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| 1 | Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer. | Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu | 2007 | World Journal of Gastroenterology2007，13，34： | 15 |
| 2 | A review on the cracking,baking and leaching processes of rare earth element concentrates显示文摘Rare earth elements(REE) are a set of seventeen chemical elements in the periodic table, which have been found in a variety classes of minerals in the world. The global demand for REE and their compounds has increased in high-tech applications over the past decades due to their chemical, catalytic, electrical, magnetic, and optical properties. After mining, comminution and ore beneficiation, hydrometallurgical and pyrometallurgical processes are carried out to recover REE compounds. The concentrate cracking is a process wherein the structure of a REE mineral is modified in order to dissolve REE in a weak acid solution. This would be accomplished through various techniques such as alkaline cracking and acid baking. The cracked concentrate is then leached to dissolve REE in a solution and subsequently recover those via neutralization, precipitation or solvent extraction methods. This paper reviewed the cracking and leaching methods applied to REE concentrates to produce an intermediate product for further REE separation. | Farzaneh Sadri Amir Mohammad Nazari Ahmad Ghahreman | 2017 | Journal of Rare Earths2017，35，8： | 11 |
| 3 | 覆冰棒板间隙直流电晕放电试验及测量显示文摘研究结果表明,在带电情况下覆冰绝缘子表面冰棱并未完全桥接,在覆冰绝缘子串两端的伞裙之间存在一定的空气间隙。为了研究这种空气间隙对放电发展的影响,提出了冰棒-冰板空气间隙模型。设计了紫外线成像仪CoroCAM IV+和基于虚拟仪器LabVIEW相结合的电晕测量系统。通过对冰棒-冰板空气间隙电晕放电脉冲的测量,证明该测试系统性能良好,能够满足试验测试要求。同时为下一步深入开展覆冰电极系统内空气间隙电晕放电的机理研究提供了试验平台。 | 冯杰 司马文霞 余德芬 杨庆 赖向平 张建辉 M Farzaneh | 2006 | 高电压技术2006，32，5： | 11 |
| 4 | Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review显示文摘The inflammatory process plays a central role in the development and progression of numerous pathological situations,such as inflammatory bowel disease(IBD),autoimmune and neurodegenerative diseases,metabolic syndrome,and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease(CD) and ulcerative colitis(UC). Both pathological situations usually involve recurring or bloody diarrhea,pain,fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However,surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants,including vegetables and fruits which are the major dietary sources of these compounds for humans,together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids,evidencing a remarkable free-radical scavenging capacity. However,accumulating evidence suggests that flavonoids have many other biological properties,including anti-inflammatory,antiviral,anticancer,and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs. | Ali Salaritabar Behrad Darvishi Farzaneh Hadjiakhoondi Azadeh Manayi Antoni Sureda Seyed Fazel Nabavi Leo R Fitzpatrick Seyed Mohammad Nabavi Anupam Bishayee | 2017 | World Journal of Gastroenterology2017，23，28： | 10 |
| 5 | 导线表面电场强度对导线覆冰的影响显示文摘为研究导线表面电场强度对导线覆冰的影响,在魁北克大学希库蒂米分校电网设备大气覆冰试验室(INGIVRE)的人工气候室内通过电晕笼进行导线带电覆冰试验。试验结果表明导线表面电场强度对导线覆冰质量、形状、冰凌间距、电晕损失以及泄漏电导和导线电容等产生影响。电场强度的增加使雾凇表面产生水膜、雨凇冰凌长度减少。当导线表面电场强度≤20 kV/cm时,导线表面覆冰质量随电场强度的增加而增加。电场强度进一步增加时,导线表面覆冰质量减少。当被导线捕获的水滴在重力作用下流到导线下表面后立即被冻结时,冰凌间距和场强无关。当降雨量较大时,冰凌间距随着场强的增加而减少。导线在雾凇和雨凇覆冰时,电晕损失和由电晕产生的电导随场强的增加而增加。雨凇覆冰时,由于冰凌长度的影响,导线表面电场强度为5 kV/cm时导线的单位长度电容反而比电场强度为25 kV/cm时大。 | 尹芳辉 蒋兴良 Masoud Farzaneh | 2018 | 高电压技术2018，44，3： | 9 |
| 6 | 大荨麻提取物对高胆固醇血症大鼠血脂的影响(英文)显示文摘目的:探讨大荨麻提取物对高胆固醇血症大鼠血脂的影响。方法:雄性大鼠口服高胆固醇饮食(10mL/kg)4周,制备高胆固醇血症大鼠模型。造模同时灌服100、300mg/kg大荨麻提取物或10mg/kg洛伐他汀。观察大荨麻提取物对大鼠血脂、肝功能和肝脏病理的影响。结果:100、300mg/kg大荨麻提取物可以明显减少高胆固醇血症大鼠血总胆固醇和低密度脂蛋白胆固醇含量,并可以降低丙氨酸氨基转移酶(alanine aminotransferase,ALT)和天冬氨酸氨基转移酶(aspartate aminotransferase,AST)活性。苏木精和伊红染色显示,100mg/kg大荨麻提取物组肝脏组织未见明显脂肪变性,细胞形态与对照组相似;300mg/kg大荨麻提取物组肝脏组织可见到中等程度的脂肪变性。结论:大荨麻提取物可能通过降低血浆胆固醇含量和血浆ALT、AST活性治疗大鼠高胆固醇血症。 | Marjan NASSIRI-ASL Farzaneh ZAMANSOLTANI Esmail ABBASI Mohammad-Mehdi DANESHI Amir-Abdollah ZANGIVAND | 2009 | 中西医结合学报2009，7，5： | 7 |
| 7 | Intravenous transplantation of bone marrow mesenchymal stem cells promotes neural regeneration after traumatic brain injury显示文摘To investigate the supplement of lost nerve cells in rats with traumatic brain injury by intravenous administration of allogenic bone marrow mesenchymal stem cells, this study established a Wistar rat model of traumatic brain injury by weight drop impact acceleration method and administered 3 × 106 rat bone marrow mesenchymal stem cells via the lateral tail vein. At 14 days after cell transplantation, bone marrow mesenchymal stem cells differentiated into neurons and astrocytes in injured rat cerebral cortex and rat neurological function was improved significantly. These findings suggest that intravenously administered bone marrow mesenchymal stem cells can promote nerve cell regeneration in injured cerebral cortex, which supplement the lost nerve cells. | Fatemeh Anbari Mohammad Ali Khalili Ahmad Reza Bahrami Arezoo Khoradmehr Fatemeh Sadeghian Farzaneh Fesahat Ali Nabi | 2014 | Neural Regeneration Research2014，9，9： | 6 |
| 8 | Traditional Iranian courtyards as microclimate modifiers by considering orientation, dimensions, and proportions显示文摘 | Farzaneh Soflaei Mehdi Shokouhian Seyed Majid Mofidi Shemirani | 2016 | Frontiers of Architectural Research2016，5，2： | 5 |
| 9 | GNSS smartphones positioning: advances, challenges, opportunities, and future perspectives显示文摘Starting from 2016,the raw Global Navigation Satellite System(GNSS)measurements can be extracted from the Android Nougat(or later)operating systems.Since then,GNSS smartphone positioning has been given much attention.A high number of related publications indicates the importance of the research in this field,as it has been doing in recent years.Due to the cost-effectiveness of the GNSS smartphones,they can be employed in a wide variety of applications such as cadastral surveys,mapping surveying applications,vehicle and pedestrian navigation and etc.However,there are still some challenges regarding the noisy smartphone GNSS observations,the environment effect and smartphone holding modes and the algorithm development part which restrict the users to achieve high-precision smartphone positioning.In this review paper,we overview the research works carried out in this field with a focus on the following aspects:first,to provide a review of fundamental work on raw smartphone observations and quality assessment of GNSS observations from major smart devices including Google Pixel 4,Google Pixel 5,Xiaomi Mi 8 and Samsung Ultra S20 in terms of their signal strengths and carrier-phase continuities,second,to describe the current state of smartphone positioning research field until most recently in 2021 and,last,to summarize major challenges and opportunities in this filed.Finally,the paper is concluded with some remarks as well as future research perspectives. | Farzaneh Zangenehnejad Yang Gao | 2021 | Satellite Navigation2021，2，1： | 5 |
| 10 | Ozone and ozone/hydrogen peroxide treatment to remove gemfibrozil and ibuprofen from treated sewage effluent: Factors influencing bromate formation显示文摘Reuse of treated sewage effluent is an important option to overcome water scarcity.Conventional wastewater treatment methods are inadequate for the removal of several persistent contaminants such as pharmaceuticals and personal care products(PPCPs).In this study the removal of ibuprofen and gemfibrozil by ozonation and ozone/hydrogen peroxide(O3/H2O2)advanced oxidation process(AOP),as well as the formation of bromate were investigated at different temperatures and pH values.Complete removal of gemfibrozil and a maximum of 80%ibuprofen removal were achieved using ozone dosage of 1.5 mg/L with O3:H2O2 ratio of 1:0.25 in the O3/H2O2 process.The effect of temperature on the removal efficiency of these two compounds was found to be negligible from 25 to 40ᵒC for both processes.pH effect from 6 to 9 was also found to be negligible for gemfibrozil removal,while ibuprofen had relatively lower removal by ozonation at pH 6 compared to higher pH values.Bromate formation was decreased to 0.012 mg/L when the pH was increased to 9.Increasing the temperature to 40ᵒC also resulted in less bromate formation which was the lowest value obtained in this study at 0.0102 mg/L.Addition of H2O2 did not affect the formation of bromate and in some cases it was found to be slightly higher compared with ozonation treatment. | Hajar Farzaneh Kavithaa Loganathan Jayaprakash Saththasivam Gordon McKay | 2020 | Emerging Contaminants2020，6，1： | 4 |
| 11 | Essential Oil from Citrus aurantium Alleviates Anxiety of Patients Undergoing Coronary Angiography: A Single-Blind, Randomized Controlled Trial显示文摘Objective To determine the effectiveness and safety of essential oil from Citrus aurantium on anxiety in patients undergoing coronary angiography.Methods A single-blind,randomized controlled trial was conducted in 80 patients experiencing coronary angiography in Imam Ali Hospital in Kermanshah,Iran from April to November in 2016.All patients were randomly divided into intervention and control groups by a random number table,40 cases in each group.The patients in the intervention group inhaled Citrus aurantium essential oil for 15–20 min about 60 min before angiography.Following the same procedure,distilled water was used instead of Citrus aurantium in the control group.Spielbergers State-Trait Anxiety Inventory(STAI)was filled in and vital signs including systolic blood pressure(SBP),diastolic blood pressure(DBP),respiratory and pulse rate were recorded before and 20 min after the intervention.Adverse reactions after intervention were observed.Results In the intervention group,the mean scores of STAI,SBP,DBP,respiratory and pulse rate were 53.30±10.13,134.82±11.75 mm Hg,84.49±6.99 mm Hg,17.87±1.73 times/min,and 76.48±12.55 beats/min at baseline and significantly decreased to 42.37±10.15,124.49±10.48 mm Hg,79.23±6.62 mm Hg,14.54±1.43 times/min,and 70.03±13.66 beats/min respectively 20 min after intervention(all P<0.05);however,in the control group,neither anxiety scores nor vital signs changed significantly(P>0.05).All subjects reported no adverse reactions.Conclusion Inhalation of the essential oil from Citrus aurantium was effective in reducing anxiety and stress levels in patients undergoing coronary angiography. | Khalil Moradi Hossein Ashtarian Nicholas Yakubu Danzima Hamid Saeedi Behrouz Bijan Farzaneh Akbari Mohammad Mehdi Mohammadi | 2021 | Chinese Journal of Integrative Medicine2021，27，3： | 4 |
| 12 | Minimally invasive open dismembered pyeloplasty technique: Miniature incision, muscle-splitting dissection, and nopelvis reduction in children显示文摘Objective:To report the outcomes and complications of open dismembered Anderson-Hynes pyeloplasty with miniature incision in treating children’s ureteropelvic junction obstruction.Methods:Between March 2007 and April 2011,109 children with a mean age of 2 years and 8 months old with ureteropelvic junction obstruction underwent open dismembered pyeloplasty.Clinical manifestations,radiographic assessments,incision size,surgery time,hospital stay,and complication rate were recorded.All patients had a documented ureteropelvic junction obstruction(having T1/2 more than 20 min in diethylenetriaminepentaacetic acid[DTPA]scan)with symptomatic stenosis or decreased kidney function(differential function<40%).Pyeloplasty was done by a retroperitoneal flank approach with miniature incision without pelvis reduction.One surgeon did all the surgeries.Success rate and complications were assessed in a 3-year follow-up.Results:Mean surgery time was 52 min(47e60 min).Incision size was 18e28 mm.Mean hospital stay was 3 days(2e8 days).The surgery was successful in 98.2%of patients with a mean follow-up time of 36 months(success was defined as disappearance of symptoms,if present,with improved ultrasound imaging results or Reno graphic parameters).The complication rate was 7.33%,including urinary leakage,double-J urethral stent dislocation and infection.Conclusion:Open dismembered pyeloplasty is a safe,technically feasible and effective therapy in treatment of children’s ureteropelvic junction obstruction.It takes a short time to do,requires a small incision and has few complications and a short recovery period. | Farzaneh Sharifiaghdas Mahboubeh Mirzaei Azar Daneshpajooh Shahin Abbaszadeh | 2019 | Asian Journal of Urology2019，6，3： | 4 |
| 13 | 振动搅拌摩擦焊镁合金动态再结晶过程的模拟与实验研究显示文摘采用二维元胞自动机(CA)模型分析机械振动对AZ91合金在搅拌摩擦焊(FSW)过程中组织演变的影响。将模拟结果,即晶粒拓扑结构、粒度分布、平均晶粒度以及动态再结晶(DRX)分数与实测数据进行比较。结果显示,有限元分析结果与实验数据具有充分的相似性,CA方法可用于搅拌摩擦焊AZ91合金组织演变的分析。与FSW相比,振动搅拌摩擦焊(FSVW)处理的样品中位错密度更高,形核和晶粒长大也更快。对FSVW过程中不同振动频率下的晶粒度改变和DRX现象经过详细模拟后发现,振动使形核开始时间提前,随着振动频率的提高,孕育期和再结晶的比例降低。 | Mahmoud ABBASI Behrouz BAGHERI Farzaneh SHARIFI | 2021 | Transactions of Nonferrous Metals Society of China2021，31，9： | 4 |
| 14 | Functionalized CVD monolayer graphene for label-free impedimetric biosensing显示文摘在大区域 graphene 生长的最近的进展在不同区域导致了许多应用。在现在的学习,化学蒸汽扔了(CVD ) 在玻璃底层上支持的单层 graphene 为电气化学的 biosensing 应用作为电极材料被检验。我们由在酸的水的答案在 situ 准备的 carboxyphenyl 重氮基盐的电气化学的减小为 CVD 单层 graphene 的共有原子价 functionalization 报导灵巧的策略。修改 carboxyphenyl 的 graphene 用拉曼光谱学, X 光检查光电子光谱学(XPS ) ,和原子力量被描绘显微镜学(AFM ) ,以及电气化学的阻抗光谱学(EIS ) 。我们也证明 graphene 表面上的 grafted carboxyphenyl 组的数字能被扫描为 electrografting 使用了的周期的 voltammetry (CV ) 的数字控制。我们进一步在 grafted 的激活以后在 graphene 表面上基于 ovalbumin 抗体的固定介绍 immunosensor 的制造和描述经由 EDC/NHS 化学的羧基的组。在使表面不能调动的抗体和 ovalbumin 之间的绑定然后用 Faradaic EIS 被监视在[Fe (CN )< 潜水艇 class= “ a-plus-plus ” > 6 ] 3/4 答案。费用转移抵抗的百分比变化(R < 潜水艇 class= “ a-plus-plus ” > 在绑定以后的 ct ) 为从 1.0 pg 的 ovalbumin 集中展出了线性依赖? | Shimaa Eissa Gaston Contreras Jimenez Farzaneh Mahvash Abdeladim Guermoune Chaker Tlili Thomas Szkopek Mohammed Zourob Mohamed Siaj | 2015 | Nano Research2015，8，5： | 3 |
| 15 | 介孔硅铝分子筛的合成、表征及其作为固体酸催化苯酚与1-辛烯的烷基化反应显示文摘以异丙醇铝、硅酸四乙酯和十六烷基三甲基溴化胺为原料,以乙酰丙酮为螯合剂,采用溶胶-凝胶法合成了硅铝比分别为25,50,100和150的介孔硅铝分子筛,并用其催化苯酚与1-辛烯的液相烷基化反应.X射线衍射、N2吸附、高分辨透射电镜及27Al核磁共振光谱表征结果表明,该介孔分子筛具有蠕虫状骨架结构.在160℃时,硅铝比为25的介孔硅铝分子筛催化剂上苯酚可以完全转化为单烷基苯酚. | Zahra MEHRABAN Faezeh FARZANEH Mehdi GHANDI Alireza ABBASI | 2007 | 催化学报2007，28，4： | 3 |
| 16 | Numerical analysis of the dynamic effects of shock-load-induced ice shedding on overhead ground wires显示文摘 | T. Kálmán M. Farzaneh G. McClure | 2006 | Computers and Structures2006，，7： | 3 |
| 17 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 18 | Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I–II clinical trial显示文摘 | Pedram Kharaziha Per M. Hellstr?m Babak Noorinayer Farivar Farzaneh Katayoun Aghajani Fereshteh Jafari Mohammad Telkabadi Amir Atashi Maryam Honardoost Mohammad Reza Zali Masoud Soleimani | 2009 | European Journal of Gastroenterology & Hepatology2009，，10： | 3 |
| 19 | Preoperative clinical and paraclinical predictors of choledocholithiasis显示文摘BACKGROUND:Choledocholithiasis is the most common cause of obstructive jaundice and cholangitis and occurs in about 10%of patients with symptomatic gallstone.The aim of this study was to find preoperative and non-invasive tests for predicting common bile duct stones(CBDs). METHODS:Findings of clinical examination,history laboratory tests and ultrasound(US)in 60 patients with CBDs were compared retrospectively,with 60 patients with gallstones.The data were collected from medical charts The sensitivity,specificity and positive predictive value (PPV)were determined. RESULTS:The comparison between the two groups showed significant differences in anorexia,itching,dark urine subicterus(slightly elevated serum bilirubin without clinical evidence of jaundice)and jaundice appearance increased bilirubin level,aspartate aminotransferase(AST) and alanine aminotranferase(ALT),CBD diameter>6 mm and stone observation under US(P<0.05).The highest specificity(100%)and PPV(100%)were found in dark urine and pale colored stool,history of cholangitis,and icterus.Among paraclinical tests,alkaline phosphatase (ALP)had the highest specificity(72.1%)and PPV(12.5%) Under US,stone observation in CBD was the most important factor with a sensitivity of 94.5%,a specificity of 100%and a PPV of 100%. CONCLUSIONS:The most important factors for predicting CBDs are history of cholangitis and pancreatitis,presence of icterus,dark urine,pale colored stool,elevation of ALP and sonographic evidence of chledocholithiasis. | Ali Yaghoobi Notash Javad Salimi Farzaneh Golfam Gholamreza Habibi Kamyab Alizadeh | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 3 |
| 20 | Effect of Salvia officinalis Hydroalcoholic Extract on Vincristine-induced Neuropathy in Mice显示文摘AIM:Vincristine is one of the most commonly used chemotherapeutic drugs to treat a variety of malignant diseases,including leukemia and lymphoma.Studies have shown that vincristine cause painful effects,whereas Salvia officinalis(SO) showed analgesic and anti-inflammatory effects.The aim of this study is to investigate the effects of the SO hydro-alcoholic extract on vincristine-induced peripheral neuropathy in mice in comparison with morphine.METHODS:Experiments were performed on 60 NMRI male mice weighing 25-30 g divided into six groups.The individual groups received normal saline,SO hydro-alcoholic extract,vincristine,SO hydro-alcoholic extract and vincristine(12 days before formalin test),morphine,and vincristine and morphine,respectively.The injected hind paw biting and licking was measured in a 5-minute interval for one hour.RESULTS:The results showed that formalin induce significant(P < 0.05) pain responses(the first phase:0-5 min and the second phase:15-40 min after injection).Administration of SO extract before formalin test showed significant(P < 0.05) decrease of pain response in the second phase.Administration of vincristine caused significant(P < 0.05) increase in the second phase of pain response.Injections of SO extract and vincristine showed that SO significantly(P < 0.05) decrease the second phase of vincristine-induced pain.Morphine decreased vincristine-induced pain in the first and second phase of formalin test significantly(P < 0.05).In comparison,morphine showed analgesic effects in the first phase and SO extract showed significant(P < 0.05) anti-inflammatory effects in the second phase of formalin test.CONCLUSION:Both SO and vincristine showed analgesic and painful neuropathic effects,suggesting that SO extract could be useful in the treatment of vincristine-induced peripheral neuropathic pain. | Ali Namvaran Abbas Abad Mir Hadi Khayate Nouri Farzaneh Tavakkoli | 2011 | 中国天然药物2011，9，5： | 3 |
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