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| 1 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 2 | UAV navigation in high dynamic environments:A deep reinforcement learning approach显示文摘Unmanned Aerial Vehicle(UAV) navigation is aimed at guiding a UAV to the desired destinations along a collision-free and efficient path without human interventions, and it plays a crucial role in autonomous missions in harsh environments. The recently emerging Deep Reinforcement Learning(DRL) methods have shown promise for addressing the UAV navigation problem,but most of these methods cannot converge due to the massive amounts of interactive data when a UAV is navigating in high dynamic environments, where there are numerous obstacles moving fast.In this work, we propose an improved DRL-based method to tackle these fundamental limitations.To be specific, we develop a distributed DRL framework to decompose the UAV navigation task into two simpler sub-tasks, each of which is solved through the designed Long Short-Term Memory(LSTM) based DRL network by using only part of the interactive data. Furthermore, a clipped DRL loss function is proposed to closely stack the two sub-solutions into one integral for the UAV navigation problem. Extensive simulation results are provided to corroborate the superiority of the proposed method in terms of the convergence and effectiveness compared with those of the state-of-the-art DRL methods. | Tong GUO Nan JIANG Biyue LI Xi ZHU Ya WANG Wenbo DU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 8 |
| 3 | Global Analysis of Gene Expression Profiles in Brassica napus Developing Seeds Reveals a Conserved Lipid Metabolism Regulation with Arabidopsis thaliana显示文摘以便学习 Brassica 马来麝丰满的酸(FA ) 新陈代谢和相关规章的网络,丰满的酸(FA ) 的系统的鉴定生合成相关的基因被进行。后面的基因鉴定,基因表示侧面在 B 期间。马来麝种子开发和 FA 新陈代谢被 cDNA 薄片杂交执行(> 从种子的 8000 EST 克隆) 。结果显示出那 FA 生合成和规定,和碳流动,在 B 之间被保存。马来麝和 Arabidopsis。然而,淀粉新陈代谢的一个更关键的角色为 B 被检测。马来麝种子 FA 新陈代谢和存储部件累积什么时候与 Arabidopsis 相比。另外,为 seed-to-sink 织物的转变的一个关键阶段是 1721 ? 在 flowering (DAF ) 以后的 d,而 FA 生合成相关的基因高度首先在 21 点被表示 ? DAF。发信号的荷尔蒙(植物生长素和 jasmonate ) 被发现为 FA 新陈代谢重要。这研究帮助在开发 B 揭示 FA 新陈代谢的全球规章的网络。马来麝种子。 | Ya Niu Guo-Zhang Wu Rui Ye Wen-Hui Lin Qiu-Ming Shi Liang-Jiao Xue Xiao-Dong Xu Yao Li Yu-Guang Du Hong-Wei Xue | 2009 | Molecular Plant2009，2，5： | 7 |
| 4 | Lipid analysis of three special nervonic acid resources in China显示文摘Nervonic acid plays an important role in nutrition and function of the human body.Malania oleifera,Acer truncatum and Xanthoceras sorbifolium are China’s unique woody plant rich in nervonic acid in seed oil.This study aims to investigate the lipid composition of these 3 special resources.Their fatty acids were detected by gas chromatography coupled with flame detector(GC-FID).Triglycerides(TAGs)and phospholipids(PLs)were detected by shotgun-mass spectrometry(shotgun-MS).Results showed that M.oleifera oil presented the highest level of nervonic acid(46.20±0.22%)among the 3 oils.Seeds oil of A.truncatum and X.sorbifolium had 3.53±0.20%and 1.83±0.21%nervonic acid respectively.53 species of TAGs and 15 species of PLs were identified in M.oleifera oil,with PLs content of 499.94±22.34μg/g.In A.truncatum oil,PL and TAG species were twice more than those in M.oleifera oil,and its’content of PLs was 76.27±3.21μg/g.In X.sorbifolium oil,75 TAGs and 34 PLs were detected,with the lowest PLs at 23.84±0.17μg/g.The results demonstrated that these 3 vegetable oils have great potential to become nervonic acid supplements for human health. | Xinghao Tu Jingya Wan Ya Xie Fang Wei Siewyoung Quek Xin Lv Liqing Du Hong Chen | 2020 | Oil Crop Science2020，5，4： | 7 |
| 5 | Three-dimensional Culture of Human Airway Epithelium in Matrigel for Evaluation of Human Rhinovirus C and Bocavirus Infections显示文摘Objective Newly identified human rhinovirus C(HRV-C) and human bocavirus(HBoV) cannot propagate in vitro in traditional cell culture models; thus obtaining knowledge about these viruses and developing related vaccines are difficult. Therefore, it is necessary to develop a novel platform for the propagation of these types of viruses. Methods A platform for culturing human airway epithelia in a three-dimensional(3 D) pattern using Matrigel as scaffold was developed. The features of 3 D culture were identified by immunochemical staining and transmission electron microscopy. Nucleic acid levels of HRV-C and HBoV in 3 D cells at designated time points were quantitated by real-time polymerase chain reaction(PCR). Levels of cytokines, whose secretion was induced by the viruses, were measured by ELISA. Results Properties of bronchial-like tissues, such as the expression of biomarkers CK5, ZO-1, and PCK, and the development of cilium-like protuberances indicative of the human respiration tract, were observed in 3 D-cultured human airway epithelial(HAE) cultures, but not in monolayer-cultured cells. Nucleic acid levels of HRV-C and HBoV and levels of virus-induced cytokines were also measured using the 3 D culture system. Conclusion Our data provide a preliminary indication that the 3 D culture model of primary epithelia using a Matrigel scaffold in vitro can be used to propagate HRV-C and HBoV. | CHEN Ya Xiong XIE Guang Cheng PAN Dong DU Ya Rong PANG Li Li SONG Jing Dong DUAN Zhao Jun HU Bu Rong | 2018 | Biomedical and Environmental Sciences2018，31，2： | 6 |
| 6 | Demographic Characteristics and Environmental Risk Factors Exposure of Birth Defects in Pregnant Women: A Population-based Study显示文摘Worldwide, the incidence of birth defects in low-income countries is 6.42%, while in middle-income and high-income countries it is 5.57% and 4.72%, respectively;approximately 303, 000 newborns die from birth defects each year. In China, the incidence of birth defects is about 5.6%, and around 8.14 million people have congenital disabilities, accounting for 9.6% of total disabled people[1]. Birth defect remains a major clinical and public health challenge because of its high fatality rate and protracted and severe sequela. | LIN Hong LUO Mi Yang LUO Jia You ZENG Rong LI Ya Mei DU Qi Yun FANG Jun Qun | 2019 | Biomedical and Environmental Sciences2019，32，1： | 5 |
| 7 | Hexagonal boron nitride nanosheet for effective ambient N2 fixation to NH3显示文摘Industrial production of NH3 from N2 and H2 significantly relies on Haber-Bosch process,which suffers from high energy consume and CO2 emission.As a sustainable and environmentally-benign alternative process,electrochemical artificial N2 fixation at ambient conditions,however,is highly required efficient electrocatalysts.In this study,we demonstrate that hexagonal boron nitride nanosheet (h-BNNS) is able to electrochemically catalyze N2 to NH3.In acidic solution,h-BNNS catalyst attains a high NH3 formation rate of 22.4 μg·h-1·mg-1cat.and a high Faradic efficiency of 4.7% at-0.75 V vs.reversible hydrogen electrode,with excellent stability and durability.Density functional theory calculations reveal that unsaturated boron at the edge site can activate inert N2 molecule and significantly reduce the energy barrier for NH3 fonmation. | Ya Zhang Huitong Du Yongjun Ma Lei Ji Haoran Guo Ziqi Tian Hongyu Chen Hong Huang Guanwei Cui Abdullah M. Asiri Fengli Qu Liang Chen Xuping Sun | 2019 | Nano Research2019，12，4： | 5 |
| 8 | Validation of the Simplified Chinese-character Version of the International Physical Activity Questionnaire-Long Form in Urban Community-dwelling Adults:a Cross-sectional Study in Hangzhou,China显示文摘Objective To assess the test-retest reliability and criterion validity of the Simplified Chinese-character version of the International Physical Activity Questionnaire Long form(IPAQ-L) in urban community-dwelling adults in Hanghzou,China.Methods A total of 158 eligible participants aged 25-59 years from 6 neighbourhoods in two central districts of Hangzhou completed the IPAQ-L questionnaire twice within a 7-day interval.Half of the subjects wore pedometers during the first 7 days.Test-retest reliability was examined by comparing the first(Day 1) and the second(Day 9) survey of IPAQ-L.Criterion validity was assessed by comparing IPAQ-L with pedometer data.Results Modest to good test-retest reliability was found with intraclass correlation coefficients of 0.67 for total PA,0.37 to 0.73 for specific dimensions,and 0.56 to 0.71 for different intensities of PA.Total PA measured by IPAQ-L was moderately correlated with exercise levels(partial r = 0.27,P = 0.020) and walking distance(partial r = 0.31,P = 0.007),which were measured by a pedometer,after adjusting for gender,age,educational attainment and employment status.Conclusion Our results indicate that the IPAQ-L is a reliable and validated measure for assessing physical activity levels in this population and possibly the adult population in other mainland Chinese cities. | REN Yan Jun SU Meng LIU Qing Min TAN Ya Yun DU Yu Kun LI Li Ming LYU Jun | 2017 | Biomedical and Environmental Sciences2017，30，4： | 4 |
| 9 | Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers显示文摘In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples. | Ya Li Qiang Fu Meng Liu Yuan-Yuan Jiao Wei Du Chong Yu Jing Liu Chun Chang Jian Lu | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 4 |
| 10 | Dynamical decoupling of electron spins in phosphorus-doped silicon显示文摘Quantum coherence is an important enabling feature underpinning quantum computation. However, because of couplings with its noisy surrounding environment, qubits suffer from the decoherence effects. The dynamical decoupling (DD) technique uses pulse-induced qubit flips to effectively mitigate couplings between qubits and environment. Optimal DD eliminates dephasing up to a given order with the minimum number of pulses. In this paper, we first introduce our recent work on prolonging electron spin coherence in γ-irradiated malonic acid crystals and analyze different decoherence mechanisms in this solid system. Then we focus on electron spin relaxation properties in another system, phosphorous-doped silicon (Si:P) crystals. These properties have been investigated by pulse electron paramagnetic resonance (EPR). We also investigate the performance of the dynamical decoupling technique on this system. Using 8-pulse periodic DD, the coherence time can be extended to 296 μs compared with 112 μs with one-pulse control. | RONG Xing WANG Ya YANG JiaHui ZHU JinXian XU WanJie FENG PengBo WEN XuJie SU JiHu DU JiangFeng | 2011 | Chinese Science Bulletin2011，56，7： | 4 |
| 11 | Preparation and performance of lipophilic α-zirconium phosphate with high thermal stability and its application in thermal-plastic polymers显示文摘To prepare lipophilic α-zirconium phosphate with high grafting ratio and thermal stability(OZrP-HT) and explore its potential application in thermal-plastic polymers,a novel method was developed by surface lipophilicity enhancement strategy.The commercial a-zirconium phosphate(a-ZrP) was pre-intercalated by n-propylamine(PA) and grafted by silane coupling agents.Then the pre-intercalated PA was removed by heattreatment,and the obtained OZrP-HT was utilized to fabricate the phosphorous-containing polyester(P-co-PET)/OZrP-HT nanocomposites by melt-blending method.The prepared OZrP-HT and P-co-PET/OZrP-HT nanocomposites were characterized by Wide Angle X-ray Diffraction(WAXD),Fourier Transform Infrared Spectroscopy(FTIR),Thermogravimetric Analysis(TGA),Transmission Electron Microscope(TEM),etc.The results show that OZrP-HT with high grafting ratio(13.78 wt%) and thermal stability(T_(onset)= 368℃) was successfully prepared via this novel method and was uniformly intercalated by P-co-PET molecular chains.OZrP-HT had no significant effect on the fiber processability of P-co-PET polymer,and flame retardant properties of(P-co-PET)/OZrP-HT nanocomposites were improved.This method may be suitable for organic modification of general inorganic layered compounds and could extend the potential applications in thermo-plastic polymers. | Ya Du Feng Deng Xiaoze Jiang Huquan Ji Dan Yu Wei Wang Bin Sun Meifang Zhu | 2015 | Progress in Natural Science:Materials International2015，25，5： | 3 |
| 12 | Single nucleotide polymorphisms in chicken lmbr1 gene were associated with chicken growth and carcass traits显示文摘Lmbr1 is the key candidate gene controlling vertebrate limb development, but its effects on animal growth and carcass traits have never been reported. In this experiment, lmbr1 was taken as the candi-date gene affecting chicken growth and carcass traits. T/C and G/A mutations located in exon 16 and one A/C mutation located in intron 5 of chicken lmbr1 were detected from Silky, White Plymouth Rock broilers and their F2 crossing chickens by PCR-SSCP and sequencing methods. The analysis of vari-ance (ANOVA) results suggests that T/C polymorphism of exon 16 had significant association with eviscerated yield rate (EYR), gizzard rate (GR), shank and claw rate (SCR) and shank girth (SG); A/C polymorphism of intron 5 was significantly associated with SCR, liver rate and head-neck weight (HNW), while both sites had no significant association with other growth and carcass traits. These results demonstrate that lmbr1 gene could be a genetic locus or linked to a major gene significantly affecting these growth and carcass traits in chicken. | HUANG YanQun1,2,3, DU XiaoHui2, DENG XueMei4, QIU XiangPin2, WANG ChunKao4, CHEN Wen3, LI Ning1 & WU ChangXin4 1 State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China 2 College of Animal Science, Sichuan Agricultural University, Ya’an 625014, China 3 College of Animal Husbandry and Veterinary, Henan Agricultural University, Zhengzhou 450002, China 4 College of Animal Science and Technology, China Agricultural University, Beijing 100094, China | 2007 | Science China(Life Sciences)2007，50，1： | 3 |
| 13 | Risk of Treatment Failure in Patients with Drug-susceptible Pulmonary Tuberculosis in China显示文摘The objective of this prospective study of the risks of treatment failure in patients with drug-susceptible pulmonary tuberculosis(PTB)was to provide reference data to help develop a disease control strategy.Participants were recruited in eight provinces of China from October 2008 to December2010.A total of 1447 patients with | WANG Ni MA Yan LIU YU Hong DU Jian ZHANG Hui XIE Shi Heng Zhu Kun LYU Xiao Ya SHU Wei WANG Hong Hong ZHU Guo Feng TAN Shou Yong FU Yan Yong MA Li Ping ZHANG Lian Ying LIU Fei Ying HU Dai Yu ZHANG Yan Ling LI Xiang Qun LI Liang | 2016 | Biomedical and Environmental Sciences2016，29，8： | 3 |
| 14 | Characterization of hematopoiesis in Dabry's sturgeon(Acipenser dabryanus)显示文摘The hematological indices of Dabry's sturgeon(Acipenser dabryanus)were investigated in this paper.The results showed that the count of Red blood cell(RBC)was(0.60±0.02)1012/L,and the blood glucose(GLU)was 9.32±1.00 mmol/L.Glutamic-pyruvic transaminase(ALT)and glutamic-oxalacetic transaminase(AST)were 13.75±6.65 U/L and 359.50±40.07 U/L,respectively.Smears of peripheral blood and imprints of four tissues were studied in the trial with Wright's staining method.The results indicated that Dabry's sturgeon's blood cells could be divided into five cell types,and included erythroid,granuloid,monocytoid,lymphoid and other cells.In addition,the developmental stage of each cell lineage could be subdivided into:primitive,young and mature.In the three developmental stages,the size of each cell type was similar and gradually decreased from primitive,young to mature blood cells.Among the blood cells,the monoblast and macrophage were the biggest,while the thrombocyte was the smallest.All stages of the primitive cells and young cells were observed in head kidney and all cell types,except granuloblasts,were identified in the head kidney.In contrast,primitive cells and young cells were not observed in the spleen or liver,and few orthochromatic erythroblasts were found in peripheral blood.It can be concluded that head kidney and trunk kidney are the primary organs of hematopoiesis in the Dabry's sturgeon. | Ya Liu Qing Xiao Song Yang Liulan Zhao Hongmei Fu Jun Du Zongjun Du Taiming Yan Hao Wu | 2017 | Aquaculture and Fisheries2017，2，6： | 2 |
| 15 | Deep-nanometer-scale terahertz spectroscopy using a transistor geometry with metal nanogap electrodes显示文摘Terahertz(THz)spectroscopy is a powerful tool for characterizing electronic properties and vibronic excitations in various types of solids,liquids,and gases,and it has been extensively used not only for basic science but also for industrial applications.Recently,it has become necessary to understand electronic and vibronic excitations at the nanometer(nm)scale to realize state-of-the-art quantum nanodevices and the synthesis of new molecules for medicine.However,it is challenging to perform THz spectroscopy at the nm scale because the diffraction limit of electromagnetic waves hinders tight focusing of THz radiation at the nm scale.Here,we introduce a novel technique for THz spectroscopy using metal nanogap electrodes.Metal nanogap electrodes integrated with a THz antenna are employed to capture sensing targets,such as a single semiconductor quantum dot(QD)or molecule.Even extremely weak THz absorption can be detected with high sensitivity by measuring the THz-induced photocurrent through the sensing target.Taking advantage of THz-induced photocurrent spectroscopy,the electronic structures in single QDs as well as the vibrational states in single molecules are systematically investigated.The present characterization technology for nm-scale systems provides a key scientific foundation for creating nanodevices with new functions. | Ya Zhang Shaoqing Du Kazuhiko Hirakawa | 2021 | Light(Advanced Manufacturing)2021，2，4： | 2 |
| 16 | A novel mutation in proprotein convertase subtilisin/kexin type 9 gene leads to familial hypercholesterolemia in a Chinese family显示文摘背景家庭血胆脂醇过多(FH ) 是与低密度脂蛋白(LDL ) 铺平导致早熟的冠的心疾病(CHD ) 的提高的血浆联系的正染色体的混乱。由于长期的 hyperlipemia, FH 病人将介绍 endarterium 变厚和动脉粥样硬化。在现在的学习,我们为可能的变化扫描了一个临床上诊断的正染色体的基因血胆脂醇过多家庭的相关基因并且建立了 proprotein convertase subtilisin/kexin 类型 9 的变化( PCSK9 )的真核细胞的表示向量有基因再结合的基因在低密度脂蛋白受体上调查变化的贡献的技术( LDL-R )新陈代谢和功能 alternation.Methods 变化察觉为 LDL-R 被进行, apolipoprotein B100 ( apoB10 野类型 PCSK9 基因(WT-PCSK9 ) 的全身的 cDNA 从 Bel-7402 被获得。地点 mutagenesis 被用来真核细胞的表示向量带建立 recombinant PCSK9 基因和插入的碎片的病原的类型被定序。与是的空白的向量控制, liposome transfection 方法习惯于 transfect 有 recombinant plasmid 的 Bel-7402 房间。LDL-R mRNA 的表示被 RT-PCR 检验。PCSK9 和 LDL-R 蛋白质的表示被西方的弄污决定。结果在 PCSK9 基因的 918 核苷酸的 GT 变化在 codon 由丝氨酸导致了精氨酸的替换 306 exon 6。在定序以后,确定的表示向量的插入的碎片有正确尺寸和顺序,异种高度在 Bel-7402 房间被表示,这被证实。在 LDL-R mRNA 的层次没有重要变化。在房间是由 WT-PCSK9 plasmid 的 transfected 以后, LDL-R 成熟蛋白质被 57% 减少。在房间是由变异的 R306S 的 transfected 以后,成熟 LDL-R 是由灰色的规模扫描证实了被12%显著地减少,建议新变异的 R306S 罐头显著地减少成熟 LDL-R protein.Conclusions 的表示 PCSK9 基因的一个新奇错误感觉变化, R306S ,被发现并且真核细胞的表示向量 PCSK9 变异、野类型基因被建立。在 LDL-R mRNA 的层次没有重要变化。R306S 变化能显著地导致 LDL-R 成熟蛋白质表示的减少,它可能是 FH 家庭的病原的基因。 | LIN Jie WANG Lu-ya LIU Shu WANG Xu-min YONG Qiang YANG Ya DU Lan-ping PAN Xiao-dong WANG Xu JIANG Zhi-sheng | 2010 | Chinese Medical Journal2010，，9： | 2 |
| 17 | The influence of quality characteristics of aquatic products on its price determination in China-A case of salmon products in supermarkets of Shanghai显示文摘The relationship between salmon prices and attributes were explored using the samples collected in supermarkets in Shanghai,China.The results showed that the price of the salmon did not have a significant relationship with the depth of orange color of salmon,unlike the results of stated preferences of western consumers in the previous studies.Whereas,smoked products had a positive relationship with price in the linear model form,and as the main importing country,Norway has the strongest positive relationship with price.In China salmon demand is expected to increase in future,salmon attributes highly appreciated in the market are different from western countries and salmon exporters need to recognize China as a special market for effective market. | Ya Du Xiaobo Lou Taro Oishi Yiyang Liu | 2020 | Aquaculture and Fisheries2020，5，6： | 2 |
| 18 | Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signalregulated kinase phosphorylation显示文摘BACKGROUND Liver fibrosis is a common health problem worldwide and there is still a lack of effective medicines.The Chinese herbal medicine,Gan Shen Fu Fang(GSFF)is composed of salvianolic acid B and diammonium glycyrrhizinate.In this study,we observed the effects of GSFF on liver fibrosis in vivo and in vitro in an attempt to provide some hope for the treatment.AIM To observe the effects of GSFF on liver fibrosis in vivo and in vitro and investigate the mechanism from the perspective of the inflammatory response and extracellular signal-regulated kinase(ERK)phosphorylation.METHODS Common bile duct-ligated rats were used for in vivo experiments.Hepatic stellate cells-T6(HSC-T6)cells were used for in vitro experiments.Hematoxylin and eosin staining and Masson staining,biochemical assays,hydroxyproline(Hyp)assays,enzyme-linked immunoasorbent assay and western blotting were performed to evaluate the degree of liver fibrosis,liver function,the inflammatory response and ERK phosphorylation.The CCK8 assay,immunofluorescence and western blotting were applied to test the effect of GSFF on HSC-T6 cell activation and determine whether GSFF had an effect on ERK phosphorylation in HSC-T6 cells.RESULTS GSFF improved liver function and inhibited liver fibrosis in common bile ductligated rats after 3 wk of treatment,as demonstrated by histological changes,hydroxyproline assays and collagen I concentrations.GSFF alleviated inflammatory cell infiltration and reduced the synthesis of pro-inflammatory cytokines[tumor necrosis factor-α(TNF-α)and interlukin-1β]and NF-κB.In addition,GSFF decreased ERK phosphorylation.In vitro,GSFF inhibited the viability of HSC-T6 cells with and without transforming growth factorβ1(TGF-β1)stimulation and decreased the synthesis of collagen I.GSFF had the greatest effect at a concentration of 0.5μmol/L.GSFF inhibited the expression ofα-smooth muscle actin(α-SMA),a marker of HSC activation,in HSC-T6 cells.Consistent with the in vivo results,GSFF also inhibited the phosphorylation of ERK and downregulated the expression of NF-κB.CONCLUSION GSFF inhibited liver fibrosis progression in vivo and HSC-T6 cell activation in vitro.These effects may be related to an alleviated inflammatory response and downregulated ERK phosphorylation. | Qing-Hong Du Chu-Jun Zhang Wei-Hong Li Yan Mu Ya Xu Scott Lowe Lin Han Xue Yu Shu-Yan Wang Yu Li Jian Li | 2020 | World Journal of Gastroenterology2020，26，21： | 2 |
| 19 | High-Performance 3-D Fiber Network Composite Electrolyte Enabled with Li-Ion Conducting Nanofibers and Amorphous PEO-Based Cross-Linked Polymer for Ambient All-Solid-State Lithium-Metal Batteries显示文摘Solid electrolytes have gained attention recently for the development of next-generation Li-ion batteries since they can fun-damentally improve the battery stability and safety.Among various types of solid electrolytes,composite solid electrolytes(CSEs)exhibit both high ionic conductivity and excellent interfacial contact with the electrodes.Incorporating active nanofib-ers into the polymer matrix demonstrates an effective method to fabricate CSEs.However,current CSEs based on traditional poly(ethylene oxide)(PEO)polymer suffer from the poor ionic conductivity of PEO and agglomeration effect of inorganic fillers at high concentrations,which limit further improvements in Li+conductivity and electrochemical stability.Herein,we synthesize a novel PEO based cross-linked polymer(CLP)as the polymer matrix with naturally amorphous structure and high room-temperature ionic conductivity of 2.40×10^(−4)S cm^(−1).Li_(0.3)La_(0.557)TiO_(3)(LLTO)nanofibers are incorporated into the CLP matrix to form composite solid electrolytes,achieving enhanced ionic conductivity without showing filler agglomeration.The high content of Li-conductive nanofibers improves the mechanical strength,ensures the conductive network,and increases the total Li+conductivity to 3.31×10^(−4)S cm^(−1).The all-solid-state Li|LiFePO_(4)batteries with LLTO nanofiber-incorporated CSEs are able to deliver attractive specific capacity of 147 mAh g^(−1)at room temperature,and no evident dendrite is found at the anode/electrolyte interface after 100 cycles. | Chaoyi Yan Pei Zhu Hao Jia Jiadeng Zhu R.Kalai Selvan Ya Li Xia Dong Zhuang Du Indunil Angunawela Nianqiang Wu Mahmut Dirican Xiangwu Zhang | 2019 | Advanced Fiber Materials2019，1，1： | 2 |
| 20 | The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes显示文摘 | Hong-Mei Wang Yun-Fei Xu Shang-Lei Ning Du-Xiao Yang Yi Li Yu-Jie Du Fan Yang Ya Zhang Nan Liang Wei Yao Ling-Li Zhang Li-Chuan Gu Cheng-Jiang Gao Qi Pang Yu-Xin Chen3 Kun-Hong Xiao Rong Ma Xiao Yu Jin-Peng Sun | 2014 | Cell Research2014，24，9： | 2 |
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