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| 1 | Helicobacter pylori and autoimmune disease:Cause or bystander显示文摘Helicobacter pylori(H.pylori)is the main cause of chronic gastritis and a major risk factor for gastric cancer.This pathogen has also been considered a potential trigger of gastric autoimmunity,and in particular of autoimmune gastritis.However,a considerable number of reports have attempted to link H.pylori infection with the development of extra-gastrointestinal autoimmune disorders,affecting organs not immediately relevant to the stomach.This review discusses the current evidence in support or against the role of H.pylori as a potential trigger of autoimmune rheumatic and skin diseases,as well as organ specific autoimmune diseases.We discuss epidemiological,serological,immunological and experimental evidence associating this pathogen with autoimmune diseases.Although over one hundred autoimmune diseases have been investigated in relation to H.pylori,we discuss a select number of papers with a larger literature base,and include Sj grens syndrome,rheumatoid arthritis,systemic lupus erythematosus,vasculitides,autoimmune skin conditions,idiopathic thrombocytopenic purpura,autoimmune thyroid disease,multiple sclerosis,neuromyelitis optica and autoimmune liver diseases.Specific mention is given to those studies reporting an association of anti-H.pylori antibodies with the presence of autoimmune disease-specific clinical parameters,as well as those failing to find such associations.We also provide helpful hints for future research. | Daniel S Smyk Andreas L Koutsoumpas Maria G Myt-ilinaiou Eirini I Rigopoulou Lazaros I Sakkas Dimitrios P Bogdanos | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 2 | Cartilage oligomeric matrix protein: A novel non-invasive marker for assessing cirrhosis and risk of hepatocellular carcinoma显示文摘AIM: To assess serum cartilage oligomeric matrix protein(COMP) as a marker of cirrhosis and risk of progression to hepatocellular carcinoma(HCC). METHODS: A COMP enzyme-linked immunosorbentassay was used to test 187 patients with chronic liver diseases at the time point of first evaluation. The selected patients included 72 with chronic hepatitis B infection, 75 with chronic hepatitis C infection, 22 with primary biliary cirrhosis, 7 with autoimmune hepatitis type 1, and 11 with alcoholic liver disease. Demographic, biochemical, histological and clinical characteristics of the patients were recorded at the first evaluation. One hundred and forty-seven patients were followed for a median [interquartile range(IQR)] duration of 96.5(102) mo. The clinical, biochemical and histological data, as well as the development of cirrhosis, HCC according to internationally accepted criteria and in case of death, a liver-related cause during the follow-up period, were recorded at the electronic database of our clinic. COMP determination was also performed in 43 healthy individuals who served as the control study group.RESULTS: COMP positivity(> 15 U/L) was detected in 22%-36% among chronic liver disease groups. Strikingly, almost 83% of COMP-positive patients were cirrhotic at baseline, independently of cause of liver disease. Among the patients who developed HCC during follow-up, 73.7%(14/19) were COMP positive at baseline. COMP positivity was significantly associated with older age(P < 0.001), advanced fibrosis(P = 0.001) and necroinflammatory activity(P = 0.001), higher aspartate aminotransferase(P < 0.001), alanine aminotransferase(P < 0.02), γ-glutamyl transpeptidase(P = 0.003), alkaline phosphatase(P = 0.001), bilirubin(P < 0.05), international normalized ratio(P = 0.002) and alpha-fetoprotein levels(P < 0.02), and lower albumin(P < 0.001), and platelet count(P = 0.008). COMP levels [median(IQR)] were significantly higher in cirrhotics compared to non-cirrhotics [13.8(7.9) U/L vs 9.8(4.6) U/L, respectively; P < 0.001]. On multivariate logistic regression analysis, COMP-positivity was independently associated only with cirrhosis(OR = 4.40, 95%CI: 1.33-14.69, P = 0.015). Kaplan-Meier analysis showed that COMP positivity was significantly associated with HCC development(P = 0.007) and higher incidence of liver-related death(P < 0.001). CONCLUSION: Elevated COMP levels are strongly associated with cirrhosis and HCC progression. Serum COMP is a new promising non-invasive biomarker for HCC risk assessment in surveillance programs. | Gary L Norman Nikolaos K Gatselis Zakera Shums Christos Liaskos Dimitrios P Bogdanos George K Koukoulis George N Dalekos | 2015 | World Journal of Hepatology2015，7，14： | 7 |
| 3 | Breast cancerfollowing diethylstilbestrol exposure in utero: insights from a tragedy显示文摘 | Hans O A Pagona L Dimitrios T | 2012 | European Journal of Epidemiology2012，27，1： | 1 |
| 4 | The in vivo role of p38MAP kinases in cardiac remodeling and restrictive cardiomyopathy显示文摘 | Pu L Dimitrios G Attila K | 2001 | Proc Natl Acad Sci USA2001，98，12： | 1 |
| 5 | A note on the phase locking value and its properties 显示文摘 | Sergul A Dimitrios P Richsard M L | 2013 | Neuroimage2013，74，1： | 1 |
| 6 | The safety and immunogenicity of an in ovo vaccine against newcastle disease virus differ between two lines of chicken显示文摘 | Dimitrios D Chen C L Pete K | 2007 | Vaccine2007，25，： | 1 |
| 7 | Breast cancer following diethylstilbestrol exposure in utero: insights from a tragedy 显示文摘 | Hanso A Pagona L Dimitrios T | 2012 | European Joumal of Epidemiology2012，27，1： | 1 |
| 8 | Plasma neutrophil gelatinase-associated lipocalin(NGAL)as an early predic- tive marker of contrast-induced nephropathy in hospital- ized patients undergoing computed tomography显示文摘 | Vassilis F Dimitra B Dimitrios L | 2013 | Clin Kidney J2013，6，6： | 1 |
| 9 | Design and experimental verification of an innovative steel-concrete composite beam显示文摘 | Dimitrios P Jean-Paul L | 2014 | Journal of Constructional Steel Research2014，93，6： | 1 |
| 10 | Communication and controller design for networked control systems显示文摘 | Zhang L Dimitrios H V | 2006 | Automatica2006，42，6： | 1 |
| 11 | New World Record Efficiency for Cu ( In, Ga) SO2 Thin-film Solar Ceils beyond 20% 显示文摘 | Philip J Dimitrios H Erwin L | 2011 | Progress in Photovoltaics : Research and Applications2011，19，7： | 1 |
| 12 | The p53 protein and its molecular network: modelling a missing Link between DNA damage and cell fate显示文摘 | Elia J Dimitrio L Clairambault J | 2014 | Biochim Biophys Acta2014，1844，1： | 1 |
| 13 | The electrostatic nature of C3d-complement receptor 2 association显示文摘 | Dimitrios M John D L | 2004 | J Immunol2004，172，： | 1 |
| 14 | Breast cancer following diethylsfilbestrol exposure in utero: insights from a tragedy显示文摘 | Hans OA Pagona L Dimitrios T | 2012 | European Journal of Epidemiology2012，27，1： | 1 |
| 15 | Communication and control co-design for networked control systems 显示文摘 | Zhang L Dimitrios H V | 2006 | Automatica2006，42，6： | 1 |
| 16 | Progress in Tourism Management : A Review of Website Evaluation in Tourism Research 显示文摘 | Rob L Shanshan Q Dimitrios B | 2010 | Tourism Management2010，，31： | 1 |
| 17 | The p53 protein and its molecular network:modelling a missing link between DNA damage and cell fate显示文摘 | Elias J Dimitrio L Clairambault J | 2014 | Biochim Biophys Acta2014，1844，1： | 1 |
| 18 | New world record effi- ciency for Cu(In,Ga)Se2 thin films solar cells beyond 20%显示文摘 | PHILIP J DIMITRIOS H ERWIN L | 2011 | Prog Photovolt Res Appl2011，19，7： | 1 |
| 19 | Automated pressure ulcer lesion diagnosis for telemedicine systems显示文摘 | Dimitrios I Kosmopoulo S Fotini L | | 0，，05： | 1 |
| 20 | Use o# a diathermy system in thyroid surgery显示文摘 | Kiriakopoulos A Dimitrios T Dimitrios L | 2004 | Arch Surg2004，139，9： | 1 |
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