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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells显示文摘 | Li Y Y Mctieman C F Feldman A M | 1999 | Carvasc Res1999，42，1： | 1 |
| 3 | IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EpkA3 in neonatal rat cardiomyocytes显示文摘 | LI Y Y MCTIERNAN C F FELDMAN A M | | 0，，1： | 1 |
| 4 | The angiogenesis inhibitor,endostatin,does not affect murine cutaneous wound healing显示文摘 | BERGER A C FELDMAN A L GNANT M F | 2000 | J Surg Res2000，91，1： | 1 |
| 5 | Coronary artery bypass graft surgery versus pereutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial显示文摘 | Mohr F W Moriee M C Nappetein A P Feldman T E Stfihle E Colombo A | 2013 | Lancet2013，381，： | 1 |
| 6 | Matrix metalloproteinases in pathophysiology and treatment of heart failure显示文摘 | Li Y Y McTiernan C F | 2001 | Lancet2001，357，9257： | 1 |
| 7 | Interplay of matrix metalloproteinases tissue inhibitons of metalloprotein- ases and their regulators in cardiac matrix remodeling 显示文摘 | LIY Y McTIERMAN C F FELDMAN A M | 2000 | CardiovascRes2000，46，2： | 1 |
| 8 | Interplay of matrix metallo-proteinases,tissue inhibitors of metalloproteinases and their regulators incardiac remodeling显示文摘 | Li Y Y McTiernan C F Feldman A M | 2000 | Cardiovasc Res2000，46，2： | 1 |
| 9 | Optical and structural characterization of copper indium disulfide thin films 显示文摘 | HENDERSON D O MU R UEDA A WU M H GORDON E M TUNGY S HUANG M KEAY J FELDMAN L C HOLLINGSWORTH J A BUHRO W E HARRIS J D HEPP A F RAFFAELLR P | 2001 | Materials and Design2001，22，： | 1 |
| 10 | Interplay of matrix metalloproteinases,tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling显示文摘 | Li Y Y Mc Tiernan C F Feldman A M | 2000 | Cardiovasc Res2000，46，： | 1 |
| 11 | Interplay of matrix metalloproteinases,tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling显示文摘 | LI Y Y MCTIEMAN C F FELDMAN A M | 2000 | Cardivasc Res2000，468，2： | 1 |
| 12 | Bacterial rhodopsin:evidence for a new type of phototrophy in the sea显示文摘 | Béjà O Aravind L Koorfin E V Suzuki M T Hadd A Nguyen L P Jovanovich S B Gates C M Feldman R A Spudich J L Spudich E N DeLong E F | | 0，，5486： | 1 |
| 13 | Interplay of matrix metalloproteinase,tissue inhibitors of metalloproteinase and their regulators in cardiac matrix remodeling显示文摘 | Li Y Y MC Tiernan C F Feldman A M | 2000 | Cardivasc Res2000，46，2： | 1 |
| 14 | Interplay of matrix metalloproteinases tissue inhibitors of metallproteinases and their regulators in cardiac matrix redm odeling 显示文摘 | Li Y Y Mctiernan C F Feldman A M | 2000 | Cardiovasc Res2000，46，： | 1 |
| 15 | Interplay of Matrix Metalloproteinases,Tissue Inhibitors of Metalloproteinases and Their Regulators in Cadiac Matrix Remodeling显示文摘 | Li Y Y McTiernan C F Feldman A M | 2000 | Cardiovasc Res2000，46，2： | 1 |
| 16 | Interplay of matrix metalloproteina- ses , tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling 显示文摘 | LI Y Y MCTIERNAN C F FELDMAN A M | 2000 | Cardiovase Res2000，46，2： | 1 |
| 17 | Matrix metanoproteinases in pathophysiology and treatment of heart failure 显示文摘 | Feldman A M Li Y Y Mctiernan C F | 2001 | Lancet2001，357，9257： | 1 |
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