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| 1 | Pilot study of atomoxetine in patients with Parkinson’s disease and dopa-unresponsive Freezing of Gait显示文摘Background:Freezing of gait(FoG)is a common and debilitating condition in Parkinson’s disease(PD)associated with executive dysfunction.A subtype of FoG does not respond to dopaminergic therapy and may be related to noradrenergic deficiency.This pilot study explores the effects of atomoxetine on gait in PD patients with dopaunresponsive FoG using a novel paradigm for objective gait assessment.Findings:Ten patients with PD and dopa-unresponsive FoG were enrolled in this eight-week open label pilot study.Assessments included an exploratory gait analysis protocol that quantified spatiotemporal parameters during straight-away walking and turning,while performing a dual task.Clinical,and subjective assessments of gait,quality of life,and safety were also administered.The primary outcome was a validated subjective assessment for FoG(FOG-Q).Atomoxetine was well tolerated,however,no significant change was observed in the primary outcome.The gait analysis protocol correlated well with clinical scales,but not with subjective assessments.DBS patients were more likely to increase gait velocity(p=0.033),and improved in other clinical assessments.Conclusions:Objective gait analysis protocols assessing gait while dual tasking are feasible and useful for this patient population,and may be superior correlates of FoG severity than subjective measures.These findings can inform future trials in this population. | Gonzalo J.Revuelta Aaron Embry Jordan J.Elm Chris Gregory Amy Delambo Steve Kautz Vanessa K.Hinson | 2015 | Translational Neurodegeneration2015，4，1： | 3 |
| 2 | Cross-flow analysis of injection wells in a multilayered reservoir显示文摘During fluid injection into a multilayered reservoir,a different pressure gradient is generated across the face of each permeable layer.This pressure gradient generates driving forces in the wellbore during well shut-in that causes the injected fluid moves from higher pressure layers to lower pressure layers,a phenomenon known as interwell cross-flow.Cross-flow behavior depends on the initial pressure in the permeable layers and may be referred to as natural cross-flow(identical or natural initial pressures)and forced cross-flow(different initial pressures because of exploitation).Cross-flow may induce sand production and liquefaction in the higher pressure layers as well as formation damage,filter cake build-up and permeability reduction in the lower pressure layers.Thus,understanding cross-flow during well shut-in is important from a production and reservoir engineering perspective,particularly in unconsolidated or poorly consolidated sandstone reservoirs.Natural and forced cross-flow is modeled for some injection wells in an oil reservoir located at North Sea.The solution uses a transient implicit finite difference approach for multiple sand layers with different permeabilities separated by impermeable shale layers.Natural and forced cross-flow rates for each reservoir layer during shut-in are calculated and compared with different production logging tool(PLT)measurements.It appears that forced cross-flow is usually more prolonged and subject to a higher flow rate when compared with natural cross-flow,and is thus worthy of more detailed analysis. | Mohammadreza Jalali Jean-Michel Embry Francesco Sanfilippo Frederic J.Santarelli Maurice B.Dusseault | 2016 | Petroleum2016，2，3： | 2 |
| 3 | Experimentally induced ovine phosphatic urolithiasis:Relationships involving dietary calcium,phosphorus and magnesium显示文摘 | Bushman D H Emerick R J Embry L B | 1965 | J Nutr1965，7，： | 1 |
| 4 | Absolute water depths limits of Late Devonian paleoecological zones显示文摘 | Embry A F Klovan J E | 1972 | Geology Research1972，61，2： | 1 |
| 5 | Vaccinia virus A6 is essential for virion membrane biogenesis and localiza- tion of virion membrane proteins to sites of virion as- sembly 显示文摘 | Meng X Embry A Rose L | 2012 | Journal of Virology2012，86，10： | 1 |
| 6 | The numerical range of an operator显示文摘 | EMBRY M R | 1970 | Pacific Journal of Mathematics1970，32，： | 1 |
| 7 | An overview of the petroleum geology of the Arctic显示文摘 | Spencer A M Embry A F Gautier D L | 2011 | Geological Society2011，35，1： | 1 |
| 8 | Children’s Oncology Group’s 2013 blueprint for research: Behavioral science显示文摘 | Robert B. Noll Sunita K. Patel Leanne Embry Kristina K. Hardy Wendy Pelletier Robert D. Annett Andrea Patenaude E. Anne Lown Stephen A. Sands Lamia P. Barakat | 2012 | Pediatr. Blood Cancer2012，，6： | 1 |
| 9 | Large cell neuroendocrine carcinoma of the cervix:prognostic factors and survival advantage with platinum chemotherapy显示文摘 | Embry JR Kelly MG Post MD | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 10 | A late Devonian reef tract on northeastern Banks Island, Northwest Territories 显示文摘 | Embry A Klovan J E | 1971 | Bulletin of Canadian Petroleum Geology1971，19，： | 1 |
| 11 | Spectra, tensor products, and linear operator equations 显示文摘 | Embry M R Rosenblum M | 1974 | Pacific J Math1974，53，： | 1 |
| 12 | Petroleum prospectivity of the Triassic-Jurassic suc- cession of Sverdrup Basin, Canadian Arctic Archipelago 显示文摘 | Embry A | 2011 | Geological Society London Memoirs2011，35，1： | 1 |
| 13 | Safety and meta bolic outcomes of resveratrol supplementation in older a- dults: results of atwelve-week, placebo-controlled pilot study显示文摘 | Anton SD Embry C Marsiske M et ai | 2014 | Exp Gerontol2014，，57： | 1 |
| 14 | Sverdrup Basin显示文摘 | Embry A Beauchamp B | 2008 | Sedimentary Ba- sins of the World2008，5，： | 1 |
| 15 | Sodium bentonite and sodium bicarbonate in high-concentrate diets forIambs and steers显示文摘 | Dunn B H Emerick R J Embry L B | 1979 | J Anim Sci1979，48，4： | 1 |
| 16 | Influence of calcium source,phosphorus level and acid-base-forming effects of the diet of feedlot performance and urinary calculi formation in lambs显示文摘 | HOAR D W EMERICK R J EMBRY L B | 1970 | J Anim Sci1970，31，1： | 1 |
| 17 | Sodium bentonite effect when fed at various levels with high concentrate diets to lambs显示文摘 | Huntington G B Emerick R J Embry L B | 1977 | Journal of Animal Sci- ence1977，45，1： | 1 |
| 18 | Present heat flow and paleo-geo- thermal regime in the Canadian Arctic margin: Analysis of in- dustrial thermal data and coalification gradients显示文摘 | Majorowicz J A Embry A F | 1998 | Tectono- physics1998，291，1： | 1 |
| 19 | Large cell neuroendocrine carcinoma of the cervix:prognostic factors and survival advantage with platinum chemotherapy显示文摘 | Embry J R Kelly M G Post M D | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 20 | Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy 显示文摘 | Embry JR Kelly MG Post MD | 2011 | Gynecol Oncol2011，120，3： | 1 |
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