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| 1 | Development of a quantum-dot-labelled magnetic immunoassay method for circulating colorectal cancer cell detection显示文摘AIM:To detect of colorectal cancer(CRC) circulating tumour cells(CTCs) surface antigens,we present an assay incorporating cadmium selenide quantum dots(QDs) in these paper.METHODS:The principle of the assay is the immunomagnetic separation of CTCs from body fluids in conjunction with QDs,using specific antibody biomarkers:epithelial cell adhesion molecule antibody,and monoclonal cytokeratin 19 antibody.The detection signal was acquired from the fluorescence signal of QDs.For the evaluation of the performance,the method under study was used to isolate the human colon adenocarcinoma cell line(DLD-1) and CTCs from CRC patients' peripheral blood.RESULTS:The minimum detection limit of the assay was defined to 10 DLD-1 CRC cells/mL as fluorescence was measured with a spectrofluorometer.Fluorescenceactivated cell sorting analysis and Real Time RT-PCR,they both have also been used to evaluate the performance of the described method.In conclusion,we developed a simple,sensitive,efficient and of lower cost(than the existing ones) method for the detection of CRC CTCs in human samples.We have accomplished these results by using magnetic bead isolation and subsequent QD fluorescence detection.CONCLUSION:The method described here can be easily adjusted for any other protein target of either the CTC or the host. | Maria Gazouli Anna Lyberopoulou Pericles Pericleous Spyros Rizos Gerassimos Aravantinos Nikolaos Nikiteas Nicholas P Anagnou Efstathios P Efstathopoulos | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 2 | Importance of establishing radiation protection culture in Radiology Department显示文摘The increased use of ionization radiation for diagnostic and therapeutic purposes, the rapid advances in computed tomography as well as the high radiation doses delivered by interventional procedures have raised serious safety and health concerns for both patients and medical staff and have necessitated the establishment of a radiation protection culture(RPC) in every Radiology Department. RPC is a newly introduced concept. The term culture describes the combination of attitudes, beliefs, practices and rules among the professionals, staff and patients regarding to radiation protection. Most of the time, the challenge is to improve rather than to build a RPC. The establishment of a RPC requires continuing education of the staff and professional, effective communication among stakeholders of all levels and implementation of quality assurance programs. The RPC creation is being driven from the highest level. Leadership, professionals and associate societies are recognized to play a vital role in the embedding and promotion of RPC in a Medical Unit. The establishment of a RPC enables the reduction of the radiation dose, enhances radiation risk awareness, minimizes unsafe practices, and improves the quality of a radiation protection program. The purpose of this review paper is to describe the role and highlight the importance of establishing a strong RPC in Radiology Departments with an emphasis on promoting RPC in the Interventional Radiology environment. | Agapi Ploussi Efstathios P Efstathopoulos | 2016 | World Journal of Radiology2016，8，2： | 4 |
| 3 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 2 |
| 4 | Geothermal power production from abandoned oil wells显示文摘 | Adelina P D Efstathios E M | 2009 | Energy2009，34，7： | 1 |
| 5 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 1 |
| 6 | Effects of N-doping on the microstructure, mechanical and tribological behavior of Cr-DLC films显示文摘 | Sunil K P JIANG J C Efstathios I | 2007 | Meletis Surf Coat Technol2007，201，： | 1 |
| 7 | Short Term Load Foreca-sting:the Similar Shape Functional Time-series Predictor显示文摘 | EFSTATHIOS P THEOFANIS S | 2013 | IEEE Transactions on Power Systems2013，28，4： | 1 |
| 8 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | 2010 (9756)2010，，9756： | 1 |
| 9 | Thalamic deep brain stimulation for essential tremor: relation of lead location to outcome 显示文摘 | Efstathios P Geoff R Susan H | 2004 | Neurosurgery2004，54，5： | 1 |
| 10 | Sensory and microbiological quality assessment of beef fillets using a portable electronic nose in tandem with support vector machine analysis显示文摘 | OLG A S P EFSTATHIOS Z FADY R M | 2013 | Food Research International2013，50，1： | 1 |
| 11 | Simultaneous determination of acetylsalicylic acid and salicylic acids in human serum and aspirin formulations by second-derivative synchronous fluorescence spectrometry显示文摘 | KONSTANTIANOS G D LOANNOU C P EFSTATHIO E C | 1991 | Analyst1991，116，4： | 1 |
| 12 | Clusterin/Apolipoprotein J in human aging and cancer显示文摘 | Ioannis P Trougakos Efstathios S Gonos | 2002 | International Journal of Biochemistry and Cell Biology2002，，11： | 1 |
| 13 | Exact analytic solutions for the damped Duffmg nonlinear oscillator 显示文摘 | Dimitrios E P Efstathios E T Michalis P M | 2006 | Comptes Rendus Mecanique2006，334，： | 1 |
| 14 | Michaelides geothermal power production from abandoned oil wells 显示文摘 | ADELINA P DAVIS EFSTATHIOS E | 2009 | Energy2009，34，7： | 1 |
| 15 | Nanomedicine approaches for treatment of hematologic and oncologic malignancies显示文摘Cancer is a leading cause of death worldwide.Nowadays,the therapies are inadequate and spur demand for improved technologies.Rapid growth in nanotechnology and novel nanomedicine products represents an opportunity to achieve sophisticated targeting strategies and multi-functionality.Nanomedicine is increasingly used to develop new cancer diagnosis and treatment methods since this technology can modulate the biodistribution and the target site accumulation of chemotherapeutic drugs,thereby reducing their toxicity.Cancer nanotechnology and cancer immunotherapy are two parallel themes that have emerged over the last few decades while searching for a cure for cancer.Immunotherapy is revolutionizing cancer treatment,as it can achieve unprecedented responses in advanced-stage patients,including complete cures and long-term survival.A deeper understanding of the human immune system allows the establishment of combination regimens in which immunotherapy is combined with other treatment modalities(as in the case of the nanodrug Ferumoxytol).Furthermore,the combination of gene therapy approaches with nanotechnology that aims to silence or express cancer-relevant genes via one-time treatment is gradually progressing from bench to bedside.The most common example includes lipidbased nanoparticles that target VEGF-Αand KRAS pathways.This review focuses on nanoparticle-based platforms utilized in recent advances aiming to increase the efficacy of currently available cancer therapies.The insights provided and the evidence obtained in this paper indicate a bright future ahead for immunooncology applications of engineering nanomedicines. | Polyxeni Nteli Danae Efremia Bajwa Dimitrios Politakis Charalampos Michalopoulos Anastasia Kefala-Narin Efstathios P Efstathopoulos Maria Gazouli | 2022 | World Journal of Clinical Oncology2022，13，7： | 0 |
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