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| 1 | CuZn37黄铜板料微塑性成形中的尺寸效应研究显示文摘为研究金属微塑性成形特点,对厚度不同及粗细两种晶粒尺寸的黄铜箔试样进行了单向拉伸和微弯曲实验,并采用经典塑性理论和应变梯度理论对弯曲回弹角进行了预测.粗晶粒板料试样单向拉伸实验表明,CuZn37黄铜的硬化曲线存在一种明显的尺寸效应,即板料厚度越小,屈服强度越高.弯曲回弹实验结果也存在另一种明显的尺寸效应现象,即板料厚度越小,回弹角越大.对这两种尺寸效应产生的原因进行了分析,指出应变梯度硬化对微成形工艺过程有重要影响. | 李河宗 董湘怀 王倩 申昱 DIEHL A HAGENAH H ENGEL U MERKLEIN M | 2011 | 材料科学与工艺2011，19，4： | 12 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo显示文摘 | David A Engel S | 2000 | Nat Immunol2000，1，： | 1 |
| 5 | Glucocorticoidmediated suppression of cytokine-induced matrix metalloproteinase-9 expression in rat mesangial cells: involvement of nuclear factor-kappaB and Ets transcription factors 显示文摘 | Eberhardt W Schulze M Engels C | 2002 | Mol Endocrinol2002，16，8： | 1 |
| 6 | Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation 显示文摘 | Kluge S Braune SA Engel M | 2012 | Intensive Care Med2012，38，： | 1 |
| 7 | Cellular and molecular biology of the aquaporin water channels显示文摘 | Borgnia M Nielsen S Engel A | 1999 | Biochem1999，68，： | 1 |
| 8 | Cellular and molecular biology of the aquaporin water channels显示文摘 | Borgnia M Nielsen S Engel A | 1999 | Annual Review of Biochemistry1999，68，： | 1 |
| 9 | Firm -level implications of early stage venture capital investment An empirical inves- tigation显示文摘 | Engel D Keilbach M | 2007 | Journal of Empirical Finance2007，14，2： | 1 |
| 10 | Spatial load forecasting显示文摘 | Willis H L Engel M V Buri M J | 1995 | IEEE Computer Applications in Power1995，8，2： | 1 |
| 11 | Dynamics of GATA transcription factor expression during erythroid differentiation 显示文摘 | Leonard M Brice M Engel J D | 1993 | Blood1993，82，4： | 1 |
| 12 | Explaining investment dynamics in US Manufacturing: A generalized (S, s) approach显示文摘 | Caballero R J Engel E M R A | 1999 | Econometrica1999，67，4： | 1 |
| 13 | Xenobiotic phenols in early pregnancy amniotic fluid 显示文摘 | Engel S M Levy B Liu Z | 2006 | Reproductive Toxicology2006，21，1： | 1 |
| 14 | Traeheostomy: from insertion to decannulation显示文摘 | Engels PT Bagshaw SM Meier M | 2009 | Can J Surg2009，52，： | 1 |
| 15 | Acute renal failure in pa- tients with severe sepsis and septic shock - a significant independent risk factor for mortality : results from the German prevalence Study 显示文摘 | Oppert M Engel C Bmnkhorst FM | 2008 | Nephrol Dial Trans-plant2008，23，90： | 1 |
| 16 | Audit committee compensation and the demand for monitoring of the financial reporting process显示文摘 | Engel Ellen Hayes Rachel M Wang Xue | | 0，，： | 1 |
| 17 | Comparison of the modular multilevel DC converter and the dual-active bridge converter for power conversion in HVDC and MVDC grids 显示文摘 | ENGELS P STIENEKER M SOLTAU N | 2015 | IEEE Transactions on Power Electronics2015，30，1： | 1 |
| 18 | Spatial load forecasting显示文摘 | Willis H L Engel M V Buri M J | 1995 | IEEE Computer Applications in Power1995，8，2： | 1 |
| 19 | On the glow discharge at high pressure 显示文摘 | A Von Engel R Seeliger M Steenbeck | 1933 | Zeit fuer Physik1933，85，： | 1 |
| 20 | P21cip controls proliferating cell nuclear antigen level in adult cardiomyocytes显示文摘 | Engel FB Hauck L Boehm M | 2003 | Mol Cell Biol2003，23，2： | 1 |
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