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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | The global epidemiological situation of schistosomiasis and new approaches to control and research显示文摘 | Engels D Chitsulo L Montresor A | 2002 | Acta Trop2002，82，2： | 1 |
| 5 | Formation of eight-carbon and ten-carbon components in mushrooms (Agaricus campestris)显示文摘 | Tressl R Bahri D Engel KH | 1982 | J Agric Food Chem1982，30，： | 1 |
| 6 | The plane problem of an elliptically reinforced circular hole in an ani~tropic plate or lanainate 显示文摘 | Engels H Zakharov D Bccker W | 2001 | Archive of Applied Mechanics2001，71，9： | 1 |
| 7 | Initiators for endothermic fuels 显示文摘 | Wickham D T Engel J R Hitch B D etal | 2001 | J Propul Power2001，17，： | 1 |
| 8 | Firm -level implications of early stage venture capital investment An empirical inves- tigation显示文摘 | Engel D Keilbach M | 2007 | Journal of Empirical Finance2007，14，2： | 1 |
| 9 | Dynamics of GATA transcription factor expression during erythroid differentiation 显示文摘 | Leonard M Brice M Engel J D | 1993 | Blood1993，82，4： | 1 |
| 10 | Impact of prostatitis NIH Ⅲ B(prostatodynia) on ejaculate parameters显示文摘 | Engeler D S Hauri D John H | 2003 | Eur Urol2003，44，5： | 1 |
| 11 | Impact of prostatitis NIH-IIIB (prostatodynia) on ejaculate parameters显示文摘 | Engeler DS Hauri D John H | 2003 | Eur Urol2003，44，5： | 1 |
| 12 | Recent developments on direct relative orientation 显示文摘 | Stewenius H Engels C Nister D | 2006 | ISPRS Journal of Photogrammetry and Remote Sensing(S0924-2716)2006，60，4： | 1 |
| 13 | The Radiation Sensitivities of Three Species of Fiddler Crabs显示文摘 | Engel D W | | 0，，： | 1 |
| 14 | Therapeutic T cells induce tumo directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines 显示文摘 | Winter H van den Engel NK Rfittinger D | 2007 | J Transl Med2007，5，： | 1 |
| 15 | CD4OL deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice 显示文摘 | Poggi M Engel D Christ A | 2011 | Arterinscler Thromb Vasc Biol2011，31，10： | 1 |
| 16 | Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer显示文摘 | Beji A Horst D Engel J | 2012 | Clin Cancer Res2012，18，4： | 1 |
| 17 | Safety and tolerability of sitagliptin in clinical studies:a pooled analysis of data from 10246patients with type 2 diabetes显示文摘 | Williams-Herman D Engel S S Round E | 2010 | BMC Endocr Disord2010，10，： | 1 |
| 18 | Mutations in myotilin cause myofibrillar myopathy显示文摘 | Selcen D Engel AG | 2004 | Neurology2004，62，： | 1 |
| 19 | Myofibrillar myopathy caused by novel dominant negative alphaB-crystallin mutations 显示文摘 | Selcen D Engel AG | 2003 | Ann Neurol2003，54，： | 1 |
| 20 | Conditioned media derived from glial cell lines promote survival and differentiation of dopaminergic neurons in vitro: role of mesencephalic glia显示文摘 | Schubert D Bohn MC | 1991 | J Neurosci Res1991，30，： | 1 |
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