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| 1 | Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer显示文摘17β-hydroxysteroid dehydrogenase(17β-HSD)type 1 is known as a critical target to block the final step of estrogen production in estrogen-dependent breast cancer.Recent confirmation of the role of dyhydroxytestosterone(DHT)in counteracting estrogeninduced cell growth prompted us to study the reductive 17β-HSD type 7(17β-HSD7),which activates estrone while markedly inactivatingDHT.The role ofDHTin breast cancer cell proliferation isdemonstratedby its independent suppression of cell growthin the presence of a physiological concentration of estradiol(E2).Moreover,an integral analysis of a large number of clinical samples in Oncomine datasets demonstrated the overexpression of 17β-HSD7 in breast carcinoma.Inhibition of 17β-HSD7 in breast cancer cells resulted in a lower level of E2 and a higher level of DHT,successively induced regulation of cyclinD1,p21,Bcl-2,and Bik,consequently arrested cell cycle in the G0/G1 phase,and triggered apoptosis and auto-downregulation feedback of the enzyme.Such inhibition led to significant shrinkage of xenograft tumors with decreased cancer cell density and reduced 17β-HSD7 expression.Decreased plasma E2 and elevated plasma DHT levels were also found.Thus,the dual functional 17β-HSD7 is proposed as a novel target for estrogen-dependent breast cancer by regulating the balance of E2 andDHT.Thisdemonstrates aconceptual advance on the general belief that the major role of this enzyme is in cholesterol metabolism. | Xiaoqiang Wang Catherine Gérard Jean-Francois Thériault Donald Poirier Charles J.Doillon Sheng-Xiang Lin | 2015 | Journal of Molecular Cell Biology2015，7，6： | 2 |
| 2 | Conjunctival rotation autograft for pterygium: an alternative to conjunctival autografting显示文摘 | Jap A Chan C Lim L Donald TH | 1999 | Ophthalmology1999，106，： | 1 |
| 3 | Bibliometrics of electronic journals in information science显示文摘 | Donald TH | 2002 | Information Research2002，7，2： | 1 |
| 4 | Long-term occlusal and soft- tissue profile outcomes after treatthent of Class II Division 1 maloc- clusion with fixed appliances 显示文摘 | Niall JP Donald JB Orlagh TH | 2011 | Am J Orthod and DentofacialOrthop2011，139，3： | 1 |
| 5 | Hybrid submental flaps for reconstruction in the head and neck: part free显示文摘 | Hayden RE Nagel TH Donald CB | 2014 | Laryngoscope2014，124，3： | 1 |
| 6 | Corneal transplantation显示文摘 | Donald TH Tan John KG Dart Edward J Holland Shigeru Kinoshita | 2012 | The Lancet2012，，9827： | 1 |
| 7 | Oncologic safety of the submental flap for reconstruction in ot'al cavity malig- nancies 显示文摘 | Howard BE Nagel TH 'Donald CB | 2014 | Otolaryngol Head Neck Surg2014，150，4： | 1 |
| 8 | Expression of p63 in pterygium and normal conjunctiva显示文摘 | Pompilas Sakoonwatanyoo Donald TH Tan Duncan R Smith | 2004 | Cornea2004，23，1： | 1 |
| 9 | Ocular surface changes in pterygium显示文摘 | Cordelia ML Chan Yan Ping Liu Donald TH Tan | 2002 | Cornea2002，21，1： | 1 |
| 10 | Tan ocular surface changes in pterygium显示文摘 | ML Chan Liu YP Donald TH | 2002 | Cornea2002，21，： | 1 |
| 11 | Current concepts and techniques in pterygium treatment显示文摘 | Leonard PK Ang Jocelyn LL Chua Donald TH Tan | 2007 | Current Opinion in Ophthalmology2007，，4： | 1 |
| 12 | Corneal transplantation显示文摘 | Donald TH Tan John KG Dart Edward J Holland Shigeru Kinoshita | 2012 | The Lancet2012，，9827： | 1 |
| 13 | Therapeutic approaches for control of transcription factors in allergic disease 显示文摘 | Cousins DJ Mc Donald J Lec TH | 2008 | J Allergy Clin Immunol2008，121，4： | 1 |
| 14 | Oncologic safety of the submental flap for reconstruction in oral cavity malignancies 显示文摘 | Howard BE Nagel TH Donald CB | 2014 | Otolaryngol Head Neck Surg2014，150，4： | 1 |
| 15 | Oncologie Safety of the Submental Flap for Reconstruction in Oral Cavity Malignancies 显示文摘 | Howard BE Nagel TH Donald CB | 2014 | Otolaryngology Head and Neck Surgery2014，150，4： | 1 |
| 16 | Development of a conjunctival epithelial equivalent with improved preliferative properties using a multistep serum-free culture system显示文摘 | Leonard PK Donald TH Roger W | 2004 | Investigative Ophthalmology and Visual Science2004，45，6： | 1 |
| 17 | Clinical and microbial spectrum of fungal keratitis in Singapore: a 5-year retrospective study 显示文摘 | Wang TY Fong KS Donald TH | 1997 | Intern Ophthalmol1997，21，： | 1 |
| 18 | STABILITY OF NIANCHU RIVER AFTER REGULATION BYSTRAIGHTENING: A CASE STUDY FROM TIBET, CHINA显示文摘More than 200 km of levees were built along the Nianchu River in Tibet, China in the period 1978- 1982. The regulation involved a large number of cut-offs and straightening of meandering and braided reaches. This study focuses on the stability of the river, erosion of levees, and some particular sediment technical problems. Numerical model and physical models were employed in this study. Training approaches and strategies are suggested based upon field investigations and river stability analysis. | LIU Xingnian CAO Shuyou KNIGHT Donald W BAN Jiu (1 This study is supported by the joint key project of the National Natural Science Foundation and the Ministry of Water Resources China. No. 59890200 by the British Council, Red PEK\0992\296 and by th | 1999 | International Journal of Sediment Research1999，14，2： | 0 |
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