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| 1 | Stable carbon and hydrogen isotopes of gases from the large tight gas fields in China显示文摘By the end of the year 2010,a total of 15 large tight gas fields have been found in China,located in the Ordos,Sichuan,and Tarim basins.The annual production and total reserves of these fields in 2010 were 222.5×108and 28657×108m3,respectively,accounting for 23.5%and 37.3%,respectively,of the total annual production and reserves of natural gases in China.They took a major part of all natural gas production and reserves in China.According to the analyses of 81 gas samples,the stable carbon and hydrogen isotopic compositions of tight gases in China have following characteristics:(1)Plots of 13C1-13C2-13C3,13C1-C1/C2+3and 13C1-13C2demonstrate the coal-derived origin of tight gases in China;(2)For the primary alkane gases,both carbon and hydrogen isotopic values increase with increasing molecular mass,i.e.,13C1<13C2<13C3<13C4and2H1<2H2<2H3;(3)The isotopic differences of 13C2-13C1,13C3-13C1,2H2-2H1and 2H3-2H1decrease with increasing Ro(%)and C1/C1–4;(4)There are seven causes for the carbon and hydrogen isotopic reversal,however,the carbon and hydrogen isotopic reversal of tight gases in China is caused mainly by multiple stages of gas charge and accumulation. | DAI JinXing NI YunYan HU GuoYi HUANG ShiPeng LIAO FengRong YU Cong GONG DeYu WU Wei | 2014 | Science China Earth Sciences2014，57，1： | 17 |
| 2 | Rock burst prevention based on dissipative structure theory显示文摘Dynamic collapses of deeply mined coal rocks are severe.In order to explore new ideas for rock burst prevention,the relationship between entropy equations and dissipative structure was studied,and a concept-rock burst activity system(RAS) was proposed and its entropy was analyzed.The energy features of RAS were analyzed,and the relationship between electromagnetic radiation(EMR) intensity E and dissipated energy Ud was initially established.We suggest that rock burst normally happens only when diS deS in RAS;RAS is the dissipative structure before collapse,and after which it become a new orderly structure,i.e.,a ''dead'',a statically orderly structure.We advanced that the effective way to prevent rock burst is to introduce entropy to the system for it keeps the system away from the dissipative structure.E and Ud of RAS are positively related,which is used as a bridge between dissipative structure theory and rock burst prevention engineering applications.Based on this,and using the data of rock burst prevention for working face No.250205up of Yanbei coal mine,an engineering verification for the dissipative structure of RAS was carried out,which showed good results. | Song Dazhao Wang Enyuan Li Nan Jin Mingyue Xue Shipeng | 2012 | International Journal of Mining Science and Technology2012，22，2： | 17 |
| 3 | Infrared radiation signature of exhaust plume from solid propellants with different energy characteristics显示文摘The infrared radiation signature of the plume from solid propellants with different energy characteristics is not the same. Three kinds of double-base propellants of different energy characteristics are chosen to measure the infrared spectral radiance from 1000 cm 1 to 4500 cm 1 of their plumes. The radiative spectrum is obtained in the tests. The experimental results indicate that the infrared radiation of the plume is determined by the energy characteristics of the propellant. The radiative transfer calculation models of the exhaust plume for the solid propellants are established. By including the chemical reaction source term and the radiation source term into the energy equation, the plume field and the radiative transfer are solved in a coupled way. The calculated results are consistent with the experimental data, so the reliability of the models is confirmed. The temperature distribution and the extent of the afterburning of the plume are distinct for the propellants of different energy characteristics, therefore the plume radiation varies for different propellants. The temperature of the fluid cell in the plume will increase or decrease to some extent by the influence of the radiation term. | Wang Weichen Li Shipeng Zhang Qiao Wang Ningfei | 2013 | Chinese Journal of Aeronautics2013，26，3： | 14 |
| 4 | Gene expression signatures for phlegm-dampness constitution of Chinese Medicine显示文摘Dear Editor,The term'individualized medicine'was first used in Biochemistry Individuality in 1956 by Williams(Williams et al.,1956).With the emergence of the post-genome era in the21st century,individualized precision medicine has attracted increasing attention.In traditional Chinese medicine(TCM),there is also concept of individualized medicine,which is known as the Chinese constitutional theory,proposed in the1970s(Wang,2012).According to this theory,the | Lingru Li Juan Feng Haiqiang Yao Lan Xie Yu Chen Lingling Yang Shujuan Hou Shipeng Zhao Ranran Sun Yanling Wu Tongtong Bai Yingshuai Li Ruoxi Yu Ji Wang Qi Wang | 2017 | Science China(Life Sciences)2017，60，1： | 13 |
| 5 | Gene mutations and clinical phenotypes in Chinese children with Blau syndrome显示文摘The mutations of CARD15 gene and clinical features of Chinese patients with Blau syndrome were analyzed. We identified10 missense mutations, out of which five were new: R334 L, E383 D, R471 C, C495 R and D512 F. The rest of them, R334 W,R334Q, G481 D, M513 T and R587 C, have been reported previously. Among all the mutations, R334 W, R334 Q and C495 R had the highest frequency. Blau syndrome was found at early age after birth. It began with lepidic rash and symmetric polyarthritis and was phenotypically characterized by typical rash, arthritis, iridocyclitis and arteritis. Cardiac involvement was also found in Blau syndrome. In addition to nerve deafness, renal involvement, osteochondroma and central nervous system involvement were also found in our patients. Therefore, Chinese children with Blau syndrome have unique gene mutations and complicated clinical phenotypes. Pathologic examination and CARD15 mutation testing should be considered for diagnosis as early as possible for suspected patients. | Caifeng Li Junmei Zhang Shipeng Li Tongxin Han Weiying Kuang Yifang Zhou Jianghong Deng Xiaohua Tan | 2017 | Science China(Life Sciences)2017，60，7： | 13 |
| 6 | Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome(CAPS)显示文摘The aim of our study is to explore the features of clinical manifestations and genetic mutations in Chinese CAPS patients. Fifteen confirmed patients with CAPS were enrolled. The onset time ranges from 2 days after birth to 6 years and 1 month. Recurrent urticaria rash(93.3%) with fever(100%) were two dominant characteristics of these patients that were presented as either acute or chronic process. Systemic involvements were found in all patients except for one with only rash and fever. The top three symptoms were fever(100%), rash(93.3%) and myalgia(76%). Other clinical manifestations include arthritis(11 cases), lung involvement(seven cases), optical dysfunction(seven cases), nerve deafness(six cases), nervous system involvement(five cases), hepatomegaly, splenomegaly and lymphadenectasis(five cases). Also, four patients had heart involvement and one patient suffered kidney involvement. The laboratory inflammation index such as leukocyte counts, platelet counts, erythrocyte sedimentation rate(ESR), C-reactive protein(CRP), serum amyloid A(SAA) and fibrinogen(FIB) increased significantly at initial stage, but decreased after therapy. As for gene mutation detection, Twelve out of 15 patients were confirmed with mutation in NLRP3, including 11 mutant site: c1789 A>G, c.1703 T>A, c.913 G>A, c.1710 G>C, c.1057 G >T, c.2335 C>T, c.932 T>C,c.296 G>C, c.663 C>T, t.1702 T>A, 299 G>A. Mutation sites c.1703 T>A, c.2335 C>T, c.296 G>C, c.663 C>T, and 299 G>A were newly identified. The association between gene mutation and clinical manifestation shows that D305 N was highly associated with severe organs involvements, and therefore, the time of therapy and regimen were critical for the prognosis of disease. As the largest cohort study of Chinese CAPS patients, we confirmed that all patients presented typical clinical manifestations, identified five new mutation sites on NLRP3 and analyzed the correlation between the genotypes and phenotypes. We also raise concerns for one case with serious conditions that only had two nonsense mutations(c.663 C>T and t.1702 T>A) detected. | Caifeng Li Xiaohua Tan Junmei Zhang Shipeng Li Wenxiu Mo Tongxin Han Weiying Kuang Yifang Zhou Jianghong Deng | 2017 | Science China(Life Sciences)2017，60，12： | 9 |
| 7 | ANISOTROPIC BIQUADRATIC ELEMENT WITH SUPERCLOSE RESULT显示文摘这篇论文的主要目的是在各向异性的网孔上为第二个顺序问题学习四乘幂的有限元素的集中。由使用一些新奇途径和技术,最佳的错误估计被获得。同时,各向异性的 supercloseresults 也被完成。而且,数字结果被给表明我们的理论分析。 | Dongyang SHI Shipeng MAO Hui LIANG | 2006 | Journal of Systems Science & Complexity2006，19，4： | 8 |
| 8 | Progress of the satellite laser ranging system TROS1000显示文摘The mobile satellite laser ranging system TROS1000, successfully developed in 2010, achieves a high repetition rate and enables daytime laser ranging. Its measurement range has reached up to 36000 km with an accuracy as precise as 1 cm. Using recent observations in Wuhan, Jiufeng, Xianning, and Rongcheng, Shandong, we introduce the progress made using this mobile observation system. | Guo Tangyong Wang Peiyuan Li Xin Zhu Wei Zou Tong Li Shipeng Luo Qingshan | 2015 | Geodesy and Geodynamics2015，6，1： | 7 |
| 9 | 5-Ethynyl-2′-deoxyuridine as a molecular probe of cell proliferation for high-content siRNA screening assay by “click” chemistry显示文摘Labelling and identification of proliferating cells is important for the study of physiological or pathological processes in high-content screening (HCS) assays. Here we describe ethynyl deoxyuridine (EdU) as a biomarker for the assessment of cell proliferation and clearly demonstrate the feasibility of the EdU-labelling method for use in HCS assays. EdU detection is highly robust, reproducible, technically simple, and well suited for automated segmentation, which provides an excellent al- ternative for setting up multiplexed HCS assays of siRNA, miRNA and small-molecule libraries. | CHEN MiaoJuan QU DeZhong CHI WeiLin WANG Wei REN XiaoShuai CONG ShuJie LIANG PeiZhou FENG ShiPeng ZHANG BiLiang | 2011 | Science China Chemistry2011，54，11： | 6 |
| 10 | On the error bounds of nonconforming finite elements显示文摘We prove that the error estimates of a large class of nonconforming finite elements are dominated by their approximation errors, which means that the well-known Cea's lemma is still valid for these nonconforming finite element methods. Furthermore, we derive the error estimates in both energy and L2 norms under the regularity assumption u ∈ H1+s(Ω) with any s > 0. The extensions to other related problems are possible. | MAO ShiPeng SHI ZhongCi | 2010 | Science China Mathematics2010，53，11： | 6 |
| 11 | Effect of miniscalpel-needle on relieving the pain of myofascial pain syndrome: a systematic review显示文摘OBJECTIVE: To evaluate the effect and safety of miniscalpel-needle(MSN) on reducing the pain of myofascial pain syndrome(MPS).METHODS: We reviewed the available literatures inception up to February 2014 using Pubmed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure Database, Chinese Biomedical Database and Wanfang Database.RESULTS: Eight randomized controlled trials were finally identified. The main controls involved acupuncture, medications, injection, massage and cupping. We found that all of the studies agreed on the potential benefit of MSN as a strategy for MPS and the superiority compared to the controls, however,randomized methods applied in most of the trials could be criticized for their high or unclear risk of bias. Further research is also needed to clarify questions around the appropriate frequency and number of treatment sessions of MSN.CONCLUSION: This review shows that MSN might have the effect on MPS, even though there were some limitations in the studies included in the review. Studies with robust methodology are warranted to further test its pain-relieving effect on MPS. | Liu Tong Peng Yuanyuan Zhu Shipeng Chen Huan Li Fuyun Hong Peixin Cao Bingyan Peng Bo Fan Yifan Chen Yupei Zhang Li | 2015 | Journal of Traditional Chinese Medicine2015，35，6： | 6 |
| 12 | A novel implementation algorithm of asymptotic homogenization for predicting the effective coefficient of thermal expansion of periodic composite materials显示文摘Asymptotic homogenization(AH) is a general method for predicting the effective coefficient of thermal expansion(CTE) of periodic composites. It has a rigorous mathematical foundation and can give an accurate solution if the macrostructure is large enough to comprise an infinite number of unit cells. In this paper, a novel implementation algorithm of asymptotic homogenization(NIAH) is developed to calculate the effective CTE of periodic composite materials. Compared with the previous implementation of AH, there are two obvious advantages. One is its implementation as simple as representative volume element(RVE).The new algorithm can be executed easily using commercial finite element analysis(FEA) software as a black box. The detailed process of the new implementation of AH has been provided. The other is that NIAH can simultaneously use more than one element type to discretize a unit cell, which can save much computational cost in predicting the CTE of a complex structure. Several examples are carried out to demonstrate the effectiveness of the new implementation.This work is expected to greatly promote the widespread use of AH in predicting the CTE of periodic composite materials. | Yongcun Zhang Shipeng Shang Shutian Liu | 2017 | Acta Mechanica Sinica2017，33，2： | 6 |
| 13 | EXPLICIT ERROR ESTIMATES FOR MIXED AND NONCONFORMING FINITE ELEMENTS显示文摘在这份报纸,我们在混合的最低顺序和 nonconforming 的错误估计学习常数的明确的表情有限元素方法。我们以在最低顺序 Raviart-Thomas 插值错误的错误常数和三角的几何人物之间的一种明确的关系开始。这给最低顺序经常的一个明确的错误混合有限元素方法。而且,类似的结果能被扩大到 nonconforming P [1 ] 与最低顺序 Raviart-Thomas 方法基于它的靠近的连接策划。同时,如此的明确一个 priori 错误估计罐头被用作可计算出来的错误界限,它与为最佳的错误估计的最大的角度条件也一致混合并且 nonconforming 有限元素方法。[从作者抽象] | Shipeng Mao Zhong-ci Shi | 2009 | Journal of Computational Mathematics2009，27，4： | 5 |
| 14 | Cancer metabolism and tumor microenvironment:fostering each other?显示文摘The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.Metabolic reprogramming supports tumor cells’high demand of biogenesis for their rapid proliferation,and helps tumor cells to survive under certain genetic or environmental stresses.Emerging evidence suggests that metabolic alteration is ultimately and tightly associated with genetic changes,in particular the dysregulation of key oncogenic and tumor suppressive signaling pathways.Cancer cells activate HIF signaling even in the presence of oxygen and in the absence of growth factor stimulation.This cancer metabolic phenotype,described firstly by German physiologist Otto Warburg,ensures enhanced glycolytic metabolism for the biosynthesis of macromolecules.The conception of metabolite signaling,i.e.,metabolites are regulators of cell signaling,provides novel insights into how reactive oxygen species(ROS)and other metabolites deregulation may regulate redox homeostasis,epigenetics,and proliferation of cancer cells.Moreover,the unveiling of noncanonical functions of metabolic enzymes,such as the moonlighting functions of phosphoglycerate kinase 1(PGK1),reassures the importance of metabolism in cancer development.The metabolic,microRNAs,and ncRNAs alterations in cancer cells can be sorted and delivered either to intercellular matrix or to cancer adjacent cells to shape cancer microenvironment via media such as exosome.Among them,cancer microenvironmental cells are immune cells which exert profound effects on cancer cells.Understanding of all these processes is a prerequisite for the development of a more effective strategy to contain cancers. | Yiyuan Yuan Huimin Li Wang Pu Leilei Chen Dong Guo Hongfei Jiang Bo He Siyuan Qin Kui Wang Na Li Jingwei Feng Jing Wen Shipeng Cheng Yaguang Zhang Weiwei Yang Dan Ye Zhimin Lu Canhua Huang Jun Mei Hua-Feng Zhang Ping Gao Peng Jiang Shicheng Su Bing Sun Shi-Min Zhao | 2022 | Science China(Life Sciences)2022，65，2： | 5 |
| 15 | Key technologies implementation of high-repetition-rate satellite laser ranging显示文摘Satellite laser ranging (SLR) is one of the major space geodetic instruments, which has various applications in earth science. In this paper, we introduce several issues regarding the key technology implementation of high-repetition-rate SLR system. Compared with traditional technology, using kHz and 8ps pulse width laser component, the data quantity and quality of high-repetition-rate satellite laser ranging (SLR) can be significantly improved. The characteristics of high-repetition-rate laser ranging and the key technologies are presented, including the event timer with the precision of picosecond, the generation of range gate signal, and so on. All of them are based on the Field Programmable Gate Arrays (FPGA) and tested on China mobile SLR system-TROS1000. Finally, the observations of satellite Beacon-C are given. | Wang Peiyuan Guo Tangyong Gao Hao Li Xin Zhu Wei Zou Tong Li Shipeng | 2013 | Geodesy and Geodynamics2013，4，1： | 4 |
| 16 | Effect of acupuncture at Renying(ST 9) on gene expression profile of hypothalamus in spontaneously hypertensive rats显示文摘OBJECTIVE: To investigate changes in gene expression profiles in the hypothalamus related to the effects of acupuncture at the Renying(ST 9) acupoint in spontaneously hypertensive(SH) rats.METHODS: We randomly divided 18 SH rats into Renying(ST 9) group and model control group, 9 body weight-matched Wistar-Kyoto rats were used as blank controls. Acupuncture was performed manually for 20-min daily over 28 d in the Renying(ST 9) group. Rat Gene 2.0 array technology was used for the determination of gene expression profiles and the screened key genes were verified by real-time quantitative polymerase chain reaction(RT-PCR) analyses.RESULTS: The different groups exhibited differential gene expression: compared with the blank control group, 48 genes were up-regulated and 91 genes were down-regulated in the model group;compared with the model group, 79 genes were up-regulated and 80 genes were down-regulated in Renying(ST 9) group. The RT-PCR results of the key genes including Chi3 l1, Ephx2, Klk1, 5-HT1 A and Cbs were consistent with that of gene chip analysis.CONCLUTION: Acupuncture at Renying(ST 9)could significantly lower the blood pressure of SH rats and affect their hypothalamic gene expression profile. Genes associated with the contraction of vascular smooth muscle and the regulation of inflammation, neurotransmitters may be involved in acupuncture's antihypertensive mechanism. | Guo Yan Lu Juan Liang Jingrong Zhao Ruili Xu Jing Zhang Wei Park Kibeum Zhu Shipeng Chen Huan Ma Liangxiao | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 4 |
| 17 | Present advances and perspectives of broadband photo-detectors based on emerging 2D-Xenes beyond graphene显示文摘As an excellent optical device,photodetectors have many important applications,such as communication technology,display technology,scientific measurement,fire monitoring,aerospace and biomedical research,and ifs of great significance in the research of nanotechnology and optoelectronics.Graphene,as the first two-dimensional(2D)single-element nanomaterial,has the advantages of high carrier mobility,high strength,high light transmittance and excellent thermal conductivity,and ifs widely used in various nano-optical devices.The great success of graphene has led scientists to extensive research on other 2D single-element nanomaterials.Recently,a group of novel 2D single-element nanomaterials have attracted a lot of attention from scientists because of its excellent physical,chemical,electronic,mechanical and optical properties.Furthermore,it has opened a new door for the realization of new and efficient photodetectors.The group of 2D single-element nanomaterials are called 2D-Xenes and used to make high-performance photodetectors.Currently,there are few studies on photodetectors based on 2D-Xenes,but some 2D-Xenes have been applied to photodetectors and reported.Some of these have excellent photodetection performance,such as high photoresponsivity(R),broad spectral response range,fast photoresponse speed and high specific detectivity(D).Based on the novel 2D-Xenes,this review explores the types and preparation methods of 2D-Xenes,and the working mechanisms of 2D-Xenes photodetectors.Finally,the challenges and development trends of 2D-Xenes in the future are discussed.The research of 2D-Xenes is of great significance for the development of high-performance photodetectors in the future,and is expected to be widely used in other nanoelectronics and optical devices. | Bing Wang Shipeng Zhong Yanqi Ge Huide Wang Xiaoling Luo Han Zhang | 2020 | Nano Research2020，13，4： | 4 |
| 18 | Influence of thermal inhibitor position and temperature on vortex-shedding-driven pressure oscillations显示文摘Vortex-acoustic coupling is one of the most important potential sources of combustion instability in solid rocket motors (SRMs). Based on the Von Karman Institute for Fluid Dynamics (VKI) experimental motor, the influence of the thermal inhibitor position and temperature on vortex-shedding-driven pressure oscillations is numerically studied via the large eddy simulation (LES) method. The simulation results demonstrate that vortex shedding is a periodic process and its accurate frequency can be numerically obtained. Acoustic modes could be easily excited by vortex shedding. The vortex shedding frequency and second acoustic frequency dominate the pressure oscillation characteristics in the chamber. Thermal inhibitor position and gas temperature have little effect on vortex shedding frequency, but have great impact on pressure oscillation amplitude. Pressure amplitude is much higher when the thermal inhibitor locates at the acoustic velocity anti-nodes. The farther the thermal inhibitor is to the nozzle head, the more vortex energy would be dissipated by the turbulence. Therefore, the vortex shedding amplitude at the second acoustic velocity antinode near 3/4L (L is chamber length) is larger than those of others. Besides, the natural acoustic frequencies increase with the gas temperature. As the vortex shedding frequency departs from the natural acoustic frequency, the vortex-acoustic feedback loop is decoupled. Consequently, both the vortex shedding and acoustic amplitudes decrease rapidly. | Su Wanxing Li Shipeng Zhang Qiao Li Junwei Ye Qingqing Wang Ningfei | 2013 | Chinese Journal of Aeronautics2013，26，3： | 4 |
| 19 | Uptake of graphene enhanced the photophosphorylation performed by chloroplasts in rice plants显示文摘New and enhanced functions were potentially imparted to the plant organelles after interaction with nanoparticles.In this study,we found that∼44%and∼29%of the accumulated graphene in the rice leaves passively transported to the chloroplasts and thylakoid,respectively,significantly enhanced the fluorescence intensity of chloroplasts,and promoted about 2.4 times higher adenosine triphosphate production than that of controls.The enhancement of graphene on the photophosphorylation was ascribed to two reasons:One is that graphene facilitates the electron transfer process of photosystem II in thylakoid,and the other is that graphene protects the photosystem II against photo-bleaching by acting as a scavenger of reactive oxygen species.Overall,our work here confirmed that graphene translocating in the thylakoid promoted the photosynthetic activity of chloroplast in vivo and in vitro,providing new opportunities for designing biomimetic materials to enhance the solar energy conversion systems,especially for repairing or increasing the photosynthesis activity of the plants grown under stress environment. | Kun Lu Danlei Shen Shipeng Dong Chunying Chen Sijie Lin Shan Lu Baoshan Xing Liang Mao | 2020 | Nano Research2020，13，12： | 4 |
| 20 | A Novel Orthogonal LoRa Multiple Access Algorithm for Satellite Internet of Things显示文摘In recent years,LoRa has been extensively researched in the satellite Internet of Things(IoT).However,the multiple access technology of LoRa is still one of the bottlenecks of satellite IoT.To improve the multiple access performance of LoRa satellite IoT,based on the orthogonality of LoRa symbols in the fractional domain,this paper proposes a low complexity Orthogonal LoRa Multiple Access(OLMA)algorithm for multiple LoRa users occupying the same frequency bandwidth.The algorithm introduces the address code to divide the fractional bandwidth into multiple parts,and the OLMA users with different address codes occupy different parts to transmit the information code,thus avoiding mutual interference caused by collisions in the same frequency bandwidth.The multiple access capability of OLMA can be flexibly configured only by simply adjusting the length of the address code according to the actual application requirements of data transmission.Theoretical analysis and simulation results show that the OLMA algorithm can greatly improve the multiple access capability and the total transmission bit rate of LoRa IoT without changing the existing LoRa modulation parameters and process. | Chengwen Zhang Liankai Wang Libin Jiao Shipeng Wang Jun Shi Jia Yue | 2022 | China Communications2022，19，3： | 4 |
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