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| 1 | Preprocessing of 2-Dimensional Gel Electrophoresis Images Applied to Proteomic Analysis: A Review显示文摘Various methods and specialized software programs are available for processing twodimensional gel electrophoresis(2-DGE)images.However,due to the anomalies present in these images,a reliable,automated,and highly reproducible system for 2-DGE image analysis has still not been achieved.The most common anomalies found in 2-DGE images include vertical and horizontal streaking,fuzzy spots,and background noise,which greatly complicate computational analysis.In this paper,we review the preprocessing techniques applied to 2-DGE images for noise reduction,intensity normalization,and background correction.We also present a quantitative comparison of non-linear?ltering techniques applied to synthetic gel images,through analyzing the performance of the?lters under speci?c conditions.Synthetic proteins were modeled into a two-dimensional Gaussian distribution with adjustable parameters for changing the size,intensity,and degradation.Three types of noise were added to the images:Gaussian,Rayleigh,and exponential,with signal-to-noise ratios(SNRs)ranging 8–20 decibels(d B).We compared the performanceof wavelet,contourlet,total variation(TV),and wavelet-total variation(WTTV)techniques using parameters SNR and spot ef?ciency.In terms of spot ef?ciency,contourlet and TV were more sensitive to noise than wavelet and WTTV.Wavelet worked the best for images with SNR ranging 10–20 d B,whereas WTTV performed better with high noise levels.Wavelet also presented the best performance with any level of Gaussian noise and low levels(20–14 d B)of Rayleigh and exponential noise in terms of SNR.Finally,the performance of the non-linear?ltering techniques was evaluated using a real 2-DGE image with previously identi?ed proteins marked.Wavelet achieved the best detection rate for the real image. | Manuel Mauricio Goez Maria Constanza Torres-Madronero Sarah Rothlisberger Edilson Delgado-Trejos | 2018 | Genomics, Proteomics & Bioinformatics2018，16，1： | 5 |
| 2 | In vivo activity of Sapindus saponaria against azole - susceptible and - resistant human vaginal Candida species 显示文摘 | Edilson Damke Joyce K Tsuzuki Diogenes AG Cortez | 2011 | BMC Complementary and Alternative Medicine2011，11，35： | 1 |
| 3 | Spermicidal and anti - Trichomonas vaginalis activity of Brazilian Sapindus saponaria 显示文摘 | Edilson Damke Joyee K Tsuzuki Francieli Chassot | 2013 | Complementary and Altemative Medicine2013，13，7： | 1 |
| 4 | Four-port coupled channel-guide device based on 2D photonic crys- tal structure 显示文摘 | Edilson A C Harold M H C Richard M | 2004 | Photonics and Nanostructures2004，2，1： | 1 |
| 5 | Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host显示文摘Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host. | Vitor Sueth-Santiago Debora Decote-Ricardo Alexandre Morrot Celio Geraldo Freire-de-Lima Marco Edilson Freire Lima | 2017 | World Journal of Biological Chemistry2017，8，1： | 1 |
| 6 | Effect of bone marrow-derived mesenchymal stem cells on endotoxin-induced oxidation of plasma cysteine and glutathione in mice显示文摘 | Smita S.Iyer Edilson Torres-Gonzalez David C Neujahr | | 0，，： | 1 |
| 7 | Multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones with a Cu/silica xerogel composite catalyst显示文摘 | Dennis R Edilson VB Gabriela SR | 2007 | Letters in Organic Chemistry2007，4，1： | 1 |
| 8 | Use of neural networks in the mathematical modelling of the enzymic synthesis of amoxicillin catalysed by penicillin G acylase immobilized in chitosan显示文摘 | James A. Silva Edilson Holanda Costa Neto Wellington S. Adriano Andrea L. O. Ferreira Luciana R. B. Gon?alves | 2008 | World Journal of Microbiology and Biotechnology2008，，9： | 1 |
| 9 | Inhibition of NF-B signaling reduces virus load and gammaherpesvirus-indueed pulmonary fibrosis 显示文摘 | Laurie TK Edilson TG Qin QH | 2010 | Am J Pathol2010，177，： | 1 |
| 10 | Theoretical investigation of the gas phase oxidation mechanism of dimethyl sulfoxide by OH radical显示文摘 | LEONARDO B EDILSON C S GRACIELA A | 2008 | Journal of Molecular Structure:Theo Chem2008，851，： | 1 |
| 11 | Determination of salt solubility data for ternary aqueous systems with a quasiisothermic thermometric technique显示文摘 | Edilson C. Tavares Susana I.S. Marcelino Osvaldo Chiavone-Filho Carlson P. Souza | 1999 | Thermochimica Acta1999，，1： | 1 |
| 12 | Treatment of developmental dys- plasia of the hip after walking age with open reduction ,femoral short- ening,and acetabular osteotomy显示文摘 | Edilson F Luiz A Munhoz C | 2006 | Orthop Clin N Am2006，37，： | 1 |
| 13 | Reduction in Plasma Levels of Inflammatory and Oxidative Stress Indicators After Roux-En-Y Gastric Bypass显示文摘 | Edilson Jo?o Cabrera Antonio Carlos Valezi Vinicius Daher Alvares Delfino Edson Lopes Lavado Decio Sabbatini Barbosa | 2010 | Obesity Surgery2010，，1： | 1 |
| 14 | Inhibition of NF- κB signaling reduces virus load and gammaherpesvirus- induced pulmonary fibrosis 显示文摘 | Laurie TK Edilson TG Qin QH | 2010 | Am J Pathol2010，177，2： | 1 |
| 15 | Mapping QTLs for aluminum tolerance in maize显示文摘 | Fernando Enrique Ninamango-Cárdenas Claudia Teixeira Guimar?es Paulo Roberto Martins Sidney Netto Parentoni Newton Portilho Carneiro Maurício Ant?nio Lopes José Roberto Moro Edilson Paiva | 2003 | Euphytica2003，，2： | 1 |
| 16 | Evaluation of Propargyl Alcohol as a Corrosion Inhibitor for Duplex Stainless Steel in Hydrochloric Acid显示文摘ASTM A182 F51 duplex stainless steel with a 50:50 ratio of austenite to ferrite microstructure is a material used in mechanical engineering.Its uses include the manufacturing of equipment and components subject to acidification or acid stimulation for oil and gas industries.During acid stimulation or acidification,hydrochloric acid(HCl)solution with concentrations ranging from 5%to 28%(by volume)is injected into the limestone(CaCO3)and dolomite(CaCO3·MgCO3)reservoir rock to restore permeability and consequently increase oil well productivity.Therefore,it is important to use a corrosion inhibitor,such as propargyl alcohol,to prevent or inhibit the aggressive attack of HCl on duplex stainless steel.The present study evaluates the corrosion resistance of ASTM A182 F51 stainless steel using gravimetric(mass loss)and electrochemical(polarization)tests.Studies were completed with and without the addition of 500 and 1,000 mg/L propargyl alcohol in HCl solutions with concentrations of 10%and 15%(by volume)at temperatures of 25,40 and 55°C.The good protection by propargyl alcohol of duplex steel immersed in HCl is observed. | Fernando Benedicto Mainier Virgílio P.dos Reis Edilson Ferreira de Barros Brígida B.de Almeida | 2020 | Journal of Civil Engineering and Architecture2020，14，7： | 0 |
| 17 | The Tesistan, Mexico earthquake (M_w 4.9) of 11 May 2016: seismic-tectonic environment and resonance vulnerability on buildings显示文摘To highlight the importance of small earthquakes in seismic hazard, a study of the 11 May 2016, Mw 4.9, Tesistan, Mexico earthquake is presented. Due to the close proximity of the event to the city, accelerations were considerably higher than those caused by historical severe earthquakes (6.0 < Mw < 8.2). This paper addresses two objectives related to the Tesistan event: the fi rst is to estimate the focal mechanism solution in order to place the event in the context of the tectonic environment of this area. The second is focused on a vulnerability evaluation of buildings that suff ered resonance. Several building′s typologies with variations in construction system and height are assessed in terms of resonance with the structural and soil periods. The results show that around the Zapopan station, strong damage is expected in intermediate to high-rise buildings (12-30 m) with moment resistant frame systems and in reinforced concrete shear walls. Masonry structures around this station may not present resonance. In contrast, in the surroundings of the Guadalajara station, all intermediate height buildings from 9 to 21 m may present resonance. | Alejandro Ramírez-Gaytán Adolfo Preciado William L. Bandy Edilson F. Salazar-Monroy Miguel A. Jaimes Leonardo Alcantara | 2019 | Earthquake Engineering and Engineering Vibration2019，18，3： | 0 |
| 18 | Association of TNFA(-308G/A),IFNG(+874 A/T)and IL-10(-819 C/T)polymorphisms with protection and susceptibility to dengue in Brazilian population显示文摘Objective: To evaluate gene polymorphisms and their association with susceptibility to dengue.Methods: A retrospective case-control study was performed with 262 subjects,comprising 78 dengue fever(DF) patients, 49 dengue hemorrhagic fever(DHF) patients and 135 healthy controls. Genotypic and allelic profiles were identified using polymerase chain reaction based in real time and amplification-refractory mutation system.Results: We observed a protective association of IL-10(-819 C/T) C allele(P = 0.028,OR = 0.56, CI = 0.34–0.91) against DHF, while the C/T(P = 0.047, OR = 2.10,CI = 1.01–4.38) and T/T(P = 0.008, OR = 3.82, CI = 1.38–10.59) genotypes were associated with DHF and DF, respectively. The dominant model TNFA-308 GA + AA(P = 0.043, OR = 0.45, CI = 0.20–1.00) genotypes were found to have protective effect against dengue infection. A protective association among the IFNG(+874 A/T) A/T genotype against DF(P = 0.02, OR = 0.46, CI = 0.24–0.89) and DHF(P = 0.034,OR = 0.43, CI = 0.19–0.95) was observed. When the studied single-nucleotide polymorphism was analyzed in combination, the combination GTA(P = 0.022, OR = 2.95,CI = 1.18–7.41) was statistically significantly associated with susceptibility to DF and the combination GCT(P = 0.035, OR = 0.28, CI = 0.08–0.90) with protection against the development of DHF.Conclusions: This research identifies the association of the IFNG(+874 A/T), TNFA(-308 G/A), IL-10(-819 C/T) genotypes as a factor for protection, susceptibility and severity to dengue. | Ana Caroline Melo dos Santos Edilson Leite de Moura Jean Moises Ferreira Alexandre Wendell Araujo de Moura Ailson Darlan Sales Ferreira Rubens Pereira Bezerra Diego de Siqueira Figueiredo Karol Fireman de Farias Tiago Gomes de Andrade Elaine Virginia Martins de Souza Figueiredo | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，11： | 0 |
| 19 | Kaphta:Text mining web tool to extract information on the anticancer activity of polyphenols显示文摘In this paper,we describe the application of Kaphta architecture,a resource for text mining of the anticancer activity of polyphenols.The anticancer activity of these compounds against different types of cancer has been widely reported in the literature and they are one of the most promising molecules for the development of anticancer drugs.The architecture,which comprises four sequential and well-defined steps,uses a hybrid approach composed of a dictionary,rules and machine learning to identify abstracts containing sentences with associations between polyphenol,cancer and gene entities.The application of the architecture on 23826 PubMed abstracts generated a knowledge base of indexed abstracts with 172169 sentences containing,polyphenol-cancer and polyphenol-gene associations.A Web tool was implemented that allowed the user to search for information on 2006 polyphenols,240 cancers and 3121 genes entities,and 11750 polyphenol-cancer and 9160 polyphenol-gene associations indexed in the knowledge base.A ranking algorithm calculates scores for each indexed abstract considering the number and type of sentences with entities and rules recognized.A test with users demonstrated that the visualization resources on the web tool contributes to the understanding of the association between polyphenols,genes and cancers,in comparison with the PubMed Tool.The Kaphta architecture and web tool permits to extract knowledge on the anticancer activity of polyphenols and can thus contribute to the exploration of these molecules in the development of anticancer therapies. | Ramon Gustavo Teodoro Marques da Silva Samuel Lucas Santos Gomes Paulo Muniz deÁvila Gustavo Joséda Silva Ana Lucia Fachin Edilson Carlos Caritá Mozart Marins | 2022 | Journal of Polyphenols2022，4，2： | 0 |
| 20 | Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa(Jacq.) Raf.(Cleomaceae)显示文摘Objective: To evaluate the antibacterial activity and neuroprotective capacity of the ethanolic and aqueous extracts of Tarenaya spinosa(T. spinosa) as well as to determine and quantify some of its polyphenols by high performance liquid chromatography with diode-array detection(HPLC-DAD). Methods: The bacterial Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa strains, grown in Heart Agar Infusion, were tested. The drugs gentamicin, norfloxacin and imipenem were used to evaluate the modulating or antagonistic capacity of the T. spinosa extracts. The extract was analysed by HPLC-DAD to determine the main phenolic compounds. For the cell viability tests, individual heads of the Nauphoeta cinerea arthropod model were removed, homogenized in Trifluoromethyl ketone and centrifuged afterwards. Subsequently, 20 μL of NaN O2 were added to the biological material, except in the control group, to evaluate the protection capacity of the extracts. The homogenate of the insect heads was incubated for 2 h in tubes containing tetrazolium bromide. Results: HPLC-DAD demonstrated that the ethanolic extract of T. spinosa presented caffeic acid as the major compound. The ethanolic extract also showed neuroprotective effects at concentrations ≥ 10 μg/mL, while aqueous extract was shown to have a protective effect only at the concentration of 100 μg/mL. The aqueous extract demonstrated a clinically relevant antibacterial activity against the Staphylococcus aureus multidrug resistant strain-MDR, with MIC 512 μg/m L. However, when the extracts were associated with gentamicin and imipenem, a synergism was detected against Staphylococcus aureus and Escherichia coli MDR strains. Conclusions: Although it does not present an antibacterial action, the extracts of T. spinosa can be used in the pharmaceutical industries since its extracts show modulating action of drugs. Besides, these natural products have neuroprotective capacity. | Francisca Samara Muniz dos Santos Jose Weverton Almeida Bezerra Jean Paul Kamdem Aline Augusti Boligon Marli Matiko Anraku Ana Raquel Pereira da Silva Kleber Ribeiro Fidelis Nadghia Figueiredo Leite Antonio Ivanildo Pinho Henrique Douglas Melo Coutinho Jose Edilson Goncalves dos Santos | 2019 | Asian Pacific Journal of Tropical Biomedicine2019，9，1： | 0 |
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