Fatty liver disease:Disparate predictive ability for cardiometabolic risk and all-cause mortality

查看全文 作　　者：Altan [1]Onat;Günay [2]Can;Aysem [3]Kaya;Tugba [4]Akbas;Fatma Ozpamuk-[5]Karadeniz;Baris [6]Simsek;Hakan [7]Cakir;Hüsniye [1]Yüksel

机构地区：[1]Department of Cardiology,Cerrahpasa Medical Faculty,Istanbul University;[2]Department of Public Health,Cerrahpasa Medical Faculty,Istanbul University;[3]Section of Biochemistry,Institute of Cardiology,all Istanbul University;[4]Bagcilar Educational Hospital;[5]Balikligol State Hospital;[6]Department of Cardiology,S.Ersek Center for Cardiovascular Surgery;[7]Darica Farabi State Hospital

出　　处：《World Journal of Gastroenterology》索引2015年第21卷第48期,共11页

基　　金：Supported by automotive company TOFAS;Istanbul;Turkey 摘　　要：AIM: To assess the association of a surrogate of fatty liver disease(FLD) with incident type-2 diabetes, coronary heart disease, and all-cause mortality.METHODS: In a prospective population-based study on 1822 middle-aged adults, stratified to gender, we used an algorithm of fatty liver index(FLI) to identify associations with outcomes. An index ≥ 60 indicated the presence of FLD. In Cox regression models, adjusted for age, smoking status, high-density lipoprotein cholesterol, and systolic blood pressure, we assessed the predictive value of FLI for incident diabetes, coronary heart disease(CHD), and all-cause mortality.RESULTS: At a mean 8 year follow-up, 218 and 285 incident cases of diabetes and CHD, respectively, and 193 deaths were recorded. FLD was significantly associated in each gender with blood pressure, total cholesterol, apolipoprotein B, uric acid, and C-reactive protein; weakly with fasting glucose; and inversely with high-density lipoprotein-cholesterol and sex hormonebinding globulin. In adjusted Cox models, FLD was(with a 5-fold HR) the major determinant of diabetes development. Analyses further disclosed significant independent prediction of CHD by FLD in combined gender [hazard ratio(HR) = 1.72, 95% confidence interval(CI): 1.17-2.53] and men(HR = 2.35, 95%CI: 1.25-4.43). Similarly-adjusted models for all-cause mortality proved, however, not to confer risk, except for a tendency in prediabetics and diabetic women.CONCLUSION: A surrogate of FLD conferred significant high risk of diabetes and coronary heart disease, independent of some metabolic syndrome traits. Allcause mortality was not associated with FLD, except likely in the prediabetic state. Such a FLI may reliably be used in epidemiologic studies. 关键词：All-cause death Coronary heart disease Hepatic steatosis Metabolic syndrome Turkish adultrisk factor study

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Fatty liver disease:Disparate predictive ability for cardiometabolic risk and all-cause mortality

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