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| 1 | Cholesterol metabolism in cholestatic liver disease and liver transplantation:From molecular mechanisms to clinical implications显示文摘The aim of this review is to enlighten the critical roles that the liver plays in cholesterol metabolism. Liver transplantation can serve as gene therapy or a source of gene transmission in certain conditions that affect cholesterol metabolism, such as low-density-lipoprotein(LDL) receptor gene mutations that are associated with familial hypercholesterolemia. On the other hand, cholestatic liver disease often alters cholesterol metabolism. Cholestasis can lead to formation of lipoprotein X(Lp-X), which is frequently mistaken for LDL on routine clinical tests. In contrast to LDL, Lp-X is non-atherogenic, and failure to differentiate between the two can interfere with cardiovascular risk assessment, potentially leading to prescription of futile lipid-lowering therapy. Statins do not effectively lower Lp-X levels, and cholestasis may lead to accumulation of toxic levels of statins. Moreover, severe cholestasis results in poor micellar formation, which reduces cholesterol absorption, potentially impairing the cholesterol-lowering effect of ezetimibe. Apolipoprotein B-100 measurement can help distinguish between atherogenic and non-atherogenic hypercholesterolemia. Furthermore, routine serum cholesterol measurements alone cannot reflect cholesterol absorption and synthesis. Measurements of serum non-cholesterol sterol biomarkers- such as cholesterol precursor sterols, plant sterols, and cholestanol- may help with the comprehensive assessment of cholesterol metabolism. An adequate cholesterol supply is essential for liver-regenerative capacity. Low preoperative and perioperative serum cholesterol levels seem to predict mortality in liver cirrhosis and after liver transplantation. Thus, accurate lipid profile evaluation is highly important in liver disease and after liver transplantation. | Katriina Nemes Fredrik Aberg Helena Gylling Helena Isoniemi | 2016 | World Journal of Hepatology2016，8，22： | 6 |
| 2 | Alternative routes to vincamine 显示文摘 | Nemes A Czibula L Visky G | 1991 | Heterocycles1991，32，12： | 1 |
| 3 | Characterizing DP-steels using micromechanical modeling of cells 显示文摘 | A1-Abbaso F M Nemes J A | 2007 | Computational Materials Science2007，39，2： | 1 |
| 4 | Embryos generated using testicular spermatozoa have higher develop- mental potential than those obtained using epididymal spermatozoa in men with obstructive azoospermia 显示文摘 | Dozortsev D Neme R Diamond MP | 2006 | Fertil Steril2006，86，3： | 1 |
| 5 | Bricks and mortar of the epidermal barrier显示文摘 | Nemes Z Steinert PM | 1999 | Exp Mol Med1999，31，1： | 1 |
| 6 | Effect of microstructure and chemical composition on dynamic factor of high strength steels显示文摘 | Qu J Dabboussi W Nemes J | 2008 | Materials Science and Technology2008，24，8： | 1 |
| 7 | Histological classifica- tion of endometriosis as a predictor of response to treatment显示文摘 | Abrao M S Neme R M Carvalho F M | 2003 | lnt J Gynaecol Obstet2003，82，1： | 1 |
| 8 | Load shift of the intervertebral disc after a vertebroplasty:a finite-element study显示文摘 | Baroud G Nemes J Heini P | | 0，，： | 1 |
| 9 | Long-term prognostic role of coronary flow velocity reserve in patients with aortic valve stenosisinsights from the SZEGED Study显示文摘 | Nemes A Balázs E Csanády M | 2009 | Clin Physiol Funct Imaging2009，29，6： | 1 |
| 10 | Deep infiltrating colorectal endometriosis treated with robotic-assisted rectosigmoidectomy显示文摘 | Neme RM Schraibman V Okazaki S | 2013 | JSLS2013，17，2： | 1 |
| 11 | Coronary flow velocity reserve predicts survival in non-diabetic patients 显示文摘 | NEMES A BALAZS E PINTER K S | 2012 | Cent lEur J Med2012，7，6： | 1 |
| 12 | A randomised comparison of transradial and transfemoral approach for carotid artery stenting: RADCAR (RADial access for CARotid artery stenting) study显示文摘 | Ruzsa Z Nemes B Pintr L | 2014 | EuroIntervention2014，10，3： | 1 |
| 13 | Load shift of the intervertebral disc after a vertebroplasty: a finite-element study 显示文摘 | Baroud G Nemes J Heini P | 2003 | Eur Spine J2003，12，4： | 1 |
| 14 | Evaluation of left atrial systolic function in noncompaetion cardiomyopathy by real-time three-dimensional echocardiography显示文摘 | Nemes A Anwar AM Caliskan K | 2008 | Int J Cardiovasc Imaging2008，24，3： | 1 |
| 15 | Aortic distensibility indices evaluated by transoesophageal echocardiography in patients with coronary artery disease or aortic valve stenosis显示文摘 | NEMES A FORSTER T GRUBER N | 2004 | Orv Hetil2004，145，38： | 1 |
| 16 | Active infective endocarditis : 152 cases显示文摘 | Kazelian LR Vidal LA Neme R | 2012 | Medicina (B Aires)2012，72，2： | 1 |
| 17 | Load shift of the intervertebral disc after a vertebroplasty:a finite element study显示文摘 | Baroud G Nemes J Heini P | 2003 | Eur Spine J2003，12，4： | 1 |
| 18 | Lateralizing signs during seizures in infants显示文摘 | Wyllie E Neme S | 2004 | J Neurol2004，251，9： | 1 |
| 19 | Integrated Rural Development the Concept and its Operation显示文摘 | Nemes Gusztav | 2005 | KTI/IE discussion papers2005，，6： | 1 |
| 20 | Spraying mode effect on droplet formation and ion chemistry in electrosprays 显示文摘 | Nemes P Marginean I Vertes A | 2007 | Analytical chemistry2007，79，8： | 1 |
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