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| 1 | Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation显示文摘The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes.However, the effects of CHR’s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9 C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide(3 AB)and ABT888. Ectopic expression of PARP1 effectively blocked this CHR’s cardioprotection against DOX-induced cardiomyocyte injury in H9 C2 cells. Furthermore, pre-administration with both CHR and 3 AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague–Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy. | Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 2 | Blood Pressure Associated With Sleep-Disordered Breathing in a Population Sample of Children显示文摘 | Edward O. Bixler Alexandros N. Vgontzas Hung-Mo Lin Duanping Liao Susan Calhoun Fred Fedok Vukmir Vlasic Gavin Graff | 2008 | Hypertension2008，，5： | 1 |
| 3 | Relationship between carotid artery stiffness and retinal arteriolar narrowing in healthy middle-aged persons显示文摘 | Duanping liao Tien yin Wong Ronald Klein | 2004 | Stroke2004，35，4： | 1 |
| 4 | Adsorption behavior of herbicide butachlor on typical soils in China andhumic acids from the soil samples显示文摘 | Xu Duanping Xu Zhonghou Zhu Shuquan | 2005 | Journal of Colloid and Interface Science2005，285，2： | 1 |
| 5 | Relationship Between Carotid Artery Stiffness and Retinal Arteriolar Narrowing in Healthy Middle-Aged Persons显示文摘 | Duanping Liao Tien Yin Wong Ronald Klein Daniel Jones Larry Hubbard A. Richey Sharrett | 2004 | Stroke: Journal of the American Heart Association2004，，4： | 1 |
| 6 | Adsorption behavior of herbicide butachlor on typical soils in China and humic acids from the soil samples显示文摘 | Duanping Xu Zhonghou Xu Shuquan Zhu | 2005 | Journal of Colloid and Interface Science2005，，285： | 1 |
| 7 | Hypertension, Blood Pressure, and Heart Rate Variability: The Atherosclerosis Risk in Communities (ARIC) Study显示文摘 | Emily B. Schroeder Duanping Liao Lloyd E. Chambless Ronald J. Prineas Gregory W. Evans Gerardo Heiss | 2003 | Hypertension: Journal of The American Heart Association2003，，6： | 1 |
| 8 | relationship between carotid artery stiffness and retinal arteriolar narrowing in healthy middle-aged persons显示文摘 | Duanping Liao Tien Yin wong Ronald Klein | 2004 | Stroke2004，35，4： | 1 |
| 9 | PETROLEUM GEOLOGY AND RECOVERY EFFICIENCY显示文摘 | Wang Duanping | 2014 | 油气地质与采收率2014，21，2： | 0 |
| 10 | Recent progress in aptamer-based microfluidics for the detection of circulating tumor cells and extracellular vesicles显示文摘Liquid biopsy is a technology that exhibits potential to detect cancer early,monitor therapies,and predict cancer prognosis due to its unique characteristics,including noninvasive sampling and real-time analysis.Circulating tumor cells(CTCs)and extracellular vesicles(EVs)are two important components of circulating targets,carrying substantial disease-related molecular information and playing a key role in liquid biopsy.Aptamers are single-stranded oligonucleotides with superior affinity and specificity,and they can bind to targets by folding into unique tertiary structures.Aptamer-based microfluidic platforms offer new ways to enhance the purity and capture efficiency of CTCs and EVs by combining the advantages of microfluidic chips as isolation platforms and aptamers as recognition tools.In this review,we first briefly introduce some new strategies for aptamer discovery based on traditional and aptamer-based microfluidic approaches.Then,we subsequently summarize the progress of aptamer-based microfluidics for CTC and EV detection.Finally,we offer an outlook on the future directional challenges of aptamer-based microfluidics for circulating targets in clinical applications. | Duanping Sun Ying Ma Maoqiang Wu Zuanguang Chen Luyong Zhang Jing Lu | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 0 |
| 11 | PETROLEUM GEOLOGY AND RECOVERY EFFICIENCY显示文摘 | Wang Duanping | 2014 | 油气地质与采收率2014，21，4： | 0 |
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