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1篇 您的检索式：作者名="Dimitrios Politakis"

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		题名	作者	年代	出处	被引量
	1	Nanomedicine approaches for treatment of hematologic and oncologic malignancies显示文摘Cancer is a leading cause of death worldwide.Nowadays,the therapies are inadequate and spur demand for improved technologies.Rapid growth in nanotechnology and novel nanomedicine products represents an opportunity to achieve sophisticated targeting strategies and multi-functionality.Nanomedicine is increasingly used to develop new cancer diagnosis and treatment methods since this technology can modulate the biodistribution and the target site accumulation of chemotherapeutic drugs,thereby reducing their toxicity.Cancer nanotechnology and cancer immunotherapy are two parallel themes that have emerged over the last few decades while searching for a cure for cancer.Immunotherapy is revolutionizing cancer treatment,as it can achieve unprecedented responses in advanced-stage patients,including complete cures and long-term survival.A deeper understanding of the human immune system allows the establishment of combination regimens in which immunotherapy is combined with other treatment modalities(as in the case of the nanodrug Ferumoxytol).Furthermore,the combination of gene therapy approaches with nanotechnology that aims to silence or express cancer-relevant genes via one-time treatment is gradually progressing from bench to bedside.The most common example includes lipidbased nanoparticles that target VEGF-Αand KRAS pathways.This review focuses on nanoparticle-based platforms utilized in recent advances aiming to increase the efficacy of currently available cancer therapies.The insights provided and the evidence obtained in this paper indicate a bright future ahead for immunooncology applications of engineering nanomedicines.	Polyxeni Nteli Danae Efremia Bajwa Dimitrios Politakis Charalampos Michalopoulos Anastasia Kefala-Narin Efstathios P Efstathopoulos Maria Gazouli	2022	World Journal of Clinical Oncology2022，13，7：	0

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