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| 1 | 肠源性感染的实验研究显示文摘感染仍然是外科危重病人的主要死因之一。30%以上死于感染和多脏器功能衰竭病人的感染病灶,即使在尸检时也从未明确。多数感染都是由G^-杆菌、肠球菌以及白色念株菌这一类肠道常驻菌群所致。设想肠道可以是全身感染的感染源。细菌经由肠道通过肠粘膜侵入肠系膜淋巴结及体内其他脏器中的过程,国外称之谓“细菌的移居”,我们长期以来称之为“肠源性感染”。 在外科临床上,休克、营养不良、内毒素血症及以肠道内容物郁滞为特征的肠麻痹等因素常常合并存在,这些因素对于临床的感染率和病死率有促进作用。为澄清它们与肠源性感染之间的关系,本实验选用950只无特殊致病动物及无菌动物,以细菌学研究为主,病理学观察为辅,结合生化和药理学方法;利用烧伤、出血性休克、内毒素血症、蛋白质营养不良及小肠梗阻等不同动物模型;从多个方面,不同层次,对创伤后早期阶段肠源性感染的发生、发展等方面进行了系统的研究。结果发现:烧伤后早期肠道内细菌可以侵入体内;一定时限的低血容量性休克能够造成肠源性感染;循环中的内毒素可以促进肠道中细菌的侵入;蛋白质营养不良对内毒素上述的致病作用具有协同作用以及单纯小肠梗阻后肠道内细菌可进行性地侵入体内;最终导致致死性的肠源性感染。实验证明,创伤后早期阶段。 | 马利 黎鳌 肖光夏 Edwin A Deitch | 1990 | 第三军医大学学报1990，12，1： | 25 |
| 2 | Mesenchymal stem cell-derived exosomes promote neurogenesis and cognitive function recovery in a mouse model of Alzheimer’s disease显示文摘Studies have shown that mesenchymal stem cell-derived exosomes can enhance neural plasticity and improve cognitive impairment.The purpose of this study was to investigate the effects of mesenchymal stem cell-derived exosomes on neurogenesis and cognitive capacity in a mouse model of Alzheimer’s disease.Alzheimer’s disease mouse models were established by injection of beta amyloid 1?42 aggregates into dentate gyrus bilaterally.Morris water maze and novel object recognition tests were performed to evaluate mouse cognitive deficits at 14 and 28 days after administration.Afterwards,neurogenesis in the subventricular zone was determined by immunofluorescence using doublecortin and PSA-NCAM antibodies.Results showed that mesenchymal stem cells-derived exosomes stimulated neurogenesis in the subventricular zone and alleviated beta amyloid 1?42-induced cognitive impairment,and these effects are similar to those shown in the mesenchymal stem cells.These findings provide evidence to validate the possibility of developing cell-free therapeutic strategies for Alzheimer’s disease.All procedures and experiments were approved by Institutional Animal Care and Use Committee(CICUAL)(approval No.CICUAL 2016-011)on April 25,2016. | Edwin E. Reza-Zaldivar Mercedes A. Hernández-Sapiéns Yanet K. Gutiérrez-Mercado Sergio Sandoval-ávila Ulises Gomez-Pinedo Ana L. Márquez-Aguirre Estefanía Vázquez-Méndez Eduardo Padilla-Camberos Alejandro A. Canales-Aguirre | 2019 | Neural Regeneration Research2019，14，9： | 19 |
| 3 | Status review of mercury control options for coal-fired power plants显示文摘 | John H Pavlish Everett A Sondreal Michael D Mann Edwin S Olson Kevin C Galbreath Dennis L Laudal Steven A Benson | 2003 | Fuel Processing Technology2003，，2： | 4 |
| 4 | PERSISTENT HIF-1α ACTIVATION IN GUT ISCHEMIA/REPERFUSION INJURY: POTENTIAL ROLE OF BACTERIA AND LIPOPOLYSACCHARIDE显示文摘 | Jadd Koury Edwin A Deitch Hiroshi Homma Billy Abungu Pranoti Gangurde Michael R Condon Qi Lu Da-Zhong Xu Rena Feinman | 2004 | Shock2004，，3： | 3 |
| 5 | A method for producing digital probabilistic seismic landslide hazard maps显示文摘 | Randall W Jibson Edwin L Harp John A Michael | 2000 | Engineering Geology2000，，3： | 2 |
| 6 | 内毒素导致肠源性感染发病机理的实验研究显示文摘我们观察了内毒素所致肠源性感染与肠粘膜形态学改变和黄嘌呤氧化酶、黄嘌呤脱氢酶活性变化之间的相关性。结果显示,循环中的内毒素主要是损伤回肠和盲肠粘膜屏障,导致肠源性细菌感染。同时回肠和盲肠粘膜中黄嘌呤氧化酶和黄嘌呤脱氢酶活性显著增高,本文对此进行了讨论。 | 马利 马敬文 肖光夏 黎鳌 Edwin A Deitch | 1990 | 中华整形烧伤外科杂志1990，6，3： | 2 |
| 7 | Adaptive Sampling for Network Management显示文摘 | Edwin A Hernandez Mathew C Chidester Alan D George | 2001 | JNSM2001，9，4： | 1 |
| 8 | Chemical Coal Cleaning Using Selective Oxidation显示文摘 | Stephen R P Edwin J H Xavier A D | 1994 | Fuel1994，73，2： | 1 |
| 9 | Cell wall polysaccharides in black currants and bilberries-characterization in berries,juice and press cake显示文摘 | Hauke Hilz Edwin J Bakx Henk A Schols | 2005 | Carbohydrate Polymers2005，58，： | 1 |
| 10 | A multilevel investigation of the motivational mechanisms underlying knowledge sharing and performance显示文摘 | Quigley Narda R Tesluk Paul E Locke Edwin A Bartol Kathryn M | 2007 | Organization Science2007，18，1： | 1 |
| 11 | THE ROLE OF LYMPH FACTORS IN LUNG INJURY, BONE MARROW SUPPRESSION, AND ENDOTHELIAL CELL DYSFUNCTION IN A PRIMATE MODEL OF TRAUMA-HEMORRHAGIC SHOCK显示文摘 | Edwin A Deitch Raquel Forsythe Dev Anjaria David H Livingston Qi Lu Da-Zhong Xu Heinz Redl | 2004 | Shock2004，，3： | 1 |
| 12 | Facial gender classification using shape-from-shading 显示文摘 | Wu J William A P Edwin R | 2010 | Image and Vision Computing2010，28，6： | 1 |
| 13 | Responsive supply chain:A competitive strategy in a networked economy显示文摘 | Gunasekaran A Lai K-h Edwin Cheng T | | 0，，04： | 1 |
| 14 | Role of the gut in multiple organ failure:bacterial translacation and premaeability changes显示文摘 | Edwin A | 1996 | Word J Surg1996，20，4： | 1 |
| 15 | Resveratrol: influences on gene expression in human skin 显示文摘 | EDWIN D L JOHN M S MERRITT B A | 2014 | Journal of Functional Foods2014，10，： | 1 |
| 16 | 'Black-box'and'gray-box' supplier integration in product-de- velopment:Antecedents, consequences and the moderating role of firm size显示文摘 | XENOPHON A K CHENG T C Edwin KEE Hunglai | 2007 | Journal of Operations Management2007，，25： | 1 |
| 17 | Minimally invasive direct coronary artery bypass graft: intermediate-term results显示文摘 | Vassiliades Jr Edwin W | 2000 | Ann Thorac Sury2000，70，： | 1 |
| 18 | Amino acid derivatives of D-glucosamine显示文摘 | Doherty D G Edwin A | 1953 | J Am Chem Soc1953，75，： | 1 |
| 19 | The JPL telerobot teleoperation system 显示文摘 | EDWIN P K EDMUND A | 1990 | International Journal of Robotics and Automation1990，5，1： | 1 |
| 20 | Parental occupational exposure to pesticides and childhood brain cancer 显示文摘 | Van Wijngaarden Edwin Stewart Patricia A Olshan Andrew F | 2003 | Epidemiology2003，157，11： | 1 |
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