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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure显示文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P<0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation. | Necdet Guler Omer Unalp Ayse Guler Onur Yaprak Murat Dayangac Murat Sozbilen Murat Akyildiz Yaman Tokat | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 9 |
| 3 | NO Level and Endothelial NO Synthase Gene Polymorphism (Glu298Asp) in the Patients with Coronary Artery Disease from the Turkish Population显示文摘Nitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene. This study was performed to investigate the relationship between the serum nitric oxide level and eNOS gene polymorphism in the Turkish population with angiographically diagnosed coronary artery disease (63.47 ± 9.10 years old, n=250) and control subjects without any history and/or risk factors of coronary artery disease (60.71 ± 9.14 years old, n=150). Griess assay and PCR-RFLP analysis were used to measure the serum nitric oxide metabolites and genotypes, respectively. It was found that Glu/Glu, Glu/Asp and Asp/ Asp genotype frequencies of the eNOS were 49.3%, 41.3% and 9.3% respectively in the control group, and 45.6%, 41.2% and 13.2% in the patient group. Serum nitric oxide levels were (32.56 ± 17.26) μM in controls and (29.84 ± 11.88) μM in patients. Neither the frequencies of the Glu298Asp genotypes nor the serum nitric oxide levels showed a significant difference between the groups. There was also no correlation between serum nitric oxide levels and the frequencies of the eNOS genotypes. Result showed that the coronary artery disease of the Turkish population seemed to develop without any alterations in eNOS Glu298Asp genotype frequency and the serum nitric oxide level. | Lale AFRASYAPDepartment of Biochemistry Faculty of Health Mugla University Mugla Turkey Guler OZTURK | 2004 | Acta Biochimica et Biophysica Sinica2004，36，10： | 5 |
| 4 | Major complications of adult right lobe living liver donors显示文摘BACKGROUND:The right lobe of the liver is generally preferred for living donor liver transplantation in adult patients with end-stage liver disease.It is important to know the preoperative factors relating to the major postoperative complications.We therefore evaluated the possible risk factors for predicting postoperative complications in right lobe liver donors.METHODS:Data from 378 donors who had undergone | Necdet Guler Onur Yaprak Yusuf Gunay Murat Dayangac Murat Akyildiz Fisun Yuzer Yildiray Yuzer Yaman Tokat | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 5 | 一种研究沥青混凝土温度疲劳行为的室内试验方法显示文摘由于温度疲劳现象引起的裂缝会导致沥青混凝土路面结构性能和使用质量的严重下降。温度疲劳裂缝发生在气候温和的地区,是受约束的铺装层内部温度循环应变/应力的结果。该文介绍一种在恒定应变荷载作用下测量沥青混凝土试样抗温度疲劳的试验装置。为了模拟沥青混凝土的温度疲劳行为,采用机械方法对沥青混凝土进行单轴加载,在0.01 Hz的频率下实现恒幅正弦应变。试验结果表明:沥青含量、集料来源和沥青结合料等级对沥青混凝土的抗温度疲劳性能影响最大。 | 冯新军 肖洪海(编译) Ali Arabzadeh Murat Guler | 2021 | 中外公路2021，41，5： | 2 |
| 6 | A methodology for lining design of circular mine shafts in different rock masses显示文摘In this study, the finite element numerical modelling of 2D shaft sections in a Hoek–Brown medium are carried out in a non-hydrostatic stress state in an attempt to predict pressures developing around mine shafts. An iterative process of applying support pressure until observing no failure zone around the shaft is used to simulate the required lining support pressure for different shaft models. Later, regression analysis is carried out to find a generic shaft pressure equation representing the rock mass and the stress state. Finally, the developed pressure equation which shows a good agreement with a case study is used in elastic ‘‘thick-walled cylinder' equation to calculate the lining thickness required to prevent the development of a failure zone around the shaft. At the end of the study, a user-friendly object-oriented computer program ‘‘Shaft 2D' is developed to simplify the rigorous shaft lining thickness calculation process. | Ozturk Hasan Guler Erdogan | 2016 | International Journal of Mining Science and Technology2016，26，5： | 2 |
| 7 | Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers显示文摘BACKGROUND Diabetic polyneuropathy is a very common complication of diabetes.Numerous studies are available in terms of pathogenesis.But examination methods with low reliability are still not standardized and generally time consuming.Highsensitive,easy-to-access methods are expected.Biochemical markers are one of the subjects of research.We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy.AIM To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder.METHODS A total of 392 patients with type 2 diabetes mellitus were included in the study.The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination.The biochemical parameters,oxidative stress markers,visfatin,and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs.RESULTS Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration(P<0.005).Neuropathy related symptoms were present in 20.7%of the patients,but neuropathy related findings were observed in 43.9%of the patients.Serum glucose,glycated hemoglobin,and visfatin were positively correlated with each other.Also,these parameters were positively correlated with the total oxidative stress index.Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status.Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status(P<0.005).There was no correlation between visfatin and thiol-disulphide(P=0.092,r=0.086).However,a significant negative correlation was observed between visfatin and total with native thiol(P<0.005,r=-0.338),(P<0.005,r=-0.448).CONCLUSION Diagnosis of neuropathy is one of the issues studied in patients with diabetes.Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results. | Banu Buyukaydin Eray Metin Guler Tahsin Karaaslan Atilla Olgac Mehmet Zorlu Muharrem Kiskac Abdurrahim Kocyigit | 2020 | World Journal of Diabetes2020，11，7： | 2 |
| 8 | Strong strain path dependence of strain localizations and fracture in magnesium AZ31 sheet显示文摘This study compares the deformation and fracture behavior of a basal-textured Mg AZ31 alloy sheet under uniaxial tension and biaxial stretching by using an in-plane biaxial test setup capable of observing and measuring the deformation at both meso(millimeter)and microstructure scales.Strain distributions at the mesoscale and accompanying fracture surfaces indicate a significant dependence on strain path.At the microscale,limited slip activity in biaxial case promotes contraction twins,where severe strain localizations(εmax/εmean≈220)to the twins and their boundaries cause mainly transgranular fracture.This leads to a brittle,and a more pronounced shear-type fracture under biaxial stretching.In uniaxial case,considerable tensile twinning activity reorients the initial texture for slip activity.Strain localizations(εmax/εmean≈2)to the grain interiors and boundaries initiate mainly intergranular fracture.Samples fail by displaying both brittle and ductile fracture structures,with smaller shear lips compared to the biaxial case. | Kivanc Alkan O.Berk Aytuna Baran Guler Mert Efe | 2020 | Journal of Magnesium and Alloys2020，8，2： | 2 |
| 9 | 真空辅助熔模铸造制备A6063/SiC-B_4C混杂复合材料(英文)显示文摘采用真空辅助熔模铸造技术制备A6063/SiC-B4C混杂复合材料。首先,采用平均粒径分别为60μm和55μm、质量比为85%和15%的SiC和B4C粉末制备圆柱形的SiC-B4C预制块。然后,将预制块放入圆柱形石膏粘结块熔模中,在真空辅助铸造机中将A6063铝熔体浸渗到预制块中。采用阿基米德方法测定预制块中的孔隙度。对制备的复合材料进行硬度测试、图像分析、SEM观察和EDX成分分析。结果表明,采用真空辅助熔模铸造技术,铝熔体能将够成功地浸渗到预制块中。 | Alptekin KISASOZ Kerem Altug GULER Ahmet KARAASLAN | 2012 | Transactions of Nonferrous Metals Society of China2012，22，7： | 2 |
| 10 | Investigation of carbon contamination in lost foam castings of low carbon steel显示文摘Lost foam casting(LFC) process is a special casting method in which polymeric foam patterns with refractory coatings are utilized as a mould component. In this work, four types of foam: expandable polyethylene(EPE), expandable polypropylene(EPP) and expandable polystyrene(EPS) foams with two different densities were employed as pattern materials. LFC and conventional green sand mould casting methods were used to cast a low carbon steel, A216 Grade WCB. Both casting processes were carried out at 1,580 °C. Chemical analysis results showed that the carbon contamination level was high and was influenced by pattern type. Metallographic investigations revealed a significant increase in the percentage of pearlite phase in all LFC samples. Densities of manufactured samples were calculated in order to evaluate porosity of the products. It was determined that the densities of the LFC samples were lower than the green sand mould cast reference sample(RS). Vickers hardness tests were also carried out and increments in hardness values with increased carbon content was observed. | Oznur Kilic Serhat Acar Alptekin Kisasoz Kerem Altug Guler | 2018 | China Foundry2018，15，5： | 2 |
| 11 | Evaluation of 532-nm KTP laser treatment efficacy on acne vulgaris with once and twice weekly applications显示文摘 | Ozlem Yilmaz Nilgun Senturk Esra Pancar Yuksel Fatma Aydin Muge Guler Ozden Tayyar Canturk Ahmetyasar Turanli | 2011 | Journal of Cosmetic and Laser Therapy2011，，6： | 2 |
| 12 | T6热处理对触变锻造加低过热铸造制备的A356和A380铝合金的影响(英文)显示文摘研究T6热处理对触变锻造A356和A380铝合金的影响。采用低过热铸造(LSC)技术制备用于触变锻造的样品。为了获得等轴晶粒并防止枝晶生长,将样品在高于液相温度20°C时进行浇铸,将浇铸坯料再加热不同时间(20~80 min)后进行触变锻造,变形量为50%,再将触变锻造后的A356和A380铝合金样品进行T6热处理。用光学显微镜、能量弥散X射线谱仪、扫描电镜和布氏硬度仪对经触变锻造、固溶处理和时效处理后样品的显微组织和硬度变化进行检测。结果表明,T6热处理后合金的显微组织更均匀,并分别在A356和A380坯料中形成了新的析出相Mg_2Si和Al_2Cu。相应地,经过人工时效后,样品的硬度大幅度提高,A356铝合金的硬度达到HB 93,A380铝合金的硬度达到HB 120。 | Ridvan GECU Serhat ACAR Alptekin KISASOZ Kerem ALTUG GULER Ahmet KARAASLAN | 2018 | Transactions of Nonferrous Metals Society of China2018，28，3： | 2 |
| 13 | Effects of Sleep Disorders on Hemoglobin Alc Levels in Type 2 Diabetic Patients显示文摘 | Ahmet Keskin Murat Unalacak Ugur Bilge Pinar Yildiz Seda Guler Engin Burak Selcuk Muzaffer Bilgin | 2015 | Chinese Medical Journal2015，，24： | 2 |
| 14 | Atypical teratoid/rhabdoid tumors : imaging findings of two cases and review of the literature 显示文摘 | Tez S Koktener A Guler G | 2008 | Turk Neurosurg2008，18，1： | 1 |
| 15 | Plasma kinetic va-porization of the prostate:clinical evaluation of a new technique显示文摘 | DINCEL C SAMLI MM GULER C | 2004 | J Endourol2004，18，3： | 1 |
| 16 | The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma 显示文摘 | Guler G Uner A Guler N | 2004 | Cancer2004，100，8： | 1 |
| 17 | Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins显示文摘 | Guler R Olleros ML Vesin D Parapanov R Vesin C Kantengwa S | 2004 | J Hepatol2004，41，5： | 1 |
| 18 | Propofol and propofol ketamine in pediatric patients undergoing cardiac catheterization显示文摘 | Akin A Esmaoglu A Guler G | | 0，，： | 1 |
| 19 | Propofol and Propofol–Ketamine in Pediatric Patients Undergoing Cardiac Catheterization显示文摘 | A. Akin A. Esmaoglu G. Guler R. Demircioglu N. Narin A. Boyaci | 2005 | Pediatric Cardiology2005，，5： | 1 |
| 20 | The effects of dexmedetomidine on the cardiovascular responses to tracheal extubation and quality of tracheal extubation in elderly patients undergoing cataract surgery 显示文摘 | Guler G Akin A Tosun Z | 2005 | J Turk Anesthesiol Intensive Care Soc2005，33，1： | 1 |
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