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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | Prevalence and risk factors for adenomas in the ileal pouch and the afferent loop after restorative proctocolectomy for patients with familial adenomatous polyposis显示文摘 | Elise Pommaret Ariane Vienne Jérémie H. Lefevre Philippe Sogni Christian Florent Beno?t Desaint Yann Parc | 2013 | Surgical Endoscopy2013，，10： | 1 |
| 4 | Expression and functional analysis of ToASY1 during meiosis of bread wheat (Triticum aestivum)显示文摘 | SCOTT A B NADIM S ELISE J T | 2007 | BMC Molecular Biology2007，8，： | 1 |
| 5 | Identification of a hu- man helper T cell population that has abundant production of interleukin 22 and is distinct from Thl, Thl7 and Th2 cells 显示文摘 | Sara T Charles DK Elise HT | 2009 | Nat Immuno12009，10，8： | 1 |
| 6 | Motion sickness, body movement, and claustrophobia during passive restraint 显示文摘 | Elise Faugloire Crdrick T Bonnet | 2007 | Exp Brain Res2007，177，： | 1 |
| 7 | Population toxicokinet- its of benzene 显示文摘 | Frederic Y B Elise T J Kaija Pekari | 1996 | Environmental Health Perspectives1996，104，6： | 1 |
| 8 | The occurrence of depression in parkinson's disease显示文摘 | Elise T Jan P Larsen DA | 1996 | Arch Neurol1996，53，2： | 1 |
| 9 | Managing stakeholders:A tourism planning model显示文摘 | ELISE T S BIRGIT L | 1999 | Annals of Tourism Research1999，，2： | 1 |
| 10 | The occurrence of depression in Parkinson's disease显示文摘 | ELISE T JAN P LARSEN D A | 1996 | Arch Neurol1996，53，2： | 1 |
| 11 | The occurrence of depression in Parkinson's disease显示文摘 | Elise T Jan P Larsen DA | 1996 | Arch Neurol1996，53，2： | 1 |
| 12 | Leapfrogging in international competition: a theory of cycles in national technology leadership 显示文摘 | ELISE S PAUL R K DANIEL T | 2004 | The American Economic Review2004，83，5： | 1 |
| 13 | In vivo treatment of acute Chlamydia pneumoniac infection with the flavonoids quercetin and luteolin and an alkyl gallate,octyl gallate,in u mouse model显示文摘 | Liisa T Pia V Elise S | 2005 | Biochemical Pharmacology2005，70，8： | 1 |
| 14 | Detection of different variants of ostreid herpesvirus 1 in the pacific oyster, crassostrea gigas between 2008 and 2010显示文摘 | Claire M Elise O Emmanuelle T | 2011 | Virus Research2011，160，： | 1 |
| 15 | Risk and managementof blood-borne infections in health care workers显示文摘 | Elise M B Ian T W Craig N S | 2000 | Clin Microbiol Rev2000，13，3： | 1 |
| 16 | Identification of a human helper T cell population that has abundant production ofinterleukin 22 and is distinct from Th1,Th17 and Th2 cells显示文摘 | Sara T Charles DK Elise HT | 2009 | Nat Immunol2009，10，8： | 1 |
| 17 | Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from TH-17, TH1 and TH2 cells显示文摘 | Sara T Charles DK Elise HT | 2009 | Nat lmmunol2009，10，8： | 1 |
| 18 | In vivo treatment of acute Chlamydia pneumoniae infection with the flavonoids quercetin and luteolin and an alkyl gallate,octyl gallate,in a mouse model显示文摘 | Liisa T Pia V Elise S | | 0，，08： | 1 |
| 19 | Sperm aneupioidy among Chinese pesticide factory workers: Scoring by the FISH method显示文摘 | Padungtod C Hassold T J Elise Millie | 1999 | American Journal of Industrial Medicine1999，36，2： | 1 |
| 20 | The occurrence of depression in parkinson's disease 显示文摘 | Elise T Jan P Larsen DA | 1996 | Arch Neurol1996，53，2： | 1 |
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