|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Asthma and gastroesophageal reflux disease: Effect of long-term pantoprazole therapy显示文摘AIM: To define the prevalence of gastroesophageal reflux disease (GERD) in mild persistent asthma and to value the effect of pantoprazole therapy on asthmatic symptoms.METHODS: Seven of thirty-four asthmatic patients without GERD served as the non-GERD control group.Twenty-seven of thirty-four asthmatic patients had GERD (7/27 also had erosive esophagitis, sixteen of them presented GERD symptoms. An upper gastrointestinal endoscopy was performed in all the subjects to obtain five biopsy specimens from the lower 5 cm of the esophagus. Patients were considered to have GERD when they had a dilation of intercellular space (DIS)>0.74 μm at transmission electron microscopy.Patients with GERD were treated with pantoprazole,80 mg/day. Forced expiratory volume in one second (FEV1) was performed at entry and after 6 mo of treatment. Asthmatic symptoms were recorded. The required frequency of inhaling rapid acting 32-agonists was self-recorded in the patients' diaries.RESULTS: Seven symptomatic patients presented erosive esophagitis. Among the 18 asymptomatic patients, 11 presented DIS, while all symptomatic patients showed ultrastructural esophageal damage.Seven asymptomatic patients did not present DIS. At entry the mean of FEV1 was 1.91 L in symptomatic GERD patients and 1.88 L in asymptomatic GERD patients.After the treatment, 25 patients had a complete recovery of DIS and reflux symptoms. Twenty-three patients presented a regression of asthmatic symptoms with normalization of FEV1. Four patients reported a significant improvement of symptoms and their FEV1 was over 80%.CONCLUSION: GERD is a highly prevalent condition in asthma patients. Treatment with pantoprazole (80 mg/day)determines their improvement and complete regression. | Calabrese Carlo Fabbri Anna Areni Alessandra Scialpi Carlo Zahlane Desiree Di Febo Giulio | 2005 | World Journal of Gastroenterology2005，11，48： | 10 |
| 2 | 纳米压痕仪和激光超声技术检测薄膜弹性模量显示文摘在薄膜材料的力学性能测定中,弹性模量是衡量材料软硬程度的重要指标。为了测定弹性模量,本文选取不同种类和厚度的金属薄膜材料,采用纳米压痕技术(nanoindentation)和激光超声技术(laser-acoustics)两种测试方法相互比较,以确保测试的准确性。两种方法在膜厚较大的试样测试中得到了大致相符的试验结果,相对误差最小达到2%。 | 陈倩栎 Konrad Herrmann Febo Menelao | 2007 | 中国测试技术2007，33，1： | 8 |
| 3 | Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux显示文摘AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER.METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry.Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM).Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed.RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagus,5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis.After 3 mo of therapy, 13/15 patients (86.7%, P<0.01)showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months,complete recovery of DIS and heartburn were achieved in one.CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases. | Carlo Calabrese Anna Fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio Di Febo | 2005 | World Journal of Gastroenterology2005，11，12： | 3 |
| 4 | Chemical modification of carbon fiber surfaces显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro Luca Posca | 2002 | Carbon2002，，5： | 2 |
| 5 | Esophageal cell proliferation in gastroesophageal reflux disease: Clinical-morphological data before and after pantoprazole显示文摘AIM: To evaluate esophageal mucosal defense mechanisms at an epithelial level to establish if pantoprazole treatment can induce ultrastructural healing and improvement in the proliferation activity of the esophageal epithelium in gastroesophageal reflux disease (GERD). METHODS: This was a single-blinded study for pHmonitoring, and histological, ultrastructural and MIB1 immunostaining evaluation. Fifty eight patients with GERD were enrolled and underwent 24 h pH-monitoring and endoscopy. Patients were treated for 12 and 24 mo with pantoprazole. Esophageal specimens were taken for histological and ultrastructural evaluation, before and after the treatment. RESULTS: With transmission electron microscopy, all patients with GERD showed ultrastructural signs of damage with dilation of intercellular spaces (DIS). After 3 mo of therapy the mean DIS values showed asignificant reduction and the mean MIB1-LI values of GERD showed an increase in cell proliferation. A further 3 mo of therapy significantly increased cell proliferation only in the erosive esophagitis (ERD) group. CONCLUSION: Three months of pantoprazole therapy induced ultrastructural healing of mucosal damage in 89% and 93% of ERD and non-erosion patients, respectively. Moreover, long-term pantoprazole treatment may be helpful in increasing the capability for esophageal cell proliferation in GERD, particularly in ERD patients. | Carlo Calabrese Davide Treré Giuseppina Liguori Veronica Gabusi Manuela Vici Giovanna Cenacchi Massimo Derenzini Giulio Di Febo | 2009 | World Journal of Gastroenterology2009，15，8： | 2 |
| 6 | Glutathione S-transferase Pl genotype and prognosis in Hodgkin's lymphoma显示文摘 | Hohaus S Di Ruscio A Di Febo A | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 7 | Chemical modification of carbon fiber surfaces显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro | 2002 | Carbon2002，40，5： | 1 |
| 8 | Beta-blockade therapy in chronic heart failure:Diastolic function and mitral regurgitation improvement by carvedilol显示文摘 | Capomolla S Febo O Gnemmi M | 2000 | Am Heart J2000，139，4： | 1 |
| 9 | Chemical modification of carbon fiber surfaces 显示文摘 | Severini Febo Formaro Leonardo Pegoraro Mario | 2002 | Carbon2002，40，4： | 1 |
| 10 | Intercondylar eminence avulsion fracture in children:long-term follow-up of 14 cases at the end of skeletal growth显示文摘 | Tudisco C Giovarruscio R Febo A | 2010 | J Pediatr Orthop B2010，19，5： | 1 |
| 11 | Prognostic Implications of Baroreflex Sensitivity in Heart Failure Patients in the Beta-Blocking Era显示文摘 | Maria Teresa La Rovere Gian Domenico Pinna Roberto Maestri Elena Robbi Angelo Caporotondi Gianpaolo Guazzotti Peter Sleight Oreste Febo | 2009 | Journal of the American College of Cardiology2009，，： | 1 |
| 12 | Estimation of true corneal power after keratorefractive surgery in eyes requiring cataract surgery:BESST formula显示文摘 | Edmondo Borasio MedCBQ Ophth FEBO | 2006 | Cataract Refract surg2006，32，： | 1 |
| 13 | Treatment of case of advanced periodontitis, clinical procedures utilizing the 'combined prepartion'technique 显示文摘 | DI FEBO G CARNEVALE G STERRANTION S E | 1985 | Int J Periodontics Restorative Dent1985，1，： | 1 |
| 14 | Chemical modification of carbon fiber surface显示文摘 | Febo Severini Leonardo Formaro Mario Pegoraro | 2002 | Carbon2002，40，5： | 1 |
| 15 | Intercondylar eminence avutsion fracture in children: tong-term follow-up of 14 cases at the end of skeletal growth显示文摘 | Tudisco C Giovarruscio R Febo A | 2010 | J Pediatr Orthop B2010，19，5： | 1 |
| 16 | β-Blockade therapy in chronic heart failure: Diastolic function and mitral regurgitation improvement by carvedilol显示文摘 | Soccorso Capomolla Oreste Febo Marco Gnemmi Giorgio Riccardi Cristina Opasich Angelo Caporotondi Andrea Mortara GianDomenico Pinna Franco Cobelli | 2000 | American Heart Journal2000，，： | 1 |
| 17 | - blockade therapy in chronic heart failure diastolic function and mitral Regurgitation improvement by carvedilol显示文摘 | Capomolla S Febo O Gnemmi M | 2000 | Am Heart J2000，139，4： | 1 |
| 18 | β-blockade therapy in chronic heart failure:diastolic function and mitral regurgitation improvement by carvedilol显示文摘 | Febo O Gnemmi M Riccardi G Opasich C Caporotondi A | 2000 | Am Heart J2000，139，4： | 1 |
| 19 | Differentiating embryonic stem-derived neural stem cells show a maturation-dependent pat- tern of voltage-gated sodium current expression and graded action potentials显示文摘 | Biella G Di Febo F Goffredo D | 2007 | Neuroscience2007，149，1： | 1 |
| 20 | Role of nitrous acid on the oxidation processes in the Mediterranean urban areas 显示文摘 | Allegrini I Febo A 1995 | 1995 | Ann Chim1995，85，78： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员