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| 1 | Calcineurin inhibitor sparing strategies in renal transplantation, part one: Late sparing strategies显示文摘Kidney transplantation improves quality of life and reduces the risk of mortality. A majority of the success of kidney transplantation is attributable to the calcineurin inhibitors(CNIs), cyclosporine and tacrolimus, and their ability to reduce acute rejection rates. However, longterm graft survival rates have not improved over time, and although controversial, evidence does suggest a role of chronic CNI toxicity in this failure to improve outcomes. Consequently, there is interest in reducing or removing CNIs from immunosuppressive regimens in an attempt to improve outcomes. Several strategies exist to spare calcineurin inhibitors, including use of agents such as mycophenolate mofetil(MMF), mycophenolate sodium(MPS), sirolimus, everolimus or belatacept to facilitate late calcineurin inhibitor withdrawal, beyond 6 mo post-transplant; or using these agents to plan early withdrawal within 6 mo; or to avoid the CNIs all together using CNI-free regimens. Although numerous reviews have been written on this topic, practice varies significantly between centers. This review organizes thedata based on patient characteristics(i.e., the baseline immunosuppressive regimen) as a means to aid the practicing clinician in caring for their patients, by matching up their situation with the relevant literature. The current review, the first in a series of two, examines the potential of immunosuppressive agents to facilitate late CNI withdrawal beyond 6 mo post-transplant, and has demonstrated that the strongest evidence resides with MMF/MPS. MMF or MPS can be successfully introduced/maintained to facilitate late CNI withdrawal and improve renal function in the setting of graft deterioration, albeit with an increased risk of acute rejection and infection. Additional benefits may include improved blood pressure, lipid profile and serum glucose.Sirolimus has less data directly comparing CNI withdrawal to an active CNI-containing regimen, but modest improvement in short-term renal function is possible, with an increased risk of proteinuria, especially in the setting of baseline renal dysfunction and/or proteinuria. Renal outcomes may be improved when sirolimus is used in combination with MMF. Although data with everolimus is less robust, results appear similar to those observed with sirolimus. | Andrew Scott Mathis Gwen Egloff Hoytin Lee Ghin | 2014 | World Journal of Transplantation2014，4，2： | 5 |
| 2 | Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer显示文摘 | Egloff AM Vella LA Finn OJ | 2006 | Cancer Res2006，66，： | 1 |
| 3 | HGF and c-Met paticipate in pararrino tumorigenic pathways in head and neck squamous cell cancer显示文摘 | Knowles L M Stabile L P Egloff A M | | 0，，11： | 1 |
| 4 | Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer显示文摘 | Egloff AM VeUa LA Finn OJ | 2006 | Cancer Res2006，66，1： | 1 |
| 5 | Nondermatomal somatosensory deficits in patients with chronic pain disorder: clinical findings and hypometabolic pattern in FDG-PET显示文摘 | Egloff N Sabbioni ME Salathe C | 2009 | Pain2009，145，12： | 1 |
| 6 | Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma显示文摘 | Koppikar P Choi SH Egloff AM | 2008 | Clin Cancer Res2008，14，13： | 1 |
| 7 | Interracial activation of the lipase-proeolipase complex by mixed micelles revealed by X-ray crystallography 显示文摘 | Van Tilbeurgh H Egloff M P Martinez C etal | 1993 | Nature1993，362，6423： | 1 |
| 8 | Is interoceptive awareness really altered in somatoform disorders? Testing competing theories with two paradigms of heartbeat perception显示文摘 | Schaefer M Egloff B Witth(o)ft M | | 0，，： | 1 |
| 9 | HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer显示文摘 | Knowles L M Stabile L P Egloff A M | 2009 | Clin Cancer Res2009，15，11： | 1 |
| 10 | The structure and mechanism of protein phosphatases : insights into catalysis and regulation显示文摘 | Barford D Das AK Egloff MP | 1998 | Biophys Biomol Struct1998，27，： | 1 |
| 11 | Inteffacial activation of the lipase - procolipase complex by mixed micells revealed by X - ray crystallography 显示文摘 | VanTilbeurgh H Egloff MP Martinez C | 1993 | Nature1993，362，： | 1 |
| 12 | Algometry with a clothes peg compared to an electronic pressure algome- ter: a randomized cress-sectional study in pain patients显示文摘 | EGLOFF N KLINGLER N VON KANEL R | 2011 | BMC Musculaskelet Disord2011，12，： | 1 |
| 13 | Biomeehanics and pathomechanisms of osteoarthritis 显示文摘 | Egloff C Htigle T Valderrabano V | 2012 | Swiss Medical Weekly2012，142，13583： | 1 |
| 14 | The mutational landscape of head and neck squamous cell carcinoma显示文摘 | Stransky N Egloff AM Tward AD | 2011 | Science2011，333，6046： | 1 |
| 15 | Predictive validity of an implicit associa- tion test for assessing anxiety 显示文摘 | Egloff B Schmukle SC | 2002 | J Soc Pers Relat2002，83，6： | 1 |
| 16 | Biomechanics and pathomechanisms of osteoarthritis显示文摘 | Egloff C Hugle T Valderrabano V | 2012 | Swiss Med Wk- ly2012，142，13： | 1 |
| 17 | Benefits and risks of MRI in pregnancy显示文摘 | Bulas D Egloff A | 2013 | Seminars in Perinatology2013，37，5： | 1 |
| 18 | Predation by Acartia tonsa Dana on planktonic ciliates and rotifers显示文摘 | Stocker D K Egloff D A | 1987 | Journal of Experimental Marine Biology and Ecology1987，110，： | 1 |
| 19 | Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial显示文摘 | Drahomir Aujesky Pierre-Marie Roy Franck Verschuren Marc Righini Joseph Osterwalder Michael Egloff Bertrand Renaud Peter Verhamme Roslyn A Stone Catherine Legall Olivier Sanchez Nathan A Pugh Alfred N’gako Jacques Cornuz Olivier Hugli Hans-Jürg Beer Arnau | 2011 | 2011 (9785)2011，，9785： | 1 |
| 20 | Pathomorphologi- cal findings in thyroid caneers of children from the Republic of Belarus: A study of 86 cases occurring between 1986 ('post-Chernohyl') and 1991 显示文摘 | Furmanchuk AW Averkin JI Egloff B | 1992 | Histopathology1992，21，5： | 1 |
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