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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Research criteria for the diagnosis of Alzheimer's disease:revising the NINCDS-ADRDA criteria显示文摘 | Dubois B Feldman HH Jacova C | | Lancet Neurology0，，： | 2 |
| 4 | Developments in on-line,electron-beam emittence measurements using optical-transition radiation techniques显示文摘 | Feldman R B Lumpkin A H | 1990 | Nuclear Instruments and Methods in Physics Research1990，296，： | 2 |
| 5 | Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects 显示文摘 | Feldman B J Streeper RS Farese RV | 2006 | Proc Natl Acad Sci U S A2006，103，15： | 1 |
| 6 | Effect of magnesium given 1 hour after head trauma on brain edema and neurological outcome显示文摘 | Gurevitch B Artru AA | 1996 | Neurosurg1996，85，1： | 1 |
| 7 | Global elemental maps of the Moon: The lunar prospector gamma ray spectromet er显示文摘 | Lawrence D J Feldman W C Barraclough B L | 1998 | Science1998，281，： | 1 |
| 8 | Value of prenatal ultrasound and magnetic resonance imaging in assessment of congenital primary cytomegalovirus infection显示文摘 | Lipitz S Hoffmann C Feldman B | 2010 | Ultrasound Obstet Gynecol2010，36，： | 1 |
| 9 | Parental karyotype andsubsequentlive births in recurrent misearriage显示文摘 | CARP H FELDMAN B OELSNER Q | 2004 | Fertility and Sterifity2004，81，5： | 1 |
| 10 | Retinoic acid signaling restricts the cardiac progenitor pool 显示文摘 | KEEGAN B R FELDMAN J L BEGEMANN G | 2005 | Science2005，307，5707： | 1 |
| 11 | Hydride generation activity of arsenosugars and thioarsenicals显示文摘 | REGMI R MILNE B F FELDMAN J | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 12 | Parental karyotype and subsequent live births in recurrent miscarriage 显示文摘 | Carp H Feldman B Oelsner Q | 2004 | Fertil Steril2004，81，5： | 1 |
| 13 | Population structure,fitness surfaces,and linkage in the shifting balance process显示文摘 | BERGMAN A GOLDSTEIN D B FELDMAN M W | 1995 | Genetical Research1995，66，： | 1 |
| 14 | Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents:a randomized,controlled pilot study显示文摘 | EBBELING C B FELDMAN H A OSGANIAN S K | | 0，，03： | 1 |
| 15 | R&D Spillovers and the Geography of Innovation and Production显示文摘 | Audretsch D B Feldman M P | 1996 | The American Economic Review1996，，： | 1 |
| 16 | Age, disease, and changing sex hormone levers in middle-aged men: results of the massachusetts male aging study显示文摘 | GRAY A FELDMAN A MEKINLAY J B | 1991 | Clin Endocrinol Metah1991，73，： | 1 |
| 17 | A new estimate of the welfare loss of Excess health insurance 显示文摘 | Feldman R Dowd B | 1991 | The American Economic Review1991，81，1： | 1 |
| 18 | Knowledge Spillovers and The Geography of Innovation and Production显示文摘 | M P FELDMAN | 1996 | American Economic Review1996，86，： | 1 |
| 19 | Innovation in Cities:Science-based Diversity,Specialization and Localized Competition显示文摘 | Feldman M P Audretsch D B | 1999 | European Economic Review1999，43，： | 1 |
| 20 | Innovation in Cities: Science-Based Diversity, Specialization and Localized Competition 显示文摘 | AUDRETSCH D B FELDMAN M P | 1999 | European Economic Re- view1999，43，2： | 1 |
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