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| 1 | Study of the Electric Filed Around a Metal Oxide Surge Arrester: Measurement and Simulation显示文摘The study of the electric field around a surge arrester is useful for design procedures and diagnostic tests. The current work com- putes the electric field around a medium voltage gapless surge arrester using 2D and 3D representation of the arrester. The 2D simulation design, which is described in IEC 60099-4 Standard, cannot include the non symmetrical parts of the arrester geometry and the test arrange- ment. 3D simulation procedures have the advantage that takes into account these asymmetries, giving more accurate results for each measurement position. In order to confirm the suitability of the created models, the simulation results of the electric field, using the 2D and 3D edition of PC Opera, are compared with recorded measurements, which are obtained in laboratory using appropriate calibrated field meters. | Christodoulou C A Spanias C A Kontargyri V T Gonos I F Stathopulos I A | 2013 | 高电压技术2013，39，8： | 4 |
| 2 | Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases显示文摘 | Ioannis P. Trougakos Efstathios S. Gonos | 2006 | Free Radical Research2006，，12： | 2 |
| 3 | Ectopic expression of clusterin/apolipoprotein J or Bcl-2 decreases the sensitivity of HaCaT cells to toxic effects of ropivacaine显示文摘Local anesthetics inhibit cell proliferation and induce apoptosis in various cell types. Ropivacaine, a unique, novel tertiary amine-type anesthetic, was shown to inhibit the proliferation of several cell types including keratinocytes. We found that Ropivacaine could inhibit the proliferation and induce apoptosis in an immortalized human keratinocyte line, HaCaT, in a dose- and time-dependent manner and with the deprivation of serum. The dose-dependent induction of apoptosis by ropivacaine was demonstrated by DNA fragmentation analysis and the proteolytic cleavage of a caspase-3 substrate — poly (ADP-ribose) polymerase (PARP). In addition, ropivacaine downregulated the expression of clusterin/ apoliporotein J, a protein with anti-apoptotic properties, in a dose-dependent manner, which well correlated with the induction of apoptosis of HaCaT cells. To investigate the role of clusterin/apoliporotein J in ropivacaine-induced apoptosis, HaCaT cells overexpressing clusterin/apoliporotein J were generated and compared to cells expressing the well estab- lished anti-apoptotic Bcl-2 protein. Ectopic overexpression of the secreted form of clusterin/apoliporotein J or Bcl-2 decreased the sensitivity of HaCaT cells to toxic effects of ropivacaine as demonstrated by DNA fragmentation, the proteolytic cleavage of PARP and by a reduction in procaspase-3 expression. Furthermore, the downregulation of endogenous clusterin/apolipoprotein J levels by ropivacaine suggested that this might be one mechanism by which ropivacaine induced cell death in HaCaT cells. In conclusion, the ability of ropivacaine to induce antiproliferative responses and to suppress the expression of the anti-apoptotic protein clusterin/apolipoprotein J, combined with previ- ously reported anti-inflammatory activity and analgesic property of the drug, suggests that ropivacaine may have poten- tial utility in the local treatment of tumors. | Evangelos KONTARGIRIS Evangelos KOLETTAS Athina VADALOUCA Ioannis P. TROUGAKOS Efstathios S. GONOS Vasiliki KALFAKAKOU | 2004 | Cell Research2004，14，5： | 2 |
| 4 | Clusterin/apolipoprotein J in human aging and cancer显示文摘 | Trougakos IP Gonos ES | 2002 | Int J Biochem Cell Biol2002，34，： | 1 |
| 5 | Dielectric behaviors of polluted porcelain insulators显示文摘 | Topalis F V Gonos I F Stathopulos I A | 2001 | IEE Proceedings: Generation Transmission and Distribufion2001，148，4： | 1 |
| 6 | Clusterin/apolipoprotein J in human aging and cancer 显示文摘 | Trougakos IP Gonos ES | 2002 | Int J Biochem Cell Biol2002，34，11： | 1 |
| 7 | Evaluation of airway wall thickness and air trapping by HRCT in asymptomatic asthma显示文摘 | Gono H Fujimoto K Kawakami S | 2003 | Eur RespirJ2003，22，6： | 1 |
| 8 | Increased ferritin predicts development and severity of acute interstitial lung disease as a complication of dermatomyositis显示文摘 | Gono T Kawaguchi Y Hara M | | 0，，： | 1 |
| 9 | Appearance of enhanced tissue features in narrow-band endoscopic imaging显示文摘 | Gono K Obi T Yamaguchi M | 2004 | Journal of Biomedical Optics2004，9，： | 1 |
| 10 | Frequency of classⅢandⅣnephritis in systemic lupus erythematosus without clinical renal involvement:An analysis of predictive measures显示文摘 | Wakasugi D Gono T Kawaguchi Y | 2012 | J Rheumatology2012，39，1： | 1 |
| 11 | Induction of replicative senescence biomarkers by sub- lethal oxidative stresses in normal human fibroblast 显示文摘 | Dumont P Burton M Chen QM Gonos ES Frippiat C Mazarati JB | 2000 | Free Radic Biol Med2000，28，3： | 1 |
| 12 | Design of an artificial neural network for the estimation of the flashover voltage on insulators显示文摘 | V.T. Kontargyri A.A. Gialketsi G.J. Tsekouras I.F. Gonos I.A. Stathopulos | 2006 | Electric Power Systems Research2006，，12： | 1 |
| 13 | Dielectric behaviour of polluted porcelain insulators显示文摘 | Topalis F V Gonos I F Stathopulos I A | | 0，，04： | 1 |
| 14 | Discoveries in the pathophysiology of neuropsychiatric lupus erythemato- sus : consequences for therapy显示文摘 | GONO T KAWAGUCHI Y YAMANAKA H | 2013 | BMC Med2013，11，： | 1 |
| 15 | Functional analysis of elusterin/apolipoprotein J in cellular death induced by severe genotoxic stress显示文摘 | Trougakos I Gonos E | 2004 | Ann NY Acad Sci2004，1019，6： | 1 |
| 16 | Dielectric behaviour of polluted porcelain insulators 显示文摘 | Topalis F V Gonos I F Stathopulos 1 A | 2001 | IEE Proceedings-Generation Transmission and Distribution2001，148，26： | 1 |
| 17 | Increased ferritin predicts development and severity of acute interstitial lung disease as a complication of dermatomyositis显示文摘 | Gono T Kawaguchi Y Hara M | | 0，，07： | 1 |
| 18 | Clinical manifestationsof neurological involvement in primary Sjogren' s syndrome 显示文摘 | Gono T Kawaguchi Y Katsumata Y | 2011 | Clin Rheumatol2011，30，4： | 1 |
| 19 | Peripheral nerve involvement in primary systemic AL amyloidosis:a clinical and electrophysiological study显示文摘 | Matsuda M Gono T Modm H et a1 | 2011 | Eur J Neural2011，18，： | 1 |
| 20 | Dielectric behaviour of polluted porcelain insulators显示文摘 | Topalis V Gonos F Stathopulos A | 2001 | IEE Generation Transmission & Distribution2001，148，4： | 1 |
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