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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | A Mantle Plume Origin for the Siberian Traps:Uplift and Extension in the East Siberian Ba- sin, Russia显示文摘 | SAUNDERS A D ENGLAND R W REICHOW M K | 2005 | Lithos2005，79，3： | 1 |
| 3 | Health risk assessment of the migration of unleaded gasoline - a model for petroleum products 显示文摘 | Englande A J | 1992 | Wat Sci Tech1992，25，3： | 1 |
| 4 | Delayed diagnosis of appendicitis in children treated with antibiotics显示文摘 | England R J Crabbe DC | 2006 | Pediatr Surg Int2006，22，6： | 1 |
| 5 | The objective structured clinical examination: a step inthe direction of competency-based evaluation 显示文摘 | Carraccio C Englander R | 2000 | Arch Pediatr Adolese Med2000，154，7： | 1 |
| 6 | Performance of PDMS and organofunctionalised PDMS membranes for the pervaporative recovery of organics from aqueous streams 显示文摘 | Bennett M Brisdon B J England R | 1997 | J Membr Sci1997，137，1： | 1 |
| 7 | Stress - induced membrane association of the Streptococcus mutans GTP - binding protein,an essential G protein, and investigation of its physiological role by utilizing an antisense RNA strategy显示文摘 | Baev D England R Kuramitsu HK | 1999 | Infect Immun1999，67，： | 1 |
| 8 | The determination of the sequences present in the shadow bands of a dinucleotide repeat PCR显示文摘 | Murra V Monchawin C England P R | 1993 | Nucl Acid Res1993，21，： | 1 |
| 9 | Microsatellite polymorphisms in a wild population of Drosophila melanogaster显示文摘 | ENGLAND P R BRISCOE D A FRANKHAM R | 1996 | Genetical Research1996，67，： | 1 |
| 10 | The theory of one-dimensional consolidation of saturated clays,I,Finite nonlinear consolidation of thin homogeneous layers显示文摘 | Gibson R L England G L Hussey M H L | 1967 | Geotechnique1967，17，3： | 1 |
| 11 | A flexible framework for stochastic claims reserving 显示文摘 | England P D Verrall R J | 2001 | Proceedings of the Casualty Actuarial Society2001，，88： | 1 |
| 12 | Shifting paradigms: from Flexner to competencies显示文摘 | Carraccio C Wolfsthal S D Englander R et ol | 2002 | Acad Med2002，77，5： | 1 |
| 13 | Distal symmetric polyneuropathy: A definition for clinical research: Report of the American Academy of Neurology, the American Association of Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation显示文摘 | J D. England G S. Gronseth G Franklin R G. Miller A K. Asbury G T. Carter J A. Cohen M A. Fisher J F. Howard L J. Kinsella N Latov R A. Lewis P A. Low A J. Sumner | 2005 | Neurology2005，，2： | 1 |
| 14 | Electrochemical oxidation of chalcopyrite and the related metal-enrlched derivatives Cu4Fe5S8 , Cu9Fe9S16, and Cu9Fe18aS16 显示文摘 | Vaughan D J England K E R Kelsall G H | 1995 | Am Miner1995，80，： | 1 |
| 15 | Detection and treatment of multiple canals in mandibular premolars 显示文摘 | England M C Hartwell G R Lance J R | 1991 | JEndod1991，17，4： | 1 |
| 16 | The effect of pH of douching solutions on mucociliary clearance显示文摘 | HOMER J J ENGLAND R J WILDE A D | 1999 | Clin Otolaryngol Allied Sci1999，24，： | 1 |
| 17 | Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter显示文摘 | Delpire E Lu J England R | 1999 | Nat Genet1999，22，2： | 1 |
| 18 | Water Balance and Unsaturated Flow 显示文摘 | WELLINGS S R Recharge of the Chalk Aquifer at a Site in Hampshire England 1 | 1984 | Journal of Hydrology1984，69，1： | 1 |
| 19 | Production of clonal plantlets of tropical pine in tissue culture via axillary shoot activation 显示文摘 | Baxter R Brown S N England N F Ludlow C H M Taylor S L Womack R W Dunstan D I | 1989 | Can J Forest Res1989，19，10： | 1 |
| 20 | Recommendations of the international council for standardization in heamatology for ethylendiamine tertraacetic acid anticoagulation of blood for blood cell counting and sizing显示文摘 | England J M Rowan R m Van Assendeltf O W | 1993 | AMJ Clin Pathol1993，100，： | 1 |
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