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| 1 | 原子力显微镜评价奥氏体不锈钢晶间腐蚀敏感性的研究显示文摘由13Cr可焊马氏体不锈钢(WMSGSS)制造的油气管线由于价格便宜,相对于昂贵的耐腐蚀合金来说是一个很有竞争力的选择。但是实验室试验和现场经历表明,13Cr马氏体不锈钢焊接接头热影响区发生了沿晶应力腐蚀开裂(IGSCC)。对于低等级的马氏体不锈钢来说,沿晶应力腐蚀开裂机理被认为是在晶界的碳化物附近存在贫铬区。对于中等级和高等级马氏体不锈钢来说,只在实验室试验发现有应力腐蚀开裂。它们的应力腐蚀开裂机理还没有明确,虽然最可能的应力腐蚀开裂机理也被认为和低等级马氏体不锈钢的应力腐蚀开裂机理类似。原子力显微镜(AFM)已开始广泛用于材料显微组织和环境敏感断裂的研究中。高等级马氏体不锈钢焊接接头对晶间腐蚀/应力腐蚀开裂敏感性很有希望由原子力显微镜检测到。在原子力显微镜技术应用于这项研究之前,用由304不锈钢准备的不同敏化度的试样来确定它的适用性是十分有益的。本文用原子力显微镜研究了不同敏化程度的304不锈钢的晶间腐蚀敏感性并和SEM和EDS结果进行了对比。 | 黄彦良 Brian Kinsella Thomas Becker 黄偲迪 张杨扬 | 2008 | 材料开发与应用2008，23，3： | 5 |
| 2 | BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing显示文摘DNA 失配修理(MMR ) 与象 6-thioguanine (6-TG ) 和 5 氟尿嘧啶(5-FU ) 那样的临床上重要的 nucleoside 类似物处理化学上导致的错误对追随者处理。这些药处理的 MMR 为不可弥补的 DNA 损坏为修理和 apoptosis 或 autophagy 的以后的正式就职在延长 G2/M 房间周期拘捕的激活被含有。在这研究,我们在 autophagy,和在 G2/M 房间周期拘捕之间的时间的关系的激活和 6-TG 和 5-FU 处理的调停 BNIP3 的 autophagy 追随者 MMR 的激活调查了 Bcl2 和侵入人体气管粘膜的病菌 E1B Nineteen-kilodalton 交往蛋白质(BNIP3 ) 的角色。我们发现 BNIP3 蛋白质层次是在一个 MLH1 (MMR+) 依赖者的 upregulated 方式追随者 6-TG 和 5-FU 处理。随后的小介入的 RNA (siRNA ) 调停了 BNIP3 击倒废除 6-TG-induced autophagy。我们也发现击倒的 p53 或由 rapamycin cotreatment 的 mTOR 活动的抑制损害 6-TG- 和 BNIP3 蛋白质层次和 autophagy 的 5-FU-induced upregulation。而且,检查点 kinase 的抑制 1 (Chk1 ) 有在由 Chk1 siRNA 的 6-TG-induced G2/M 房间周期拘捕的随后的减小的表示支持 6-TG-induced autophagy 的程度。这些调查结果建议 BNIP3 调停以一种 p53 依赖、 mTOR 依赖的方式的 6-TG- 和 5-FU-induced autophagy。另外,激活 Chk1 的 G2/M 房间周期拘捕的持续时间决定这些 nucleoside 类似物处理的 autophagy 追随者 MMR 的水平。 | Xuehuo Zeng | 2010 | Cell Research2010，20，6： | 4 |
| 3 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 4 | Attentional deficits following closed head injury显示文摘 | Ponsford J Kinsella G | 1992 | Journal of Clinical and Experimental Neuropsychology1992，14，： | 2 |
| 5 | An investigation of the formation and destruction of corrosion inhibitor films using electrochemical impedance spectroscopy (EIS)显示文摘 | Y.J. Tan S. Bailey B. Kinsella | 1996 | Corrosion Science1996，，9： | 2 |
| 6 | Mapping non-uniform corrosion using the wire beam electrode method. I. Multi-phase carbon dioxide corrosion显示文摘 | Yong-Jun Tan Stuart Bailey Brian Kinsella | 2001 | Corrosion Science2001，，10： | 2 |
| 7 | Bronchopulmonary dysplasia 显示文摘 | Kinsella JP Greenough A Abman SH | 2006 | Lancet2006，367，9520： | 1 |
| 8 | A prospective audit of regional anaesthesia failure in 5080 caesarean sections 显示文摘 | Kinsella S M | 2008 | Anaesthesia2008，63，8： | 1 |
| 9 | Inhibition of human LDL oxidation by resveratml显示文摘 | FRANKEL E N WATERHOUSE A L KINSELLA J E | 1993 | Lancet1993，341，8852： | 1 |
| 10 | Expression and tissue distribution of the mRNAs encoding the human thromboxane A2 receptor (TP) α and β isoforms 显示文摘 | Miggin SM Kinsella BT | 1998 | Biochim Biophys Acta1998，1425，： | 1 |
| 11 | Complex iliac and bilateral common femoral artery aneurysms:a novel hybrid procedure显示文摘 | Wolthuis AM Watkinson AF Kinsella DC | 2006 | Surgeon2006，4，2： | 1 |
| 12 | A Collaborative Study to Develop a Standardized Food Protein Solubility Procedure 显示文摘 | MORt~ C V GERMAN B KINSELLA J E | 1985 | Journal of Food Science1985，50，： | 1 |
| 13 | BMP-2-mediated regeneration of large-scale cranial defects in the canine:an examination of different carriers显示文摘 | Kinsella CR Bykowski MR Lin AY | 2011 | Plast Reconstr Surg2011，127，5： | 1 |
| 14 | Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn显示文摘 | Kinsella JP Neish SR Shaffer E | 1992 | Lancet1992，340，8823： | 1 |
| 15 | Bronchopulmonary dysplasia显示文摘 | John P Kinsella Anne Greenough Steven H Abman | 2006 | The Lancet2006，，9520： | 1 |
| 16 | Extensive cervical lymphadenitis due to Mycobacterium avium-intracellulare显示文摘 | Kinsella J P Culver K Jeffrey R B | 1987 | Pediatr Infect Dis J1987，6，： | 1 |
| 17 | Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography-tandem mass spectrometry with rapid polarity switching显示文摘 | WHELAN M KINSELLA B FUREY A | 2010 | Journal of Chromatography A2010，1217，27： | 1 |
| 18 | Inhaled nitric oxide therapy in premature newbo-rns显示文摘 | Kinsella JP | 2006 | Curr Opin Pediatr y2006，18，2： | 1 |
| 19 | Emulsifying properties of proteins evaluation of a turbidimetric technique显示文摘 | PEARCE K N KINSELLA J E | 1978 | Journal of Agricultural and Food Chemistry1978，26，3： | 1 |
| 20 | In vitro radiation and chemotherapy sensitivity of established cell lines of human small-cell lung cancer and it's large cell morphological variantans显示文摘 | Garney DN Mitchell JB Kinsella TJ | | 0，，06： | 1 |
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