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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Apoptotic effect of ginsenoside Rh2 on human malignant melanoma A375 -S2 cells显示文摘 | Fei XF Wang BX Tashiro S | 2002 | Aeta Pharmacol Sin2002，23，4： | 1 |
| 3 | Fumigaclavine C, an fungal metabolite, improves experimental colitis in mice via downregulating Th1 cytokine production and matrix metalloproteinase activity显示文摘 | Wu XF Fei MJ Shu RG | 2005 | Int Immunopharmacol2005，5，10： | 1 |
| 4 | Down-regulation of Homerlb/c attenuates glutamate-mediated excitotoxicity though endoplasmic reticulum and mitochondria pathways in rat cortical neurons 显示文摘 | Chen T Fei F Jiang XF | 2012 | Free Radical Bio Med2012，52，5： | 1 |
| 5 | Apoptotic effects of ginsen- oside Rh2 on human malignant melanoma A375-S2 cells 显示文摘 | Fei XF Wang BX Tashiro S | 2002 | Ac- ta Pharmacol Sin2002，23，： | 1 |
| 6 | Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells显示文摘 | FEI XF WANG BX TASHIRO S | 2002 | Acta Pharmacol Sin2002，23，： | 1 |
| 7 | Draft genome of the kiwifruit Actinidia chinensis 显示文摘 | Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS | 2013 | Nat Commun2013，4，： | 1 |
| 8 | Apoptosis effect of ginseno side Rh2 on human malignant melanoma A375-S2 cells显示文摘 | Wang BX Tashiro S | 2002 | Acta Pharmacol Sin2002，23，4： | 1 |
| 9 | Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons显示文摘 | Chen T Fei F Jiang XF | 2012 | Free Radic Biol Med2012，，1： | 1 |
| 10 | Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375 -S2 cells显示文摘 | Fei XF Wang BX Tashiro S | 2002 | Acta Pharmacol Sin2002，323，4： | 1 |
| 11 | An assessment of the genetic diversity within Ganoderma strains with AFLP and ITS PCR-RFLP显示文摘 | Zheng LY Jia DH Fei XF | | 0，，03： | 1 |
| 12 | Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons显示文摘 | Chen T Fei F Jiang XF | 2012 | Free Radic Biol Med2012，52，1： | 1 |
| 13 | Removal of large benign cephalonasal tumours by transbasal surgery combined with endonasal endoscopic sinus surgery and neuronavigation显示文摘 | Fei Z Zhang X Jiang XF | 2007 | J Craniomaxillofac Surg2007，35，1： | 1 |
| 14 | Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells显示文摘 | Fei XF Wang BX Tashiro S | 2002 | Acta Pharmacol Sin2002，23，4： | 1 |
| 15 | Apoptotic effects of ginsenoside Rh2 on human malignant melanoma A375-S2 cells显示文摘 | Fei XF Wang BX Tashiro S Li TJ Ma JS Ikejima T | 2002 | Acta Pharmacol Sin2002，23，： | 1 |
| 16 | Down-regulation of Homer1b/c attenuates glutamate-mediated excitotoxicity through endoplasmic reticulum and mitochondria pathways in rat cortical neurons显示文摘 | Chen T Fei F Jiang XF | 2012 | Free Radical Biology and Medicine2012，52，1： | 1 |
| 17 | Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells 显示文摘 | Fei XF Wang BX Li TJ | 2003 | Cancer Sci2003，94，1： | 1 |
| 18 | Evodiamine,a constituent of Evodiae Fructus, induces anti - proliferating effects in tumor cells显示文摘 | Fei XF Wang BX Li TJ | 2003 | Cancer Sci2003，94，1： | 1 |
| 19 | Evodiamine, a constituent of Evodiae fructus, induces anti-proliferating effects in tumor cells 显示文摘 | Fei XF Wang BX Li TJ | 2003 | Cancer Sci2003，94，： | 1 |
| 20 | Effects of polysaccharides (FI0-c) from myeelium of Ganoderma tsugae on proinflammatory cytokine production by THP-1 cells and human PBMC (Ⅱ)显示文摘 | Gao XX Wang BX Fei XF | 2000 | Acta Pharmacol Sin2000，21，12： | 1 |
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