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| 1 | 胃食管反流病食管上皮损伤的机制显示文摘胃食管反流病(gastroesophageal reflux disease,GERD)是消化内科常见的疾病.国内对GERD机制的阐述较集中在引起反流的解剖基础上,如降低的食管下括约肌的张力(lower esophaheal sphincter,LES)、一过性的食管下括约肌的松弛(transient esophaheal sphincter relaxation,tLESR)以及膈疝等,而对于各种反流物:胃酸、胃蛋白酶以及胆汁在存在反流的解剖基础上反流至食管远端引起食管上皮组织学的改变,包括细胞坏死、扩大的细胞间隙增宽(dialeted intercellular space,DIS)、炎症细胞的浸润等改变机制的探讨较少.本文就常见的反流物引起的食管上皮组织损伤的细胞分子层面的机制予以阐述,并且重点介绍、分析近来引起学界广泛关注的免疫损伤机制. | 徐特 张晓琦 邹晓平 | 2014 | 世界华人消化杂志2014，22，21： | 2 |
| 2 | Cell proliferation of esophageal squamous epithelium in erosive and non-erosive reflux disease显示文摘AIM:To elucidate cell proliferation in erosive reflux disease (ERD) and non-erosive reflux disease (NERD), we evaluated markers in squamous epithelial cells. METHODS: Thirty-four consecutive patients with gas-troesophageal-reflux-disease-related symptoms (21 NERD and 13 ERD) were evaluated for the enrolment into the study. All patients underwent 24-h pH monitoring, standard endoscopy, and biopsy for histological evaluation. The expression of cyclins D and A was evaluated by real-time reverse transcription polymerase chain reaction (RT-PCR) from isolated epithelial cells. In all samples, analysis of the isolated cell population revealed the presence of epithelial cells only. RESULTS:Real-time RT-PCR showed that, in patients with ERD, the relative expression of cyclin D1 mRNA in esophageal epithelium was strongly decreased in comparison with NERD patients. The mean value of relative expression of cyclin D1 mRNA in NERD patients was 3.44 ± 1.9, whereas in ERD patients, it was 1.32 ± 0.87 (P = 0.011). Real-time RT-PCR showed that, in patients with ERD, relative expression of cyclin A mRNA in esophageal epithelium was decreased in comparison with that in NERD patients (2.31 ± 2.87 vs 0.66 ± 1.11). The mean bromodeoxyuridine labeling index in the NERD patients was 5.42% ± 1.68%, whereas in ERD patients, it was 4.3% ± 1.59%. CONCLUSION:We confirmed reduced epithelial pro- liferation in ERD compared with NERD patients, and that individuals who develop ERD are characterized by weaker epithelial cell proliferation. | Carlo Calabrese Lorenzo Montanaro Giuseppina Liguori Elisa Brighenti Mauela Vici Paolo Gionchetti Fernando Rizzello Massimo Campieri Massimo Derenzini Davide Trerè | 2011 | World Journal of Gastroenterology2011，17，40： | 1 |
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