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| 1 | Transcatheter aortic valve replacement and stroke: a comprehensive review显示文摘Transcatheter 大动脉的阀门培植(TAVR ) 与严重大动脉的狭窄和高外科的风险为病人作为一种其他的、很快演变的治疗选择出现了。此后摸破坏复杂并发症主要在 periprocedural 和 30 天的时期追随者 TAVR 正在被限制,与更低、相对经常的频率。早击在过程期间主要由于碎片 embolization,而以后的事件与耐心的特定的因素被联系。尽管临床的击的率常常与起始的 TAVR 经验相比一直在减少,有 MRI 的现代 neuro 成像建议新 ischemic 损害 post-TAVR 是几乎通用的。后者的影响大部分是未知的。然而,他们似乎在 neurocognitive 功能与减小相关。因为 TAVR 被设置扩展它的指示降低外科风险的病人,摸预防在期间并且在 TAVR 以后降临到首要的重要性。基于临床并且 pathophysiological 证据,研究的三根线活跃地向这个方向被采用:在有到有钙化的大动脉的拱门的还原剂操作和接触的一个目的阀门和本国的阀门, antithrombotic 治疗,和插子的保护设备的改进。小心的耐心的选择,过程的设计,和尊重这张易碎的人口的流血风险的定制的 antithrombotic 策略对击追随者 TAVR 组成主要防卫。 | Periklis A Davlouros Virginia C Mplani Ioanna Koniari Grigorios Tsigkas George Hahalis | 2018 | Journal of Geriatric Cardiology2018，15，1： | 7 |
| 2 | Small bowel ulcerative lesions are common in elderly NSAIDs users with peptic ulcer bleeding显示文摘AIM: To determine the frequency of small bowel ulcerative lesions in patients with peptic ulcer and define the significance of those lesions. METHODS: In our prospective study, 60 consecutive elderly patients with upper gastrointestinal bleeding from a peptic ulceration(cases) and 60 matched patients with a non-bleeding peptic ulcer(controls) underwent small bowel capsule endoscopy, after a negative colonoscopy(compulsory in our institution). Controls were evaluated for non-bleeding indications. Known or suspected chronic inflammatory conditions and medication that could harm the gut were excluded. During capsule endoscopy, small bowel ulcerative lesions were counted thoroughly and classified according to Graham classification. Other small bowellesions were also recorded. Peptic ulcer bleeding was controlled endoscopically, when adequate, proton pump inhibitors were started in both cases and controls, and Helicobacter pylori eradicated whenever present. Both cases and controls were followed up for a year. In case of bleeding recurrence upper gastrointestinal endoscopy was repeated and whenever it remained unexplained it was followed by repeat colonoscopy and capsule endoscopy.RESULTS: Forty(67%) cases and 18(30%) controls presented small bowel erosions(P = 0.0001), while 22(37%) cases and 4(8%) controls presented small bowel ulcers(P < 0.0001). Among non-steroidal antiinflammatory drug(NSAID) consumers, 39(95%) cases and 17(33%) controls presented small bowel erosions(P < 0.0001), while 22(55%) cases and 4(10%) controls presented small bowel ulcers(P < 0.0001). Small bowel ulcerative lesions were infrequent among patients not consuming NSAIDs. Mean entry hemoglobin was 9.3(SD = 1.4) g/d L in cases with small bowel ulcerative lesions and 10.5(SD = 1.3) g/dL in those without(P = 0.002). Cases with small bowel ulcers necessitate more units of packed red blood cells. During their hospitalization, 6(27%) cases with small bowel ulcers presented bleeding recurrence most possibly attributed to small bowel ulcers, nevertheless 30-d mortality was zero. Presence of chronic obstructive lung disease and diabetes was related with unexplained recurrence of hemorrhage in logistic regression analysis, while absence of small bowel ulcers was protective(relative risk 0.13, P = 0.05).CONCLUSION: Among NSAID consumers, more bleeders than non-bleeders with peptic ulcers present small bowel ulcers; lesions related to more severe bleeding and unexplained episodes of bleeding recurrence. | Panagiotis Tsibouris Chissostomos Kalantzis Periklis Apostolopoulos Antonios Zalonis Peter Edward Thomas Isaacs Mark Hendrickse Georgios Alexandrakis | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 6 |
| 3 | Capsule endoscopy retention as a helpful tool in the management of a young patient with suspected small-bowel disease显示文摘Capsule endoscopy is an easy and painless procedure permitting visualization of the entire small-bowel during its normal peristalsis. However, important problems exist concerning capsule retention in patients at risk of small bowel obstruction. The present report describes a young patient who had recurrent episodes of overt gastrointestinal bleeding of obscure origin, 18 years after small bowel resection in infancy for ileal atresia. Capsule endoscopy was performed, resulting in capsule retention in the distal small bowel. However, this event contributed to patient management by clearly identifying the site of obstruction and can be used to guide surgical intervention, where an anastomotic ulcer is identified. | Chryssostomos Kalantzis Periklis Apostolopoulos Panagiota Mavrogiannis Dimitrios Theodorou Xenophon Papaharalampous Ioannis Bramis Nikolaos Kalantzis | 2007 | World Journal of Gastroenterology2007，13，8： | 5 |
| 4 | Tregs and kidney: From diabetic nephropathy to renal transplantation显示文摘Kidney transplantation is recognised as the most effective treatment for patients with end-stage renal disease(ESRD). Kidney transplantation continues to face several challenges including long-term graft and patient survival, and the side effects of immunosuppressive therapy. The tendency in kidney transplantation is to avoid the side effects of immunosuppresants and induce immune tolerance. Regulatory T-cells(Tregs) contribute to self-tolerance, tolerance to alloantigen and transplant tolerance, mainly by suppressing the activation and function of reactive effector T-cells. Additionally, Tregs are implicated in the pathogenesis of diabetes, which is the leading cause of ESRD, suggesting that these cells play a role both in the pathogenesis of chronic kidney disease and the induction of transplant tolerance. Several strategies to achieve immunological tolerance to grafts have been tested experimentally, and include combinations of co-stimulatory blockade pathways, T-cell depletion, in vivo Treg-induction and/or infusion of exvivo expanded Tregs. However, a successful regimen that induces transplant tolerance is not yet available for clinical application. This review brings together certain key studies on the role of Tregs in ESRD, diabetes and kidney transplantation, only to emphasize that many more studies are needed to elucidate the clinical significance and the therapeutic applications of Tregs. | Periklis Dousdampanis Kostantina Trigka Athanasia Mouzaki | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 5 | 结肠的腺癌和麦芽淋巴瘤的同时的出现: 一系列三个盒子显示文摘 Simultaneous development of adenocarcinoma and primary B cell lymphoma of mucosa-associated lymphoid tissue(MALT) lymphoma of the colon is rare;only one case has so far been reported out of 13 cases with the coexistence of colonic adenocarcinoma with involvement of the colon by lymphoma.We hereby present three more cases,two females(aged 75 and 71 years) and a male(aged 72 years).All three underwent colectomy based on a preoperative biopsy revealing colonic carcinoma.Histological examination of the resection specimens disclosed a colonic adenocarcinoma in two cases,whereas a tubulovillous adenoma with superficial foci of intraepithelial adenocarcinoma was seen in the thirdcase.Moreover,in all three cases,a coexisting MALT lymphoma was diagnosed in the colon(1 case),in both colon and adjacent lymph nodes(1 case) or in colonic lymph nodes and omentum(1 case).In the last case,a post-operative bone marrow biopsy revealed extensive infiltration of the bone marrow,due to which the patient received postoperative chemotherapy.Diagnostic and treatment issues are briefly discussed. | Theodoros Argyropoulos Periklis Foukas Maria Kefala Panagiotis Xylardistos Sotirios Papageorgiou Nikolaos Machairas Evmorfia Boltetsou Anastasios Machairas Ioannis G Panayiotides | 2012 | World Journal of Gastrointestinal Oncology2012，4，4： | 4 |
| 6 | Evaluation of capsule endoscopy in active, mild-to-moderate, overt, obscure GI bleeding <ce:link locator='fx1'/>显示文摘 | Periklis Apostolopoulos Christos Liatsos Ian M. Gralnek Chrissostomos Kalantzis Eleftheria Giannakoulopoulou Georgios Alexandrakis Panagiotis Tsibouris Evagelos Kalafatis Nikolaos Kalantzis | 2007 | Gastrointestinal Endoscopy2007，，6： | 3 |
| 7 | Transcatheter versus surgical aortic valve replacement in severe, symptomatic aortic stenosis显示文摘大动脉的狭窄(作为) 是瓣膜的心疾病在的最普通的类型老。外科的大动脉的阀门代替(SAVR ) 是为对待的标准实践严重、作为征兆,却最近新治疗选择出现了。Transcatheter 大动脉的阀门代替(TAVR ) 现在是在在高外科的风险的病人的一种确定的治疗选择。在这评论,我们集中于最近的开发并且以功效和安全在特定的人口比较二个治疗方法(例如在有优先的胸的外科的历史的病人,采用的麻醉打字,存取使用的地点或为永久踱步需要) 。comorbidities (肺的高血压,动脉的高血压和肥胖悖论) 的影响,在象应得进一步的调查的问题一样的 transcatheter 阀门技术的 TAVR 对 SAVR 和进展的划算进一步被讨论。而且,在不同风险范畴(极其高、高、中间、低的风险) 的病人的 TAVR 的结果和复杂并发症被分析。我们强烈相信在下列年期间, TAVR 可以在病人的一个更宽广的组作为选择的治疗演变与与中间、高风险的特征作为并且在那些以外征兆。 | Tsigkas Grigorios Despotopoulos Stefanos Makris Athanasios Koniari Ioanna Armylagos Stylianos Davlouros Periklis Hahalis George | 2018 | Journal of Geriatric Cardiology2018，15，1： | 2 |
| 8 | Emergence, development, and future of cardio-oncology in China: cardiohypersensitivity, cardiotoxicity and the Kounis syndrome显示文摘To the Editor:Cancer and cardiovascular disease constitute the two major causes of death worldwide. Whereas the incidence of cancer increases among adults up to 74 years of age, above this age the cardiovascular disease surpasses cancer as the primary cause of mortality.[1] Currently, chemotherapy, radiation therapy, and surgery are the main modalities for the treatment of cancer. However, chemotherapy can induce cardiovascular worsening, manifesting as acute and chronic symptomatology. Therefore, the verv interesting report published in Chinese Medical Journal[2] concerning a 60-year-old male patient suffering from coronary artery disease and squamous cell carcinoma of the left lung who developed an ST segment elevation myocardial infarction following treatment with afatinib (tyrosine kinase inhibitor) and gemcitabine (antimetabolite pyrimidine antagonist) and cisplatin (platinum based DNA replication inhibitor) and the subsequent discussion raise several important considerations on cardiac toxicity, cardiac hypersensitivity and the Kounis-hypersensitivity acute coronary syndrome. | Nicholas G. Kounis Ioanna Koniari Panagiotis Plotas George D. Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2019 | Chinese Medical Journal2019，，6： | 2 |
| 9 | Kounis syndrome caused by double allergens: the more allergens present, the easier, the quicker, and the more severe the anaphylaxis显示文摘To the Editor:In the very interesting report published in the Chinese Medical Journal,[1] a 42-year-old Chinese male patient who had not any previous history of cardiovascular disease,but only bee stings without any sequelae,was stung again while was cycling outdoors. | Nicholas G.Kounis Ioanna Koniari Panagiotis Plotas George D.Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2020 | Chinese Medical Journal2020，，15： | 2 |
| 10 | Acute Myocardial Infarction Induced by Anaphylaxis in China: The Kounis Syndrome显示文摘 | Nicholas G Kounis Ioanna Koniari Emmanouil Chourdakis George D Soufras Grigorios Tsigkas Periklis Davlouros George Hahalis | 2018 | Chinese Medical Journal2018，，19： | 2 |
| 11 | Intravitreal Adalimumab for Refractory Uveitis-Related Macular Edema显示文摘 | Sofia Androudi Evangelia Tsironi Christos Kalogeropoulos Athina Theodoridou Periklis Brazitikos | 2010 | Ophthalmology2010，，8： | 1 |
| 12 | Diffusion tensor and dynamic susceptibility contrast MRI in glioblastoma显示文摘 | Anastasia K. Zikou George A. Alexiou Paraskevi Kosta Ann Goussia Loukas Astrakas Periklis Tsekeris Spyridon Voulgaris Vasiliki Malamou-Mitsi Athanasios P. Kyritsis Maria I. Argyropoulou | 2011 | Clinical Neurology and Neurosurgery2011，，6： | 1 |
| 13 | Effects of immediate loading with threaded hydrox- yapatite- coated root-form implants on single premolar replacements: a preliminary report显示文摘 | Periklis P Kan J Lozada | 2002 | Int J Oral Maxillofac Implants2002，17，4： | 1 |
| 14 | Mechano-Electrical Interaction Late After Fontan Operation: Relation Between P-Wave Duration and Dispersion, Right Atrial Size, and Atrial Arrhythmias显示文摘 | Tom Wong Periklis A. Davlouros Wei Li Catherine Millington-Sanders Darrel P. Francis Michael A. Gatzoulis | 2004 | Circulation: Journal of the American Heart Association2004，，19： | 1 |
| 15 | A grating-based OCDMA coding-decoding system incorporating a nonlinear optical loop mirror for improved code recognition and noise reduction显示文摘 | LEE Ju Han TEH Peh Chiong PERIKLIS Petropoulos | 2002 | Journal of Lightwave Technology2002，20，1： | 1 |
| 16 | A dose escalation and pharmacokinetic study of the biweekly administration of paclitaxel, gemcitabine and oxaliplatin in patients with advanced solid tumors显示文摘 | Zacharenia Saridaki Periklis Pappas John Souglakos | 2010 | Cancer Chemotherapy and Pharmacology2010，65，1： | 1 |
| 17 | Farming and wildlife in Mediterranean agroecosystems显示文摘 | Christos K. Sokos Andreas P. Mamolos Kiriaki L. Kalburtji Periklis K. Birtsas | 2012 | Journal for Nature Conservation2012，，： | 1 |
| 18 | Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence显示文摘Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Plateletrich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application. | Eleftherios Spartalis Periklis Tomos Demetrios Moris Antonios Athanasiou Charalampos Markakis Michael D Spartalis Theodore Troupis Dimitrios Dimitroulis Despina Perrea | 2015 | World Journal of Cardiology2015，7，10： | 1 |
| 19 | A comparative study of the performance of seven and 63-chip optical code-division multiple-access encoders and decoders based on superstructured fiber Bragg gratings显示文摘 | Peh Chiong Teh Periklis Petropoulos Morten lbsen | 2001 | Journal ofLightwave Technology2001，19，19： | 1 |
| 20 | Interleukin-6 and the matrix metalloproteinase response in the vitreous during proliferative vitreoretinopathy显示文摘 | Chrysanthos Symeonidis Eleni Papakonstantinou Sofia Androudi Tryfon Rotsos Eudoxia Diza Periklis Brazitikos George Karakiulakis Stavros A. Dimitrakos | 2011 | Cytokine2011，，2： | 1 |
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