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| 1 | Resveratrol engages selective apoptotic signals in gastric adenocarcinoma cells显示文摘AIM: To investigate the intracellular apoptotic signals engaged by resveratrol in three gastric adenocarcinoma cancer cell lines, two of which (AGS and SNU-1) express p53 and one (KATO-Ⅲ) with deleted p53. METHODS: Nuclear fragmentation was used to quanti- tate apoptotic cells; caspase activity was determined by photometric detection of cleaved substrates; formation of oxidized cytochrome C was used to measure cytochrome C activity, and Western blot analysis was used to determine protein expression. RESULTS: Gastric cancer cells, irrespective of their p53 status, responded to resveratrol with fragmentation of DNA and cleavage of nuclear lamins A and B and PARP. Resveratrol, however, has no effect on mitochondria-associated apoptotic proteins Bcl-2, Bcl- xl, Bax, Bid or Smac/Diablo, and did not promote sub- cellular redistribution of cytochrome C, indicating that resveratrol-induced apoptosis of gastric carcinoma cells does not require breakdown of mitochondrial membrane integrity. Resveratrol up-regulated p53 protein in SNU-1 and AGS cells but there was a difference in response of intracellular apoptotic signals between these cell lines. SNU-1 cells responded to resveratrol treatment with down-regulation of survivin, whereas in AGS and KATO- Ⅲ cells resveratrol stimulated caspase 3 and cytochrome C oxidase activities. CONCLUSION: These findings indicate that even within a specific cancer the intracellular apoptotic signals engaged by resveratrol are cell type dependent and suggest that such differences may be related to differentiation or lack of differentiation of these cells. | William L Riles Jason Erickson Sanjay Nayyar Mary Jo Atten Bashar M Attar Oksana Holian | 2006 | World Journal of Gastroenterology2006，12，35： | 8 |
| 2 | Analysis of a Successful Immune Response against Hepatitis C Virus显示文摘 | Stewart Cooper Ann L Erickson Erin J Adams Joe Kansopon Amy J Weiner David Y Chien Michael Houghton Peter Parham Christopher M Walker | 1999 | Immunity1999，，4： | 3 |
| 3 | p27kipl: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers 显示文摘 | Lloyd VR Erickson LA Jin L | 1999 | Am J Pathol1999，154，2： | 1 |
| 4 | A two-locus global DNA barcodefor land plants: the coding rbcL gene complements the non-codingtmH-psbA spacer region显示文摘 | Kress W J Erickson D L | 2007 | PloS One2007，2，： | 1 |
| 5 | Bearing capacity of circular footings显示文摘 | Erickson H L Drescher A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering2002，128，1： | 1 |
| 6 | MRI patterns in orbital malignant lymphoma and atypical lymphocytic infiltrates显示文摘 | Akansel G Hendrix L Erickson BA | 2005 | Eur J Radiol2005，53，2： | 1 |
| 7 | p27kip1:a multifunctional cyclin dependent kinase inhibitor with prognostic significance in human cancers 显示文摘 | Lloyd RV Erickson LA Jin L | 1999 | Am J Pathol1999，154，9： | 1 |
| 8 | Expression ofp27KIPl and Ki-67 in benign and malignant thyroid tumors显示文摘 | Erickson LA Jin L Wollan PC | 1998 | Mod Pathol1998，11，： | 1 |
| 9 | Sequence of cDNA forrat cystathionine gamma-lyase and comparison of deducedamino acid sequence with related Escherichia coli enzymes 显示文摘 | Erickson P Maxwell I Su L | 1990 | Biochem J1990，269，： | 1 |
| 10 | Foliar morphology and canopy nitrogen as predictors of lightuse efficiency in terrestrial vegetation显示文摘 | Green D S Erickson J E Kruger E L | 2003 | Agricultural and Forest Meteorology2003，115，： | 1 |
| 11 | Paternal inheritance of mitochondria in rapeseed (Brassica napus)显示文摘 | Erickson L Kemble R | 1990 | Mol Gen Genet1990，222，： | 1 |
| 12 | A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation 显示文摘 | ERICKSON J R JOINER M L GUAN X | 2008 | Cell2008，133，3： | 1 |
| 13 | Problem and pathological gambling are associated with poorer mental and physical health in older adults显示文摘 | ERICKSON L MOLINA C A LADD G T | 2005 | Int J Geriatric Psych2005，20，8： | 1 |
| 14 | Plant enhanced remediation of glycol-based aircraft deicing fluids显示文摘 | GARRISON S DAVIS L C ERICKSON L E | 2001 | Waste Manage2001，5，3： | 1 |
| 15 | A study of structural memory effects in synthetic hydrotalcites using environmental SEM 显示文摘 | K L Erickson T E Bostrom R L Frost | 2005 | Materials Letters2005，59，23： | 1 |
| 16 | The financial rewards of new product introductions in the personal computer industry显示文摘 | BAYUS B L ERICKSON G JACOBSONR | 2003 | Management Science2003，49，2： | 1 |
| 17 | Botulinum toxin A and chronic low back pain : a randomized, double-blind study显示文摘 | Foster L Clapp L Erickson M | 2001 | Neurology2001，56，10： | 1 |
| 18 | 显示文摘 | Halvorson R H Erickson R L Davidson C L | 2003 | Dental Materials2003，19，： | 1 |
| 19 | Mieronutrients and innate immunity显示文摘 | Erickson K L Medina E A Hubbard N E | 2000 | J Infect Dis2000，182，1： | 1 |
| 20 | Oxyphil parathyroid carci- nomas: a clinicopathologic and immunohistochemical study of 10 cases显示文摘 | Erickson L A Jin L Papotti M | 2002 | Am J Surg Pathol2002，26，3： | 1 |
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