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| 1 | Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) includes two entities, Crohn’s disease and ulcerative colitis. Both are chronic conditions with frequent complications and surgical procedures and a great impact on patient’s quality of life. The thiopurine antimetabolites azathioprine and 6-mercaptopurine are widely used in IBD patients. Current indications include maintenance therapy, steroid-dependant disease, fistula closure, prevention of infliximab immunogenicity and prevention of Crohn’s disease recurrence. Surprisingly, the wide use of immunosuppressants in the last decades has not decreased the need of surgery, probably because these treatments are introduced at too late stages in disease course. An earlier use of immunossupressants is now advocated by some authors. The rational includes: (1) failure to modify IBD natural history of present therapeutic approach, (2) demonstration that azathioprine can induce mucosal healing, a relevant prognostic factor for Crohn’s disease and ulcerative colitis, and (3) demonstration that early immunossupression has a very positive impact on pediatric, recently diagnosed Crohn’s disease patients. We are now awaiting the results of new studies, to clarify the contribution of azathioprine, as compared to infliximab (SONIC Study), and to demonstrate the usefulness of azathioprine in recently diagnosed adult Crohn’s disease patients (AZTEC study). | María Josefina Etchevers Montserrat Aceituno Miquel Sans | 2008 | World Journal of Gastroenterology2008，14，36： | 10 |
| 2 | Human neural tube defects: developmental biology, epidemiology, and genetics 显示文摘 | Detrait ER George TM Etchevers HC Gilbert JR Vekemans M Speer MC | 2005 | Neurotoxicol Teratol2005，27，3： | 1 |
| 3 | Pre - stall Behavior of Several High - speed Compressors显示文摘 | Tryfonidis M Etchevers O Paduano J D | 1995 | ASME J of Turbomachinery1995，117，1： | 1 |
| 4 | Human neural tube defects: developmental biology, epidemiology, and genetics显示文摘 | Detrait ER George TM Etchevers HC | 2005 | Neurotoxicol Teratol2005，27，3： | 1 |
| 5 | Recalibration of the lumbarCanal,an alternative to laminectomy in the treatment of lumbar canalstenosis 显示文摘 | Sengupta T Etchevers JP Vital JM | 1988 | Rev Chir Orthop Reparatrice Appar Mot1988，74，： | 1 |
| 6 | Short-term changes in C and N distribution in soil particle size fractions induced by agricultural practices in a cultivated volcanic soil from Mexico显示文摘 | Sara Covaleda Silvia Pajares Juan F. Gallardo Jorge D. Etchevers | 2006 | Organic Geochemistry2006，，12： | 1 |
| 7 | Pre-stall behavior of several high-speed eompressors显示文摘 | Tryfonidis M Etchevers O Paduano J D | 1995 | Journal of Turbomachinery1995，17，1： | 1 |
| 8 | Human neural tube defects : developmental biology, epide- miology, and genetics显示文摘 | Detrait ER George TM Etchevers HC Gilbert JR Vekemans M Speer MC | 2005 | Neurotoxicol Teratol2005，27，3： | 1 |
| 9 | Soil C and N dynamics in primary and secondary seasonally dry tropical forests in Mexico显示文摘 | Saynes V Hidalgo C Etchevers J D | 2005 | Applied Soil Ecology2005，29，3： | 1 |
| 10 | Soil C and N dynamics in primary and secondary seasonally dry tropical forests in Mexico显示文摘 | Saynes V Hidalgo C Etchevers J D | 2005 | Applied Soil Ecology2005，29，： | 1 |
| 11 | Pre-stall behavior of several high-speed compressors 显示文摘 | Tryfonidis M Etchevers O Paduano J D | 1995 | ASME Journal of Turbomachinery1995，17，1： | 1 |
| 12 | Pre- stall Behavior of Several High-Speed Compressors 显示文摘 | Tryfonidis M Hendricks G J Etchevers O | 1995 | Journal of Turbomachinery1995，117，1： | 1 |
| 13 | Short-term compost effect on macro-aggregation in a sandy soil under low rainfall in the valley of Mexico显示文摘 | DE LEON-GONZALEZ F HERNANDEZ-SERRANO M M ETCHEVERS J D | 2000 | Soil Tillage Res2000，56，： | 1 |
| 14 | Pre - Stall Behavior of Several High - Speed Compressors 显示文摘 | Tryfonidis M Etchevers O Paduano J D | 1995 | ASME J Turbomachinery1995，117，1： | 1 |
| 15 | Prestall be- havior of several high-speed compressors 显示文摘 | Tryfonidis M Etchevers O Paduano J D | 1995 | Journal of Tnr-bomachinery1995，117，1： | 1 |
| 16 | Recalibration of the lumbar canal, an alternative to laminectomy in the treatment of lumbar canal stenosis 显示文摘 | Senegas J Etchevers J P Vital J M | 1988 | Rev Chir Orthop Reparatrice Appar Mot1988，74，1： | 1 |
| 17 | Pre-Stall Behavior of Several High-Speed Compressor显示文摘 | Tryfonidis M Etchevers O Paduano J D | | 0，，01： | 1 |
| 18 | Conservation agriculture, increased organic carbon in the top-soil macro- aggregates and reduced soil CO2 emissions 显示文摘 | FUENTES M HIDALGO C ETCHEVERS J | 2012 | Plant and Soil2012，355，12： | 1 |
| 19 | Characterization, functioning and classification of two volcanic soil profiles under different land uses in Central Mexico显示文摘 | B. Prado C. Duwig C. Hidalgo D. Gómez H. Yee C. Prat M. Esteves J.D. Etchevers | 2007 | Geoderma2007，，3： | 1 |
| 20 | Matthew-Wood Syndrome Is Caused by Truncating Mutations in the Retinol-Binding Protein Receptor Gene STRA6显示文摘 | Christelle Golzio Jelena Martinovic-Bouriel Sophie Thomas Soumaya Mougou-Zrelli Bettina Grattagliano-Bessières Maryse Bonnière Sophie Delahaye Arnold Munnich Férechté Encha-Razavi Stanislas Lyonnet Michel Vekemans Tania Attié-Bitach Heather C. Etchevers | 2007 | The American Journal of Human Genetics2007，，6： | 1 |
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