bearing gas reservoirs. Huge in resources, it is an important gas source in the natural gas industry. The formation and distribution characteristics of coal-measure gas in San Juan, Surat, West Siberia and Ordos basins are introduced in this paper. By reviewing the progress of exploration and development of coal-measure gas around the world, the coal-measure gas is confirmed as an important strategic option for gas supply. This understanding is mainly manifested in three aspects. First, globally, the Eurasian east-west coal-accumulation belt and North American north-south coal-accumulation belt are two major coal-accumulation areas in the world, and the Late Carboniferous–Permian, Jurassic and end of Late Cretaceous–Neogene are 3 main coal-accumulation periods. Second, continuous-type and trap-type are two main accumulation modes of coal-measure gas;it is proposed that the area with gas generation intensity of greater than 10×10^8 m^3/km^2 is essential for the formation of large coal-measure gas field, and the CBM generated by medium- to high-rank coal is usually enriched in syncline, while CBM generated by low-rank coal is likely to accumulate when the source rock and caprock are in good configuration. Third, it is predicted that coal-measure gas around the world has huge remaining resources, coal-measure gas outside source is concentrated in Central Asia-Russia, the United States, Canada and other countries/regions, while CBM inside source is largely concentrated in 12 countries. The production of coal-measure gas in China is expected to exceed 1000×10^8 m^3 by 2030, including (500–550)×10^8 m^3 conventional coal-measure gas,(400–450)×10^8 m^3 coal-measure tight gas, and (150–200)×10^8 m^3 CBM. | ZOU Caineng YANG Zhi HUANG Shipeng MA Feng SUN Qinping LI Fuheng PAN Songqi TIAN Wenguang | 2019 | Petroleum Exploration and Development2019，46，3： | 1 |
| 11 | A Framework for Efficient Progressive Fine Granularity Scalable Video Coding显示文摘 | Feng Wu Shipeng Li Ya-Qin Zhang | 2001 | IEEE Transactions On Circuits And Systems For Video Technology2001，11，3： | 1 |
| 12 | Image Compression With Edge-Based Inpainting显示文摘 | Dong Liu Xiaoyan Sun Feng Wu Shipeng Li Ya-Qin Zhang | 2007 | IEEE Transaction on Circuits and Systems for Video Technology2007，17，10： | 1 |
| 13 | A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts显示文摘 | Ronghui Li Jialiang Liang Su Ni Ting Zhou Xiaobing Qing Huapeng Li Wenzhi He Jiekai Chen Feng Li Qiang Zhuang Baoming Qin Jianyong Xu Wen Li Jiayin Yang Yi Gan Dajiang Qin Shipeng Feng Hong Song Dongshan Yang Biliang Zhang Lingwen Zeng Liangxue Lai Miguel | 2010 | Cell Stem Cell2010，，1： | 1 |
| 14 | Optimal Rate Allocation for Progressive Fine Granularity Scalable Video Coding显示文摘 | Qi Wang Zixiang Xiong Feng Wu Shipeng Li | 2002 | IEEE signal processing letters Februaby2002，9，2： | 1 |
| 15 | Affecting factors and application of the stable hydrogen isotopes of alkane gases显示文摘To study the composition, affecting factors of the stable hydrogen isotopes of alkane gases and their application to identification of the natural gas origin and maturities, the chemical and isotopic compositions of 118 gas samples of Carboniferous- Permian in the Ordos Basin, and of Triassic in the Sichuan Basin, combined with 68 gas samples from the Sinian and Cambrian reservoirs in the Sichuan Basin, and Ordovician and Siliurian reservoirs of Tarim Basin, are analyzed comprehensively. The following conclusions are obtained:(1) Natural gases in the study area and strata of the Ordos and Sichuan basins are dominated by alkane gases, and the dryness coefficients and maturities of the Carboniferous-Permian gases in the Ordos Basin are higher than the gases in the Triassic Xujiahe Formation of the Sichuan Basin, while the hydrogen isotopes of the latter ones are much enriched in 2H than the former.(2) The δ2HCH4-C1/C2+3 genetic identification diagram of natural gas was drawn, and the diagrams of hydrogen isotopic differences between the heavy alkane gases and methane vs. hydrogen isotopes of alkane gases can also be used in natural gas genetic identification.(3) The δ2HCH4-Ro formulas of coal-formed gas in different areas of the two basins are given, and the δ2HC2H6-δ2HCH4 is a new index for maturity, and the (δ2HC2H6-δ2HCH4)-Ro formula of the coal-formed gas can be used to calculate the maturity of the natural gas.(4) The stable hydrogen isotopes of alkane gases are affected by parent materials in source rocks, maturity, mixing and the aqueous medium conditions, among which the aqueous paleo-salinity is the key factor. To sum up, the hydrogen isotopes of alkane gases are affected by multiple factors, and they are significant to the identification of the origin, and maturity of natural gas, and the water environment during the deposition of source rocks. | HUANG Shipeng DUAN Shufu WANG Zecheng JIANG Qingchun JIANG Hua SU Wang Feng Qingfu HUANG Tongfei YUAN Miao REN Mengyi CHEN Xiaoyue | 2019 | Petroleum Exploration and Development2019，46，3： | 0 |
| 16 | Type and distribution of Mid-Permian Maokou Formation karst reservoirs in southern Sichuan Basin,SW China显示文摘Based on the analysis of the responses of conventional logs such as natural gamma(GR), density(DEN), acoustic interval transit time(AC), compensated neutron(CNL), dual lateral resistivity(Rlld, Rlls), and caliper log(CAL), combined with drilling data,cores, thin section and productivity of 65 wells, the reservoirs in the Mid-Permian Maokou Formation of southern Sichuan Basin were divided into four types, fractured-vuggy, pore-vuggy, fractured and fractured-cavity. The main reservoirs in high productivity wells are fractured-vuggy and pore-vuggy. The reservoirs of Maokou Formation are generally thin, and can be divided into the upper reservoir segment(layer a of the second member to the third member of Maokou Formation, P_2 m^2 a-P_2 m^3) and the lower segment(layer b of the second member of Maokou Formation, P_2 m^2 b). The two reservoir segments are mainly controlled by two grain beaches during the sedimentation of P_2 m^2 a-P_2 m^3 and P_2 m^2 b, the vertical zonation of karst, and the fractures. The upper reservoir segment is generally better than the lower one in development degree and single well productivity, and is much thicker than the lower one. It is thicker in the Yibin-Zigong-Weiyuan-Dazu area, the southwestern area of Chongqing and the southeastern area of Luzhou, while the lower segment is thicker in the Neijiang-Zigong-Luzhou area and the Dazu-Luzhou area. The areas with big reservoir thickness at tectonic slope or syncline parts are the favorable exploration areas. | HUANG Shipeng JIANG Qingchun FENG Qingfu WU Ya LU Weihua SU Wang CHEN Xiaoyue REN Mengyi PENG Hui | 2019 | Petroleum Exploration and Development2019，46，2： | 0 |
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