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| 1 | Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation显示文摘Regulatory T cells(Tregs)play a pivotal role in immune-tolerance,and loss of Treg function can lead to the development of autoimmunity.Natural Tregs generated in the thymus substantially contribute to the Treg pool in the periphery,where they suppress self-reactive effector T cells(Teff)responses.Recently,we showed that OX40L(TNFSF4)is able to drive selective proliferation of peripheral Tregs independent of canonical antigen presentation(CAP-independent)in the presence of low-dose IL-2.Therefore,we hypothesized that OX40 signaling might be integral to the TCR-independent phase of murine and human thymic Treg(tTreg)development.Development of tTregs is a two-step process:Strong T-cell receptor(TCR)signals in combination with co-signals from the TNFRSF members facilitate tTreg precursor selection,followed by a TCR-independent phase of tTreg development in which their maturation is driven by IL-2.Therefore,we investigated whether OX40 signaling could also play a critical role in the TCR-independent phase of tTreg development.OX40−/−mice had significantly reduced numbers of CD25−Foxp3low tTreg precursors and CD25+Foxp3+mature tTregs,while OX40L treatment of WT mice induced significant proliferation of these cell subsets.Relative to tTeff cells,OX40 was expressed at higher levels in both murine and human tTreg precursors and mature tTregs.In ex vivo cultures,OX40L increased tTreg maturation and induced CAP-independent proliferation of both murine and human tTregs,which was mediated through the activation of AKT-mTOR signaling.These novel findings show an evolutionarily conserved role for OX40 signaling in tTreg development and proliferation,and might enable the development of novel strategies to increase Tregs and suppress autoimmunity. | Prabhakaran Kumar Alejandra Marinelarena Divya Raghunathan Vandhana K Ragothaman Shikha Saini Palash Bhattacharya Jilao Fan Alan L Epstein Ajay V Maker Bellur S Prabhakar | 2019 | Cellular & Molecular Immunology2019，16，2： | 4 |
| 2 | A near-infrared squaraine dye as a latent ratiometric fluorophore for the detection of aminothiol content in blood plasma显示文摘 | Sreejith S Divya K P Ajayaghosh A | | 0，，41： | 1 |
| 3 | Biodegradationof cassava starch factory residue using a combination of cel-lulases,xylanases and hemicellulases显示文摘 | Divya Nair M P Padmaja G Moorthy S N | 2011 | Biomass and Bioen-ergy2011，35，3： | 1 |
| 4 | Correlation of the day 3 FSH/ LH ratio and LH concentration in predicting IVF outcome 显示文摘 | Prasad S Gupta T Divya A | 2013 | J Reprod Infertil2013，14，： | 1 |
| 5 | Effect of grid voltage and frequency variations on the output of wind generators显示文摘 | Nagendra Rao P S | 2008 | Electric Power Components and Systems2008，36，6： | 1 |
| 6 | Transgenie to- bacco and peanut plants expressing a mustard defensin show resistance to fungal pathogens显示文摘 | Swathi Anuradha T Divya K Jami S K | 2008 | Plant Cell Rep2008，27，11： | 1 |
| 7 | Carbonyl sulfide removal with compost and wood chip biofilters, and in the presence of hydrogen sulfide显示文摘 | Melanie L S Divya R G Chandraprakash S N | 2009 | Journal of the Air & Waste Management Association2009，59，12： | 1 |
| 8 | Identifying theage cohort responsible for transmission in a natural outbreak of Bor-detella bronchiseptica显示文摘 | GRAINNE H L DIVYA S ANDREW F R | 2010 | PLoS Pathogens2010，6，12： | 1 |
| 9 | Structral basis of heparin bingding to camel peptidoglycan recognition protein-S显示文摘 | Pradeep S Divya D Mau S | 2012 | Int J Biochem Mol Biol2012，3，1： | 1 |
| 10 | Strength, permeability and microstructure of self-compacting concrete containing rice husk ash 显示文摘 | Divya C Rafat S Kunal | 2015 | Biosystemsengineering2015，30，： | 1 |
| 11 | Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape 显示文摘 | Amber L J Hwajin K Divya S etal | | Proc Natl Acad Sci U S A0，，： | 1 |
| 12 | Kinetic and Equilibrium Characterization of Uranium (Ⅳ)Adsorption Onto Carboxylate-Functionalized PolyGrafted Lignocellulosics显示文摘 | Anirudhan T S Divya L Suchithra P S | | 0，，： | 1 |
| 13 | Medicinal and biological significance of quinazoline:a highly important scaffold for drug discovery:a review 显示文摘 | MANJULA S N BHARAT E N DIVYA B | 2011 | Int J Pharm Bio Sci2011，2，1： | 1 |
| 14 | Correlation of the day 3 FSH/LH ratio and LH concentration in predicting IVF outcome显示文摘 | Prasad S Gupta T Divya A | 2013 | J Reprod Infertil2013，14，1： | 1 |
| 15 | A novel AGC simulation scheme based on reduced order prime mover models显示文摘 | Divya K C Nagendra Rao P S | 2003 | Control Systems and Applications2003，3，： | 1 |
| 16 | Cissus quadrangularis extract attenuates hyperglycaemia- mediated oxidative stress in streptozotocin-induced diabetic rats显示文摘 | Lekshmi RK Divya BT Mini S | 2014 | Redox Rep2014，19，5： | 1 |
| 17 | Cloning and characterization of truncated crylAb gene from a new in- digenous isolate of Bacillus thuringiensis 显示文摘 | Darsi S Divya Prakash G Udayasuriyan V | 2010 | Biotechnol Lett2010，32，9： | 1 |
| 18 | Production of polygalacturonase by immobilized cells of Aspergillus niger using orange peel as inducer显示文摘 | Sadhana N Yashdeep P Divya S | 2006 | Process Biochemistry2006，41，： | 1 |
| 19 | Kinetic and equilibrium characterization of uranium(Ⅵ) adsorption onto carboxylate-functionalized poly (hydroxyethylmethacrylate) -grafted lignocellulosics显示文摘 | Anirudhan T S Divya L Suchithra P S | 2009 | J Environmental Management2009，90，1： | 1 |
| 20 | Enhanced Th2 immuni- ty after DNA prime -protein boost immunization with am- yloid beta (1 -42 ) plus CpG oligodeoxynucleotides in aged rats 显示文摘 | Subramanian S Divya Shree AN | 2008 | Neurosci Lett2008，436，2： | 1 |
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