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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 3 | A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation 显示文摘 | ERICKSON J R JOINER M L GUAN X | 2008 | Cell2008，133，3： | 1 |
| 4 | Botulinum toxin A and chronic low back pain : a randomized, double-blind study显示文摘 | Foster L Clapp L Erickson M | 2001 | Neurology2001，56，10： | 1 |
| 5 | Oxyphil parathyroid carci- nomas: a clinicopathologic and immunohistochemical study of 10 cases显示文摘 | Erickson L A Jin L Papotti M | 2002 | Am J Surg Pathol2002，26，3： | 1 |
| 6 | Is there a link between executive equity Ineentive,s and accounting fraud?显示文摘 | Erickson M Hanlon M Maydew E L | 2006 | Journal of Accounting Research2006，44，1： | 1 |
| 7 | Surgical management of comp- lex spinal deformity 显示文摘 | Erickson M M Currier B L | 2012 | Orthop Clin North Am2012，43，1： | 1 |
| 8 | Arm edema in breast cancer patients显示文摘 | ERICKSON V S PEARSON M L GANZ P A | 2001 | J Natt Cancer Inst2001，93，2： | 1 |
| 9 | Confu- sion in the ranks: IT service management practice and terminology 显示文摘 | WINNIFORD M A CONGER S ERICKSON - HARRIS L | 2009 | Information systems management2009，26，2： | 1 |
| 10 | The reaction of sulfur dioxide with ozone in water and its possible atmospheric significance显示文摘 | ERICKSON R E YATES L M CLARK R L | 1976 | Atmospheric Environment1976，9，11： | 1 |
| 11 | Place and Space in the Networked City:Conceptualizing the Integrated Metropolis显示文摘 | Roberts M Jones T L Erickson B | 1999 | Journal of Urban Design1999，4，1： | 1 |
| 12 | Rapeseed mutants with reduced levels of polyunsaturated fatty acids and increased levels of oleic acid 显示文摘 | Auld D L Heikkinen M K Erickson D A | 1992 | Crop Sci1992，3，： | 1 |
| 13 | Rapeseed mutants with reduced levels of polyunsaturated fatty acids and increased levels of oleic acid显示文摘 | AULD D L HEIKKINEN M K ERICKSON D A | 1992 | Crop Science1992，32，： | 1 |
| 14 | Modulation of the im-mune system by human milk and infant formula containing nu- cleotides显示文摘 | Pickering L K Granoff D M Erickson J R | 1998 | Pediatrics1998，101，： | 1 |
| 15 | Effects of enamel conditioning on bond strength with a restorative light-cured glass ionomer显示文摘 | Ewoldsen N Beatty M W Erickson L | 1995 | J Clin Orthod1995，29，10： | 1 |
| 16 | Static frictional force and surface rougness of nickel-titanium arch wires显示文摘 | Prososki R R Bagby M D Erickson L C | 1991 | Am J Orthod Dento facial Orthop1991，100，4： | 1 |
| 17 | Pressure and particlevelocity measurements in solids subjected to dynamic loading显示文摘 | Urtiew P A Erickson L M Hayes B | 1986 | Fizika Goreniya i Vzryva1986，22，5： | 1 |
| 18 | Correlations between micro structural parameters,micromechanical properties and wear resistance of plasma-sprayed cermaic coatings显示文摘 | Erickson L C Hawthorne H M Troczynski T | 2001 | Wear2001，250，1112： | 1 |
| 19 | Near infrared reflectance properties of metal oxide nanoparticles 显示文摘 | JEEVANANDAM P MULUKUTAL R S PHILLIPS M CHAUDHURI S ERICKSON L E KLABUNDE K J | 2007 | The Journal of Physical Chemistry C2007，111，： | 1 |
| 20 | Modeling decomposition of uncomfined rigid polyurethane foam显示文摘 | Hobbs M L Erickson K L Chu T Y | 2000 | Polymer Degradation and Stability2000，69，1： | 1 |
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