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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Overcoming free riding behavior in peer-to-peer systems 显示文摘 | Feldman M Chuang C | 2005 | ACM Sigecom Exchanges2005，5，4： | 2 |
| 4 | Research criteria for the diagnosis of Alzheimer's disease:revising the NINCDS-ADRDA criteria显示文摘 | Dubois B Feldman HH Jacova C | | Lancet Neurology0，，： | 2 |
| 5 | 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines显示文摘 | Mariell Jessup William T. Abraham Donald E. Casey Arthur M. Feldman Gary S. Francis Theodore G. Ganiats Marvin A. Konstam Donna M. Mancini Peter S. Rahko Marc A. Silver Lynne Warner Stevenson Clyde W. Yancy Sharon Ann Hunt William T. Abraham Marshall H. C | 2009 | Circulation2009，，14： | 2 |
| 6 | Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal resuhs from the massachusetts male aging study 显示文摘 | Feldman HA Longcope C Derby CA | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 7 | A 50% reduction in the Psoriasis Area and Severity Index (PASI 50) is a clinically significant endpoint in the assessment of psoriasis显示文摘 | Carlin C S Feldman S R Krueger J G | 2004 | J Am Acad Dermatol2004，50，6： | 1 |
| 8 | Global elemental maps of the Moon: The lunar prospector gamma ray spectromet er显示文摘 | Lawrence D J Feldman W C Barraclough B L | 1998 | Science1998，281，： | 1 |
| 9 | Clinical determination of myocardial vs load effects of OPC-18790,a novel intravenous agent for the treatment of patients with congestive heart failure显示文摘 | Feldman M D Haber H L Wu C C | 1993 | Circulation1993，88，42： | 1 |
| 10 | Hepatitis C in patients with porphyria cutanea tarda显示文摘 | Koester G Feldman J Bigler C | 1996 | JAm Acad Dermatol1996，34，2： | 1 |
| 11 | Solar wind electrons 显示文摘 | FELDMAN W C ASBRIDGE J R BAME S J | 1975 | J Geophys Res1975，80，： | 1 |
| 12 | Value of prenatal ultrasound and magnetic resonance imaging in assessment of congenital primary cytomegalovirus infection显示文摘 | Lipitz S Hoffmann C Feldman B | 2010 | Ultrasound Obstet Gynecol2010，36，： | 1 |
| 13 | Routines as a source of change in organizational schemata: The role of trialand-error learning显示文摘 | Rerup C Feldman M S | 2011 | The Academy of Management Journal2011，54，3： | 1 |
| 14 | Changing trends in mortality and admissions to hospital for elderly patients with congestive heart failure in Montreal显示文摘 | Feldman DE Thivierge C Guerard L | 2001 | CMAJ2001，165，8： | 1 |
| 15 | Clinical and bacteriological outcomes in hospitalised patients with community - acquired pneumonia treated with azithromycin plus ceftriaxone, or ceftriaxone plus clarithro- mycin or erythromycin: A prospective, randomised, multieentre study 显示文摘 | Tamm M Todisco T Feldman C | 2007 | Clin Microbiol Infect2007，13，2： | 1 |
| 16 | Mechanisms of disease:the oxidative stress theory of diabetic neuropathy显示文摘 | Figueroa-Romero C Sadidi M Feldman EL | 2008 | Rev Endocr Metab Disord2008，9，4： | 1 |
| 17 | Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells显示文摘 | Li Y Y Mctieman C F Feldman A M | 1999 | Carvasc Res1999，42，1： | 1 |
| 18 | Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents:a randomized,controlled pilot study显示文摘 | EBBELING C B FELDMAN H A OSGANIAN S K | | 0，，03： | 1 |
| 19 | Osteitis is associated with P-glycoprotein overexpression in patients with chronic sinusitiswithout nasal polyps显示文摘 | Giinel C Feldman KE Bleier BS | 2014 | Am J Rhinol Allergy2014，28，2： | 1 |
| 20 | Hopeful choices: A school counselorg guide to hope theory显示文摘 | Snyder C R Feldman D Shorey H Rand K | 2002 | Journal of Personality2002，5，5： | 1 |
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