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| 1 | Calcium signaling in cholangiocytes显示文摘Cytosolic Ca2+ 是在房间的几乎每种类型的一个重要的秒送信人。而且, Ca2+ 通常在单个房间以内调整多重活动。这篇文章考察为在 cholangiocytes 发信号的 Ca2+ 负责的细胞的机械。另外,在 cholangiocytes 的二个调停 Ca2+ 的事件被讨论:酸式碳酸盐分泌物和 apoptosis。最后,新兴的证据被考察发信号的 Ca2+ 涉及影响表明小径的胆汁的树和那 Ca2+ 的疾病的致病,这能在胆汁郁积的混乱的治疗被操作到治疗学的优点。 | Noritaka Minagawa Barbara E Ehrlich Michael H Nathanson | 2006 | World Journal of Gastroenterology2006，12，22： | 4 |
| 2 | Ranibizumab for Diabetic Macular Edema显示文摘 | Quan Dong Nguyen David M. Brown Dennis M. Marcus David S. Boyer Sunil Patel Leonard Feiner Andrea Gibson Judy Sy Amy Chen Rundle J. Jill Hopkins Roman G. Rubio Jason S. Ehrlich | 2012 | Ophthalmology2012，，4： | 4 |
| 3 | Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli显示文摘Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P < 0.05) growth performance and intestinal villi height, whereas increased(P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P < 0.05) and d 0 to 11 PI(P = 0.058). Supplementation of high dose of Bacillus subtilis reduced(P < 0.05) both transcellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P < 0.05)the m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P < 0.05) expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P < 0.05) the m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P < 0.05) the m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P < 0.05) in ileal mucosa of E. coli infected pigs.Conclusions: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli. | Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 4 | Effect of Gd3+-,Pr3+-or Sm3+-substituted cobalt-zinc ferrite on photodegradation of methyl orange and cytotoxicity tests显示文摘Gd3+-,Pr3+-or Sm3+-doped Co-Zn(Co0.5Zn0.5Fe2 O4)magnetic ferrites(i.e.,Co0.5Zn0.5Gd0.1Fe1.9O4,Co0.5Zn0.5Pr0.1Fe1.9O4 and Co0.5Zn0.5Sm0.1Fe1.9O4)were prepared using a facile sol-gel approach,and the structure,surface morphology and chemical composition of the products were studied by means of scanning electron microscopy(SEM),energy dispersive X-ray analysis(EDX),X-ray diffraction(XRD),UVvisible diffuse reflectance spectroscopy(DRS),photoluminescence(PL)spectroscopy,Fourier transform infrared spectroscopy(FT-IR)and vibrating sample magnetometer(VSM)spectroscopy.XRD patterns show the Co-Zn product is composed of cubic spinel phases with few impurities or secondary phases,and the average crystallite sizes of the samples are determined to be approximately^51—80,~99—181,~68—103 and^83—133 nm.Also the coercivity and remnant and saturation magnetizations,evaluated by vibrating sample magnetometer(VSM),are found to increase linearly with the incorporation of Gd3+,Pr3+and Sm3+in the product formulation.The CO1-xZnxFe2-yRyO4 photocatalyst sample is found to display a red shift in its absorption,and exhibits outstanding photocatalytic effects in the degradation of MO under ultraviolet(UV)light.This is attributed to the reduction of the band gap of cobalt-zinc ferrite due to the presence of rare earth ions.Further in vitro evaluations of the cytotoxic effects of the synthesized nanoparticles were performed on a HeLa cell line. | Seyed Mahdi Peymani-Motlagh Nadia Moeinian Mojtaba Rostami Mahdi Fasihi-Ramandi Ali Sobhani-Nasab Mehdi Rahimi-Nasrabadi Mohammad Eghbali-Arani Mohammad Reza Ganjali Teofil Jesionowski Hermann Ehrlich Mohammad Ali Karimi Narges Ajami | 2019 | Journal of Rare Earths2019，37，12： | 3 |
| 5 | Best practices for prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis显示文摘Acute pancreatitis is of one the most common gastroenterology-related indications for hospital admissions worldwide.With the widespread reliance on endoscopic retrograde cholangiopancreatography(ERCP)for the management of pancreaticobiliary conditions,post-ERCP pancreatitis(PEP)has come to represent an important etiology of acute pancreatitis.Despite many studies aiming to better understand the pathogenesis and prevention of this iatrogenic disorder,findings have been heterogeneous,and considerable variation in clinical practice exists.Herein,we review the literature regarding PEP with the goal to raise awareness of this entity,discuss recent data,and present evidence-based best practices.We believe this manuscript will be useful for gastrointestinal endoscopists as well as other specialists involved in the management of patients with PEP. | Simcha Weissman Mohamed Ahmed Matthew R Baniqued Dean Ehrlich James H Tabibian | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，6： | 2 |
| 6 | Effect of different lens status on intraocular pressure elevation in patients treated with anti-vascular endothelial growth factor injections显示文摘AIM: To assess the effect of lens status on sustained intraocular pressure(IOP) elevation in patients treated intravitreally with anti-vascular endothelial growth factor(VEGF) agents. METHODS: Data were retrospectively collected for all patients treated with intravitreal injections of anti-VEGF medication at a tertiary medical center in July 2015. Findings were analyzed by lens status during 6 months' follow-up. The main outcome measure was a sustained increase in IOP(≥21 mm Hg or change of ≥6 mm Hg from baseline on ≥2 consecutive visits, or addition of a new IOPlowering medication during follow-up). RESULTS: A total of 119 eyes of 100 patients met the study criteria: 40 phakic, 40 pseudophakic, and 39 pseudophakic after Nd:YAG capsulotomy. The rate of sustained IOP elevation was significantly higher in the postcapsulotomy group(23.1%) than in the phakic/pseudophakic groups(8.1%;P=0.032), with no statistically significant differences among the 3 groups in mean number of injections, either total(P=0.82) or by type of anti-VEGF mediation(bevacizumab: P=0.19;ranibizumab: P=0.13), or mean follow-up time(P=0.70). CONCLUSION: Nd:YAG capsulotomy appears to be a risk factor for sustained IOP elevation in patients receiving intravitreal anti-VEGF injections. This finding has important implications given the growing use of anti-VEGF treatment and the irreversible effects of elevated IOP. | Amir Sternfeld Rita Ehrlich Dov Weinberger Assaf Dotan | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 7 | Refinement of CARTO-guided substrate modification in patients with ventricular tachycardia after myocardial infarction显示文摘背景:CARTO 系统指导的底层修正被介绍了在心肌的梗塞(MI ) 以后便于心室性心博过速(vt ) 的线性脱离。然而,没有为画这些脱离线可得到的通常接受的标准途径。因此,现在的学习的目的是实际上这次精制消费过程。方法:底层修正用 CARTO 系统在 MI 以后与经常的 vt 在 23 个连续病人被执行。起始的目标地点(它的) 因为脱离被印射的步(下午) 在 vt 期间在室性节律或乘火车踱步(他们) 期间识别。根据起始的目标地点,二条途径被使用。在途径一的起始的目标地点从刺激作为 vt 和间隔有类似的 QRS 形态学到=的 QRS ( S-QRS )的发作 50 ms 在在室性节律或在间隔和 vt 上踱步的柱子的差别的下午期间骑车长度= 30 ms 在隐藏的乘火车期间 vt 踱步;在途径二的起始的目标地点作为 vt 和 <
的 S-QRS 有类似的 QRS 形态学 50 ms 在在室性节律的下午期间。结果:总的来说, 50 根线被执行与一段(35 +/- 11 ) 公里。平均的过程时间(232 +/- 56 ) 分钟,荧光检查时间(10 +/- 8 ) 分钟。十六个病人开始被包含进途径一。在 1 脱离衬里的 3 +/- 的结束以后,没有进一步的 vt 在 13 个病人是可诱导的。留下 3 个病人被换到选择接近的使用。然而,在没有,他们,其他的途径是成功的。途径二开始在 7 个病人被使用。在 1 脱离衬里的 3 +/- 的结束以后,没有进一步的 vt 在仅仅 2 个病人是可诱导的。留下 5 个病人被换到接近一个,它在他们中的 4 个导致了 vt 的 noninducibility。起始的成功的率在途径二的组在与那相比的途径一的组是显著地更高的(13/16 病人对 2/7 病人, P 0.026 ) 。结论:为在 MI 以后的 vt 的底层修正的途径能被在慢传导的地区以内与特定的特征识别适当起始的目标地点优化。精制途径可以便于 vt 的线性脱离,并且进一步减少过程和荧光检查时间。 | LI Yi-gang WANG Qun-shan Gerian Gronefeld Carsten Israel LU Shang-biao SHAO Yun Joachim R. Ehrlich Stefan H. Hohnloser | 2008 | Chinese Medical Journal2008，，2： | 2 |
| 8 | A gene for hereditary pancreatitis maps to chromosome 7q35显示文摘 | DC Whitcomb RA Preston CE Aston MJ Sossenheimer PS Barua Y Zhang A Wong- Chong GJ White PG Wood LK Gates C Ulrich SP Martin JC Post GD Ehrlich | 1996 | Gastroenterology1996，，6： | 2 |
| 9 | Epiretinal membrane following pars plana vitrectomy for rhegmatogenous retinal detachment repair显示文摘AIM: To determine the rate and possible contributors for post-pars plana vitrectomy(PPV) epiretinal membrane(ERM) in patients treated for rhegmatogenous retinal detachment(RRD). METHODS: This prospective, nonrandomized study comprised 47 consecutive patients(47 eyes) with acute RRD treated with 23 G post-PPV. All participants were followed prospectively for 6 mo for the development of ERM using spectral domain optical coherence tomography. Preoperative and intraoperative data were collected by questionnaires to surgeons. Main outcome measure was the percentage of the ERM formation following post-PPV for RRD. RESULTS: ERM developed postoperatively in 23 eyes(48.9%), none necessitated surgical removal. There was a statistically significant difference between patients with and without ERM postoperatively in preoperative best corrected visual acuity(median log MAR 1.9 vs 0.3, respectively;P=0.003) rate of macula-off(69.6% vs 37.5%, respectively, P=0.028), and rate of ≥5 cryo-applications(55.6% and 18.8%, respectively, P=0.039). ERM developed mainly between the 1st and 3rd months of follow-up. Macula-off status increased the risk of ERM, with the odds ratio of 3.81(P=0.031). CONCLUSION: ERM is a frequent post RRD finding, and its development is associated with macula-off RRD. | Ruti Sell Amir Sternfeld Ivan Budnik Ruth Axer-Siegel Rita Ehrlich | 2019 | International Journal of Ophthalmology(English edition)2019，12，12： | 2 |
| 10 | Surface discharges across insulators in vacuum 显示文摘 | Boersch H Hamisch H Ehrlich W | 1963 | Z Angew Phys1963，15，6： | 1 |
| 11 | MIP-lalpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells 显示文摘 | Oba Y Lee JW Ehrlich LA | 2005 | Exp Hematol2005，33，3： | 1 |
| 12 | Impact of Population Growth显示文摘 | Ehrlich P R Holden J P | 1971 | Science1971，，171： | 1 |
| 13 | Instability of the distal tibiofibular syndesmosis after bimalleolar and trimalleolar ankle fractures显示文摘 | Leeds HC Ehrlich MG | 1984 | J Bone Joint Sury(Am)1984，66，4： | 1 |
| 14 | Human population and theglobal environment 显示文摘 | HOLDREN J P EHRLICH P R | 1974 | American Scientist1974，62，： | 1 |
| 15 | Microbial formation and degradation of metals 显示文摘 | Silvennan M P Ehrlich H L | 1964 | Advances in Applied Microbiology1964，6，： | 1 |
| 16 | Identification of Stress-inducible Proteins in Lactobacillus delbrueckii subsp, bulgaricus 显示文摘 | LIME M EHRLICH S D and MAGUIN E | 2000 | Electrophoresis2000，21，： | 1 |
| 17 | Hyaluronan induces scarless repair in mouse limb organ culture 显示文摘 | Iocono JA Ehrlich HP Keefer KA | 1998 | J Pediatr Surg1998，33，4： | 1 |
| 18 | Novel approaches for pharmacological management of atrial fibrillation显示文摘 | Ehrlich JR Nattel S | | 0，，07： | 1 |
| 19 | Patients diagnosed with diabetes are at increased risk for asthma,chronic obstructive pulmonary disease,pulmonary fibrosis,and pneumonia but not lung cancer显示文摘 | Ehrlich SF Quesenberry CJ Van Den Eeden SK | | 0，，1： | 1 |
| 20 | Human population and the global envi- ronment 显示文摘 | Holdren J P Ehrlich P R | 1974 | American Scientist1974，62，3： | 1 |
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