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| 1 | Sudden hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment显示文摘在丙肝处理期间与木钉干扰素和 ribavirin 联系的不利效果是众所周知的。突然的听觉损失很少被报导了。包含的可能的机制包括干扰素,汽车免疫,和 hematological 变化的直接 ototoxicity。听觉损失充分经常在抗病毒的治疗的中止以后被解决。我们与长期的丙肝报导一个 47 岁的人,遗传型 2 交流在以木钉干扰素高山开始治疗以后开发了突然的听觉损失 22 wk 哈在 180 mug/wk 和 ribavirin 的剂量的 2a 800 mg 每天。因为症状没变得更坏,抗病毒的治疗为 2 wk 被继续,根据病人的愿望。听见损失在治疗的结束以后在 2 wk 以内解决了。浆液肝丙氨酸 aminotransferase 仍然保持正常在期间并且在抗病毒的治疗的结束以后。HCV RNA 在治疗的结束是无法发现的并且仍然保持否定 24 wk 以后。因此,病人们应该知道听觉损失可以与木钉干扰素治疗,而是决定发生是否继续或到站,治疗基于医生的临床的判断和病人的愿望。 | Héla Elloumi Fatma Houissa Najet Bel Hadj Dalila Gargouri Malika Romani Jamel Kharrat AbdelJabbar Ghorbel | 2007 | World Journal of Gastroenterology2007，13，40： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | Elecro- chemical synthesis of a polyphenylene deriving from p- methoxytoluene 显示文摘 | Ayoub H S Dridi C Roudesli S Fatma M M | 2000 | Eur Polym J2000，36，： | 1 |
| 4 | Mechanistic in- vestigation of the anodic oxidation of 3,4,5-trimethoxy- toluene in acetonitrile 显示文摘 | Ayoub H S Fatma M M Christian A | 2002 | J Electroanal Chem2002，537，： | 1 |
| 5 | Mechanistic in- vestigation of the anodic oxidation of p-methoxytoluene in dry and wet acetonitrile 显示文摘 | Ayoub H S Fatma M M Christian A | 1999 | J Electroanal Chem1999，464，： | 1 |
| 6 | Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients显示文摘 | Yusuf Tavil Nihat Sen Hü seyin Yazici Murat Turfan Fatma Hizal Atiye ? engel Adnan Abaci | 2010 | Platelets2010，，5： | 1 |
| 7 | Synthesis,antimicrobial activity and mi- cellization of Gemini anionic surfactants in a pure state as well as mixed with a conventional nonlonic surfactant显示文摘 | Abd EI-Salam Fatma H | 2009 | Surfact Deterg2009，12，4： | 1 |
| 8 | Relationship between antioxidant capacity and oxidative stress in children with acute hepatitis A显示文摘AIM: To investigate in children with acute hepatitis A. According to our knowledge, there are no data about the blood levels of malondialdehyde (MDA, an indicator of oxidative stress) and nonenzymic antioxidants in children with acute hepatitis A. METHODS: Whole blood MDA and reduced glutathione (GSH), serum β-carotene, retinol, vitamin E and vitamin C levels were studied in 19 (10 females, 9 males) children with acute hepatitis A and in 29 (13 females, 16 males) healthy control subjects. RESULTS: There was a statistically significant difference between patients and controls for all parameters (P < 0.05). Lipid peroxidation marker MDA was significantly elevated (P < 0.001), while antioxidants β-carotene, retinol and GSH were significantly decreased (all P < 0.001) in patients compared to healthy subjects. In addition, α-tocopherol and ascorbic acid levels were significantly lower in patients when compared to age and sex matched controls (P < 0.05, P < 0.01, respectively). CONCLUSION: Our study shows that hepatitis A virus induces oxidative stress in childern with hepatitis A. This finding could be taken into consideration to improve the therapeutic approach in acute hepatitis A. | Mustafa Cemek Semiha Dede Fahri Bayiro■lu Hseyin aksen Fatma Cemek Nihat Mert | 2006 | World Journal of Gastroenterology2006，12，38： | 1 |
| 9 | Effect of CeO2 on the Crystallization Behavior and Magnetic Properties of Zn-ferrite Glass Ceramics显示文摘 | Salwa A M Abdel-Hameed Fatma H Margha Mona A Ouis | 2013 | Journal of Alloys and Compounds2013，554，： | 1 |
| 10 | Quality improvement and shelf-life extension of refrigerated Nile tilapia (Oreochromis niloticus) fillets using natural herbs显示文摘 | Fathy A Khalafalla Fatma H M Ali Abdel-Rahim H A Hassan | 2015 | Beni-Suef University Journal of Basic and Applied Sciences2015，4，1： | 1 |
| 11 | Preparation, Crystallization Behavior and Magnetic Properties of Nanoparticles Magnetic Glass- ceramics in the Systems Fe2 03 -CoO-MnO2 , Fe2 03 -NiO-MoO3 and Fe2 03 -CoO-Vz 05 显示文摘 | Salwa A M Abdel-Hameed Fatma H Margha | 2012 | Journal of Non-Crystalline Solids2012，358，： | 1 |
| 12 | 显示文摘 | Fatma H ElBatal Amany Elkheshen | 2008 | Mater Chem Phys2008，110，： | 1 |
| 13 | Quantitation of aflatoxins in pistachios and groundnuts using HPLC-FLD method显示文摘 | FATMA H OZGUR G BULENT K | 2014 | Food Control2014，38，： | 1 |
| 14 | HLA-DQB1 * 等位基因和基因危险性到类型 1 糖尿病 mellitus显示文摘 AIM: To determine human leukocyte antigen (HLA)DQB1 allele association with susceptibility to type 1 diabetes (T1D) and to clinical and laboratory findings. METHODS: This study was conducted on 85 unrelated Egyptian children with T1D recruited consecutively from the Pediatric Diabetes Endocrinology outpatients Clinic; Mansoura University Children’s Hospital, Egypt. Patient mean follow up period was 2.5 years. Patients were subdivided according to level of HbA1c (optimal/suboptimal control < 8.5% and poor control ≥ 8.5%). Thecontrol group consisted of 113 unrelated ageand sexmatched healthy subjects without T1D or other autoimmune diseases. Genomic DNA extraction was done for all subjects using a DNA isolation kit. HLA-Class Ⅱ-DQB1 allele typing was carried out with a polymerase chain reaction-sequence-specific oligonucleotide probe using a INNO-LiPA HLA-DQB1 update kit. RESULTS: Significant differences were detected between Egyptian patients with T1D and control groups in the frequencies of DQB1*02 [44.4% vs 18.6%, corrected P value (Pc) < 0.001] and DQB1*03 (41.2% vs 24.4%, Pc < 0.001). Significant differences were also observed between control groups and T1D patients in the frequencies of DQB1*05 (14.6% vs 7.2%, P = 0.029) and DQB1*06 (34.1% vs 7.2%, P < 0.001). However, after correction for multiple comparisons, the significance was retained for HLA-DQB1*06 (Pc < 0.001) but lost for HLA-DQB1*05. HLA-DQB1*0201, *0202, *030201 were positively associated with T1D (Pc = 0.014, Pc < 0.001, and Pc < 0.001 respectively), while HLA-DQB1*060101 was negatively associated (Pc < 0.001) with the condition. Although the HLA-DQB1 alleles 030101 and 050101 were significantly higher in controls (P = 0.016, P = 0.025 respectively), both of them lost statistical significance after correction of P value. The frequency of the HLA-DQB1 genotypes 02/02, 02/03, and 03/03 was higher in T1D patients, and the frequency of the genotypes 03/06, 05/06, and 06/06 was higher in controls, these differences being statistically significant before correction. After correction, the genotypes 02/02, 02/03 in T1D, and the genotypes 03/06, 06/06 in controls were still significant (Pc = 0.01, Pc < 0.001, Pc < 0.001, and Pc = 0.04, respectively). Non-significant associations were found between the frequency HLA-DQB1 alleles and genotypes in T1D in relation to the grade of diabetic control, Microalbuminuria, age, gender, age of presentation, weight, height, frequency of diabetic ketoacidosis (P =0.42), serum cholesterol, and fasting and post-prandial level of C-peptide (P = 0.83, P = 0.9, respectively). CONCLUSION: The Current work suggests that HLADQB1 alleles *030201, *0202, *0201, and genotypes 02/03, 02/02 may be susceptibility risk factors for development of T1D in Egyptian children, while the HLADQB1*060101 allele, and 03/06, 06/06 genotypes may be protective factors. HLA-DQB1 alleles and genotypes do not contribute to microalbuminuria or grade of diabetic control. | Youssef M Mosaad Fatma A Auf Shereen S Metwally Ashraf A Elsharkawy Amany K El-Hawary Rasha H Hassan Ziyad E Tawhid Farha A El-Chennawi | 2012 | World Journal of Diabetes2012，3，8： | 1 |
| 15 | Using Objective Structured Clinical Examination (OSCE) in Undergraduate Psychiatric Nursing Education: Is It Reliable and Valid?显示文摘 | Abeer A S Fatma H R Mervat M E | 2012 | Nurse Edue Today2012，32，3： | 1 |
| 16 | Synthesis antimicrobial activity and micellization of gemini anionic surfactants in a pure state as well as mixed with a conventional nonionic surfaetant显示文摘 | Fatma H E1-Salam Abd | 2009 | Journal of Surfactants andDetergents2009，12，4： | 1 |
| 17 | Cross-validation of the Turkish Version of the 25-Item National Eye Institute Visual Functioning Questionnaire (NEI-VFQ 25)显示文摘 | Ahmet Baris Toprak Erhan Eser Cenap Guler Fatma Esin Baser Hüseyin Mayali | 2005 | Ophthalmic Epidemiology2005，，4： | 1 |
| 18 | Synthesis, antimicrobial activity and micellization of gemini anionic surfactants in a pure state as well as mixed with a conventional nonionic surfactant 显示文摘 | FATMA H ABD EL - SALAM | 2009 | Surfact Deterg2009，12，： | 1 |
| 19 | Fatty liver disease:Disparate predictive ability for cardiometabolic risk and all-cause mortality显示文摘AIM: To assess the association of a surrogate of fatty liver disease(FLD) with incident type-2 diabetes, coronary heart disease, and all-cause mortality.METHODS: In a prospective population-based study on 1822 middle-aged adults, stratified to gender, we used an algorithm of fatty liver index(FLI) to identify associations with outcomes. An index ≥ 60 indicated the presence of FLD. In Cox regression models, adjusted for age, smoking status, high-density lipoprotein cholesterol, and systolic blood pressure, we assessed the predictive value of FLI for incident diabetes, coronary heart disease(CHD), and all-cause mortality.RESULTS: At a mean 8 year follow-up, 218 and 285 incident cases of diabetes and CHD, respectively, and 193 deaths were recorded. FLD was significantly associated in each gender with blood pressure, total cholesterol, apolipoprotein B, uric acid, and C-reactive protein; weakly with fasting glucose; and inversely with high-density lipoprotein-cholesterol and sex hormonebinding globulin. In adjusted Cox models, FLD was(with a 5-fold HR) the major determinant of diabetes development. Analyses further disclosed significant independent prediction of CHD by FLD in combined gender [hazard ratio(HR) = 1.72, 95% confidence interval(CI): 1.17-2.53] and men(HR = 2.35, 95%CI: 1.25-4.43). Similarly-adjusted models for all-cause mortality proved, however, not to confer risk, except for a tendency in prediabetics and diabetic women.CONCLUSION: A surrogate of FLD conferred significant high risk of diabetes and coronary heart disease, independent of some metabolic syndrome traits. Allcause mortality was not associated with FLD, except likely in the prediabetic state. Such a FLI may reliably be used in epidemiologic studies. | Altan Onat Günay Can Aysem Kaya Tugba Akbas Fatma Ozpamuk-Karadeniz Baris Simsek Hakan Cakir Hüsniye Yüksel | 2015 | World Journal of Gastroenterology2015，21，48： | 1 |
| 20 | Synthesis Antimicrobial Activity and Micellization of Gemini Anionic Surfactants in a Pure State as Well as Mixed With a Conventional Nonionic Surfactant 显示文摘 | Fatma H E1-Salam Abd | 2009 | Jour- nal of Surfactants and Detergents2009，12，4： | 1 |
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