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| 1 | Antidiarrheal activity of Pterocarpus erinaceus methanol leaf extract in experimentally-induced diarrhea显示文摘Objective:To investigate the antidiarrheal activity of the methanol leaf extract of Pterocarpus erinaceus in vivo.Methods:The methanol leaf extract of Ptemcarpus erinaceus was evaluated using different doses(100,200 and 400 mg/kg body weight) orally for antidiarrheal activity using castor oil-induced diarrhea,charcoal meal transit lime and castor oil-induced enteropooling in different groups of albino Wistar mice.The activity of the extract at different doses were compared to diphenoxylate(3 mg/kg) and atropine sulphate(3 mg/kg) which were used as standard reference drugs and also to the distilled water administered negative control group of mice.Results:The extract at the doses used caused a significant(P< 0.01) reduction in the wet faeces passed by the mice in the castor oil-induced diarrhea,decreased the distance travelled by the charcoal meal by up to 54.8%and also caused a dose dependent and significant(P< 0.001) reduction in the intraluminal fluid accumulation in the castor oil-induced enteropooling. Conclusions:Our results indicate that Pterocarpits erinaceus extract produced significant antidiarrheal activity and the action may attribute to inhibition of gastrointestinal movement and fluid secretion. | Ezeja Maxwell I Ezeigbo Ihechiluru I Madubuike Kelechi G Udeh Nkiru E Ukweni Iheanacho A Akomas Stella C Ifenkwe Daniel C | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 3 |
| 2 | Optimization and kinetic studies for enzymatic hydrolysis and fermentation of colocynthis vulgaris Shrad seeds shell for bioethanol production显示文摘The key process parameters for the hydrolysis and fermentation of Colocynthis vulgaris Shrad seeds shell(CVSSS)were optimized using the Box-Behnken Design(BBD)of Response Surface Methodology(RSM).Kinetic study was also carried out.The proximate analysis of the CVSSS was done by the method of the Association of Organic and Applied Chemistry(AOAC).Enzymatic hydrolysis was experimented by using Aspergillus Niger as a crude enzyme isolated from soil at sawdust dump site and screened for cellulosic activities.Factors that affected the hydrolysis of the CVSSS were screened by using the Greco-Latin square design of experiment.However,for Saccharomyces cerevisiae,factors that affected the fermentation of the CVSSS were screened by using the same Greco-Latin square design of experiment.Meanwhile,the result of the proximate analysis revealed that the CVSSS had 73.54%cellulose which could be converted to bioethanol.It was established that temperature,pH and time had significant effect on hydrolysis,while the optimum results were obtained at 46.8℃,3.32 d,5.68 and 59.87%for temperature,time,pH and glucose yield,respectively.Temperature,yeast dosage,pH and time had significant effect on fermentation,while the optimum results from optimization were found to be 33.58℃,7.0,3.55 d,1.65 g per 50 mL and 25.6%for temperature,pH,time,yeast dosage and ethanol yield,respectively.The kinetics of both the enzymatic hydrolysis and fermentation agreed with the Michealis-Menten kinetic model with the correlation coefficients(R^(2))of 0.9708 and 0.8773,respectively.However,from the error analysis,the experimental and predicted values had a very good relationship as described by Michaelis-Menten model. | Igwilo Christopher Nnaemeka Egbuna Samuel O Onoh Maxwell I Asadu OChristain Onyekwulu Chinelo S | 2021 | Journal of Bioresources and Bioproducts2021，6，1： | 3 |
| 3 | Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste显示文摘 | Chee-Sanford Joanne C Mackie Roderick I Koike Satoshi Krapac Ivan G Lin Yu-Feng Yannarell Anthony C Maxwell Scott Aminov Rustam I | 2009 | Journal of Environmental Quality2009，，3： | 3 |
| 4 | A simple model for grain refinement during solidification显示文摘 | Maxwell I Hellawell A | 1975 | Acta Metallurgica1975，23，： | 1 |
| 5 | Sequence of cDNA forrat cystathionine gamma-lyase and comparison of deducedamino acid sequence with related Escherichia coli enzymes 显示文摘 | Erickson P Maxwell I Su L | 1990 | Biochem J1990，269，： | 1 |
| 6 | New and improved catalytic processes for clean fuels显示文摘 | Maxwell I E Naber J E | 1992 | Catal Lett1992，12，： | 1 |
| 7 | RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway显示文摘 | Ruth M C Xu Y Maxwell I H | 2006 | J Invest Dermatol2006，126，4： | 1 |
| 8 | Emulsion polymerization of butyl acrylate显示文摘 | Maxwell I A Napper D H Gilbert R G | 1987 | Journal of Chemical Society Faraday Transaction Ⅰ1987，，83： | 1 |
| 9 | 显示文摘 | | 1987 | Catal Today1987，2，： | 1 |
| 10 | Dashing away hypertension: Evaluating the efficacy of the dietary approaches to stop hypertension diet in controlling high blood pressure显示文摘The dietary approaches to stop hypertension(DASH) diet has been developed and popularized as a nonpharmaceutical intervention for high blood pressure reduction since 1995.However,to date,a comprehensive description of the biochemical rationale behind the diet's principal guidelines has yet to be compiled.With rising interest for healthy and reliable life-style modifications to combat cardiovascular disease,this review aims to compile the most recent and relevant studies on this topic and make an informed assessment as to the efficacy of and underlying mechanisms operant in the DASH diet.Specifically,the merits of lowering dietary intake of sodium and saturated fat,as well as increasing the intake of fruits,vegetables,fiber,and dairy,have been shown to attenuate hypertension individually.Upon review of this evidence,we conclude that the combination of dietary patterns proposed in the DASH diet is effective in attenuating high blood pressure.We also suggest that efforts to more widely implement adoption of the DASH diet would be beneficial to public health. | Preeya T Shah Kyle D Maxwell Joseph I Shapiro | 2015 | World Journal of Hypertension2015，5，4： | 1 |
| 11 | Inhibition of glutathione-S-transferases by thonningianin A,isolat from the african medicinal herb,thonningia sanguinea,in vitro显示文摘 | Maxwell A G Ikuko I O Etsuki S | 2004 | Food Chem Toxicol2004，42，9： | 1 |
| 12 | A simple model for grain refinement during solidification 显示文摘 | Maxwell I Hellawell A | 1975 | Acta Metallurgica1975，23，： | 1 |
| 13 | Development and validation of a preoperative scoring system to predict 30 day mortality in patients un-dergoing hip fracture surgery显示文摘 | Maxwell MJ Moran C G Moppett I K | 2008 | BrJ Anaesth2008，101，4： | 1 |
| 14 | Thermodynamics of swelling of latex Particles with two monomers显示文摘 | Kurja J Van Doeemaele G H J German A L | 1992 | Makromol Chem1992，193，： | 1 |
| 15 | Protection against soman or VX poisoning by human butyrylcholinesterase in guinea pigs and cynomolgus monkeys 显示文摘 | Lenz D E Maxwell D M Koplovitz I | 2005 | Chemico-Biological Interactions2005，157，： | 1 |
| 16 | PTEN mutation in endometrial cancer is associated with favorable clinical and pathologic chracteristic 显示文摘 | Rinsinger J I Hayes K Maxwell G L | 1998 | Clin Cancer Res1998，4，： | 1 |
| 17 | A simple model for refinement during solidification 显示文摘 | Maxwell I Hellawell A | 1975 | ActaMetallurgica1975，23，： | 1 |
| 18 | Emulsion polymerization of butyl acrylate, kinetics of particle growth 显示文摘 | MAXWELl I A NAPPER D H GILBERT R G | 1987 | J Chem Soc Faraday Trans 11987，83，5： | 1 |
| 19 | Tropic determinant for canine parvovirus and feline panleukopenia virus functions through the capsid protein VP2显示文摘 | Spitzer A L Parrish C R Maxwell I H | 1997 | J Gen Virol1997，78，4： | 1 |
| 20 | Zeolite catalysts in hydroprocessing technology显示文摘 | Maxwell I E | 1987 | Catal IE Maxwell Today1987，，1： | 1 |
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