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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 3 | Wheeling rates based on marginal-cost theory 显示文摘 | MERRIL H M ERICKSON B W | 1989 | IEEE Trans on Power Systems1989，4，4： | 2 |
| 4 | Unified mechanisms of Ca2 + regulation across the Ca2 + channel family显示文摘 | DEMARIA C D ERICKSON M G | 2003 | Neuron2003，39，6： | 1 |
| 5 | Content - Centered Collaboration Spaces in the Cloud 显示文摘 | ERICKSON J S SPENCE S RHODES M | 2009 | IEEE Internet Computing2009，13，5： | 1 |
| 6 | Negative regulation of neural stem: progenitor cell proliferation by the pten tumor suppressor gene in vivo显示文摘 | Groszer M Erickson R Scripture-Adams DD | 2001 | Science2001，294，5549： | 1 |
| 7 | Ther apeutic effects of massage therapy and handling touch on caregivers of patients undergoing autologous hematopoietic stem cell transplant 显示文摘 | Rexilius SJ Mundt C Erickson Megel M | 2002 | Oncol Nurs Forum2002，29，3： | 1 |
| 8 | Interferon alpha down-regulates telomerase reverse transcriptase and telomerase activity in human malignant and nonmalignant hematopoietic cells显示文摘 | Xu D Erickson S Szeps M | 2000 | Blood2000，96，13： | 1 |
| 9 | Efficacy and safety of duloxetine in the treatment of generalized anxiety disorder : a flexibledose, progressive-titration, placebo- controlled trial显示文摘 | Rynn M Russell J Erickson J | 2008 | Depress Anxiety2008，25，3： | 1 |
| 10 | The change in information uncertainty and acquirer wealth losses显示文摘 | Erickson M Wang S W Zhang F | 2012 | Review of Accounting Studies2012，17，4： | 1 |
| 11 | PTEN negatively regulates neural stem cell self - renewal by modulating G0 - G1 cell cycle entry显示文摘 | Groszer M Erickson R Scripture - Adams D | 2006 | Proc Nat Acad Sci USA2006，103，1： | 1 |
| 12 | Age-related decline in controlled retrieval:The role of the PFC and sleep 显示文摘 | Wilckens K A Erickson K I Wheeler M E | 2012 | Neural Plast2012，2012，62： | 1 |
| 13 | Decreased methadone effect after ritonavir initiation显示文摘 | GELETKO S M ERICKSON A D | 2000 | Pharmacotherapy2000，20，1： | 1 |
| 14 | Interferon alpha down-regulates telomerase reverse transeriptase and telomerase activity in human malignant and nonmalig- nant hematopoietie cells 显示文摘 | Xu D Erickson S Szeps M | 2000 | Blood2000，96，13： | 1 |
| 15 | Multi-objective Optimal Design of Groundwater Remediation Systems:Application of the Niched Pareto Genetic Algorithm (NPGA)显示文摘 | ERICKSON M MAYER A HORN J | 2002 | Advances in Water Resources2002，25，1： | 1 |
| 16 | Measurement Error and the Relationship between Investment and q 显示文摘 | Erickson T Whited T M | 2000 | Journal of Political Economy2000，108，5： | 1 |
| 17 | Summer meeting 2007-the problems with fresh produce:an overview显示文摘 | Doyle M P Erickson M C | 2008 | J Appl Microbiol2008，105，： | 1 |
| 18 | Supplementation of Dairy Cow Diets with Calcium Salts of Longchain Fatty Acids and Nicotinic Acid in Early Lactation显示文摘 | Erickson P S Murphy M R Clark J H | 1992 | J Dairy Sci1992，，75： | 1 |
| 19 | A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation 显示文摘 | ERICKSON J R JOINER M L GUAN X | 2008 | Cell2008，133，3： | 1 |
| 20 | PTEN negatively regulates neural stem cell self - renewal by modulating G0- G1 cell cycle entry显示文摘 | Groszer M Erickson R Scripture - Adams DD | 2006 | Proc Natl Acad Sci USA2006，103，1： | 1 |
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